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Biomolecules, Vol. 13, Pages 61: Targeted Epigenetic Interventions in Cancer with an Emphasis on Pediatric Malignancies

Over the past two decades, novel hallmarks of cancer have been described, including the altered epigenetic landscape of ma...

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Biomolecules, Vol. 13, Pages 67: Cancer-Associated Fibroblast Heterogeneity, Activation and Function: Implications for Prostate Cancer

The continuous remodeling of the tumor microenvironment (TME) during prostate tumorigenesis is emerging as a critical even...

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Biomolecules, Vol. 13, Pages 69: Metabolic Maturation Exaggerates Abnormal Calcium Handling in a Lamp2 Knockout Human Pluripotent Stem Cell-Derived Cardiomyocyte Model of Danon Disease

Danon disease (DD) is caused by mutations of the gene encoding lysosomal-associated membrane protein type 2 (LAMP2), which...

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Biomolecules, Vol. 13, Pages 65: Intensification of Biophenols Extraction Yield from Olive Pomace Using Innovative Green Technologies

Olive pomace is the main by-product generated by the olive oil production process. Although toxic to the environment, oliv...

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Biomolecules, Vol. 13, Pages 66: Human Alpha-1 Antitrypsin Attenuates ENaC and MARCKS and Lowers Blood Pressure in Hypertensive Diabetic db/db Mice

Hypertension may develop before or after the onset of diabetes and it is known to increase the risk of developing diabetic...

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Biomolecules, Vol. 13, Pages 64: Druggable Pockets at the RNA Interface Region of Influenza A Virus NS1 Protein Are Conserved across Sequence Variants from Distinct Subtypes

Influenza A viruses still represent a major health issue, for both humans and animals. One of the main viral proteins of i...

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Biomolecules, Vol. 13, Pages 46: Heritability of Protein and Metabolite Biomarkers Associated with COVID-19 Severity: A Metabolomics and Proteomics Analysis

Objectives: Prior studies have characterized protein and metabolite changes associated with SARS-CoV-2 infection; we hypot...

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Biomolecules, Vol. 13, Pages 47: Application of Single-Cell RNA Sequencing in Ovarian Development

The ovary is a female reproductive organ that plays a key role in fertility and the maintenance of endocrine homeostasis, ...

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Biomolecules, Vol. 13, Pages 56: Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects

L-Glutamic acid is the main excitatory neurotransmitter in the central nervous system (CNS). Its associated receptors loca...

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Biomolecules, Vol. 13, Pages 55: Advances and Innovations of 3D Bioprinting Skin

Three-dimensional (3D) bioprinted skin equivalents are highlighted as the new gold standard for alternative models to anim...

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Biomolecules, Vol. 13, Pages 54: Novel Set of Diarylmethanes to Target Colorectal Cancer: Synthesis, In Vitro and In Silico Studies

Distinctive structural, chemical, and physical properties make the diarylmethane scaffold an essential constituent of many...

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Biomolecules, Vol. 13, Pages 53: Development of Lanzyme as the Potential Enzyme Replacement Therapy Drug for Fabry Disease

Fabry disease (FD) is a progressive multisystemic disease characterized by lysosomal enzyme deficiency. Enzyme replacement...

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Biomolecules, Vol. 13, Pages 52: Genes Modulating Butyrate Metabolism for Assessing Clinical Prognosis and Responses to Systematic Therapies in Hepatocellular Carcinoma

Butyrate, one of the major products of the gut microbiota, has played notable roles in diverse therapies for multiple tumo...

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Biomolecules, Vol. 13, Pages 51: Age- and Sex-Dependent Behavioral and Neurochemical Alterations in hLRRK2-G2019S BAC Mice

The G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene is associated with late-onset Parkinson’s d...

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Biomolecules, Vol. 13, Pages 50: Hypoxia-Inducible Factor 1 and Mitochondria: An Intimate Connection

The general objective of the review is to explain the interaction between HIF-1 and mitochondria. On the one hand, this re...

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Biomolecules, Vol. 13, Pages 49: Morphometric Changes of Osteocyte Lacunar in Diabetic Pig Mandibular Cancellous Bone

Osteocytes play an important role in bone metabolism. The interactions of osteocytes with the surrounding microenvironment...

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Biomolecules, Vol. 13, Pages 48: Relationship among Body Composition, Adipocytokines, and Irisin on Exercise Capacity and Quality of Life in COPD: A Pilot Study

Adipose tissue is an endocrine organ that interferes with the severity of chronic obstructive pulmonary disease (COPD). Al...

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Biomolecules, Vol. 13, Pages 60: Single-Cell Transcriptome Analysis of H5N1-HA-Stimulated Alpaca PBMCs

Avian influenza A virus H5N1 is a highly pathogenic and persistently a major threat to global health. Vaccines and antibod...

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Biomolecules, Vol. 13, Pages 37: CISD1 Is a Breast Cancer Prognostic Biomarker Associated with Diabetes Mellitus

Women with diabetes mellitus are believed to have increased risk of developing breast cancer and lower life expectancies. ...

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Biomolecules, Vol. 13, Pages 38: Approaches and Vectors for Efficient Cochlear Gene Transfer in Adult Mouse Models

Inner ear gene therapy using adeno-associated viral vectors (AAVs) in neonatal mice can alleviate hearing loss in mouse mo...

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Biomolecules, Vol. 13, Pages 39: Identification of Immune Infiltration and the Potential Biomarkers in Diabetic Peripheral Neuropathy through Bioinformatics and Machine Learning Methods

Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications in diabetes. Previous studies have sh...

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Biomolecules, Vol. 13, Pages 40: The Regulatory Mechanism of miR-574-5p Expression in Cancer

MicroRNAs (miRNAs) are a group of small, single-stranded, non-coding RNAs approximately 22 nucleotides in length. The dysr...

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Biomolecules, Vol. 13, Pages 35: Short-Term Consequences of Single Social Defeat on Accumbal Dopamine and Behaviors in Rats

The present study aimed to explore the consequences of a single exposure to a social defeat on dopamine release in the rat...

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Biomolecules, Vol. 13, Pages 34: Urinary Proteome Changes during Pregnancy in Rats

Pregnancy involves a significant number of physiological changes. A normal pregnancy is essential to ensure healthy matern...

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Biomolecules, Vol. 13, Pages 31: Circulating Fibroblast Growth Factor-23 Levels Can Predict Rapid Kidney Function Decline in a Healthy Population: A Community-Based Study

Background: Fibroblast growth factor-23 (FGF-23) associates with decreased kidney function in patients with chronic kidney...

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Biomolecules, Vol. 13, Pages 33: First Evidence of the Protective Effects of 2-pentadecyl-2-oxazoline (PEA-OXA) in In Vitro Models of Acute Lung Injury

Acute respiratory distress syndrome (ARDS) is a serious inflammatory lung disorder and a complication of SARS-CoV-2 infect...

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Biomolecules, Vol. 13, Pages 19: Differential Gene Expression Induced by Different TLR Agonists in A549 Lung Epithelial Cells Is Modulated by CRISPR Activation of TLR10

Toll-like receptor 10 (TLR10) is the only member of the TLR family whose function and ligand have not been clearly describ...

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Biomolecules, Vol. 13, Pages 18: Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related Disorders

Non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, circRNAs, and piRNAs, do not encode proteins. Nonetheless, they have ...

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Biomolecules, Vol. 13, Pages 27: Persulfidation of DJ-1: Mechanism and Consequences

DJ-1 (also called PARK7) is a ubiquitously expressed protein involved in the etiology of Parkinson disease and cancers. At...

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Biomolecules, Vol. 13, Pages 23: HIF1A Knockout by Biallelic and Selection-Free CRISPR Gene Editing in Human Primary Endothelial Cells with Ribonucleoprotein Complexes

Primary endothelial cells (ECs), especially human umbilical vein endothelial cells (HUVECs), are broadly used in vascular ...

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