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A phase 1 clinical trial of the repurposable acetyllysine mimetic, n-methyl-2-pyrrolidone (NMP), in relapsed or refractory multiple myeloma
A phase 1 clinical trial of the repurposable acetyllysine mimetic, n-methyl-2-pyrrolidone (NMP), in relapsed or refractory multiple myeloma
N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applications ...
The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma
The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma
Renal cell carcinoma (RCC) is not sensitive to immunotherapy and has poor prognosis. DNA methylation regulates gene expres...
Epigenetic dysregulation-mediated COL12A1 upregulation predicts worse outcome in intrahepatic cholangiocarcinoma patients
Epigenetic dysregulation-mediated COL12A1 upregulation predicts worse outcome in intrahepatic cholangiocarcinoma patients
Collagen type XII alpha 1 chain (COL12A1) is associated with human cancer progression. Nevertheless, the expression patter...
Azithromycin attenuates wheezing after pulmonary inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2
Azithromycin attenuates wheezing after pulmonary inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2
Histone methylation modification plays an irreplaceable role in the wheezing diseases. The aim of this study was to explor...
Long-term impact of paediatric critical illness on the difference between epigenetic and chronological age in relation to physical growth
Long-term impact of paediatric critical illness on the difference between epigenetic and chronological age in relation to physical growth
Altered DNA-methylation affects biological ageing in adults and developmental processes in children. DNA-methylation is al...
Vitamin C boosts DNA demethylation in TET2 germline mutation carriers
Vitamin C boosts DNA demethylation in TET2 germline mutation carriers
Accurate regulation of DNA methylation is necessary for normal cells to differentiate, develop and function. TET2 catalyze...
Drugging the epigenome in the age of precision medicine
Drugging the epigenome in the age of precision medicine
Modulating the epigenome has long been considered a potential opportunity for therapeutic intervention in numerous disease...
Methylation in MAD1L1 is associated with the severity of suicide attempt and phenotypes of depression
Methylation in MAD1L1 is associated with the severity of suicide attempt and phenotypes of depression
Depression is a multifactorial disorder representing a significant public health burden. Previous studies have linked mult...
Publisher Correction: Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker
Publisher Correction: Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker
Reiner SiebertPresent address: Institute of Human Genetics, University of Ulm and University Medical Center Ulm, Ulm, Germ...
Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer
Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer
Combination chemotherapy has contributed to increased survival from Hodgkin disease (HD) and testicular cancer (TC). Howev...
Hepatocellular carcinoma detection via targeted enzymatic methyl sequencing of plasma cell-free DNA
Hepatocellular carcinoma detection via targeted enzymatic methyl sequencing of plasma cell-free DNA
Epigenetic variants carried by circulating tumor DNA can be used as biomarkers for early detection of hepatocellular carci...
Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation
Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation
Cardiac surgery and cardiopulmonary bypass induce a substantial immune and inflammatory response, the overactivation of wh...
DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity
DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity
Epigenetic modifications in mammalian DNA are commonly manifested by DNA methylation. In the stomach, altered DNA methylat...
Whole-blood methylation signatures are associated with and accurately classify multiple sclerosis disease severity
Whole-blood methylation signatures are associated with and accurately classify multiple sclerosis disease severity
The variation in multiple sclerosis (MS) disease severity is incompletely explained by genetics, suggesting genetic and en...
Genome-wide placental DNA methylations in fetal overgrowth and associations with leptin, adiponectin and fetal growth factors
Genome-wide placental DNA methylations in fetal overgrowth and associations with leptin, adiponectin and fetal growth factors
Fetal overgrowth “programs” an elevated risk of type 2 diabetes in adulthood. Epigenetic alterations may be a ...
Maintenance of methylation profile in imprinting control regions in human induced pluripotent stem cells
Maintenance of methylation profile in imprinting control regions in human induced pluripotent stem cells
Parental imprinting is an epigenetic mechanism that leads to monoallelic expression of a subset of genes depending on thei...
Association of nutritional glycaemic indices with global DNA methylation patterns: results from the Moli-sani cohort
Association of nutritional glycaemic indices with global DNA methylation patterns: results from the Moli-sani cohort
High dietary glycaemic index (GI) and load (GL) have been associated with increased risk of various cardiometabolic condit...
Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy
Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy
DNA methylation profiling of circulating cell-free DNA (cfDNA) has rapidly become a promising strategy for biomarker ident...
BDNF exon IV promoter methylation and antidepressant action: a complex interplay
BDNF exon IV promoter methylation and antidepressant action: a complex interplay
BDNF exon IV promoter methylation is a potential biomarker for treatment response to antidepressants in MDD. We have previ...
Altered DNA methylation in estrogen-responsive repetitive sequences of spermatozoa of infertile men with shortened anogenital distance
Altered DNA methylation in estrogen-responsive repetitive sequences of spermatozoa of infertile men with shortened anogenital distance
It has been suggested that antenatal exposure to environmental endocrine disruptors is responsible for adverse trends in m...
Identification of hepatocellular carcinoma subtypes based on PcG-related genes and biological relevance with cancer cells
Identification of hepatocellular carcinoma subtypes based on PcG-related genes and biological relevance with cancer cells
Hepatocellular carcinoma (HCC) is an extensive heterogeneous disease where epigenetic factors contribute to its pathogenes...
Tumor mutation burden involving epigenetic regulatory genes and the RhoA GTPase predicts overall survival in nodal mature T-cell lymphomas
Tumor mutation burden involving epigenetic regulatory genes and the RhoA GTPase predicts overall survival in nodal mature T-cell lymphomas
Nodal mature T-cell lymphomas (nMTCL) comprises a heterogeneous group of rare malignancies with aggressive biological beha...
DNA methylation patterns associated with konzo in Sub-Saharan Africa
DNA methylation patterns associated with konzo in Sub-Saharan Africa
Konzo, a disease characterized by sudden, irreversible spastic paraparesis, affecting up to 10% of the population in some ...