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Correction: Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells
Correction: Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells
Clemens Zwergel and Michael Schnekenburger contributed equally to this work.Department of Chemistry and Technologies of Dr...
Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer
Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer
Lung cancer patients are diagnosed at late stages when curative treatments are no longer possible; thus, molecular biomark...
DNA methylation and aeroallergen sensitization: The chicken or the egg?
DNA methylation and aeroallergen sensitization: The chicken or the egg?
DNA methylation (DNAm) is considered a plausible pathway through which genetic and environmental factors may influence the...
Serum level of total histone 3, H3K4me3, and H3K27ac after non-emergent cardiac surgery suggests the persistence of smoldering inflammation at 3 months in an adult population
Serum level of total histone 3, H3K4me3, and H3K27ac after non-emergent cardiac surgery suggests the persistence of smoldering inflammation at 3 months in an adult population
Despite clinical relevance of immunological activation due to histone leakage into the serum following cardiac surgery, lo...
Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell line
Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell line
Azacytidine (AzaC) and decitabine (AzadC) are cytosine analogs that covalently trap DNA methyltransferases, which place th...
BladMetrix: a novel urine DNA methylation test with high accuracy for detection of bladder cancer in hematuria patients
BladMetrix: a novel urine DNA methylation test with high accuracy for detection of bladder cancer in hematuria patients
Cystoscopy is the gold standard for bladder cancer detection, but is costly, invasive and has imperfect diagnostic accurac...
OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder
OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder
The neuropeptide oxytocin (OXT) plays a role in the regulation of eating behavior and metabolism. OXT functioning is alter...
Integrated single-cell RNA-seq and DNA methylation reveal the effects of air pollution in patients with recurrent spontaneous abortion
Integrated single-cell RNA-seq and DNA methylation reveal the effects of air pollution in patients with recurrent spontaneous abortion
Maternal air pollutants exposure is associated with a number of adverse pregnancy outcomes, including recurrent spontaneou...
DNA methylation analysis of normal colon organoids from familial adenomatous polyposis patients reveals novel insight into colon cancer development
DNA methylation analysis of normal colon organoids from familial adenomatous polyposis patients reveals novel insight into colon cancer development
Familial adenomatous polyposis (FAP) is an inherited colorectal cancer (CRC) syndrome resulting from germ line mutations i...
Epigenetic tumor heterogeneity in the era of single-cell profiling with nanopore sequencing
Epigenetic tumor heterogeneity in the era of single-cell profiling with nanopore sequencing
Nanopore sequencing has brought the technology to the next generation in the science of sequencing. This is achieved throu...
Integrated multi-omics analyses reveal that BCAM is associated with epigenetic modification and tumor microenvironment subtypes of clear cell renal cell carcinoma
Integrated multi-omics analyses reveal that BCAM is associated with epigenetic modification and tumor microenvironment subtypes of clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most common and highly heterogeneous subtype of renal cell carcinoma. Dysre...
Identification of influential probe types in epigenetic predictions of human traits: implications for microarray design
Identification of influential probe types in epigenetic predictions of human traits: implications for microarray design
CpG methylation levels can help to explain inter-individual differences in phenotypic traits. Few studies have explored wh...
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature
Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic mechanism of gene activation. It is mediated...
Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer
Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer
Interferon gamma (IFNγ) is a pro-inflammatory cytokine that directly activates the JAK/STAT pathway. However, the tem...
Correction: miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway
Correction: miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
A critical appraisal of clinical epigenetics
A critical appraisal of clinical epigenetics
Modern epigenetics emerged about 40 years ago. Since then, the field has rapidly grown. Unfortunately, this devel...
Persistent blood DNA methylation changes one year after SARS-CoV-2 infection
Persistent blood DNA methylation changes one year after SARS-CoV-2 infection
We recently reported the COVID-19-induced circulating leukocytes DNA methylation profile. Here, we hypothesized that some ...
Identification of clinical implications and potential prognostic models of chromatin regulator mutations in multiple myeloma
Identification of clinical implications and potential prognostic models of chromatin regulator mutations in multiple myeloma
With the rapid development of next-generation sequencing (NGS) technologies, researchers are making efforts to reveal the ...
Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression
Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression
SLC5A7 (solute carrier family 5 member 7), also known as choline transporter 1 (CHT1), is downregulated in colorectal canc...
Psychostimulant-induced aberrant DNA methylation in an in vitro model of human peripheral blood mononuclear cells
Psychostimulant-induced aberrant DNA methylation in an in vitro model of human peripheral blood mononuclear cells
Several reports have provided crucial evidence in animal models that epigenetic modifications, such as DNA methylation, ma...
Shifts in the immunoepigenomic landscape of monocytes in response to a diabetes-specific social support intervention: a pilot study among Native Hawaiian adults with diabetes
Shifts in the immunoepigenomic landscape of monocytes in response to a diabetes-specific social support intervention: a pilot study among Native Hawaiian adults with diabetes
Native Hawaiians are disproportionately affected by type 2 diabetes mellitus (DM), a chronic metabolic, non-commu...
Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women
Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women
Cardiovascular disease (CVD) remains the leading cause of death among postmenopausal women but standard primary prevention...
An epigenome-wide association study of insulin resistance in African Americans
An epigenome-wide association study of insulin resistance in African Americans
African Americans have a high risk for type 2 diabetes (T2D) and insulin resistance. Studies among other population groups...
Maternal–fetal stress and DNA methylation signatures in neonatal saliva: an epigenome-wide association study
Maternal–fetal stress and DNA methylation signatures in neonatal saliva: an epigenome-wide association study
Maternal stress before, during and after pregnancy has profound effects on the development and lifelong function of the in...
Noninvasive early detection of colorectal cancer by hypermethylation of the LINC00473 promoter in plasma cell-free DNA
Noninvasive early detection of colorectal cancer by hypermethylation of the LINC00473 promoter in plasma cell-free DNA
Current noninvasive assays have limitations in the early detection of colorectal cancer. We evaluated the clinical utility...
Relative contributions of six lifestyle- and health-related exposures to epigenetic aging: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Relative contributions of six lifestyle- and health-related exposures to epigenetic aging: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
DNA methylation-based GrimAge acceleration (GrimAA) is associated with a wide range of age-related health outcomes includi...
Chidamide and venetoclax synergistically exert cytotoxicity on multiple myeloma by upregulating BIM expression
Chidamide and venetoclax synergistically exert cytotoxicity on multiple myeloma by upregulating BIM expression
Multiple myeloma (MM) is the second most common hematologic malignancy with almost all patients eventually having relapse ...
Longitudinal associations of DNA methylation and sleep in children: a meta-analysis
Longitudinal associations of DNA methylation and sleep in children: a meta-analysis
Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onward...
DNA methylation: a potential mediator between air pollution and metabolic syndrome
DNA methylation: a potential mediator between air pollution and metabolic syndrome
Given the global increase in air pollution and its crucial role in human health, as well as the steep rise in prevalence o...
Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms
Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms
Epigenetic abnormalities in DNA hydroxymethylation (5hmC) have been detected in patients with myeloid neoplasms, suggestin...
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