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Structurally diverse chromane meroterpenoids from Rhododendron capitatum with multifunctional neuroprotective effects
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Synthesis and clinical application of new drugs approved by NMPA in 2023
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Novel steroidal β-carboline derivatives as promising antibacterial candidates against methicillin-resistant Staphylococcus aureus
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Synthetic approaches and clinical applications of representative HDAC inhibitors for cancer therapy: A review
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Designing novel Au(III) complexes based on the structure of diazepam: Achieving a multiaction mechanism against glioma
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Discovery of SET domain-binding primary alkylamine-tethered degraders for the simultaneous degradation of NSD2-long and RE-IIBP isoforms
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Clinically approved representative small-molecule drugs for cardiopathy therapy
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Discovery and biological evaluation of potent 2-trifluoromethyl acrylamide warhead-containing inhibitors of protein disulfide isomerase
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Discovery of novel XPO1 PROTAC degraders for the treatment of acute myeloid leukemia
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Dihydrofolate reductase inhibitory potential of 1H-indole-based-meldrum linked 1H-1,2,3-triazoles as new anticancer derivatives: In-vitro and in-silico studies
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Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier
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Design and synthesis of novel 3,7-dihydro-1H-purine-2,6-diones as DPP-4 inhibitors: An in silico, in vitro and in vivo approach
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Structure-based development of N-Arylindole derivatives as Pks13 inhibitors against Mycobacterium tuberculosis
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Unravelling the potential of natural chelating agents in the control of Staphylococcus aureus and Pseudomonas aeruginosa biofilms
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Discovery of pyridine-based derivatives as FLT3 inhibitors for the treatment of acute myeloid leukemia
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Design, synthesis and biological evaluation of new H2S-releasing rivastigmine derivatives as neuroprotective molecules
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A novel cyanine photosensitizer for sequential dual-site GSH depletion and ROS-potentiated cancer photodynamic therapy
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Gold(I) complexes bearing EGFR-inhibiting ligands as anti-HCC agents through dual targeting of EGFR and TrxR
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Structure-activity relationship studies and design of a PTPN22 inhibitor with enhanced isozyme selectivity and cellular efficacy
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The novel β-hairpin antimicrobial peptide D-G(RF)3 demonstrates exceptional antibacterial efficacy
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Catalytic Lysine745 targeting strategy in fourth-generation EGFR tyrosine kinase inhibitors to address C797S mutation resistance
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Achieving theranostic probes targeting BRD3/BRD4 for imaging and therapy of tumor
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Hydroxyl-based acid-hypersensitive acetal ester bond: Design, synthesis and the application potential in nanodrugs
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Prodrugging fungicidal amphotericin B significantly decreases its toxic effects
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Discovery of novel hybrid tryptamine-rivastigmine molecules as potent AChE and BChE inhibitors exhibiting multifunctional properties for the management of Alzheimer's disease
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Discovery of 22(S)-23-phenyl-24-norchol-5-en-3β,22-diol (PFM046) as the first-in-class, steroidal, non-sulfated Liver X Receptor antagonist with anticancer activity
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Design, synthesis, and biological evaluation of steroidal indole derivatives as membrane-targeting antibacterial candidates
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Synthesis and mechanistic studies of 4-aminoquinoline-Isatin molecular hybrids and Schiff's bases as promising antimicrobial agents
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Triterpenoid phthalimides as selective anti-cancer agents targeting mitochondrial apoptosis
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Design, synthesis, and evaluation of novel benzofuran and pyrazole-based derivatives as dual AChE/BuChE inhibitors with antioxidant properties for Alzheimer's disease management
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