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Biomolecules, Vol. 12, Pages 1796: Hydrogel-Encapsulated Heterogenous Mesoporous Resin Catalyst for In Situ Anti-Cancer Agent Production under Biological Conditions
A heterogenous Palladium anchored Resorcinol-formaldehyde-hyperbranched PEI mesoporous catalyst, made by one-pot synthesis...
Biomolecules, Vol. 12, Pages 1795: Acyl-Lipid Δ6-Desaturase May Act as a First FAD in Cyanobacteria
Fatty acid desaturases (FADs) play important roles in various metabolic and adaptive pathways in all living organisms. The...
Biomolecules, Vol. 12, Pages 1797: Metabolic Profiling of Chestnut Shell (Castanea crenata) Cultivars Using UPLC-QTOF-MS and Their Antioxidant Capacity
The inner shell of the chestnut (Castanea crenata) has long been used in Asia as a medicinal herb for improving digestion ...
Biomolecules, Vol. 12, Pages 1798: Structural Insights into the Dimeric Form of Bacillus subtilis RNase Y Using NMR and AlphaFold
RNase Y is a crucial component of genetic translation, acting as the key enzyme initiating mRNA decay in many Gram-positiv...
Biomolecules, Vol. 12, Pages 1805: Alteration of Cellular Energy Metabolism through LPAR2-Axin2 Axis in Gastric Cancer
Lysophosphatidic acid (LPA), a multifunctional endogenous phospholipid, plays a vital role in cellular homeostasis and the...
Biomolecules, Vol. 12, Pages 1804: Role of Pyroptosis in Intervertebral Disc Degeneration and Its Therapeutic Implications
Intervertebral disc degeneration (IDD), a progressive and multifactorial pathological process, is predominantly associated...
Biomolecules, Vol. 12, Pages 1802: New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common type of dementia, but its pathogenesis is not fully understood, and ...
Biomolecules, Vol. 12, Pages 1803: Anti-Inflammatory Effects of Encapsulated Human Mesenchymal Stromal/Stem Cells and a Method to Scale-Up Cell Encapsulation
Mesenchymal stem/stromal cells (MSC) promote recovery in a wide range of animal models of injury and disease. They can act...
Biomolecules, Vol. 12, Pages 1779: SNARE Modulators and SNARE Mimetic Peptides
The soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor (SNARE) proteins play a central rol...
Biomolecules, Vol. 12, Pages 1777: Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer
Previously, we reported that MTH1 inhibitors TH588 and TH1579 selectively induce oxidative damage and kill Ras-expressing ...
Biomolecules, Vol. 12, Pages 1784: Benzodiazepine Modulation of GABAA Receptors: A Mechanistic Perspective
Benzodiazepines (BZDs) are a class of widely prescribed psychotropic drugs that target GABAA receptors (GABAARs) to tune i...
Biomolecules, Vol. 12, Pages 1785: PDX-1: A Promising Therapeutic Target to Reverse Diabetes
The pancreatic duodenum homeobox-1 (PDX-1) is a transcription factor encoded by a Hox-like homeodomain gene that plays a c...
Biomolecules, Vol. 12, Pages 1788: Galectin-3 and Myeloperoxidase May Monitor Cancer-Therapy-Related Cardiotoxicity? A Systematic Review and Meta-Analysis
Galectin-3 and myeloperoxidase (MPO) are novel biomarkers in the field of cardio-oncology, but conflicting results have be...
Biomolecules, Vol. 12, Pages 1792: Heparan Sulfate Proteoglycans in Tauopathy
Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by i...
Biomolecules, Vol. 12, Pages 1786: Substrate Type and Concentration Differently Affect Colon Cancer Cells Ultrastructural Morphology, EMT Markers, and Matrix Degrading Enzymes
Aim of the study was to understand the behavior of colon cancer LoVo-R cells (doxorubicin-resistant) vs. LoVo-S (doxorubic...
Biomolecules, Vol. 12, Pages 1790: Profiles of Metabolic Genes in Uncaria rhynchophylla and Characterization of the Critical Enzyme Involved in the Biosynthesis of Bioactive Compounds-(iso)Rhynchophylline
Rhynchophylline (RIN) and isorhynchophylline (IRN), two of the representative types of indole alkaloids, showed the unique...
Biomolecules, Vol. 12, Pages 1787: Combining Dietary Intervention with Metformin Treatment Enhances Non-Alcoholic Steatohepatitis Remission in Mice Fed a High-Fat High-Sucrose Diet
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are serious health concerns for which l...
Biomolecules, Vol. 12, Pages 1791: Pseudocholinesterase as a Biomarker for Untreated Wilson’s Disease
The aim of this study was to demonstrate that pseudocholinesterase (CHE) serum level is a useful diagnostic biomarker for ...
Biomolecules, Vol. 12, Pages 1789: A Large-Scale High-Throughput Screen for Modulators of SERCA Activity
The sarco/endoplasmic reticulum Ca-ATPase (SERCA) is a P-type ion pump that transports Ca2+ from the cytosol into the endo...
Biomolecules, Vol. 12, Pages 1771: Sequence-Based Prediction of Protein Phase Separation: The Role of Beta-Pairing Propensity
The formation of droplets of bio-molecular condensates through liquid-liquid phase separation (LLPS) of their component pr...
Biomolecules, Vol. 12, Pages 1770: The Pathophysiological Significance of “Mitochondrial Ejection” from Cells
Mitochondria have beneficial effects on cells by producing ATP and contributing to various biosynthetic procedures. On the...
Biomolecules, Vol. 12, Pages 1778: GRP75 Modulates Endoplasmic Reticulum–Mitochondria Coupling and Accelerates Ca2+-Dependent Endothelial Cell Apoptosis in Diabetic Retinopathy
Endoplasmic reticulum (ER) and mitochondrial dysfunction play fundamental roles in the pathogenesis of diabetic retinopath...
Biomolecules, Vol. 12, Pages 1775: Ribose Intake as Food Integrator: Is It a Really Convenient Practice?
Reports concerning the beneficial effects of D-ribose administration in cardiovascular and muscle stressful conditions has...
Biomolecules, Vol. 12, Pages 1776: Evaluation of Biointegration and Inflammatory Response to Blood Vessels Produced by Tissue Engineering—Experimental Model in Rabbits
Peripheral arterial disease (PAD) is the main cause of mortality in the western population and requires surgical intervent...
Biomolecules, Vol. 12, Pages 1762: Structural Studies of Piperine Inclusion Complexes in Native and Derivative β-Cyclodextrins
Piperine (PN), the primary pungent alkaloid in black pepper shows several biological activities such as antioxidant, antim...
Biomolecules, Vol. 12, Pages 1760: Evolutionary Diversity of Dus2 Enzymes Reveals Novel Structural and Functional Features among Members of the RNA Dihydrouridine Synthases Family
Dihydrouridine (D) is an abundant modified base found in the tRNAs of most living organisms and was recently detected in e...
Biomolecules, Vol. 12, Pages 1759: Radiotherapy Side Effects: Comprehensive Proteomic Study Unraveled Neural Stem Cell Degenerative Differentiation upon Ionizing Radiation
Cranial radiation therapy is one of the most effective treatments for childhood brain cancers. Despite the ameliorated sur...
Biomolecules, Vol. 12, Pages 1756: EIF4G1 Is a Potential Prognostic Biomarker of Breast Cancer
Background: Breast cancer (BRCA) is one of the most common cancers in women worldwide and a leading cause of death from ma...
Biomolecules, Vol. 12, Pages 1757: Macrophage-Conditioned Media Promotes Adipocyte Cancer Association, Which in Turn Stimulates Breast Cancer Proliferation and Migration
Background: Breast cancer is the most common cancer in women and the leading cause of female cancer deaths worldwide. Obes...
Biomolecules, Vol. 12, Pages 1755: Protein Targeting to Glycogen (PTG): A Promising Player in Glucose and Lipid Metabolism
Protein phosphorylation and dephosphorylation are widely considered to be the key regulatory factors of cell function, and...
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