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Low levels of circulating methylated IRX3 are related to worse outcome after transcatheter aortic valve implantation in patients with severe aortic stenosis
Low levels of circulating methylated IRX3 are related to worse outcome after transcatheter aortic valve implantation in patients with severe aortic stenosis
Aortic stenosis (AS) is one of the most common cardiac diseases and major cause of morbidity and mortality in the elderly....
Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and ...
Unlocking the potential of targeting histone-modifying enzymes for treating IBD and CRC
Unlocking the potential of targeting histone-modifying enzymes for treating IBD and CRC
Dysregulation of histone modifications has been implicated in the pathogenesis of both inflammatory bowel disease (IBD) an...
Crosstalk between DNA methylation and hypoxia in acute myeloid leukaemia
Crosstalk between DNA methylation and hypoxia in acute myeloid leukaemia
Acute myeloid leukaemia (AML) is a deadly disease characterised by the uncontrolled proliferation of immature myeloid cell...
Evaluation of commercial kits for isolation and bisulfite conversion of circulating cell-free tumor DNA from blood
Evaluation of commercial kits for isolation and bisulfite conversion of circulating cell-free tumor DNA from blood
DNA methylation biomarkers in circulating cell-free DNA (cfDNA) have great clinical potential for cancer management. Most ...
Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2 diabetics
Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2 diabetics
First-degree relatives of type 2 diabetics (FDR) exhibit a high risk of developing type 2 diabetes (T2D) and feature subcu...
A quantum physics layer of epigenetics: a hypothesis deduced from charge transfer and chirality-induced spin selectivity of DNA
A quantum physics layer of epigenetics: a hypothesis deduced from charge transfer and chirality-induced spin selectivity of DNA
Epigenetic mechanisms are informational cellular processes instructing normal and diseased phenotypes. They are associated...
Correction: Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis
Correction: Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Evaluation of pediatric epigenetic clocks across multiple tissues
Evaluation of pediatric epigenetic clocks across multiple tissues
Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clock...
Fathers’ preconception smoking and offspring DNA methylation
Fathers’ preconception smoking and offspring DNA methylation
Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transm...
Evaluation of the pooled sample method in Infinium MethylationEPIC BeadChip array by comparison with individual samples
Evaluation of the pooled sample method in Infinium MethylationEPIC BeadChip array by comparison with individual samples
The pooled sample method is used in epigenomic research and expression analysis and is a cost-effective screening approach...
Correction : HTRA1 methylation in peripheral blood as a potential marker for the preclinical detection of stroke: a case–control study and a prospective nested case–control study
Correction : HTRA1 methylation in peripheral blood as a potential marker for the preclinical detection of stroke: a case–control study and a prospective nested case–control study
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Abnormal DNA methylation analysis of leucine-rich glioma-inactivated 1 antibody encephalitis reveals novel methylation-driven genes related to prognostic and clinical features
Abnormal DNA methylation analysis of leucine-rich glioma-inactivated 1 antibody encephalitis reveals novel methylation-driven genes related to prognostic and clinical features
Aberrant DNA methylation occurs commonly during pathogenesis of neuroimmunological diseases and is of clinical value in va...
Association of DNA methylation of vitamin D metabolic pathway related genes with colorectal cancer risk
Association of DNA methylation of vitamin D metabolic pathway related genes with colorectal cancer risk
Vitamin D might have anti-tumor effect, which is affected by the genes related to vitamin D metabolic pathway. Epigenetic ...
Associations between nutrients in one-carbon metabolism and fetal DNA methylation in pregnancies with or without gestational diabetes mellitus
Associations between nutrients in one-carbon metabolism and fetal DNA methylation in pregnancies with or without gestational diabetes mellitus
Gestational diabetes mellitus (GDM), characterized by hyperglycemia that develops during pregnancy, increases the risk of ...
Objective and subjective measures of sleep initiation are differentially associated with DNA methylation in adolescents
Objective and subjective measures of sleep initiation are differentially associated with DNA methylation in adolescents
The onset of puberty is associated with a shift in the circadian timing of sleep, leading to delayed sleep initiation [i.e...
The inactive X chromosome accumulates widespread epigenetic variability with age
The inactive X chromosome accumulates widespread epigenetic variability with age
Loss of epigenetic control is a hallmark of aging. Among the most prominent roles of epigenetic mechanisms is the inactiva...
Cell-free DNA 5-hydroxymethylcytosine is highly sensitive for MRD assessment in acute myeloid leukemia
Cell-free DNA 5-hydroxymethylcytosine is highly sensitive for MRD assessment in acute myeloid leukemia
Measurable residual disease (MRD) is an important biomarker in acute myeloid leukemia (AML). However, MRD cannot be detect...
CRISPR/dCAS9-mediated DNA demethylation screen identifies functional epigenetic determinants of colorectal cancer
CRISPR/dCAS9-mediated DNA demethylation screen identifies functional epigenetic determinants of colorectal cancer
Promoter hypermethylation of tumour suppressor genes is frequently observed during the malignant transformation of colorec...
Association between acetaminophen metabolites and CYP2E1 DNA methylation level in neonate cord blood in the Boston Birth Cohort
Association between acetaminophen metabolites and CYP2E1 DNA methylation level in neonate cord blood in the Boston Birth Cohort
Acetaminophen is a commonly used medication by pregnant women and is known to cross the placenta. However, little is known...
Cross-platform comparisons for targeted bisulfite sequencing of MGISEQ-2000 and NovaSeq6000
Cross-platform comparisons for targeted bisulfite sequencing of MGISEQ-2000 and NovaSeq6000
An accurate and reproducible next-generation sequencing platform is essential to identify malignancy-related abnormal DNA ...
Globally elevated levels of histone H3 lysine 9 trimethylation in early infancy are associated with poor growth trajectory in Bangladeshi children
Globally elevated levels of histone H3 lysine 9 trimethylation in early infancy are associated with poor growth trajectory in Bangladeshi children
Stunting is a global health problem affecting hundreds of millions of children worldwide and contributing to 45% of deaths...
Introduction of a multiplex amplicon sequencing assay to quantify DNA methylation in target cytosine markers underlying four selected epigenetic clocks
Introduction of a multiplex amplicon sequencing assay to quantify DNA methylation in target cytosine markers underlying four selected epigenetic clocks
DNA methylation analysis has proven to be a powerful tool for age assessment. However, the implementation of epigenetic ag...
Global effects of identity and aging on the human sperm methylome
Global effects of identity and aging on the human sperm methylome
As the average age of fatherhood increases worldwide, so too does the need for understanding effects of aging in male germ...
Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis
Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis
Long-term environmental exposure to metals leads to epigenetic changes and may increase risks to human health. The relatio...
DNA methylation as a triage marker for colposcopy referral in HPV-based cervical cancer screening: a systematic review and meta-analysis
DNA methylation as a triage marker for colposcopy referral in HPV-based cervical cancer screening: a systematic review and meta-analysis
Screening plays a key role in secondary prevention of cervical cancer. High-risk human papillomavirus (hrHPV) testing, a h...
PAX1 hypomethylation as a prognostic biomarker for radioresistance of cervical cancer
PAX1 hypomethylation as a prognostic biomarker for radioresistance of cervical cancer
PAX1 gene methylation plays an important role in the development of cervical cancer. However, its prognostic value after r...
Update on histone deacetylase inhibitors in peripheral T-cell lymphoma (PTCL)
Update on histone deacetylase inhibitors in peripheral T-cell lymphoma (PTCL)
Peripheral T-cell lymphomas (PTCLs) are a group of highly aggressive malignancies with generally poor prognoses, and the f...
DNA methylation and 28-year cardiovascular disease risk in type 1 diabetes: the Epidemiology of Diabetes Complications (EDC) cohort study
DNA methylation and 28-year cardiovascular disease risk in type 1 diabetes: the Epidemiology of Diabetes Complications (EDC) cohort study
The potential for DNA methylation (DNAm) as an early marker for cardiovascular disease (CVD) and how such an association m...
DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma
DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma
Adrenocortical carcinoma is rare and aggressive endocrine cancer of the adrenal gland. Within adrenocortical carcinoma, a ...
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