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Characterization of exosome-mediated propagation of systemic inflammatory responses into the central nervous system
Characterization of exosome-mediated propagation of systemic inflammatory responses into the central nervous system
The mechanisms through which systemic inflammation exerts its effect on the central nervous system (CNS) are still not com...
Chronic corticosterone exposure causes anxiety- and depression-related behaviors with altered gut microbial and brain metabolomic profiles in adult male C57BL/6J mice
Chronic corticosterone exposure causes anxiety- and depression-related behaviors with altered gut microbial and brain metabolomic profiles in adult male C57BL/6J mice
Chronic exposure to glucocorticoids in response to long-term stress is thought to be a risk factor for major depression. D...
Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity
Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity
Understanding the mechanisms of synaptic plasticity is crucial for elucidating how the brain adapts to internal and extern...
NDRG1 upregulation by ubiquitin proteasome system dysfunction aggravates neurodegeneration
NDRG1 upregulation by ubiquitin proteasome system dysfunction aggravates neurodegeneration
Protein turnover is crucial for cell survival, and the impairment of proteostasis leads to cell death. Aging is associated...
Ultrastructural characterization of hippocampal inhibitory synapses under resting and stimulated conditions
Ultrastructural characterization of hippocampal inhibitory synapses under resting and stimulated conditions
The present study uses electron microscopy to document ultrastructural characteristics of hippocampal GABAergic inhibitory...
Mechanisms of glutamate receptors hypofunction dependent synaptic transmission impairment in the hippocampus of schizophrenia susceptibility gene Opcml-deficient mouse model
Mechanisms of glutamate receptors hypofunction dependent synaptic transmission impairment in the hippocampus of schizophrenia susceptibility gene Opcml-deficient mouse model
Schizophrenia is a severe psychiatric disorder with high heritability, characterized by positive and negative symptoms as ...
Improving working memory by electrical stimulation and cross-frequency coupling
Improving working memory by electrical stimulation and cross-frequency coupling
Working memory (WM) is essential for the temporary storage and processing of information required for complex cognitive ta...
Shank3 deficiency alters midbrain GABAergic neuron morphology, GABAergic markers and synaptic activity in primary striatal neurons
Shank3 deficiency alters midbrain GABAergic neuron morphology, GABAergic markers and synaptic activity in primary striatal neurons
Abnormalities in gamma-aminobutyric acid (GABA)ergic neurotransmission play a role in the pathogenesis of autism, although...
Electroacupuncture inhibited carrageenan-induced pain aversion by activating GABAergic neurons in the ACC
Electroacupuncture inhibited carrageenan-induced pain aversion by activating GABAergic neurons in the ACC
Pain aversion is an avoidance response to painful stimuli. Previous research has indicated that the anterior cingulate cor...
γ-Aminobutyric acid type A receptor β1 subunit gene polymorphisms are associated with the sedative and amnesic effects of midazolam
γ-Aminobutyric acid type A receptor β1 subunit gene polymorphisms are associated with the sedative and amnesic effects of midazolam
Midazolam is widely used for intravenous sedation. However, wide interindividual variability is seen in the sensitivity to...
Deoxyhypusine synthase deficiency syndrome zebrafish model: aberrant morphology, epileptiform activity, and reduced arborization of inhibitory interneurons
Deoxyhypusine synthase deficiency syndrome zebrafish model: aberrant morphology, epileptiform activity, and reduced arborization of inhibitory interneurons
DHPS deficiency syndrome is an ultra-rare neurodevelopmental disorder (NDD) which results from biallelic mutations in the ...
TRPM4 inhibition slows neuritogenesis progression of cortical neurons
TRPM4 inhibition slows neuritogenesis progression of cortical neurons
TRPM4 is a non-selective cation channel activated by intracellular Ca2+ but only permeable to monovalent cations, its acti...
Running-induced neurogenesis reduces CA1 perineuronal net density without substantial temporal delay
Running-induced neurogenesis reduces CA1 perineuronal net density without substantial temporal delay
Aerobic exercise has many effects on brain function, particularly at the hippocampus. Exercise has been shown to increase ...
Absence of ATG9A and synaptophysin demixing on Rab5 mutation-induced giant endosomes
Absence of ATG9A and synaptophysin demixing on Rab5 mutation-induced giant endosomes
ATG9A is the only integral membrane protein among core autophagy-related (ATG) proteins. We previously found that ATG9A do...
Felodipine attenuates neuroinflammatory responses and tau hyperphosphorylation through JNK/P38 signaling in tau-overexpressing AD mice
Felodipine attenuates neuroinflammatory responses and tau hyperphosphorylation through JNK/P38 signaling in tau-overexpressing AD mice
We previously demonstrated that felodipine, an L-type calcium channel blocker, inhibits LPS-mediated neuroinflammatory res...
Electroacupuncture reduces inflammatory damage following cerebral ischemia–reperfusion by enhancing ABCA1-mediated efferocytosis in M2 microglia
Electroacupuncture reduces inflammatory damage following cerebral ischemia–reperfusion by enhancing ABCA1-mediated efferocytosis in M2 microglia
Ischemic stroke (IS) is a severe cerebrovascular disease with high disability and mortality rates, where the inflammatory ...
Altered brain connectivity in mild cognitive impairment is linked to elevated tau and phosphorylated tau, but not to GAP-43 and Amyloid-β measurements: a resting-state fMRI study
Altered brain connectivity in mild cognitive impairment is linked to elevated tau and phosphorylated tau, but not to GAP-43 and Amyloid-β measurements: a resting-state fMRI study
Mild Cognitive Impairment (MCI) is a neurological condition characterized by a noticeable decline in cognitive abilities t...
Astrocyte-derived dominance winning reverses chronic stress-induced depressive behaviors
Astrocyte-derived dominance winning reverses chronic stress-induced depressive behaviors
Individuals with low social status are at heightened risk of major depressive disorder (MDD), and MDD also influences soci...
Protocadherin 19 regulates axon guidance in the developing Xenopus retinotectal pathway
Protocadherin 19 regulates axon guidance in the developing Xenopus retinotectal pathway
Protocadherin 19 (Pcdh19) is a homophilic cell adhesion molecule and is involved in a variety of neuronal functions. Here,...
Comprehensive identification of ubiquitin-like 3 (UBL3)-interacting proteins in the mouse brain
Comprehensive identification of ubiquitin-like 3 (UBL3)-interacting proteins in the mouse brain
Discovery of novel post-translational modifications provides new insights into changes in protein function, localization, ...
Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease
Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease
Several prior studies have proposed the involvement of various brain regions and cell types in Parkinson’s disease (...
Research progress of brain organoids in the field of diabetes
Research progress of brain organoids in the field of diabetes
Human embryonic stem cells and human induced pluripotent stem cells may be used to create 3D tissues called brain organoid...
Astrocytic activation increases blood flow in the adult olfactory bulb
Astrocytic activation increases blood flow in the adult olfactory bulb
Activation of astrocytes after sensory stimulation has been reported to be involved in increased blood flow in the central...
Neurexin-3 in the paraventricular nucleus of the hypothalamus regulates body weight and glucose homeostasis independently of food intake
Neurexin-3 in the paraventricular nucleus of the hypothalamus regulates body weight and glucose homeostasis independently of food intake
Neurexin-3 (Nrxn3) has been genetically associated with obesity, but the underlying neural mechanisms remain poorly unders...
The myelin water imaging transcriptome: myelin water fraction regionally varies with oligodendrocyte-specific gene expression
The myelin water imaging transcriptome: myelin water fraction regionally varies with oligodendrocyte-specific gene expression
Identifying sensitive and specific measures that can quantify myelin are instrumental in characterizing microstructural ch...
Spared nerve injury leads to reduced activity of neurons projecting from the ventrolateral periaqueductal gray to the locus coeruleus
Spared nerve injury leads to reduced activity of neurons projecting from the ventrolateral periaqueductal gray to the locus coeruleus
The ventrolateral periaqueductal gray (vlPAG) serves as a central hub for descending pain modulation. It receives upstream...
β-hydroxybutyrate and ischemic stroke: roles and mechanisms
β-hydroxybutyrate and ischemic stroke: roles and mechanisms
Stroke is a significant global burden, causing extensive morbidity and mortality. In metabolic states where glucose is lim...
Systemic inflammation attenuates the repair of damaged brains through reduced phagocytic activity of monocytes infiltrating the brain
Systemic inflammation attenuates the repair of damaged brains through reduced phagocytic activity of monocytes infiltrating the brain
In this study, we examined how systemic inflammation affects repair of brain injury. To this end, we created a brain-injur...
The duality of amyloid-β: its role in normal and Alzheimer’s disease states
The duality of amyloid-β: its role in normal and Alzheimer’s disease states
Alzheimer’s disease (AD) is a degenerative neurological condition that gradually impairs cognitive abilities, disrup...
MicroRNAs as the pivotal regulators of Temozolomide resistance in glioblastoma
MicroRNAs as the pivotal regulators of Temozolomide resistance in glioblastoma
Glioblastoma (GBM) is an aggressive nervous system tumor with a poor prognosis. Although, surgery, radiation therapy, and ...
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