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Development of selective deconjugases for membrane-anchored LC3A/B in post-mitotic neurons
Development of selective deconjugases for membrane-anchored LC3A/B in post-mitotic neurons
Neuronal autophagy is essential for maintaining protein and organelle turnover, thereby safeguarding neuronal health. LC3,...
Acid sphingomyelinase modulates anxiety-like behavior likely through toll-like receptor signaling pathway
Acid sphingomyelinase modulates anxiety-like behavior likely through toll-like receptor signaling pathway
Recent studies have shown that abnormal activity of acid sphingomyelinase (Asm) has been associated with a range of psychi...
Surgery impairs glymphatic activity and cognitive function in aged mice
Surgery impairs glymphatic activity and cognitive function in aged mice
Delirium is a common complication in elderly surgical patients and is associated with an increased risk of dementia. Altho...
Distribution and functional significance of KLF15 in mouse cerebellum
Distribution and functional significance of KLF15 in mouse cerebellum
Kruppel-like factor 15 (KLF15), a member of the KLF family, is closely involved in many biological processes. However, the...
Correction to: Roles of Rufy3 in experimental subarachnoid hemorrhage-induced early brain injury via accelerating neuronal axon repair and synaptic plasticity
Correction to: Roles of Rufy3 in experimental subarachnoid hemorrhage-induced early brain injury via accelerating neuronal axon repair and synaptic plasticity
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Alternative 3′ UTR polyadenylation is disrupted in the rNLS8 mouse model of ALS/FTLD
Alternative 3′ UTR polyadenylation is disrupted in the rNLS8 mouse model of ALS/FTLD
Recent research has highlighted widespread dysregulation of alternative polyadenylation in amyotrophic lateral sclerosis (...
Knockout of AMPA receptor binding protein Neuron-specific gene 2 (NSG2) enhances associative learning and cognitive flexibility
Knockout of AMPA receptor binding protein Neuron-specific gene 2 (NSG2) enhances associative learning and cognitive flexibility
The vast majority of gene mutations and/or gene knockouts result in either no observable changes, or significant deficits ...
Dynamic changes in the hippocampal neuronal circuits activity following acute stress revealed by miniature fluorescence microscopy imaging
Dynamic changes in the hippocampal neuronal circuits activity following acute stress revealed by miniature fluorescence microscopy imaging
Coordinated activity of neuronal ensembles is a basis for information processing in the brain. Recent development of minis...
Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry
Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry
Rapid adaptation to novel environments is crucial for survival, and this ability is impaired in many neuropsychiatric diso...
Serotonin enhances neurogenesis biomarkers, hippocampal volumes, and cognitive functions in Alzheimer’s disease
Serotonin enhances neurogenesis biomarkers, hippocampal volumes, and cognitive functions in Alzheimer’s disease
Research on serotonin reveals a lack of consensus regarding its role in brain volume, especially concerning biomarkers lin...
Synthetic data-driven overlapped neural spikes sorting: decomposing hidden spikes from overlapping spikes
Synthetic data-driven overlapped neural spikes sorting: decomposing hidden spikes from overlapping spikes
Sorting spikes from extracellular recordings, obtained by sensing neuronal activity around an electrode tip, is essential ...
Chemogenetic silencing of the subiculum blocks acute chronic temporal lobe epilepsy
Chemogenetic silencing of the subiculum blocks acute chronic temporal lobe epilepsy
Temporal lobe epilepsy (TLE) is the most common form of medically-intractable epilepsy. Subicular hyperexcitability is fre...
Post-conditioning sleep deprivation facilitates delay and trace fear memory extinction
Post-conditioning sleep deprivation facilitates delay and trace fear memory extinction
Trace and delay auditory fear conditioning involve different memory association strategies based on working memory involve...
Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism
Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism
Recessive loss-of-function mutations in the mitochondrial enzyme Glutamate Pyruvate Transaminase 2 (GPT2) cause intellectu...
Transcutaneous auricular vagus nerve stimulation in anesthetized mice induces antidepressant effects by activating dopaminergic neurons in the ventral tegmental area
Transcutaneous auricular vagus nerve stimulation in anesthetized mice induces antidepressant effects by activating dopaminergic neurons in the ventral tegmental area
Depression, a prevalent neuropsychiatric disorder, involves the dysregulation of neurotransmitters such as dopamine (DA). ...
AKAP6 controls NFATc4 activity for BDNF-mediated neuroprotection
AKAP6 controls NFATc4 activity for BDNF-mediated neuroprotection
Brain-derived neurotrophic factor (BDNF) is known for its potent prosurvival effect. Despite successfully replicating this...
NEK7 induces lactylation in Alzheimer’s disease to promote pyroptosis in BV-2 cells
NEK7 induces lactylation in Alzheimer’s disease to promote pyroptosis in BV-2 cells
Alzheimer’s disease (AD), an age-related neurodegenerative disorder, is characterized by irreversible brain tissue d...
Sonic hedgehog signalling pathway in CNS tumours: its role and therapeutic implications
Sonic hedgehog signalling pathway in CNS tumours: its role and therapeutic implications
CNS tumours encompass a diverse group of neoplasms with significant morbidity and mortality. The SHH signalling pathway pl...
A structural analysis of the splice-specific functional impact of the pathogenic familial hemiplegic migraine type 1 S218L mutation on Cav2.1 P/Q-type channel gating
A structural analysis of the splice-specific functional impact of the pathogenic familial hemiplegic migraine type 1 S218L mutation on Cav2.1 P/Q-type channel gating
P/Q-type (Cav2.1) calcium channels mediate Ca2+ influx essential for neuronal excitability and synaptic transmission. The ...
Intravitreal injection of the Galectin-3 inhibitor TD139 provides neuroprotection in a rat model of ocular hypertensive glaucoma
Intravitreal injection of the Galectin-3 inhibitor TD139 provides neuroprotection in a rat model of ocular hypertensive glaucoma
Neuroinflammation is a significant contributor to the pathology of glaucoma. Targeting key-mediators in this process is a ...
Characterization of exosome-mediated propagation of systemic inflammatory responses into the central nervous system
Characterization of exosome-mediated propagation of systemic inflammatory responses into the central nervous system
The mechanisms through which systemic inflammation exerts its effect on the central nervous system (CNS) are still not com...
Chronic corticosterone exposure causes anxiety- and depression-related behaviors with altered gut microbial and brain metabolomic profiles in adult male C57BL/6J mice
Chronic corticosterone exposure causes anxiety- and depression-related behaviors with altered gut microbial and brain metabolomic profiles in adult male C57BL/6J mice
Chronic exposure to glucocorticoids in response to long-term stress is thought to be a risk factor for major depression. D...
Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity
Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity
Understanding the mechanisms of synaptic plasticity is crucial for elucidating how the brain adapts to internal and extern...
NDRG1 upregulation by ubiquitin proteasome system dysfunction aggravates neurodegeneration
NDRG1 upregulation by ubiquitin proteasome system dysfunction aggravates neurodegeneration
Protein turnover is crucial for cell survival, and the impairment of proteostasis leads to cell death. Aging is associated...
Ultrastructural characterization of hippocampal inhibitory synapses under resting and stimulated conditions
Ultrastructural characterization of hippocampal inhibitory synapses under resting and stimulated conditions
The present study uses electron microscopy to document ultrastructural characteristics of hippocampal GABAergic inhibitory...
Mechanisms of glutamate receptors hypofunction dependent synaptic transmission impairment in the hippocampus of schizophrenia susceptibility gene Opcml-deficient mouse model
Mechanisms of glutamate receptors hypofunction dependent synaptic transmission impairment in the hippocampus of schizophrenia susceptibility gene Opcml-deficient mouse model
Schizophrenia is a severe psychiatric disorder with high heritability, characterized by positive and negative symptoms as ...
Improving working memory by electrical stimulation and cross-frequency coupling
Improving working memory by electrical stimulation and cross-frequency coupling
Working memory (WM) is essential for the temporary storage and processing of information required for complex cognitive ta...
Shank3 deficiency alters midbrain GABAergic neuron morphology, GABAergic markers and synaptic activity in primary striatal neurons
Shank3 deficiency alters midbrain GABAergic neuron morphology, GABAergic markers and synaptic activity in primary striatal neurons
Abnormalities in gamma-aminobutyric acid (GABA)ergic neurotransmission play a role in the pathogenesis of autism, although...
Electroacupuncture inhibited carrageenan-induced pain aversion by activating GABAergic neurons in the ACC
Electroacupuncture inhibited carrageenan-induced pain aversion by activating GABAergic neurons in the ACC
Pain aversion is an avoidance response to painful stimuli. Previous research has indicated that the anterior cingulate cor...
γ-Aminobutyric acid type A receptor β1 subunit gene polymorphisms are associated with the sedative and amnesic effects of midazolam
γ-Aminobutyric acid type A receptor β1 subunit gene polymorphisms are associated with the sedative and amnesic effects of midazolam
Midazolam is widely used for intravenous sedation. However, wide interindividual variability is seen in the sensitivity to...
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