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Crowdsourcing for mining new fungal sources for addressing the need for novel antibiotics against multidrug resistant pathogens
There are a limited number of new antibiotics to manage the health crisis caused by the evolution and spread of antimicrob...
Professor Teruhiko Beppu (March 9, 1934–November 10, 2023)—the path he had walked
Professor Teruhiko Beppu (March 9, 1934–November 10, 2023)—the path he had walked
Professor Teruhiko BeppuTeruhiko Beppu, a Japanese microbiologist, passed from this life at 89 years ...
A new polycyclic tetramate macrolactam from Allostreptomyces RD068384: stereochemistry and antifungal potential
A new polycyclic tetramate macrolactam from Allostreptomyces RD068384: stereochemistry and antifungal potential
A new polycyclic tetramate macrolactam designated allostreptamide (1), together with four known congeners, were isolated f...
New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239
New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239
During our screening for anti-mycobacterial agents against Mycobacterium avium complex (MAC), two new polycyclic tetramate...
Actinomycetospora termitidis sp. nov., an insect-derived actinomycete isolated from termite (Odontotermes formosanus)
Actinomycetospora termitidis sp. nov., an insect-derived actinomycete isolated from termite (Odontotermes formosanus)
Strain Odt1-22T, an insect-derived actinomycete was isolated from a termite (Odontotermes formosanus) that was collected f...
Tumescenamide C, a cyclic lipodepsipeptide from Streptomyces sp. KUSC_F05, exerts antimicrobial activity against the scab-forming actinomycete Streptomyces scabiei
Tumescenamide C, a cyclic lipodepsipeptide from Streptomyces sp. KUSC_F05, exerts antimicrobial activity against the scab-forming actinomycete Streptomyces scabiei
The antimicrobial activity of tumescenamide C against the scab-forming S. scabiei NBRC13768 was confirmed with a potent IC...
Okichromanone, a new antiviral chromanone from a marine-derived Microbispora
Okichromanone, a new antiviral chromanone from a marine-derived Microbispora
Okichromanone (1), a new chromanone, was isolated from the culture extract of a sponge-derived actinomycete Microbispora, ...
Three new phthalide derivatives from culture broth of Dentipellis fragilis and their cytotoxic activities
Three new phthalide derivatives from culture broth of Dentipellis fragilis and their cytotoxic activities
Three new phthalide derivatives (1‒3) together with two known compounds, erinaceolactone B (4) and hericerin III (5)...
Uncovering the potentiality of quinazoline derivatives against Pseudomonas aeruginosa with antimicrobial synergy and SAR analysis
Uncovering the potentiality of quinazoline derivatives against Pseudomonas aeruginosa with antimicrobial synergy and SAR analysis
Antimicrobial resistance has emerged as a covert global health crisis, posing a significant threat to humanity. If left un...
Structure of prolylrapamycin: confirmation through a revised and detailed NMR assignment study
Structure of prolylrapamycin: confirmation through a revised and detailed NMR assignment study
A complete and detailed characterization of Rapamycin (1) and Prolylrapamycin (2) has been conducted by homo- and hetero-n...
Correlation between the spread of IMP-producing bacteria and the promoter strength of blaIMP genes
Correlation between the spread of IMP-producing bacteria and the promoter strength of blaIMP genes
The first report of transmissible carbapenem resistance encoded by blaIMP-1 was discovered in Pseudomonas aeruginosa GN172...
Pharmacokinetics, tissue distribution, bioavailability and excretion of the anti-virulence drug Fluorothiazinon in rats and rabbits
Pharmacokinetics, tissue distribution, bioavailability and excretion of the anti-virulence drug Fluorothiazinon in rats and rabbits
Growing antimicrobial resistance has accelerated the development of anti-virulence drugs to suppress bacterial toxicity wi...
Efflux pump inhibitor, phenylalanine-arginine beta-naphthylamide analog potentiates the activity of 5-O-mycaminosyltylonolide for multi-drug resistant Pseudomonas aeruginosa
Efflux pump inhibitor, phenylalanine-arginine beta-naphthylamide analog potentiates the activity of 5-O-mycaminosyltylonolide for multi-drug resistant Pseudomonas aeruginosa
The emergence and spread of antimicrobial resistance are global threats. Pseudomonas aeruginosa (P. aeruginosa) is respons...
New antimalarial iromycin analogs produced by Streptomyces sp. RBL-0292
New antimalarial iromycin analogs produced by Streptomyces sp. RBL-0292
Two new antimalarial compounds, named prenylpyridones A (1) and B (2), were discovered from the actinomycete cultured mate...
Biofilm formation and antimicrobial resistance pattern of uropathogenic E. coli ST131 isolated from children with malignant tumors
Biofilm formation and antimicrobial resistance pattern of uropathogenic E. coli ST131 isolated from children with malignant tumors
The multidrug-resistant clone identified as Escherichia coli sequence type 131 (E. coli ST131) has spread world-wide. This...
In vitro and ex vivo activity of the fluoroquinolone DC-159a against mycobacteria
In vitro and ex vivo activity of the fluoroquinolone DC-159a against mycobacteria
Antimicrobial resistance is a global health problem. In 2021, it was estimated almost half a million of multidrug-resistan...
Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds
Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds
The biosynthetic gene clusters (BGCs) for the macrocyclic lactone-based polyketide compounds are extremely large-sized bec...
Proansamycin B derivatives from the post-PKS modification gene deletion mutant of Amycolatopsis mediterranei S699
Proansamycin B derivatives from the post-PKS modification gene deletion mutant of Amycolatopsis mediterranei S699
Ten new proansamycin B congeners (1–10) together with one known (11) were isolated and characterized on the basis of...
Actinobacterial chalkophores: the biosynthesis of hazimycins
Actinobacterial chalkophores: the biosynthesis of hazimycins
Copper is a transition metal element with significant effects on the morphological development and secondary metabolism of...
Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-8058
Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-8058
Two new pramanicin analogs, named virgaricins C (1) and D (2), were discovered by physicochemical screening from a static ...
Substance Index for Volumne 76
3-Acetyl-5,7-dihydroxy-3,4-dimethylisobenzofuran-1(3H)-one474Allopteridic acid A, B, C305Berkeleyone ...
Author Index for Volume 76
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Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity
Synthesis and biological evaluation of nectriatide derivatives, potentiators of amphotericin B activity
Nectriatide 1a, a naturally occurring cyclic tetrapeptide, has been reported to a potentiator of amphotericin B (AmB) acti...
Precursor-directed biosynthesis and biological activity of tripropeptin Cpip, a new tripropeptin C analog containing pipecolic acid
Precursor-directed biosynthesis and biological activity of tripropeptin Cpip, a new tripropeptin C analog containing pipecolic acid
Tripropeptin C, a non-ribosomal cyclic lipopeptide containing three proline residues, exhibits excellent efficacy in the m...
Antibacterial p-terphenyl and α‑pyrone derivates isolated from the marine-derived actinomycete Nocardiopsis sp. HDN154086
Antibacterial p-terphenyl and α‑pyrone derivates isolated from the marine-derived actinomycete Nocardiopsis sp. HDN154086
Assisted by OSMAC strategy, one new p-terphenyl and two new α‑pyrone derivates, namely nocarterphenyl I (1) and...
Mass spectrometry-guided isolation of thiodiketopiperazines from an EtOAc-extract of Setosphaeria rostrata culture medium and their anti-skin aging effects on TNF-α-induced human dermal fibroblasts
Mass spectrometry-guided isolation of thiodiketopiperazines from an EtOAc-extract of Setosphaeria rostrata culture medium and their anti-skin aging effects on TNF-α-induced human dermal fibroblasts
Using mass spectrometry (MS)-guided isolation methods, a new thiodiketopiperazine derivative (1) and exserohilone (2) were...
The tunicamycin derivative TunR2 exhibits potent antibiotic properties with low toxicity in an in vivo Mycobacterium marinum-zebrafish TB infection model
The tunicamycin derivative TunR2 exhibits potent antibiotic properties with low toxicity in an in vivo Mycobacterium marinum-zebrafish TB infection model
Tunicamycins (TUN) are well-defined, Streptomyces-derived natural products that inhibit protein N-glycosylation in eukaryo...
Semi-synthesis and structure-activity relationship study yield antibacterial vicenistatin derivatives with low cytotoxicity
Semi-synthesis and structure-activity relationship study yield antibacterial vicenistatin derivatives with low cytotoxicity
Vicenistatin (1) is a 20-membered polyketide macrocyclic antibiotic with potent antimicrobial and cytotoxic activities. In...
Design, biological characteristics, and antibacterial mechanism of high therapeutic index antimicrobial peptides with PRRP as central axis
Design, biological characteristics, and antibacterial mechanism of high therapeutic index antimicrobial peptides with PRRP as central axis
As the important components of biological innate immunity, antimicrobial peptides (AMPs) were found in a variety of organi...
Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10–13
Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10–13
A novel antibiotic biosynthetic precursor of cezomycin, named precezomycin (1), was isolated from culture broth of actinom...
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