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The key amino acid sites 199–205, 269, 319, 321 and 324 of ALV-K env contribute to the weaker replication capacity of ALV-K than ALV-A
The key amino acid sites 199–205, 269, 319, 321 and 324 of ALV-K env contribute to the weaker replication capacity of ALV-K than ALV-A
Avian leukosis virus (ALV) is an infectious retrovirus, that mainly causes various forms of tumours, immunosuppression, a ...
The KT Jeang Retrovirology prize 2022: Florence Margottin-Goguet
The KT Jeang Retrovirology prize 2022: Florence Margottin-Goguet
Margottin F, Dujardin G, Gerard M, Egly JM, Huet J, Sentenac A. Participation of the TATA factor in transcription of the y...
Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency
Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency
The generation of over 69 spliced HIV-1 mRNAs from one primary transcript by alternative RNA splicing emphasizes the centr...
CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection
CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection
Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HI...
Two lymphoid cell lines potently silence unintegrated HIV-1 DNAs
Two lymphoid cell lines potently silence unintegrated HIV-1 DNAs
Mammalian cells mount a variety of defense mechanisms against invading viruses to prevent or reduce infection. One such de...
Innate immune regulation in HIV latency models
Innate immune regulation in HIV latency models
Innate immunity and type 1 interferon (IFN) defenses are critical for early control of HIV infection within CD4 +...
Interview with a Retrovirologist: Wibke Bayer in conversation with Hung Fan
Interview with a Retrovirologist: Wibke Bayer in conversation with Hung Fan
Dr. Wibke Bayer (Fig. 2) is a group leader at the Institute for Virology at the University Hospital Essen of the Universit...
Defective HIV-1 genomes and their potential impact on HIV pathogenesis
Defective HIV-1 genomes and their potential impact on HIV pathogenesis
Defective HIV-1 proviruses represent a population of viral genomes that are selected for by immune pressures, and clonally...
Repression of HIV-1 reactivation mediated by CRISPR/dCas9-KRAB in lymphoid and myeloid cell models
Repression of HIV-1 reactivation mediated by CRISPR/dCas9-KRAB in lymphoid and myeloid cell models
Despite antiretroviral treatment efficacy, it does not lead to the complete eradication of HIV infection. Consequently, re...
Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome
Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome
Human endogenous retroviruses (HERVs) result from ancestral infections caused by exogenous retroviruses that beca...
No evidence of bovine leukemia virus proviral DNA and antibodies in human specimens from Japan
No evidence of bovine leukemia virus proviral DNA and antibodies in human specimens from Japan
The potential risk and association of bovine leukemia virus (BLV) with human remains controversial as it has been reported...
Simon Litvak (1942–2022)
Simon Litvak (1942–2022)
Litvak S, Agosin M. Protein synthesis in polysomes from houseflies and the effect of DDT. Biochemistry. 1968;7:1560–7.CAS ...
Correction to: A novel Betaretrovirus discovered in cattle with neurological disease and encephalitis
Correction to: A novel Betaretrovirus discovered in cattle with neurological disease and encephalitis
Following publication of the original article [1], it was reported that the text did not contain reference to the NCBI Gen...
YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity
YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity
The recent discovery of the role of m6A methylation in the regulation of HIV-1 replication unveiled a novel layer of regul...
Bone marrow stromal antigen 2 (BST-2) genetic variants influence expression levels and disease outcome in HIV-1 chronically infected patients
Bone marrow stromal antigen 2 (BST-2) genetic variants influence expression levels and disease outcome in HIV-1 chronically infected patients
Bone marrow stromal antigen 2 (BST-2) also known as Tetherin (CD317/HM1.24), is a host restriction factor that blocks the ...
HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65
HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65
The NF-κB family of transcription factors and associated signalling pathways are abundant and ubiquitous in human imm...
Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda
Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda
Our understanding of the peripheral human immunodeficiency virus type 1 (HIV-1) reservoir is strongly biased towards subty...
Rotten to the core: antivirals targeting the HIV-1 capsid core
Rotten to the core: antivirals targeting the HIV-1 capsid core
The capsid core of HIV-1 is a large macromolecular assembly that surrounds the viral genome and is an essential component ...
A novel Betaretrovirus discovered in cattle with neurological disease and encephalitis
A novel Betaretrovirus discovered in cattle with neurological disease and encephalitis
The majority of emerging infectious diseases in humans are of animal origin, and many of them are caused by neuropathogeni...
Editing out HIV: application of gene editing technology to achieve functional cure
Editing out HIV: application of gene editing technology to achieve functional cure
Highly active antiretroviral therapy (HAART) successfully suppresses human immunodeficiency virus (HIV) replication and im...
Trim28 acts as restriction factor of prototype foamy virus replication by modulating H3K9me3 marks and destabilizing the viral transactivator Tas
Trim28 acts as restriction factor of prototype foamy virus replication by modulating H3K9me3 marks and destabilizing the viral transactivator Tas
Prototype foamy virus (PFV) is nonpathogenic complex retroviruses that express a transcriptional transactivator Tas, which...
HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio
HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio
During HIV-1 maturation, Gag and Gag-Pol polyproteins are proteolytically cleaved and the capsid protein polymerizes to fo...
An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation
An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation
Retroviruses utilize multiple unique RNA elements to control RNA processing and translation. However, it is unclear what f...
Diverse antiviral IgG effector activities are predicted by unique biophysical antibody features
Diverse antiviral IgG effector activities are predicted by unique biophysical antibody features
The critical role of antibody Fc-mediated effector functions in immune defense has been widely reported in various viral i...
Integration of SARS-CoV-2 RNA in infected human cells by retrotransposons: an unlikely hypothesis and old viral relationships
Integration of SARS-CoV-2 RNA in infected human cells by retrotransposons: an unlikely hypothesis and old viral relationships
Zhang et al. (Proc Natl Acad Sci 118:e2105968118, 2021) recently reported that SARS-CoV-2 RNA can be retrotranscribed and ...
HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules
HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules
The HIV-1 capsid, a conical shell encasing viral nucleoprotein complexes, is involved in multiple post-entry processes dur...