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Stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons
Stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons
Somatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receiv...
Beta amyloid deposition and cognitive decline in Parkinson’s disease: a study of the PPMI cohort
Beta amyloid deposition and cognitive decline in Parkinson’s disease: a study of the PPMI cohort
The accumulation of beta amyloid in the brain has a complex and poorly understood impact on the progression of Parkinson&#...
Prior episode of colitis impairs contextual fear memory
Prior episode of colitis impairs contextual fear memory
Accumulating evidence has shown that intestinal inflammations in inflammatory bowel disease (IBD) also drive pathological ...
Genome-wide analysis of genes encoding core components of the ubiquitin system during cerebral cortex development
Genome-wide analysis of genes encoding core components of the ubiquitin system during cerebral cortex development
Ubiquitination involves three types of enzymes (E1, E2, and E3) that sequentially attach ubiquitin (Ub) to target proteins...
Toll-like receptors and their role in neuropathic pain and migraine
Toll-like receptors and their role in neuropathic pain and migraine
Migraine is a complex neurological disease of unknown etiology involving both genetic and environmental factors. It has pr...
The cyclin G-associated kinase (GAK) inhibitor SGC-GAK-1 inhibits neurite outgrowth and synapse formation
The cyclin G-associated kinase (GAK) inhibitor SGC-GAK-1 inhibits neurite outgrowth and synapse formation
Protein kinases are responsible for protein phosphorylation and are involved in important signal transduction pathways; ho...
Copper ions, prion protein and Aβ modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner
Copper ions, prion protein and Aβ modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner
As in neurons, CNS myelin expresses N-Methyl-D-Aspartate Receptors (NMDARs) that subserve physiological roles, but have th...
A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism
A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism
Psychiatric disorders and neuroticism are closely associated with central nervous system, whose proper functioning depends...
Knockdown of myorg leads to brain calcification in zebrafish
Knockdown of myorg leads to brain calcification in zebrafish
Primary familial brain calcification (PFBC) is a neurogenetic disorder characterized by bilateral calcified deposits in th...
Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
The cholinesterase inhibitor donepezil is used to improve Aβ pathology and cognitive function in patients with Alzhei...
High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression
High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression
Cell senescence is a basic aging mechanism. Previous studies have found that the cellular senescence in adipose tissue and...
Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats
Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats
Previous immunohistochemical studies have shown the expression of KCNQ2 channels at nodes of Ranvier (NRs) of myelinated n...
Distribution of five clinically important neuroglial proteins in the human brain
Distribution of five clinically important neuroglial proteins in the human brain
Glial fibrillary acidic protein (GFAP), myelin basic protein (MBP), neurofilament light chain (NFL), tau and ubiquitin car...
Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8+ T cells
Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8+ T cells
Cerebral malaria is the most serious complication of malaria infection, with 26% of surviving children having neurological...
Correction to: Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson’s disease
Correction to: Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson’s disease
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Postmortem gene expression profiles in the habenulae of suicides: implication of endothelial dysfunction in the neurovascular system
Postmortem gene expression profiles in the habenulae of suicides: implication of endothelial dysfunction in the neurovascular system
The habenula (Hb) is an epithalamic structure that links multiple forebrain areas with the mid/hindbrain monoaminergic sys...
Construction of a lncRNA-associated competing endogenous RNA regulatory network after traumatic brain injury in mouse
Construction of a lncRNA-associated competing endogenous RNA regulatory network after traumatic brain injury in mouse
Traumatic brain injury (TBI) is a major public health problem worldwide which causes high mortality and disability. Functi...
Roles of Rufy3 in experimental subarachnoid hemorrhage-induced early brain injury via accelerating neuronal axon repair and synaptic plasticity
Roles of Rufy3 in experimental subarachnoid hemorrhage-induced early brain injury via accelerating neuronal axon repair and synaptic plasticity
RUN and FYVE domain-containing 3 (Rufy3) is a well-known adapter protein of a small GTPase protein family and is bound to ...
Hif1α-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model
Hif1α-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model
Hypoxia-inducible factor 1 α (Hif1α) plays a crucial role in brain development. To study the function of Hif1 ...
Chicago sky blue 6B inhibits α-synuclein aggregation and propagation
Chicago sky blue 6B inhibits α-synuclein aggregation and propagation
Abnormal deposition of α-synuclein aggregates in Lewy bodies and Lewy neurites is the hallmark lesion in Parkinson...
Locus specific reduction of L1 expression in the cortices of individuals with amyotrophic lateral sclerosis
Locus specific reduction of L1 expression in the cortices of individuals with amyotrophic lateral sclerosis
The activation and dysregulation of retrotransposons has been identified in the CNS of individuals with the fatal neurodeg...
Activity of putative orexin neurons during cataplexy
Activity of putative orexin neurons during cataplexy
It is unclear why orexin-deficient animals, but not wild-type mice, show cataplexy. The current hypothesis predicts simult...
The dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke
The dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke
Ischemic stroke, caused by a lack of blood supply in brain tissues, is the third leading cause of human death and disabili...
Brain-wide TVA compensation allows rabies virus to retrograde target cell-type-specific projection neurons
Brain-wide TVA compensation allows rabies virus to retrograde target cell-type-specific projection neurons
Retrograde tracers based on viral vectors are powerful tools for the imaging and manipulation of upstream neural networks ...
The increased in vivo firing of pyramidal cells but not interneurons in the anterior cingulate cortex after neuropathic pain
The increased in vivo firing of pyramidal cells but not interneurons in the anterior cingulate cortex after neuropathic pain
Chronic pain damages the balance between excitation and inhibition in the sensory cortex. It has been confirmed that the a...
NeuroTrace 500/525 identifies human induced pluripotent stem cell-derived brain pericyte-like cells
NeuroTrace 500/525 identifies human induced pluripotent stem cell-derived brain pericyte-like cells
In the CNS, pericytes are important for maintaining the blood–brain barrier (BBB) and for controlling blood flow. Re...
Integrated genomic and DNA methylation analysis of patients with advanced non-small cell lung cancer with brain metastases
Integrated genomic and DNA methylation analysis of patients with advanced non-small cell lung cancer with brain metastases
Brain metastasis is a common and lethal complication of non-small cell lung cancer (NSCLC). It is mostly diagnosed only af...