SCI时时刷

search
+
Discovery and technical validation of high-performance methylated DNA markers for the detection of cervical lesions at risk of malignant progression in low- and middle-income countries
Discovery and technical validation of high-performance methylated DNA markers for the detection of cervical lesions at risk of malignant progression in low- and middle-income countries
Cervical cancer remains a leading cause of death, particularly in developing countries. WHO screening guidelines recommend...
DNMT1/miR-152-3p/SOS1 signaling axis promotes self-renewal and tumor growth of cancer stem-like cells derived from non-small cell lung cancer
DNMT1/miR-152-3p/SOS1 signaling axis promotes self-renewal and tumor growth of cancer stem-like cells derived from non-small cell lung cancer
CSLCs(Cancer stem cell-like cells), which are central to tumorigenesis, are intrinsically influenced by epigenetic modific...
Polycomb repressive complex 2 and its core component EZH2: potential targeted therapeutic strategies for head and neck squamous cell carcinoma
Polycomb repressive complex 2 and its core component EZH2: potential targeted therapeutic strategies for head and neck squamous cell carcinoma
The polycomb group (PcG) comprises a set of proteins that exert epigenetic regulatory effects and play crucial roles in di...
Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk
Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk
The study of biological age acceleration may help identify at-risk individuals and reduce the rising global burden of age-...
Epigenetics in diabetic cardiomyopathy
Epigenetics in diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a critical complication that poses a significant threat to the health of patients with di...
Targeting histone demethylases JMJD3 and UTX: selenium as a potential therapeutic agent for cervical cancer
Targeting histone demethylases JMJD3 and UTX: selenium as a potential therapeutic agent for cervical cancer
The intriguing connection between selenium and cancer resembles a captivating puzzle that keeps researchers engaged and cu...
Nucleosome reorganisation in breast cancer tissues
Nucleosome reorganisation in breast cancer tissues
Nucleosome repositioning in cancer is believed to cause many changes in genome organisation and gene expression. Understan...
Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Acute lymphoblastic leukemia (ALL) is the most prevalent cancer in children, and despite considerable progress in treatmen...
Head and neck cancer of unknown primary: unveiling primary tumor sites through machine learning on DNA methylation profiles
Head and neck cancer of unknown primary: unveiling primary tumor sites through machine learning on DNA methylation profiles
The unknown tissue of origin in head and neck cancer of unknown primary (hnCUP) leads to invasive diagnostic procedures an...
Low expression of miR-182 caused by DNA hypermethylation accelerates acute lymphocyte leukemia development by targeting PBX3 and BCL2: miR-182 promoter methylation is a predictive marker for hypomethylation agents + BCL2 inhibitor venetoclax
Low expression of miR-182 caused by DNA hypermethylation accelerates acute lymphocyte leukemia development by targeting PBX3 and BCL2: miR-182 promoter methylation is a predictive marker for hypomethylation agents + BCL2 inhibitor venetoclax
miR-182 promoter hypermethylation frequently occurs in various tumors, including acute myeloid leukemia, and leads to low ...
Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health
Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health
Epigenetic Scores (EpiScores) for blood protein levels have been associated with disease outcomes and measures of brain he...
A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure
A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure
In this study, a novel restriction enzyme (RE) digestion-based droplet digital polymerase chain reaction (ddPCR) assay was...
Mother adversity and co-residence time impact mother–child similarity in genome-wide and gene-specific methylation profiles
Mother adversity and co-residence time impact mother–child similarity in genome-wide and gene-specific methylation profiles
The effects of adverse life events on physical and psychological health, with DNA methylation (DNAm) as a critical underly...
Identification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation
Identification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation
Congenital heart disease (CHD) is a prevalent congenital cardiac malformation, which lacks effective early biological diag...
Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study
Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study
Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely...
MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2
MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2
MAL (T-lymphocyte maturation-associated protein) is highly downregulated in most cancers, including cervical cancer (CaCx)...
Novel histone post-translational modifications in Alzheimer’s disease: current advances and implications
Novel histone post-translational modifications in Alzheimer’s disease: current advances and implications
Alzheimer’s disease (AD) has a complex pathogenesis, and multiple studies have indicated that histone post-translati...
DNA methylation may partly explain psychotropic drug-induced metabolic side effects: results from a prospective 1-month observational study
DNA methylation may partly explain psychotropic drug-induced metabolic side effects: results from a prospective 1-month observational study
Metabolic side effects of psychotropic medications are a major drawback to patients’ successful treatment. Using an ...
Cell-free DNA methylation reveals cell-specific tissue injury and correlates with disease severity and patient outcomes in COVID-19
Cell-free DNA methylation reveals cell-specific tissue injury and correlates with disease severity and patient outcomes in COVID-19
The recently identified methylation patterns specific to cell type allows the tracing of cell death dynamics at the cellul...
An EWAS of dementia biomarkers and their associations with age, African ancestry, and PTSD
An EWAS of dementia biomarkers and their associations with age, African ancestry, and PTSD
Large-scale cohort and epidemiological studies suggest that PTSD confers risk for dementia in later life but the biologica...
Improvements in lung function following vitamin C supplementation to pregnant smokers are associated with buccal DNA methylation at 5 years of age
Improvements in lung function following vitamin C supplementation to pregnant smokers are associated with buccal DNA methylation at 5 years of age
We previously reported in the “Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung FunctionR...
Reduced representative methylome profiling of cell-free DNA for breast cancer detection
Reduced representative methylome profiling of cell-free DNA for breast cancer detection
Whole-genome methylation sequencing of cfDNA is not cost-effective for tumor detection. Here, we introduce reduced represe...
Prediction of methylation status using WGS data of plasma cfDNA for multi-cancer early detection (MCED)
Prediction of methylation status using WGS data of plasma cfDNA for multi-cancer early detection (MCED)
Cell-free DNA (cfDNA) contains a large amount of molecular information that can be used for multi-cancer early detection (...
Epigenetic aging in older people living with HIV in Eswatini: a pilot study of HIV and lifestyle factors and epigenetic aging
Epigenetic aging in older people living with HIV in Eswatini: a pilot study of HIV and lifestyle factors and epigenetic aging
People living with HIV (PLHIV) on effective antiretroviral therapy are living near-normal lives. Although they are less su...
Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness
Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness
Critically ill children suffer from impaired physical/neurocognitive development 2 years later. Glucocorticoid tr...
Epigenetic regulation and factors that influence the effect of iPSCs-derived neural stem/progenitor cells (NS/PCs) in the treatment of spinal cord injury
Epigenetic regulation and factors that influence the effect of iPSCs-derived neural stem/progenitor cells (NS/PCs) in the treatment of spinal cord injury
Spinal cord injury (SCI) is a severe neurological disorder that causes neurological impairment and disability. Neural stem...
Epigenome-wide association study of dietary fatty acid intake
Epigenome-wide association study of dietary fatty acid intake
Dietary intake of n-3 polyunsaturated fatty acids (PUFA) may have a protective effect on the development of cardiovascular...
Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease
Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease
E-cadherin, a major actor of cell adhesion in the intestinal barrier, is encoded by the CDH1 gene associated with suscepti...
Molecular map of disulfidptosis-related genes in lung adenocarcinoma: the perspective toward immune microenvironment and prognosis
Molecular map of disulfidptosis-related genes in lung adenocarcinoma: the perspective toward immune microenvironment and prognosis
Disulfidptosis is a recently discovered form of programmed cell death that could impact cancer development. Nevertheless, ...
Kidney-specific methylation patterns correlate with kidney function and are lost upon kidney disease progression
Kidney-specific methylation patterns correlate with kidney function and are lost upon kidney disease progression
Chronological and biological age correlate with DNA methylation levels at specific sites in the genome. Linear combination...
阅读更多
format_indent_increase