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How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health
How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health
Recent studies support the influence of paternal lifestyle and diet before conception on the health of the offspring via e...
TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma
TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma
5-Hydroxymethylcytosine (5hmC) modification represents a significant epigenetic modification within DNA, playing a pivotal...
TEC-mediated tRF-31R9J regulates histone lactylation and acetylation by HDAC1 to suppress hepatocyte ferroptosis and improve non-alcoholic steatohepatitis
TEC-mediated tRF-31R9J regulates histone lactylation and acetylation by HDAC1 to suppress hepatocyte ferroptosis and improve non-alcoholic steatohepatitis
Tectorigenin (TEC) is a monomer of anthocyanin, which we found exhibits hepatoprotective effects. tRNA-derived fragments (...
Hypoxia impairs decitabine-induced expression of HLA-DR in acute myeloid leukaemia cell lines
Hypoxia impairs decitabine-induced expression of HLA-DR in acute myeloid leukaemia cell lines
Hypomethylating agents (HMA), such as azacytidine (AZA) and decitabine (DAC), are epigenetic therapies used to treat some ...
Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis
Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis
IgG4-related cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC) are chronic fibro-inflammatory hepatobiliary c...
Validation of a hypomorphic variant in CDK13 as the cause of CHDFIDD with autosomal recessive inheritance through determination of an episignature
Validation of a hypomorphic variant in CDK13 as the cause of CHDFIDD with autosomal recessive inheritance through determination of an episignature
Autosomal dominant CDK13-related disease is characterized by congenital heart defects, dysmorphic facial features, and int...
Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases
Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases
As an important element of the human body, iron participates in numerous physiological and biochemical reactions. In the p...
A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children
A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children
There is limited knowledge on how diet affects the epigenome of children. Ultra-processed food (UPF) consumption is emergi...
Impaired ARID1A expression attenuated the immune response in gastric cancer via histone acetylation
Impaired ARID1A expression attenuated the immune response in gastric cancer via histone acetylation
The primary objective of this study was to examine whether ARID1A mutations confer a fitness advantage to gastric cancer f...
Unraveling the causal impact of smoking and its DNA methylation signatures on cardiovascular disease: Mendelian randomization and colocalization analysis
Unraveling the causal impact of smoking and its DNA methylation signatures on cardiovascular disease: Mendelian randomization and colocalization analysis
To explore the mechanisms linking smoking to cardiovascular diseases (CVDs) from an epigenetic perspective. Mendelian Rand...
Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations
Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations
Lynch syndrome (LS), characterised by an increased risk for cancer, is mainly caused by germline pathogenic variants affec...
Clinical promise and applications of epigenetic biomarkers
Clinical promise and applications of epigenetic biomarkers
Berdasco M, Esteller M. Clinical epigenetics: seizing opportunities for translation. Nat Rev Genet. 2019;20(2):109–27.Arti...
Evaluating PAX1/JAM3 methylation for triage in HPV 16/18-infected women
Evaluating PAX1/JAM3 methylation for triage in HPV 16/18-infected women
Referring all women who tested positive for human papillomavirus (HPV) 16/18 to colposcopy may lead to potential over-refe...
Correction: Exploring the therapeutic potential of Sirt6-enriched adipose stem cell-derived exosomes in myocardial ischemia–reperfusion injury: unfolding new epigenetic frontiers
Correction: Exploring the therapeutic potential of Sirt6-enriched adipose stem cell-derived exosomes in myocardial ischemia–reperfusion injury: unfolding new epigenetic frontiers
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Single-cell transcriptomics reveal the prognostic roles of epithelial and T cells and DNA methylation-based prognostic models in pancreatic cancer
Single-cell transcriptomics reveal the prognostic roles of epithelial and T cells and DNA methylation-based prognostic models in pancreatic cancer
Pancreatic adenocarcinoma (PDAC) exhibits a complex microenvironment with diverse cell populations influencing patient pro...
BET inhibition revealed varying MYC dependency mechanisms independent of gene alterations in aggressive B-cell lymphomas
BET inhibition revealed varying MYC dependency mechanisms independent of gene alterations in aggressive B-cell lymphomas
MYC-driven lymphomas are a subset of B-cell lymphomas characterized by genetic alterations that dysregulate the expression...
Distinct microbiome dysbiosis and epigenetic anomaly in esophageal adenocarcinoma and its underlying Barrett’s esophagus
Distinct microbiome dysbiosis and epigenetic anomaly in esophageal adenocarcinoma and its underlying Barrett’s esophagus
Interaction between host genotoxic changes and mucosa-associated microbiome (MAM) dysbiosis may have a role in various dig...
Maximizing insights from longitudinal epigenetic age data: simulations, applications, and practical guidance
Maximizing insights from longitudinal epigenetic age data: simulations, applications, and practical guidance
Epigenetic age (EA) is an age estimate, developed using DNA methylation (DNAm) states of selected CpG sites across the gen...
Epigenetic regulation on left atrial function and disease recurrence after catheter ablation in atrial fibrillation
Epigenetic regulation on left atrial function and disease recurrence after catheter ablation in atrial fibrillation
Genetic variation and modifiable risk factors play a significant role in the pathogenesis of atrial fibrillation (AF). The...
Changes in DNA methylation are associated with systemic lupus erythematosus flare remission and clinical subtypes
Changes in DNA methylation are associated with systemic lupus erythematosus flare remission and clinical subtypes
Systemic lupus erythematosus (SLE) has numerous symptoms across organs and an unpredictable flare-remittance pattern. This...
Advancing diagnosis and early risk assessment of preeclampsia through noninvasive cell-free DNA methylation profiling
Advancing diagnosis and early risk assessment of preeclampsia through noninvasive cell-free DNA methylation profiling
Aberrant embryo implantation and suboptimal placentation can lead to (severe) complications such as preeclampsia and fetal...
DNA methylation-based analysis reveals accelerated epigenetic aging in giant cell-enriched adult-type glioblastoma
DNA methylation-based analysis reveals accelerated epigenetic aging in giant cell-enriched adult-type glioblastoma
Giant cell (gc)-enriched glioblastoma (gcGB) represents a distinct histological variant of isocitrate dehydrogenase wild-t...
BRCA1 & BRCA2 methylation as a prognostic and predictive biomarker in cancer: Implementation in liquid biopsy in the era of precision medicine
BRCA1 & BRCA2 methylation as a prognostic and predictive biomarker in cancer: Implementation in liquid biopsy in the era of precision medicine
BReast CAncer gene 1 (BRCA1) and BReast CAncer gene 2 (BRCA2) encode for tumor suppressor proteins which are critical regu...
Genome-wide DNA methylation analysis reveals a unique methylation pattern for pleural mesothelioma compared to healthy pleura and other lung diseases
Genome-wide DNA methylation analysis reveals a unique methylation pattern for pleural mesothelioma compared to healthy pleura and other lung diseases
Pleural mesothelioma (PM) is a rare and aggressive cancer type, typically diagnosed at advanced stages. Distinguishing PM ...
DNA methylation-based telomere length is more strongly associated with cardiovascular disease and long-term mortality than quantitative polymerase chain reaction-based telomere length: evidence from the NHANES 1999–2002
DNA methylation-based telomere length is more strongly associated with cardiovascular disease and long-term mortality than quantitative polymerase chain reaction-based telomere length: evidence from the NHANES 1999–2002
Telomere length (TL) serves as a pivotal gauge of cellular aging, with shorter TL linked to various age-related ailments. ...
The role of the gut microbiota in the onset and progression of heart failure: insights into epigenetic mechanisms and aging
The role of the gut microbiota in the onset and progression of heart failure: insights into epigenetic mechanisms and aging
The gut microbiota (GM) plays a critical role in regulating human physiology, with dysbiosis linked to various diseases, i...
Promoter hypermethylation-mediated downregulation of PAX6 promotes tumor growth and metastasis during the progression of liver cancer
Promoter hypermethylation-mediated downregulation of PAX6 promotes tumor growth and metastasis during the progression of liver cancer
The progression of liver cancer is a complicated process that involves genetic and epigenetic changes. Paired box 6 (PAX6)...
BRCA loss of function including BRCA1 DNA-methylation, but not BRCA-unrelated homologous recombination deficiency, is associated with platinum hypersensitivity in high-grade ovarian cancer
BRCA loss of function including BRCA1 DNA-methylation, but not BRCA-unrelated homologous recombination deficiency, is associated with platinum hypersensitivity in high-grade ovarian cancer
In high-grade ovarian cancer (HGOC), determination of homologous recombination deficiency (HRD) status is commonly used in...
Examining the potential causal relationships among smoking behaviors, blood DNA methylation profiles, and the development of coronary heart disease and myocardial infarction
Examining the potential causal relationships among smoking behaviors, blood DNA methylation profiles, and the development of coronary heart disease and myocardial infarction
Smoking has been identified as a standalone risk factor for coronary heart disease (CHD) and myocardial infarction (MI), b...
Causal association between epigenetic age acceleration and two pulmonary vascular diseases: pulmonary arterial hypertension and pulmonary embolism—a bidirectional Mendelian study
Causal association between epigenetic age acceleration and two pulmonary vascular diseases: pulmonary arterial hypertension and pulmonary embolism—a bidirectional Mendelian study
Pulmonary arterial hypertension (PAH) is a relatively rare but severe disease with a poor prognosis. Pulmonary embolism (P...
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