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Novel histone modifications and liver cancer: emerging frontiers in epigenetic regulation
Novel histone modifications and liver cancer: emerging frontiers in epigenetic regulation
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, and its onset and progressi...
Systematic review on the DNA methylation role in endometriosis: current evidence and perspectives
Systematic review on the DNA methylation role in endometriosis: current evidence and perspectives
Endometriosis appears to have a multilayered etiology, with genetic and epigenetic factors each contributing half of the p...
LSD1 is a targetable vulnerability in gastric cancer harboring TP53 frameshift mutations
LSD1 is a targetable vulnerability in gastric cancer harboring TP53 frameshift mutations
TP53 mutations are linked to aggressive progression and chemoresistance in gastric cancer (GC). Frameshift mutation is the...
MGMT epimutations and risk of incident cancer of the colon, glioblastoma multiforme, and diffuse large B cell lymphomas
MGMT epimutations and risk of incident cancer of the colon, glioblastoma multiforme, and diffuse large B cell lymphomas
Constitutional BRCA1 epimutations (promoter hypermethylation) are associated with an elevated risk of triple-negative brea...
Glucocorticoid exposure-induced alterations in epigenetic age from human preterm infants and human lung fibroblasts and hippocampal neuronal cells
Glucocorticoid exposure-induced alterations in epigenetic age from human preterm infants and human lung fibroblasts and hippocampal neuronal cells
Maternal antenatal corticosteroid treatment is standard care to accelerate fetal maturation. However, there are growing co...
Identification of 17 novel epigenetic biomarkers associated with anxiety disorders using differential methylation analysis followed by machine learning-based validation
Identification of 17 novel epigenetic biomarkers associated with anxiety disorders using differential methylation analysis followed by machine learning-based validation
The changes in DNA methylation patterns may reflect both physical and mental well-being, the latter being a relatively une...
Radiogenomic method combining DNA methylation profiles and magnetic resonance imaging radiomics predicts patient prognosis in skull base chordoma
Radiogenomic method combining DNA methylation profiles and magnetic resonance imaging radiomics predicts patient prognosis in skull base chordoma
Chordoma is a rare malignant bone tumor exhibiting poor survival and prognosis. Hence, it is crucial to develop a convenie...
DNA methylation-based telomere length is more strongly associated with long-term all-cause mortality than quantitative polymerase chain reaction-based telomere length among middle-aged and older hypertensive adults
DNA methylation-based telomere length is more strongly associated with long-term all-cause mortality than quantitative polymerase chain reaction-based telomere length among middle-aged and older hypertensive adults
Telomere length (TL) has been linked to mortality risk across various populations. However, its predictive value for morta...
Sex-specific role of epigenetic modification of a leptin upstream enhancer in adipose tissue
Sex-specific role of epigenetic modification of a leptin upstream enhancer in adipose tissue
Maternal hormonal status can have long-term effects on offspring metabolic health and is likely regulated via epigenetic m...
Vitrification affects the post-implantation development of mouse embryos by inducing DNA damage and epigenetic modifications
Vitrification affects the post-implantation development of mouse embryos by inducing DNA damage and epigenetic modifications
Vitrification is widely used in assisted reproductive technology (ART) for female infertility, but the long-term effect on...
Longitudinal maternal glycemia during pregnancy and placental epigenetic age acceleration
Longitudinal maternal glycemia during pregnancy and placental epigenetic age acceleration
Dysregulation of maternal glucose homeostasis has been related to an increased risk of morbidity and mortality in mothers ...
miR-182 promoter hypermethylation predicts the better outcome of AML patients treated with AZA + VEN in a real-world setting
miR-182 promoter hypermethylation predicts the better outcome of AML patients treated with AZA + VEN in a real-world setting
5-Azacytidine (AZA) combined with the BCL2 inhibitor Venetoclax (VEN) is the standard treatment for elderly acute myeloid ...
Age-related changes in DNA methylation in a sample of elderly Brazilians
Age-related changes in DNA methylation in a sample of elderly Brazilians
Age-related changes in DNA methylation (DNAm) play a critical role in regulating gene expression. However, most epigenome-...
Validating a clinically based MS-MLPA threshold through comparison with Sanger sequencing in glioblastoma patients
Validating a clinically based MS-MLPA threshold through comparison with Sanger sequencing in glioblastoma patients
Glioblastoma is the commonest malignant brain tumor and has a very poor prognosis. Reduced expression of the MGMT gene (10...
Blood-based epigenome-wide association study and prediction of alcohol consumption
Blood-based epigenome-wide association study and prediction of alcohol consumption
Alcohol consumption is an important risk factor for multiple diseases. It is typically assessed via self-report, which is ...
The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications
The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications
Diabetic cardiomyopathy (DbCM), a significant chronic complication of diabetes, manifests as myocardial hypertrophy, fibro...
Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium
Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium
Night shift work during pregnancy has been associated with differential DNA methylation in placental tissue, but no studie...
Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy
Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy
Enriched environment (EE), as a non-pharmacological intervention, has garnered considerable attention for its potential to...
DNA methylation profiling at base-pair resolution reveals unique epigenetic features of early-onset colorectal cancer in underrepresented populations
DNA methylation profiling at base-pair resolution reveals unique epigenetic features of early-onset colorectal cancer in underrepresented populations
The incidence of early-onset colorectal cancer (EOCRC) has been rising at an alarming rate in the USA, and EOCRC dispropor...
How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health
How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health
Recent studies support the influence of paternal lifestyle and diet before conception on the health of the offspring via e...
TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma
TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma
5-Hydroxymethylcytosine (5hmC) modification represents a significant epigenetic modification within DNA, playing a pivotal...
TEC-mediated tRF-31R9J regulates histone lactylation and acetylation by HDAC1 to suppress hepatocyte ferroptosis and improve non-alcoholic steatohepatitis
TEC-mediated tRF-31R9J regulates histone lactylation and acetylation by HDAC1 to suppress hepatocyte ferroptosis and improve non-alcoholic steatohepatitis
Tectorigenin (TEC) is a monomer of anthocyanin, which we found exhibits hepatoprotective effects. tRNA-derived fragments (...
Hypoxia impairs decitabine-induced expression of HLA-DR in acute myeloid leukaemia cell lines
Hypoxia impairs decitabine-induced expression of HLA-DR in acute myeloid leukaemia cell lines
Hypomethylating agents (HMA), such as azacytidine (AZA) and decitabine (DAC), are epigenetic therapies used to treat some ...
Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis
Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis
IgG4-related cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC) are chronic fibro-inflammatory hepatobiliary c...
Validation of a hypomorphic variant in CDK13 as the cause of CHDFIDD with autosomal recessive inheritance through determination of an episignature
Validation of a hypomorphic variant in CDK13 as the cause of CHDFIDD with autosomal recessive inheritance through determination of an episignature
Autosomal dominant CDK13-related disease is characterized by congenital heart defects, dysmorphic facial features, and int...
Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases
Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases
As an important element of the human body, iron participates in numerous physiological and biochemical reactions. In the p...
A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children
A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children
There is limited knowledge on how diet affects the epigenome of children. Ultra-processed food (UPF) consumption is emergi...
Impaired ARID1A expression attenuated the immune response in gastric cancer via histone acetylation
Impaired ARID1A expression attenuated the immune response in gastric cancer via histone acetylation
The primary objective of this study was to examine whether ARID1A mutations confer a fitness advantage to gastric cancer f...
Unraveling the causal impact of smoking and its DNA methylation signatures on cardiovascular disease: Mendelian randomization and colocalization analysis
Unraveling the causal impact of smoking and its DNA methylation signatures on cardiovascular disease: Mendelian randomization and colocalization analysis
To explore the mechanisms linking smoking to cardiovascular diseases (CVDs) from an epigenetic perspective. Mendelian Rand...
Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations
Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations
Lynch syndrome (LS), characterised by an increased risk for cancer, is mainly caused by germline pathogenic variants affec...
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