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Reduced CCR5 expression among Uganda HIV controllers
Reduced CCR5 expression among Uganda HIV controllers
Several mechanisms including reduced CCR5 expression, protective HLA, viral restriction factors, broadly neutralizing anti...
Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
Neutralizing antibodies (NAbs) protect against HIV-1 acquisition in animal models and show promise in treatment of infecti...
Origin and functional role of antisense transcription in endogenous and exogenous retroviruses
Origin and functional role of antisense transcription in endogenous and exogenous retroviruses
Most proteins expressed by endogenous and exogenous retroviruses are encoded in the sense (positive) strand of the genome ...
Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is...
Biomolecular condensates: insights into early and late steps of the HIV-1 replication cycle
Biomolecular condensates: insights into early and late steps of the HIV-1 replication cycle
A rapidly evolving understanding of phase separation in the biological and physical sciences has led to the redefining of ...
HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the...
HIV-1 infection of renal epithelial cells: 30 years of evidence from transgenic animal models, human studies and in vitro experiments
HIV-1 infection of renal epithelial cells: 30 years of evidence from transgenic animal models, human studies and in vitro experiments
Although antiretroviral therapy (ART) has increased life expectancy in people with HIV-1 (PWH), acute and chronic kidney d...
HIV infection of non-classical cells in the brain
HIV infection of non-classical cells in the brain
HIV-associated neurological disorders (HAND) affect up to 50% of people living with HIV (PLWH), even in the era of combina...
An endogenous lentivirus in the germline of a rodent
An endogenous lentivirus in the germline of a rodent
Lentiviruses (genus Lentivirus) are complex retroviruses that infect a broad range of mammals, including humans. Unlike ma...
Pericyte infection by HIV-1: a fatal attraction
Pericyte infection by HIV-1: a fatal attraction
While HIV-1 is primarily an infection of CD4 + T cells, there is an emerging interest towards understanding ho...
Modulation of human endogenous retroviruses and cytokines expression in peripheral blood mononuclear cells from autistic children and their parents
Modulation of human endogenous retroviruses and cytokines expression in peripheral blood mononuclear cells from autistic children and their parents
Putative pathogenic effects mediated by human endogenous retroviruses (HERVs) in neurological and psychiatric disorders in...
The envelope proteins from SARS-CoV-2 and SARS-CoV potently reduce the infectivity of human immunodeficiency virus type 1 (HIV-1)
The envelope proteins from SARS-CoV-2 and SARS-CoV potently reduce the infectivity of human immunodeficiency virus type 1 (HIV-1)
Viroporins are virally encoded ion channels involved in virus assembly and release. Human immunodeficiency virus type 1 (H...
A clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infection
A clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infection
Integrase strand transfer inhibitors (INSTIs) have improved the treatment of human immunodeficiency virus (HIV). There are...
HUSH-mediated HIV silencing is independent of TASOR phosphorylation on threonine 819
HUSH-mediated HIV silencing is independent of TASOR phosphorylation on threonine 819
TASOR, a component of the HUSH repressor epigenetic complex, and SAMHD1, a cellular triphosphohydrolase (dNTPase), are bot...
Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP
Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP
Although CD4+ memory T cells are considered the primary latent reservoir for HIV-1, replication competent HIV has been det...
The key amino acid sites 199–205, 269, 319, 321 and 324 of ALV-K env contribute to the weaker replication capacity of ALV-K than ALV-A
The key amino acid sites 199–205, 269, 319, 321 and 324 of ALV-K env contribute to the weaker replication capacity of ALV-K than ALV-A
Avian leukosis virus (ALV) is an infectious retrovirus, that mainly causes various forms of tumours, immunosuppression, a ...
The KT Jeang Retrovirology prize 2022: Florence Margottin-Goguet
The KT Jeang Retrovirology prize 2022: Florence Margottin-Goguet
Margottin F, Dujardin G, Gerard M, Egly JM, Huet J, Sentenac A. Participation of the TATA factor in transcription of the y...
Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency
Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency
The generation of over 69 spliced HIV-1 mRNAs from one primary transcript by alternative RNA splicing emphasizes the centr...
CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection
CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection
Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HI...
Two lymphoid cell lines potently silence unintegrated HIV-1 DNAs
Two lymphoid cell lines potently silence unintegrated HIV-1 DNAs
Mammalian cells mount a variety of defense mechanisms against invading viruses to prevent or reduce infection. One such de...
Innate immune regulation in HIV latency models
Innate immune regulation in HIV latency models
Innate immunity and type 1 interferon (IFN) defenses are critical for early control of HIV infection within CD4 +...
Interview with a Retrovirologist: Wibke Bayer in conversation with Hung Fan
Interview with a Retrovirologist: Wibke Bayer in conversation with Hung Fan
Dr. Wibke Bayer (Fig. 2) is a group leader at the Institute for Virology at the University Hospital Essen of the Universit...
Defective HIV-1 genomes and their potential impact on HIV pathogenesis
Defective HIV-1 genomes and their potential impact on HIV pathogenesis
Defective HIV-1 proviruses represent a population of viral genomes that are selected for by immune pressures, and clonally...
Repression of HIV-1 reactivation mediated by CRISPR/dCas9-KRAB in lymphoid and myeloid cell models
Repression of HIV-1 reactivation mediated by CRISPR/dCas9-KRAB in lymphoid and myeloid cell models
Despite antiretroviral treatment efficacy, it does not lead to the complete eradication of HIV infection. Consequently, re...
Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome
Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome
Human endogenous retroviruses (HERVs) result from ancestral infections caused by exogenous retroviruses that beca...