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Design and synthesis of new adamantyl derivatives as promising antiproliferative agents
A series of adamantyl carboxamide derivatives containing sulfonate or sulfonamide moiety were designed as multitargeted in...
Resveratrol derivatives: Synthesis and their biological activities
Resveratrol, a natural compound known especially for its antioxidant properties and protective action, opens the door for ...
Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71
Different viruses belonging to distinct viral families, such as enterovirus 71, rely on the host methyltransferase METTL3 ...
Novel thiazolidines of potential anti-proliferation properties against esophageal squamous cell carcinoma via ERK pathway
The discovery of a new class of extracellular-signal-regulated kinase (ERK) inhibitors has been achieved via developing no...
Structure-activity relationship study of amidobenzimidazole derivatives as stimulator of interferon genes (STING) agonists
Stimulator of interferon genes (STING) is a crucial adaptor protein that can regulate the innate immune response by induci...
Novel tryptanthrin derivatives with benzenesulfonamide substituents: Design, synthesis, and anti-inflammatory evaluation
Herein, two series of tryptanthrin derivatives with benzenesulfonamide substituents were designed and synthesized to disco...
Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs
Members of the HEPT class are potential non-nucleoside inhibitors of HIV-1 reverse transcriptase. Our previously disclosed...
Bifunctional carbazole derivatives for simultaneous therapy and fluorescence imaging in prion disease murine cell models
Volume 245, Part 1, 5 January 2023, 114923Author links open overlay panelHighlights•Synthesis of a new generation of carba...
Design, development and evaluation of a prodrug-type TrkA-selective inhibitor with antinociceptive effects in vivo
Tropomyosin receptor kinase A (TrkA) is considered a therapeutic target in pain treatment, and several TrkA inhibitors hav...
Antiproliferative, antiangiogenic and apoptotic effect of new hybrids of quinazoline-4(3H)-ones and sulfachloropyridazine
Three new sets of quinazolinones bearing sulfachloropyridazine 4a-f, 6a-i and 8a-i were designed and synthesized. All the ...
Identification of novel Pyrrolo[2,3-d]Pyrimidine-based KRAS G12C inhibitors with anticancer effects
Oncogene KRAS plays predominant roles in human cancers by regulating cell proliferation, differentiation, and migration. R...
Acyloxymethyl and alkoxycarbonyloxymethyl prodrugs of a fosmidomycin surrogate as antimalarial and antibacterial agents
Fosmidomycin is a natural antibiotic with potent IspC (DXR, 1-deoxy-d-xylulose-5-phosphate reductoisomerase) inhibitory ac...