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In vitro activity of celastrol in combination with thymol against carbapenem-resistant Klebsiella pneumoniae isolates
In vitro activity of celastrol in combination with thymol against carbapenem-resistant Klebsiella pneumoniae isolates
Klebsiella pneumoniae is an opportunistic pathogen causing nosocomial and community-acquired infections. Klebsiella has de...
Induced production of a new antioxidant phenylpropanoid from Streptomyces sp. by protoplast formation/regeneration
Induced production of a new antioxidant phenylpropanoid from Streptomyces sp. by protoplast formation/regeneration
Streptomyces sp. RD007556 regenerated from protoplast was found to produce p-coumaric acid 3,4-dihydroxybenzoate, propla a...
Microbacterium kunmingensis sp. nov., an attached bacterium of Microcystis aeruginosa
Microbacterium kunmingensis sp. nov., an attached bacterium of Microcystis aeruginosa
A Gram-stain positive, aerobic, rod-shaped actinobacterial strain designated as JXJ CY 27-2T was isolated from the culture...
Butorphanol inhibits angiogenesis and migration of hepatocellular carcinoma and regulates MAPK pathway
Butorphanol inhibits angiogenesis and migration of hepatocellular carcinoma and regulates MAPK pathway
Butorphanol, a synthetic opioid, exerts analgesic and anti-inflammatory effects against pathogenic diseases. Butorphanol r...
Causes of polymyxin treatment failure and new derivatives to fill the gap
Causes of polymyxin treatment failure and new derivatives to fill the gap
Polymyxins are a class of antibiotics that were discovered in 1947 from programs searching for compounds effective in the ...
Two new 22-membered macrolides from Streptomyces sp. HU210
Two new 22-membered macrolides from Streptomyces sp. HU210
Two new 22-membered macrolide metabolites, phthoramycins B (1) and C (2), were isolated from the fermentation broth of Str...
Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp
Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp
HPLC-UV-guided fractionation of crude extract from the marine sediment-derived bacterium Streptomyces sp. CNP-944 has yiel...
Isolation, characterization, and bioactivity profiling of oxazoline containing madurastatin siderophores from Actinomadura sp.
Isolation, characterization, and bioactivity profiling of oxazoline containing madurastatin siderophores from Actinomadura sp.
Nine new hydroxyphenyloxazolines, madurastatin B4, C2, D3 and D4, E1 and E2, F1 as well as G1 and G2 (8–16), along w...
Wychimicins, a new class of spirotetronate polyketides from Actinocrispum wychmicini MI503-A4
Wychimicins, a new class of spirotetronate polyketides from Actinocrispum wychmicini MI503-A4
In the course of our screening program for new anti-methicillin-resistant Staphylococcus aureus antibiotics, four novel an...
Bisprenyl naphthoquinone and chlorinated calcimycin congener bearing thiazole ring from an actinomycete of the genus Phytohabitans
Bisprenyl naphthoquinone and chlorinated calcimycin congener bearing thiazole ring from an actinomycete of the genus Phytohabitans
A bisprenyl naphthoquinone, phytohabinone (1), and a calcimycin congener with unusual modifications, phytohabimicin (2), w...
Cyclic enaminones and a 4-quinazolinone from an unidentified actinomycete of the family Micromonosporaceae
Cyclic enaminones and a 4-quinazolinone from an unidentified actinomycete of the family Micromonosporaceae
Four novel cyclic enaminones, designated RD4123A−D (1−4), and a new 4-quinazolinone metabolite, RD4123E (5), w...
Synergistic antibacterial and anti-biofilm activities of resveratrol and polymyxin B against multidrug-resistant Pseudomonas aeruginosa
Synergistic antibacterial and anti-biofilm activities of resveratrol and polymyxin B against multidrug-resistant Pseudomonas aeruginosa
Bacterial infection caused by multidrug-resistant Pseudomonas aeruginosa has become a challenge in clinical practice. Poly...
Two Novel Biosurfactants Produced by Aureobasidium pullulans A11211-4-57 from a Fleabane, Erigeron annus (L.) pers
Two Novel Biosurfactants Produced by Aureobasidium pullulans A11211-4-57 from a Fleabane, Erigeron annus (L.) pers
Biosurfactants have been widely used in various industrial fields including medicine, food, cosmetics, detergent, pulp and...
Benzothioate Glycoside from a terrestrial Streptomyces sp. TBRC 11511 from Thailand
Benzothioate Glycoside from a terrestrial Streptomyces sp. TBRC 11511 from Thailand
A new benzothioate glycoside metabolite, phitsanoside A, together with its new and known derivatives were isolated from St...
Landscape of blaNDM genes in Enterobacteriaceae
Landscape of blaNDM genes in Enterobacteriaceae
The blaNDM-1 gene encodes a carbapenemase, New Delhi metallo-β-lactamase (NDM-1), and the ability to produce NDM-1 is...
A novel aureothin diepoxide derivative from Streptomyces sp. NIIST-D31 strain
A novel aureothin diepoxide derivative from Streptomyces sp. NIIST-D31 strain
A novel vicinal diepoxide of alloaureothin was isolated from Streptomyces sp. NIIST-D31 strain along with three carboxamid...
Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41
Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41
The thermotolerant strain Streptomyces sp. HR41 was found to produce compound 1 only in a 45 °C culture, and no...
Penicixanthene E, a new xanthene isolated from a mangrove-derived fungus Penicillium sp.
Penicixanthene E, a new xanthene isolated from a mangrove-derived fungus Penicillium sp.
One new xanthene derivative, named penicixanthene E (1), together with one known compound 2, was isolated from the EtOAc e...
In vitro activity and adaptation strategies of eravacycline in clinical Enterococcus faecium isolates from China
In vitro activity and adaptation strategies of eravacycline in clinical Enterococcus faecium isolates from China
Eravacycline (Erava) is a synthetic fluorocycline with potent antimicrobial activity against a wide range of Gram-positive...
Phenylacetyl pepstatin inhibitors of aspartyl proteases from Streptomyces varsoviensis
Phenylacetyl pepstatin inhibitors of aspartyl proteases from Streptomyces varsoviensis
A new pepstatin with a phenylacetyl group, pepstatin Pa (1), and its methyl ester (2) were isolated from Streptomyces vars...
Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3
Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3
Amycolatopsis sp. MST-135876 was isolated from soil collected from the riverbank of El Pont de Suert, Catalonia, Spain. Cu...
Antifungal activity of dehydrocurvularin for Candida spp. through the inhibition of adhesion to human adenocarcinoma cells
Antifungal activity of dehydrocurvularin for Candida spp. through the inhibition of adhesion to human adenocarcinoma cells
Cell adhesion plays a crucial role in candidiasis through invasion of the human body and obtaining resistance to drugs by ...
Winners of the 2020 JA Ōmura Awards for excellence
Winners of the 2020 JA Ōmura Awards for excellence
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional ...
Synthetic studies for destruxins and biological evaluation for osteoclast-like multinucleated cells: a review
Synthetic studies for destruxins and biological evaluation for osteoclast-like multinucleated cells: a review
Synthesis of various destruxin analogs was accomplished using Shiina’s macrolactonization as a key reaction. Combina...