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Chiral 2‐phenyl‐3‐hydroxypropyl esters as PKC‐alpha modulators: HPLC enantioseparation, NMR absolute configuration assignment, and molecular docking studies
Chiral 2‐phenyl‐3‐hydroxypropyl esters as PKC‐alpha modulators: HPLC enantioseparation, NMR absolute configuration assignment, and molecular docking studies
Abstract Protein kinase C (PKC) isoforms play a pivotal role in the regulation of numerous cellular functions, making them...
Enantioselective synthesis and selective functionalization of 4‐aminotetrahydroquinolines as novel GLP‐1 secretagogues
Enantioselective synthesis and selective functionalization of 4‐aminotetrahydroquinolines as novel GLP‐1 secretagogues
Abstract Polysubstituted tetrahydroquinolines were obtained in moderate to high yields (28% to 92%) and enantiomeric ratio...
Molecular enantiodiscrimination by NMR spectroscopy in chiral oriented systems: Concept, tools, and applications
Molecular enantiodiscrimination by NMR spectroscopy in chiral oriented systems: Concept, tools, and applications
Abstract The study of enantiodiscriminations in relation to various facets of enantiomorphism (chirality/prochirality) and...
Photo racemization of 2,2′‐dihydroxy‐1,1′‐binaphthyl derivatives
Photo racemization of 2,2′‐dihydroxy‐1,1′‐binaphthyl derivatives
Abstract Photo racemization of 2,2′-dihydroxy-1,1′-binaphthyl (BINOL) and its monomethyl ether, monobutyl et...
Concentration and pH effect on the electronic circular dichroism and anisotropy spectra of aqueous solutions of glyceric acid calcium salt
Concentration and pH effect on the electronic circular dichroism and anisotropy spectra of aqueous solutions of glyceric acid calcium salt
Abstract Electronic circular dichroism (ECD) and anisotropy spectra carry information on differential absorption of left- ...
Resolution of (R,S)‐1‐(4‐methoxyphenyl)ethanol by lipase‐catalyzed stereoselective transesterification and the process optimization
Resolution of (R,S)‐1‐(4‐methoxyphenyl)ethanol by lipase‐catalyzed stereoselective transesterification and the process optimization
Abstract An efficient lipase-catalyzed stereoselective transesterification reaction system was established for resolution ...
Enantioselective synthesis of coumarins catalyzed by an isosteviol‐derived tertiary amine‐squaramide catalyst
Enantioselective synthesis of coumarins catalyzed by an isosteviol‐derived tertiary amine‐squaramide catalyst
Abstract A newly tertiary amine-squaramide organocatalyst has been successfully developed and applied into the asymmetric ...
Macromolecular helicity induction and static helicity memory of poly(biphenylylacetylene)s bearing aromatic pendant groups and their use as chiral stationary phases for high‐performance liquid chromatography
Macromolecular helicity induction and static helicity memory of poly(biphenylylacetylene)s bearing aromatic pendant groups and their use as chiral stationary phases for high‐performance liquid chromatography
Abstract Two novel poly(biphenylylacetylene)s (PBPAs) bearing achiral alkylphenyl groups at the 4′-position of the ...
Multigram‐scale enzymatic kinetic resolution of trans‐2‐azidocyclohexyl acetate and chiral reversed‐phase HPLC analysis of trans‐2‐azidocyclohexanol
Multigram‐scale enzymatic kinetic resolution of trans‐2‐azidocyclohexyl acetate and chiral reversed‐phase HPLC analysis of trans‐2‐azidocyclohexanol
Abstract Lipase-catalyzed hydrolytic kinetic resolution is a method of obtaining optically pure chiral alcohols and amines...
Angucycline and angucyclinone derivatives from the marine‐derived Streptomyces sp.
Angucycline and angucyclinone derivatives from the marine‐derived Streptomyces sp.
Abstract Atramycin C (1), one new angucycline bearing an O-6 rhamnose side chain, along with one new highly hydroxylated a...
Impact of cyclofructan derivatives as efficient chiral selector in chiral analysis: An overview
Impact of cyclofructan derivatives as efficient chiral selector in chiral analysis: An overview
Abstract The development of chiral selectors for the separation and analysis of chiral molecules has been an evolving proc...
Enantiomeric separation of racemic amlodipine by sequential fractional crystallization through formation of diastereomeric salt solvates and co‐crystals of solvate‐like compounds with specific structure — A tandem resolution
Enantiomeric separation of racemic amlodipine by sequential fractional crystallization through formation of diastereomeric salt solvates and co‐crystals of solvate‐like compounds with specific structure — A tandem resolution
Abstract A new resolution method of racemic amlodipine has been developed. The racemic compound is reacted in a suitable s...
Efficient preparation of stereopure amphiphilic 1,2‐amino alcohols by using preparative enantioselective HPLC
Efficient preparation of stereopure amphiphilic 1,2‐amino alcohols by using preparative enantioselective HPLC
Abstract Chiral amphiphiles are useful for controlling the structures and properties of supramolecular assemblies, but the...
Absolute configuration assignment of stigmasterol oxiranes
Absolute configuration assignment of stigmasterol oxiranes
Abstract Diastereoisomeric stigmasterol oxiranes 4, 5, 8, and 9 are known phytosterol oxidation products (POPs) that have ...
ECD exciton chirality method today: a modern tool for determining absolute configurations
ECD exciton chirality method today: a modern tool for determining absolute configurations
Abstract The application of the exciton chirality method (ECM) to interpret electronic circular dichroism (ECD) spectra is...
Chiral organic stereochemistry: Chiral HPLC, chiral auxiliaries, CD spectroscopy, X‐ray crystallography, and light‐powered chiral molecular motors
Chiral organic stereochemistry: Chiral HPLC, chiral auxiliaries, CD spectroscopy, X‐ray crystallography, and light‐powered chiral molecular motors
Abstract In the studies of chiral organic stereochemistry, it is important to use enantiopure compounds. For this purpose,...
Chirality determination in crystals
Chirality determination in crystals
Abstract This tutorial review article discusses chirality determination in the solid state, both in single crystals and in...
DABCO‐based chiral ionic liquids as recoverable and reusable organocatalyst for asymmetric Diels–Alder reaction
DABCO‐based chiral ionic liquids as recoverable and reusable organocatalyst for asymmetric Diels–Alder reaction
Abstract New DABCO-based chiral ionic liquids were synthesized and evaluated in asymmetric Diels–Alder reaction of ...
Inducing enantioselective crystallization with and self‐assembly of star‐shaped hybrid polymers prepared via “grafting to” strategy
Inducing enantioselective crystallization with and self‐assembly of star‐shaped hybrid polymers prepared via “grafting to” strategy
Abstract Helical polymers present some interesting and distinctive properties, and one of the most distinguished applicati...
A miniaturized analytical method based on molecularly imprinted absorbents for selective extraction of (S)‐1,1′‐binaphthyl‐2,2′‐diamine and combinatorial screening of polymer precursors by computational simulation
A miniaturized analytical method based on molecularly imprinted absorbents for selective extraction of (S)‐1,1′‐binaphthyl‐2,2′‐diamine and combinatorial screening of polymer precursors by computational simulation
Abstract Chiral resolution of binaphthylamine is often a toilful conundrum in the field of analytical chemistry and biomed...
Circularly polarized luminescence of Eu(III) complexes with chiral 1,1′‐bi‐2‐naphtol‐derived bisphosphate ligands
Circularly polarized luminescence of Eu(III) complexes with chiral 1,1′‐bi‐2‐naphtol‐derived bisphosphate ligands
Abstract The interest for lanthanide circularly polarized luminescence (CPL) has been quickly growing for 10 years....
A novel isosteviol‐based bifunctional squaramide organocatalyst for enantioselective Michael addition of acetylacetone to nitroolefins
A novel isosteviol‐based bifunctional squaramide organocatalyst for enantioselective Michael addition of acetylacetone to nitroolefins
Abstract Chiral amine-squaramide is a kind of effective hydrogen bond donor bifunctional catalyst to promote many asymmetr...
Transition metal complexes bearing atropisomeric saturated NHC ligands
Transition metal complexes bearing atropisomeric saturated NHC ligands
Abstract From achiral imidazolinium salts, chiral transition metal complexes containing an N-heterocyclic carbene (NHC) li...
Enantioselective analyses of chloroquine and hydroxychloroquine in rat liver microsomes through chiral liquid chromatography–tandem mass spectrometry
Enantioselective analyses of chloroquine and hydroxychloroquine in rat liver microsomes through chiral liquid chromatography–tandem mass spectrometry
Abstract An efficient, sensitive and selective liquid chromatography–tandem mass spectrometry (LC–MS/MS) chi...
Racemization mechanism of lithium tert‐butylphenylphosphido‐borane: A kinetic insight
Racemization mechanism of lithium tert‐butylphenylphosphido‐borane: A kinetic insight
Abstract The racemization mechanism of tert-butylphenylphosphido-borane is investigated experimentally and theoretically. ...
Optically active porous hybrid particles constructed by alkynylated cellulose nanocrystals, helical substituted polyacetylene, and inorganic silica for enantio‐differentiating towards naproxen
Optically active porous hybrid particles constructed by alkynylated cellulose nanocrystals, helical substituted polyacetylene, and inorganic silica for enantio‐differentiating towards naproxen
Abstract This article reports on a novel type of ternary chiral porous hybrid particles (TCPHPs) constructed by alkynylate...
Chiral symmetry conservation principle
Chiral symmetry conservation principle
Abstract We show a chiral symmetry conservation principle based on chemical kinetics using stochastic results. Suppose the...
Apple juice and red wine induced mirror‐image circular dichroism in quantum dots
Apple juice and red wine induced mirror‐image circular dichroism in quantum dots
Abstract Juices, wines, and extracts from plants contain high concentrations of various chiral compounds such as carboxyli...
New pharmaceuticals approved by FDA in 2020: Small‐molecule drugs derived from amino acids and related compounds
New pharmaceuticals approved by FDA in 2020: Small‐molecule drugs derived from amino acids and related compounds
Abstract Amino acids (AAs) play an important role in the modern health industry as key synthetic precursors for pharmaceut...
Congratulations to Benjamin List and David W. C. MacMillan, Nobel Prize winners for Chemistry 2021!
Congratulations to Benjamin List and David W. C. MacMillan, Nobel Prize winners for Chemistry 2021!
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