SCI时时刷

search
Novel 4-triazole phenyl amide (4-TPA) molecules: Potent promoters of α-synuclein fibril disassembly
Novel 4-triazole phenyl amide (4-TPA) molecules: Potent promoters of α-synuclein fibril disassembly
With the progressive demographic shift toward an aging population, the incidence of neurodegenerative diseases among the e...
Discovery of novel small molecules targeting the USP21/JAK2/STAT3 axis for the treatment of triple-negative breast cancer
Discovery of novel small molecules targeting the USP21/JAK2/STAT3 axis for the treatment of triple-negative breast cancer
Breast cancer incidence is the highest incidence of malignant tumors globally [1]. Surgery, chemotherapy, radiotherapy, an...
Piezo1 and its inhibitors: Overview and perspectives
Piezo1 and its inhibitors: Overview and perspectives
The cation channel Piezo1, a crucial mechanotransducer found in various organs and tissues, has gained considerable attent...
Molecular engineering design of twisted-backbone pure Type-I organic photosensitizers for hypoxic photodynamic therapy
Molecular engineering design of twisted-backbone pure Type-I organic photosensitizers for hypoxic photodynamic therapy
Cancer is a fatal disease that causes mass mortality every year. The most common-used therapeutics, such as surgery, chemo...
Discovery of novel EGFR-PROTACs capable of degradation of multiple EGFR-mutated proteins
Discovery of novel EGFR-PROTACs capable of degradation of multiple EGFR-mutated proteins
The latest global cancer report disclosed that there were over 20 million newly diagnosed cancer cases and more than 10 mi...
Discovery of an efficacious KDM5B PROTAC degrader GT-653 up-regulating IFN response genes in prostate cancer
Discovery of an efficacious KDM5B PROTAC degrader GT-653 up-regulating IFN response genes in prostate cancer
The role of genetic abnormalities in cancer development has been recognized for a long time, but more recent studies have ...
Analogues of the pan-selectin antagonist rivipansel (GMI-1070)
Analogues of the pan-selectin antagonist rivipansel (GMI-1070)
The selectin family consisting of E−, P- and L-selectin plays dominant roles in atherosclerosis, ischemia-reperfusion inju...
Development of novel N-aryl-2,4-bithiazole-2-amine-based CYP1B1 degraders for reversing drug resistance
Development of novel N-aryl-2,4-bithiazole-2-amine-based CYP1B1 degraders for reversing drug resistance
Non-small cell lung cancer (NSCLC) poses a significant threat to human health due to its high morbidity and poor prognosis...
Dihydroxanthene-based monoamine oxidase A-activated photosensitizers for photodynamic/photothermal therapy of tumors
Dihydroxanthene-based monoamine oxidase A-activated photosensitizers for photodynamic/photothermal therapy of tumors
Accurate tumor diagnosis is essential since cancer is an exceptionally aggressive illness with a high morbidity and death ...
Recent advances in c-Met-based dual inhibitors in the treatment of cancers
Recent advances in c-Met-based dual inhibitors in the treatment of cancers
Cancer is a hazardous and lethal disease that affects millions of people worldwide. According to the American Cancer Socie...
Recent discovery and development of AXL inhibitors as antitumor agents
Recent discovery and development of AXL inhibitors as antitumor agents
AXL, a receptor tyrosine kinase encoded by the AXL gene, is a member of the TAM (TYRO3, AXL and MER) family and is renowne...
Preferential HDAC6 inhibitors derived from HPOB exhibit synergistic antileukemia activity in combination with decitabine
Preferential HDAC6 inhibitors derived from HPOB exhibit synergistic antileukemia activity in combination with decitabine
Histone deacetylase 6 (HDAC6) is an emerging drug target to treat oncological and non-oncological conditions. Since highly...
Antiviral drug discovery: Pyrimidine entry inhibitors for Zika and dengue viruses
Antiviral drug discovery: Pyrimidine entry inhibitors for Zika and dengue viruses
Vector-borne diseases constitute more than 17 % of all infectious diseases and are caused by parasites, viruses and bacter...
Discovery of LHQ490 as a highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor
Discovery of LHQ490 as a highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor
Fibroblast growth factor receptor 2 (FGFR2) is a member of transmembrane receptor tyrosine kinase FGFR family that also co...
Anticancer activity of 8-hydroxyquinoline-triphenylphosphine rhodium(III) complexes targeting mitophagy pathways
Anticancer activity of 8-hydroxyquinoline-triphenylphosphine rhodium(III) complexes targeting mitophagy pathways
Transition metals have major advantages over organic compounds for the development of new therapeutic drugs, including var...
Recent Advances and Future Directions on Small Molecule VEGFR Inhibitors in Oncological Conditions
Recent Advances and Future Directions on Small Molecule VEGFR Inhibitors in Oncological Conditions
To date, 14 small molecules targeting the VEGFR pathway have received FDA approval for the treatment of diverse malignanci...
Research progress of prodrugs for the treatment of cerebral ischemia
Research progress of prodrugs for the treatment of cerebral ischemia
The latest research of the World Health Organization (WHO) reveals that stroke afflicts over 15 million people globally ea...