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CN1699 Our Business - Guide for Agents
分类
Chemistry, Medicinal
7090
Global Medical University
3603
Allergy
1540
Anatomy & Morphology
1308
Andrology
414
Anesthesia & Intensive Care
897
Anesthesiology
4041
Audiology & Speech-Language Pathology
299
Behavioral Sciences
80
Biochemical Research Methods
4990
Biochemistry & Molecular Biology
23430
Biodiversity Conservation
211
Biology
6060
Biophysics
5553
Biotechnology & Applied Microbiology
6232
Cardiac & Cardiovascular Systems
24345
Cardiovascular & Respiratory Systems
1137
Cell & Tissue Engineering
500
Cell Biology
9114
Chemistry, Analytical
3570
Chemistry, Applied
8828
Chemistry, Multidisciplinary
15598
Clinical Immunology & Infectious Disease
342
Clinical Medicine
7678
Clinical Neurology
12664
Clinical Psychology & Psychiatry
775
Critical Care Medicine
2276
Dentistry, Oral Surgery & Medicine
9943
Dermatology
6871
Developmental Biology
5874
Ecology
610
Education, Scientific Disciplines
1414
Emergency Medicine
2980
Endocrinology, Metabolism & Nutrition
18134
Engineering, Biomedical
2858
Entomology
316
Environmental Medicine & Public Health
3540
Evolutionary Biology
192
Gastroenterology & Hepatology
9110
General & Internal Medicine
5324
Genetics & Heredity
11448
Geriatrics & Gerontology
3989
Gerontology
258
Health Care Sciences & Services
11866
Health Policy & Services
469
Hematology
4511
Immunology
19415
Infectious Diseases
10688
Integrative & Complementary Medicine
1893
Medical Ethics
824
Medical Informatics
1529
Medical Laboratory Technology
429
Medicine, General & Internal
36244
Medicine, Legal
312
Medicine, Research & Experimental
13275
Microbiology
17757
Mycology
0
Nanoscience & Nanotechnology
3883
Neuroimaging
936
Neurology
3264
Neurosciences
30003
Nursing
7350
Nutrition & Dietetics
6884
Obstetrics & Gynecology
6301
Oncology
41259
Ophthalmology
7111
Optics
2897
Orthopedics
8643
Orthopedics, Rehabilitation & Sports Medicine
1229
Otolaryngology
1236
Otorhinolaryngology
3984
Parasitology
752
Pathology
3768
Pediatrics
16327
Peripheral Vascular Disease
3583
Pharmacology & Pharmacy
25167
Pharmacology/Toxicology
9783
Physiology
7381
Polymer Science
422
Primary Health Care
633
Psychiatry
14099
Psychology
4054
Psychology, Applied
64
Psychology, Biological
238
Psychology, Clinical
595
Psychology, Developmental
176
Psychology, Educational
89
Psychology, Experimental
85
Psychology, Mathematical
0
Psychology, Multidisciplinary
1289
Psychology, Psychoanalysis
41
Psychology, Social
78
Public Health & Health Care Science
1868
Public, Environmental & Occupational Health
21838
Quantum Science & Technology
0
Radiology, Nuclear Medicine & Imaging
9153
Radiology, Nuclear Medicine & Medical Imaging
6336
Rehabilitation
2500
Remote Sensing
0
Reproductive Biology
1952
Reproductive Medicine
848
Research/Laboratory Medicine & Medical Technology
2879
Respiratory System
5435
Rheumatology
4332
Social Sciences, Biomedical
1015
Substance Abuse
2127
Surgery
25055
Toxicology
3513
Transplantation
770
Tropical Medicine
266
Urology & Nephrology
9794
Veterinary Sciences
35
Virology
1833
Zoology
0
渠道
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
1215
DRUG DESIGN DEVELOPMENT AND THERAPY
581
FUTURE MEDICINAL CHEMISTRY
250
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
49
JOURNAL OF PERSONALIZED MEDICINE
2077
JOURNAL OF STRUCTURAL CHEMISTRY
414
MEDICINA-LITHUANIA
1739
MEDICINAL CHEMISTRY RESEARCH
299
AVICENNA JOURNAL OF PHYTOMEDICINE
107
RESEARCH IN PHARMACEUTICAL SCIENCES
111
NATURAL PRODUCTS AND BIOPROSPECTING
76
JOURNAL OF NATURAL MEDICINES
172
SCI时时刷
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Design and synthesis of novel arylurea derivatives of aryloxy(1-phenylpropyl) alicyclic diamines with antimicrobial activity against multidrug-resistant Gram-positive bacteria
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Design, synthesis, and repurposing of O6-aminoalkyl-sulfuretin analogs towards discovery of potential lead compounds as antileishmanial agents
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Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity
N-Acyl indolines 4 are potent, non-covalent Notum inhibitors developed from a covalent virtual screening hit 2a. The lead ...
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Discovery of acridine-based LSD1 inhibitors as immune activators targeting LSD1 in gastric cancer
LSD1 is overexpressed in various cancers and promotes tumor cell proliferation, tumor expansion, and suppresses immune cel...
European Journal Of Medicinal Chemistry
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Discovery of novel benzamide derivatives bearing benzamidophenyl and phenylacetamidophenyl scaffolds as potential antitumor agents via targeting PARP-1
Poly(ADP-ribose) polymerase-1 (PARP-1) plays a crucial role in DNA damage repair and has been identified as a promising th...
European Journal Of Medicinal Chemistry
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Discovery of 3,5-diaryl-1H-pyrazol-based ureas as potent RET inhibitors
Rearranged during transfection (RET) is a promising target for antitumor drug development. Multikinase inhibitors (MKI) ha...
European Journal Of Medicinal Chemistry
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Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity
Based on two previously discovered carbazole carboxamide retinoic acid receptor-related orphan receptor-γt (RORγt) agonist...
European Journal Of Medicinal Chemistry
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Optimization of triazolo[4,5-d]pyrimidines towards human CC chemokine receptor 7 (CCR7) antagonists
CCR7 signaling directs the migration of both immune cells and cancer cells to the lymph nodes, is involved in numerous chr...
European Journal Of Medicinal Chemistry
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C-glycosides analogues of the okadaic acid central fragment exert neuroprotection via restoration of PP2A-phosphatase activity: A rational design of potential drugs for Alzheimer's disease targeting tauopathies
Protein phosphatase 2A (PP2A) is an important Ser/Thr phosphatase that participates in the regulation of multiple cellular...
European Journal Of Medicinal Chemistry
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A practical “preTACs-cytoblot” platform accelerates the streamlined development of PROTAC-based protein degraders
With the growing importance of PROTAC-mediated protein degradation in drug discovery, robust synthetic methodologies and r...
European Journal Of Medicinal Chemistry
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Optically activated MEK1/2 inhibitors (Opti-MEKi) as potential antimelanoma agents
Mitogen-activated protein kinase kinases 1/2 (MEK1/2) play critical roles in the canonicalRAS/RAF/MEK/ERK pathway. Highly ...
European Journal Of Medicinal Chemistry
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Design, synthesis and biological evaluation of Nucleosidic CD99 inhibitors that selectively reduce Ewing sarcoma viability
Ewing Sarcoma (ES) is a cancer of bone and soft tissues affecting mostly children and young adults. Aggressive progression...
European Journal Of Medicinal Chemistry
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Discovery of phenylcarbamoyl xanthone derivatives as potent neuroprotective agents for treating ischemic stroke
Compounds of natural sources are widespread discovered in the treatment of ischemic stroke. Alpha-mangostin, a natural pre...
European Journal Of Medicinal Chemistry
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Antitumor effect of 3-(quinolin-2-ylmethylene)-4,6-dimethyl-5-hydroxy-7-azaoxindole down-regulating the Gas6-Axl axis
In this study, a new series of 3-arylidene-4,6-dimethyl-5-hydroxy-7-azaoxindole compounds with a wide range of functional ...
European Journal Of Medicinal Chemistry
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Development of the “hidden” multi-target-directed ligands by AChE/BuChE for the treatment of Alzheimer's disease
Accumulation of evidences suggested that excessive amounts of AChE and BuChE in the brain of AD patients at the different ...
European Journal Of Medicinal Chemistry
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3,4-Dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide analogs act as potential AMPA receptor potentiators with antidepressant activity
Major depressive disorder is a common psychiatric disorder, with ∼30% of patients suffering from treatment-resistant depre...
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Discovery of a novel 1H-pyrazole- [3,4-b] pyridine-based lysine demethylase 5B inhibitor with potential anti-prostate cancer activity that perturbs the phosphoinositide 3-kinase/AKT pathway
Lysine demethylase 5B (KDM5B) is a member of the Jumonji AT-rich interactive domain 1 family. Its main function is to deme...
European Journal Of Medicinal Chemistry
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Novel pyridinium cationic pleuromutilin analogues overcoming bacterial multidrug resistance
A series of pyridinium cation-substituted pleuromutilin analogues were designed, synthesized and evaluated for their antib...
European Journal Of Medicinal Chemistry
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Synthesis and preclinical evaluation of a heterodimeric radioligand targeting fibroblast activation protein and integrin-αvβ3
Tumor progression is accompanied by intrinsic heterogeneity and different phenotypes, which implies a different expression...
European Journal Of Medicinal Chemistry
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Discovery of orally effective and safe GPR40 agonists by incorporating a chiral, rigid and polar sulfoxide into β-position to the carboxylic acid
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European Journal Of Medicinal Chemistry
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RSK inhibitors as potential anticancer agents: Discovery, optimization, and challenges
Ribosomal S6 kinase (RSK) family is a group of serine/threonine kinases, including four isoforms (RSK1/2/3/4). As a downst...
European Journal Of Medicinal Chemistry
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From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors
An X-ray structure of a CLICK chemistry-based BET PROTAC bound to BRD2(BD2) inspired synthesis of JQ1 derived heterocyclic...
European Journal Of Medicinal Chemistry
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From lead to clinic: A review of the structural design of P2X7R antagonists
P2X7R, which is a member of the purinergic P2 receptor family, is widely expressed in many immune cells, such as macrophag...
European Journal Of Medicinal Chemistry
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Recent updates on 1,2,3-triazole-containing hybrids with in vivo therapeutic potential against cancers: A mini-review
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European Journal Of Medicinal Chemistry
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N-sulfonyl peptide-hybrids as a new class of dengue virus protease inhibitors
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European Journal Of Medicinal Chemistry
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Design, synthesis, and biological evaluation of novel dihydropteridone derivatives possessing oxadiazoles moiety as potent inhibitors of PLK1
Polo like kinase 1 (PLK1) is a serine/threonine kinase that is widely distributed in eukaryotic cells and plays an importa...
European Journal Of Medicinal Chemistry
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Korupensamine A, but not its atropisomer, korupensamine B, inhibits SARS-CoV-2 in vitro by targeting its main protease (Mpro)
By combining docking and molecular dynamics simulations, we explored a library of 65 mostly axially chiral naphthylisoquin...
European Journal Of Medicinal Chemistry
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Specific discrimination and efficient elimination of gram-positive bacteria by an aggregation-induced emission-active ruthenium (II) photosensitizer
The infections caused by Gram-positive bacteria (G+) have seriously endangered public heath due to their high morbidity an...
European Journal Of Medicinal Chemistry
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Recent advances of mitochondrial complex I inhibitors for cancer therapy: Current status and future perspectives
Mitochondrial complex I (CI) as a critical multifunctional respiratory complex of electron transport chain (ETC) in mitoch...
European Journal Of Medicinal Chemistry
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Discovery of a novel oral type Ⅰ CDK8 inhibitor against acute myeloid leukemia
CDK8 plays a key role in acute myeloid leukemia, colorectal cancer and other cancers. Here, a total of 54 compounds were d...
European Journal Of Medicinal Chemistry
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