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Quantification method of ctDNA using cell-free DNA methylation profile for noninvasive screening and monitoring of colon cancer
Quantification method of ctDNA using cell-free DNA methylation profile for noninvasive screening and monitoring of colon cancer
Colon cancer ranks as the second most lethal form of cancer globally. In recent years, there has been active investigation...
Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant
Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant
Obesity is a major health burden. Preadipocytes proliferate and differentiate in mature adipocytes in the adipogenic proce...
The association between sleep quality and accelerated epigenetic aging with metabolic syndrome in Korean adults
The association between sleep quality and accelerated epigenetic aging with metabolic syndrome in Korean adults
Healthy sleep is vital for maintaining optimal mental and physical health. Accumulating evidence suggests that sleep loss ...
Effects of walking on epigenetic age acceleration: a Mendelian randomization study
Effects of walking on epigenetic age acceleration: a Mendelian randomization study
Walking stands as the most prevalent physical activity in the daily lives of individuals and is closely associated with ph...
A systematic review on the contribution of DNA methylation to hearing loss
A systematic review on the contribution of DNA methylation to hearing loss
DNA methylation may have a regulatory role in monogenic sensorineural hearing loss and complex, polygenic phenotypic forms...
Diagnosis of pediatric central nervous system tumors using methylation profiling of cfDNA from cerebrospinal fluid
Diagnosis of pediatric central nervous system tumors using methylation profiling of cfDNA from cerebrospinal fluid
Pediatric central nervous system tumors remain challenging to diagnose. Imaging approaches do not provide sufficient detai...
DNA methylation profile of inflammatory breast cancer and its impact on prognosis and outcome
DNA methylation profile of inflammatory breast cancer and its impact on prognosis and outcome
Inflammatory breast cancer (IBC) is a rare disease characterized by rapid progression, early metastasis, and a high mortal...
Effects of improved on-farm crop storage on DNA methylation of mothers and their infants: evidence from a randomized controlled trial in Kenya
Effects of improved on-farm crop storage on DNA methylation of mothers and their infants: evidence from a randomized controlled trial in Kenya
Stress during pregnancy can lead to adverse maternal and infant health outcomes through epigenetic changes in the hypothal...
H3K27ac acts as a molecular switch for doxorubicin-induced activation of cardiotoxic genes
H3K27ac acts as a molecular switch for doxorubicin-induced activation of cardiotoxic genes
Doxorubicin (Dox) is an effective chemotherapeutic drug for various cancers, but its clinical application is limited by se...
Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception
Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception
Gastrointestinal malignancies encompass a diverse group of cancers that pose significant challenges to global health. The ...
Methylome analysis in girls with idiopathic central precocious puberty
Methylome analysis in girls with idiopathic central precocious puberty
Genetic and environmental factors are implicated in many developmental processes. Recent evidence, however, has suggested ...
Estrogen-mediated DNMT1 and DNMT3A recruitment by EZH2 silences miR-570-3p that contributes to papillary thyroid malignancy through DPP4
Estrogen-mediated DNMT1 and DNMT3A recruitment by EZH2 silences miR-570-3p that contributes to papillary thyroid malignancy through DPP4
Papillary thyroid carcinoma (PTC) is a common endocrine malignancy. Studies have indicated that estrogen can regulate the ...
DNA methylation in peripheral blood is associated with renal aging and renal function decline: a national community study
DNA methylation in peripheral blood is associated with renal aging and renal function decline: a national community study
Older patients are at risk for acute kidney injury and chronic kidney disease. Age-related increases in DNA methylation at...
Fetal hemoglobin induction in azacytidine responders enlightens methylation patterns related to blast clearance in higher-risk MDS and CMML
Fetal hemoglobin induction in azacytidine responders enlightens methylation patterns related to blast clearance in higher-risk MDS and CMML
As new treatment options for patients with higher-risk myelodysplastic syndromes are emerging, identification of prognosti...
Exploring histone deacetylases in type 2 diabetes mellitus: pathophysiological insights and therapeutic avenues
Exploring histone deacetylases in type 2 diabetes mellitus: pathophysiological insights and therapeutic avenues
Diabetes mellitus is a chronic disease that impairs metabolism, and its prevalence has reached an epidemic proportion glob...
PAX1 methylation as a robust predictor: developing and validating a nomogram for assessing endocervical curettage (ECC) necessity in human papillomavirus16/18-positive women undergoing colposcopy
PAX1 methylation as a robust predictor: developing and validating a nomogram for assessing endocervical curettage (ECC) necessity in human papillomavirus16/18-positive women undergoing colposcopy
The major challenge in routine endocervical curettage (ECC) among Human Papillomavirus (HPV) 16/18-positive patients is th...
Pathogenic sequence variant and microdeletion affecting HMGA2 in Silver–Russell syndrome: case reports and literature review
Pathogenic sequence variant and microdeletion affecting HMGA2 in Silver–Russell syndrome: case reports and literature review
Silver–Russell syndrome (SRS) is a representative imprinting disorder characterized by pre- and postnatal growth fai...
Aortic disease and cardiomyopathy in patients with a novel DNMT3A gene variant causing Tatton-Brown–Rahman syndrome
Aortic disease and cardiomyopathy in patients with a novel DNMT3A gene variant causing Tatton-Brown–Rahman syndrome
Tatton-Brown–Rahman syndrome (TBRS) is a rare congenital genetic disorder caused by autosomal dominant pathogenic va...
Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts
Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts
Epigenetic modifications, particularly DNA methylation (DNAm) in cord blood, are an important biological marker of how ext...
DNA methylation and stroke prognosis: an epigenome-wide association study
DNA methylation and stroke prognosis: an epigenome-wide association study
Stroke is the leading cause of adult-onset disability. Although clinical factors influence stroke outcome, there is a sign...
Lactylation: the novel histone modification influence on gene expression, protein function, and disease
Lactylation: the novel histone modification influence on gene expression, protein function, and disease
Lactic acid, traditionally considered as a metabolic waste product arising from glycolysis, has undergone a resurgence in ...
No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state
No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state
Methylation of serotonin-related genes has been proposed as a plausible gene-by-environment link which may mediate environ...
Longitudinal analysis of epigenome-wide DNA methylation reveals novel loci associated with BMI change in East Asians
Longitudinal analysis of epigenome-wide DNA methylation reveals novel loci associated with BMI change in East Asians
Obesity is a global public health concern linked to chronic diseases such as cardiovascular disease and type 2 diabetes (T...
Investigating neonatal health risk variables through cell-type specific methylome-wide association studies
Investigating neonatal health risk variables through cell-type specific methylome-wide association studies
Adverse neonatal outcomes are a prevailing risk factor for both short- and long-term mortality and morbidity in infants. G...
Semimethylation is a feature of diffuse large B-cell lymphoma, and subgroups with poor prognosis are characterized by global hypomethylation and short telomere length
Semimethylation is a feature of diffuse large B-cell lymphoma, and subgroups with poor prognosis are characterized by global hypomethylation and short telomere length
Large B-cell lymphoma (LBCL) is the most common lymphoma and is known to be a biologically heterogeneous disease regarding...
DNA methylation and type 2 diabetes: a systematic review
DNA methylation and type 2 diabetes: a systematic review
DNA methylation influences gene expression and function in the pathophysiology of type 2 diabetes mellitus (T2DM). Mapping...
Machine learning unveils an immune-related DNA methylation profile in germline DNA from breast cancer patients
Machine learning unveils an immune-related DNA methylation profile in germline DNA from breast cancer patients
There is an unmet need for precise biomarkers for early non-invasive breast cancer detection. Here, we aimed to identify b...
DNA methylation signatures of youth-onset type 2 diabetes and exposure to maternal diabetes
DNA methylation signatures of youth-onset type 2 diabetes and exposure to maternal diabetes
Youth-onset type 2 diabetes (T2D) is physiologically distinct from adult-onset, but it is not clear how the two diseases d...
Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids
Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids
Osteoarthritis (OA) is a complex, age-related multifactorial degenerative disease of diarthrodial joints marked by impaire...
Decitabine as epigenetic priming with CLAG induce improved outcome of relapsed or refractory acute myeloid leukemia in children
Decitabine as epigenetic priming with CLAG induce improved outcome of relapsed or refractory acute myeloid leukemia in children
Decitabine (DAC), a DNA methyltransferase inhibitor, has shown efficacy combined with chemotherapy for relapsed or refract...
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