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DMR040, a potential antifungal compound
DMR040, a potential antifungal compound
Based on DMR022 [(AEEA-Gly)2-AEEA-amphotericin B methyl ester, AEEA is the abbreviation of 8-amino-3,6-dioxaoctanoic acid]...
Cryptoic acids A and B, benzene-containing polyketides, and cyclocryptamide, a modified diketopiperazine, from an actinomycete of the genus Cryptosporangium
Cryptoic acids A and B, benzene-containing polyketides, and cyclocryptamide, a modified diketopiperazine, from an actinomycete of the genus Cryptosporangium
Two new benzene-containing polyketides, cryptoic acids A (1) and B (2), along with a new acylated diketopiperazine designa...
Aztreonam-avibactam: a new combination with activity against multidrug-resistant Klebsiella pneumoniae complex
Aztreonam-avibactam: a new combination with activity against multidrug-resistant Klebsiella pneumoniae complex
Klebsiella pneumoniae complex (KPc) is a group of opportunistic pathogens that pose a serious threat to public health. Mul...
Winners of the 2023 JA Ōmura Awards for excellence
Winners of the 2023 JA Ōmura Awards for excellence
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional ...
Activity of cefiderocol in combination with tetracycline analogues against carbapenem-resistant Acinetobacter baumannii
Activity of cefiderocol in combination with tetracycline analogues against carbapenem-resistant Acinetobacter baumannii
Therapeutic options for carbapenem-resistant Acinetobacter baumannii (CA-AB) are quite limited. Cefiderocol, a novel sider...
Novobiocin primarily targets ParE in Neisseria gonorrhoeae
Novobiocin primarily targets ParE in Neisseria gonorrhoeae
Multidrug-resistant Neisseria gonorrhoeae is a pathogenic bacterium that poses a public health concern. In this study, we ...
Therapeutic potential of isoallolithocholic acid in methicillin-resistant Staphylococcus Aureus peritoneal infection
Therapeutic potential of isoallolithocholic acid in methicillin-resistant Staphylococcus Aureus peritoneal infection
A significant increase in multidrug-resistant Methicillin-resistant Staphylococcus aureus (MRSA) infections has made it cr...
Inhibitors of acetohydroxyacid synthase as promising agents against non-tuberculous mycobacterial diseases
Inhibitors of acetohydroxyacid synthase as promising agents against non-tuberculous mycobacterial diseases
Acetohydroxyacid synthase (AHAS), exclusively present in microorganisms and plants, is a promising target for several herb...
Structure-function analysis of 2-sulfamoylacetic acid synthase in altemicidin biosynthesis
Structure-function analysis of 2-sulfamoylacetic acid synthase in altemicidin biosynthesis
Altemicidin and its analogs are valuable sulfonamide antibiotics with valuable antitumor and antibacterial activities. Str...
Differential gene expression analysis shows that cephalosporin resistance is intrinsic to Clostridioides difficile strain 630
Differential gene expression analysis shows that cephalosporin resistance is intrinsic to Clostridioides difficile strain 630
Clostridioides difficile infection (CDI) is the most common nosocomial infection in the US. CDI has become a growing conce...
Correction: Xantholipin B produced by the stnR inactivation mutant Streptomyces flocculus CGMCC 4.1223 WJN-1
Author notesThese authors contributed equally: Sifan Wu, Tingting Huang, Dan Xie.Authors and AffiliationsState Key Laborat...
Multiplexed activity metabolomics for isolation of filipin macrolides from a hypogean actinomycete
Multiplexed activity metabolomics for isolation of filipin macrolides from a hypogean actinomycete
Chemical and biological stimulus screening in a hypogean actinomycete was used to elicit secondary metabolism. Op...
A new cannabigerolic acid derivative and its unprenylated precursor produced through the reconstitution of cannabinoid biosynthesis in Streptomyces
A new cannabigerolic acid derivative and its unprenylated precursor produced through the reconstitution of cannabinoid biosynthesis in Streptomyces
A new derivative of cannabigerolic acid, designated as iso-cannabigerolic acid (iso-CBGA), a member of the cannabinoid fam...
Isolation and identification of three new isomer impurities in milbemycin oxime drug substance
Isolation and identification of three new isomer impurities in milbemycin oxime drug substance
In an effort to identification of the unknown impurities in milbemycin oxime (MO) bulk drug, three impurities 1, 2 and 3 w...
Identification of nanaomycin A and its analogs by a newly established screening method for functional inhibitors of the type IX secretion system in Porphyromonas gingivalis
Identification of nanaomycin A and its analogs by a newly established screening method for functional inhibitors of the type IX secretion system in Porphyromonas gingivalis
Porphyromonas gingivalis, a Gram-negative anaerobic bacterium, is a key pathogen in chronic periodontitis. P. gingivalis h...
Celludinone C, a new dihydroisobenzofuran isolated from Talaromyces cellulolyticus BF-0307
Celludinone C, a new dihydroisobenzofuran isolated from Talaromyces cellulolyticus BF-0307
Celludinones A and B, isolated from the fungus Talaromyces cellulolyticus BF-0307, were inhibitors of sterol O-acyltransfe...
Discovery of new AMR drugs targeting modulators of antimicrobial activity using in vivo silkworm screening systems
Discovery of new AMR drugs targeting modulators of antimicrobial activity using in vivo silkworm screening systems
Global concerns about drug-resistant bacteria have underscored the need for new antimicrobial drugs. Emerging strategies i...
Structure-activity relationship studies of ME1111, a novel antifungal agent for topical treatment of onychomycosis
Structure-activity relationship studies of ME1111, a novel antifungal agent for topical treatment of onychomycosis
Onychomycosis is a prevalent disease in many areas of the world, affecting approximately 5.5% of the global population. Am...
Antimicrobial activity of α/β hybrid peptides incorporating tBu-β3,3Ac6c against methicillin-resistant Staphylococcus aureus
Antimicrobial activity of α/β hybrid peptides incorporating tBu-β3,3Ac6c against methicillin-resistant Staphylococcus aureus
The incorporation of β-amino acids into peptides is a promising approach to develop proteolytically stable therapeuti...
Sinulariapeptide F, a new peptide from culture broth of marine-derived fungus Simplicillium sp. SCSIO 41222
Sinulariapeptide F, a new peptide from culture broth of marine-derived fungus Simplicillium sp. SCSIO 41222
One new compound named sinulariapeptide F (1) together with one known butyrolactone (2) and seven known peptides (3–...
Thiazoplanomicin, a new thiazolyl peptide antibiotic from the leaf-litter actinomycete Actinoplanes sp. MM794L-181F6
Thiazoplanomicin, a new thiazolyl peptide antibiotic from the leaf-litter actinomycete Actinoplanes sp. MM794L-181F6
A new bioactive substance was identified from a leaf-litter actinomycete strain by screening for antibacterial activity ag...
Streptomyces yaizuensis sp. nov., a berninamycin C-producing actinomycete isolated from sponge
Streptomyces yaizuensis sp. nov., a berninamycin C-producing actinomycete isolated from sponge
While screening for antibiotics in a marine sample, we discovered a berninamycin C-producing actinomycete, designated YSPA...
Resistance to linezolid in Staphylococcus aureus by mutation, modification, and acquisition of genes
Resistance to linezolid in Staphylococcus aureus by mutation, modification, and acquisition of genes
Linezolid binds to the 50S subunit of the bacterial ribosome, inhibiting bacterial protein synthesis by preventing the for...
Exploration of vanoxerine analogues as antibacterial agents
Exploration of vanoxerine analogues as antibacterial agents
Mycobacterium tuberculosis is a bacterial pathogen, responsible for approximately 1.3 million deaths in 2022 through tuber...
Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase
Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase
A new drimane sesquiterpene ester, designated insuetusolate (1), and four reported ones (2–5) were isolated from a c...
Correction: Synthesis and antibacterial action of 3’,6’-disubstituted spectinomycins
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Streptomyces albidocamelliae sp. nov., an endophytic actinomycete isolated from the leaves of Camellia oleifera
Streptomyces albidocamelliae sp. nov., an endophytic actinomycete isolated from the leaves of Camellia oleifera
A novel actinobacterium strain, HUAS 14-6T, was isolated from the healthy leaves of Camellia oleifera collected from Chang...
Winners of the 2022 JA Ōmura Awards for excellence
Winners of the 2022 JA Ōmura Awards for excellence
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional ...
Phenotypic changes and gene expression profiles of Vibrio parahaemolyticus in response to low concentrations of ampicillin
Phenotypic changes and gene expression profiles of Vibrio parahaemolyticus in response to low concentrations of ampicillin
Vibrio parahaemolyticus is a leading cause of seafood-associated gastroenteritis and possesses intrinsic resistance to amp...
Aldgamycins Q1 and Q2, two novel 16-membered macrolides from the rare actinomycete Saccharothrix sp. 16Sb2-4
Aldgamycins Q1 and Q2, two novel 16-membered macrolides from the rare actinomycete Saccharothrix sp. 16Sb2-4
Two novel 16-membered macrolides, named aldgamycin Q1 (1) and Q2 (2), were isolated from the culture broth of the rare act...
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