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MOSES: a methylation-based gene association approach for unveiling environmentally regulated genes linked to a trait or disease
MOSES: a methylation-based gene association approach for unveiling environmentally regulated genes linked to a trait or disease
DNA methylation is a critical regulatory mechanism of gene expression, influencing various human diseases and traits. Whil...
Pre-diagnosis blood DNA methylation profiling of twin pairs discordant for breast cancer points to the importance of environmental risk factors
Pre-diagnosis blood DNA methylation profiling of twin pairs discordant for breast cancer points to the importance of environmental risk factors
Assessment of breast cancer (BC) risk generally relies on mammography, family history, reproductive history, and genotypin...
Associations of epigenetic age acceleration at birth and age 12 years with adolescent cardiometabolic risk: the HOME study
Associations of epigenetic age acceleration at birth and age 12 years with adolescent cardiometabolic risk: the HOME study
Cardiometabolic risk factors among youth are rising. Epigenetic age acceleration, a biomarker for aging and disease-risk, ...
Epigenetic modifications involving ncRNAs in digestive system cancers: focus on histone modification
Epigenetic modifications involving ncRNAs in digestive system cancers: focus on histone modification
In recent years, epigenetic modifications have been strongly linked to tumor development, with histone modifications repre...
Comparison of cell type and disease subset chromatin modifications in SLE
Comparison of cell type and disease subset chromatin modifications in SLE
Systemic lupus erythematosus (SLE) is an autoimmune disease with protean manifestations. There is little understanding of ...
DNA methylation biomarkers and myopia: a multi-omics study integrating GWAS, mQTL and eQTL data
DNA methylation biomarkers and myopia: a multi-omics study integrating GWAS, mQTL and eQTL data
This study aimed to identify DNA methylation biomarkers associated with myopia using summary-data-based Mendelian randomiz...
TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights
TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights
TET2 is a critical gene that regulates DNA methylation, encoding a dioxygenase protein that plays a vital role in the regu...
DNA methylation classifier to diagnose pancreatic ductal adenocarcinoma metastases from different anatomical sites
DNA methylation classifier to diagnose pancreatic ductal adenocarcinoma metastases from different anatomical sites
We have recently constructed a DNA methylation classifier that can discriminate between pancreatic ductal adenocarcinoma (...
Integrative analysis based on ATAC-seq and RNA-seq reveals a novel oncogene PRPF3 in hepatocellular carcinoma
Integrative analysis based on ATAC-seq and RNA-seq reveals a novel oncogene PRPF3 in hepatocellular carcinoma
Assay of Transposase Accessible Chromatin Sequencing (ATAC-seq) is a high-throughput sequencing technique that detects ope...
A multi-trait epigenome-wide association study identified DNA methylation signature of inflammation among men with HIV
A multi-trait epigenome-wide association study identified DNA methylation signature of inflammation among men with HIV
Inflammation underlies many conditions causing excess morbidity and mortality among people with HIV (PWH). A handful of si...
Epigenetic signatures of asthma: a comprehensive study of DNA methylation and clinical markers
Epigenetic signatures of asthma: a comprehensive study of DNA methylation and clinical markers
Asthma, a complex respiratory disease, presents with inflammatory symptoms in the lungs, blood, and other tissues. We inve...
DNA methylation biomarker panels for differentiating various liver adenocarcinomas, including hepatocellular carcinoma, cholangiocarcinoma, colorectal liver metastases and pancreatic adenocarcinoma liver metastases
DNA methylation biomarker panels for differentiating various liver adenocarcinomas, including hepatocellular carcinoma, cholangiocarcinoma, colorectal liver metastases and pancreatic adenocarcinoma liver metastases
DNA methylation biomarkers are one of the most promising tools for the diagnosis and differentiation of adenocarcinomas of...
DNA methylation at AHRR as a master predictor of smoke exposure and a biomarker for sleep and exercise
DNA methylation at AHRR as a master predictor of smoke exposure and a biomarker for sleep and exercise
DNA methylation profiling may provide a more accurate measure of the smoking status than self-report and may be useful in ...
COL25A1 and METAP1D DNA methylation are promising liquid biopsy epigenetic biomarkers of colorectal cancer using digital PCR
COL25A1 and METAP1D DNA methylation are promising liquid biopsy epigenetic biomarkers of colorectal cancer using digital PCR
Colorectal cancer is a public health issue and was the third leading cause of cancer-related death worldwide in 2022. Earl...
Integrating D4Z4 methylation analysis into clinical practice: improvement of FSHD molecular diagnosis through distinct thresholds for 4qA/4qA and 4qA/4qB patients
Integrating D4Z4 methylation analysis into clinical practice: improvement of FSHD molecular diagnosis through distinct thresholds for 4qA/4qA and 4qA/4qB patients
Facioscapulohumeral dystrophy (FSHD) is a myopathy characterized by the loss of repressive epigenetic features affecting t...
Environmental exposures influence multigenerational epigenetic transmission
Environmental exposures influence multigenerational epigenetic transmission
Epigenetic modifications control gene expression and are essential for turning genes on and off to regulate and maintain d...
PER3 promoter hypermethylation correlates to the progression of pan-cancer
PER3 promoter hypermethylation correlates to the progression of pan-cancer
Malignant cells exhibit reduced period circadian regulator 3 (PER3) expression. However, the underlying mechanisms of vari...
Influence of physical activity on the epigenetic clock: evidence from a Japanese cross-sectional study
Influence of physical activity on the epigenetic clock: evidence from a Japanese cross-sectional study
Biological age, especially epigenetic age derived from the epigenetic clock, is a significant measure of aging, considerin...
The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage quality
The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage quality
Lack of insight into factors that determine purity and quality of human iPSC (hiPSC)-derived neo-cartilage precludes appli...
Distinct methylome profile of cfDNA in AMI patients reveals significant alteration in cAMP signaling pathway genes regulating cardiac muscle contraction
Distinct methylome profile of cfDNA in AMI patients reveals significant alteration in cAMP signaling pathway genes regulating cardiac muscle contraction
The role of epigenetics in cardiovascular diseases has paved the way for innovative therapeutic approaches. Investigating ...
A comprehensive lifestyle index and its associations with DNA methylation and type 2 diabetes among Ghanaian adults: the rodam study
A comprehensive lifestyle index and its associations with DNA methylation and type 2 diabetes among Ghanaian adults: the rodam study
A series of modifiable lifestyle factors, such as diet quality, physical activity, alcohol intake, and smoking, may drive ...
Differences in the DNA methylome of T cells in adults with asthma of varying severity
Differences in the DNA methylome of T cells in adults with asthma of varying severity
DNA methylation plays a critical role in asthma development, but differences in DNA methylation among adults with varying ...
Epigenomic biomarkers insights in PBMCs for prognostic assessment of ECMO-treated cardiogenic shock patients
Epigenomic biomarkers insights in PBMCs for prognostic assessment of ECMO-treated cardiogenic shock patients
As the global use of extracorporeal membrane oxygenation (ECMO) treatment increases, survival rates have not corresponding...
Comprehensive molecular and clinical findings in 29 patients with multi-locus imprinting disturbance
Comprehensive molecular and clinical findings in 29 patients with multi-locus imprinting disturbance
Multi-locus imprinting disturbance (MLID) with methylation defects in various differentially methylated regions (DMRs) has...
Enzymatic TET-1 inhibition highlights different epigenetic behaviours of IL-1β and TNFα in tumour progression of OS cell lines
Enzymatic TET-1 inhibition highlights different epigenetic behaviours of IL-1β and TNFα in tumour progression of OS cell lines
Osteosarcoma (OS) is the most frequent primary malignant bone tumour, whose heterogeneity represents a major challenge for...
Causal effects of cardiovascular health on five epigenetic clocks
Causal effects of cardiovascular health on five epigenetic clocks
This work delves into the relationship between cardiovascular health (CVH) and aging. Previous studies have shown an assoc...
Effects of multisuperovulation on the transcription and genomic methylation of oocytes and offspring
Effects of multisuperovulation on the transcription and genomic methylation of oocytes and offspring
Controlled ovarian stimulation is a common skill of assisted reproductive technologies (ARTs). In the clinic, some females...
Methylation alterations of imprinted genes in different placental diseases
Methylation alterations of imprinted genes in different placental diseases
Imprinted genes play important functions in placentation and pregnancy; however, research on their roles in different plac...
Technical and biological sources of unreliability of Infinium probes on Illumina methylation microarrays
Technical and biological sources of unreliability of Infinium probes on Illumina methylation microarrays
The Illumina Methylation array platform has facilitated countless epigenetic studies on DNA methylation (DNAme) in health ...
Causal association of epigenetic age acceleration and risk of subacute thyroiditis: a bidirectional Mendelian randomization study
Causal association of epigenetic age acceleration and risk of subacute thyroiditis: a bidirectional Mendelian randomization study
Epigenetic age accelerations (EAAs) are a promising new avenue of research, yet their investigation in subacute thyroiditi...
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