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The duality of amyloid-β: its role in normal and Alzheimer’s disease states
The duality of amyloid-β: its role in normal and Alzheimer’s disease states
Alzheimer’s disease (AD) is a degenerative neurological condition that gradually impairs cognitive abilities, disrup...
MicroRNAs as the pivotal regulators of Temozolomide resistance in glioblastoma
MicroRNAs as the pivotal regulators of Temozolomide resistance in glioblastoma
Glioblastoma (GBM) is an aggressive nervous system tumor with a poor prognosis. Although, surgery, radiation therapy, and ...
The overexpression of DSP1 in neurons induces neuronal dysfunction and neurodegeneration phenotypes in Drosophila
The overexpression of DSP1 in neurons induces neuronal dysfunction and neurodegeneration phenotypes in Drosophila
Dorsal switch protein 1(DSP1), a mammalian homolog of HMGB1, is firstly identified as a dorsal co-repressor in 1994. DSP1 ...
Cerebellar damage with inflammation upregulates oxytocin receptor expression in Bergmann Glia
Cerebellar damage with inflammation upregulates oxytocin receptor expression in Bergmann Glia
The cerebellum plays an important role in cognitive and social functioning. Childhood damage in the cerebellum increases t...
Long-read RNA sequencing identifies region- and sex-specific C57BL/6J mouse brain mRNA isoform expression and usage
Long-read RNA sequencing identifies region- and sex-specific C57BL/6J mouse brain mRNA isoform expression and usage
Alternative splicing (AS) contributes to the biological heterogeneity between species, sexes, tissues, and cell types. Man...
Inhibition of cortical synaptic transmission, behavioral nociceptive, and anxiodepressive-like responses by arecoline in adult mice
Inhibition of cortical synaptic transmission, behavioral nociceptive, and anxiodepressive-like responses by arecoline in adult mice
Areca nut, the seed of Areca catechu L., is one of the most widely consumed addictive substances in the world after nicoti...
Adolescent chemogenetic activation of dopaminergic neurons leads to reversible decreases in amphetamine-induced stereotypic behavior
Adolescent chemogenetic activation of dopaminergic neurons leads to reversible decreases in amphetamine-induced stereotypic behavior
Chronic perturbations of neuronal activity can evoke homeostatic and new setpoints for neurotransmission. Using chemogenet...
Chronic unpredictable stress induces autophagic death of adult hippocampal neural stem cells
Chronic unpredictable stress induces autophagic death of adult hippocampal neural stem cells
Chronic psychological stress is a critical factor for neurological complications like anxiety disorders, dementia, and dep...
S100 proteins: a new frontier in fibromyalgia research
S100 proteins: a new frontier in fibromyalgia research
Fibromyalgia (FM) is a chronic condition that causes widespread pain, fatigue, and other symptoms that significantly affec...
Hypothalamic protein profiling from mice subjected to social defeat stress
Hypothalamic protein profiling from mice subjected to social defeat stress
The Hypothalmic-Pituitary-Adrenal axis also known as the HPA axis is central to stress response. It also acts as the relay...
A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy
A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy
The aggregated alpha-synuclein (αsyn) in oligodendrocytes (OLGs) is one of the pathological hallmarks in multiple sys...
Broad proteomics analysis of seeding-induced aggregation of α-synuclein in M83 neurons reveals remodeling of proteostasis mechanisms that might contribute to Parkinson’s disease pathogenesis
Broad proteomics analysis of seeding-induced aggregation of α-synuclein in M83 neurons reveals remodeling of proteostasis mechanisms that might contribute to Parkinson’s disease pathogenesis
Aggregation of misfolded α-synuclein (α-syn) is a key characteristic feature of Parkinson’s disease (PD) a...
Region-specific activation in the accumbens nucleus by itch with modified scratch efficacy in mice – a model-free multivariate analysis
Region-specific activation in the accumbens nucleus by itch with modified scratch efficacy in mice – a model-free multivariate analysis
Itch is a protective/defensive function with divalent motivational drives. Itch itself elicits an unpleasant experience, w...
Spatiotemporal dynamics of the CD11c+ microglial population in the mouse brain and spinal cord from developmental to adult stages
Spatiotemporal dynamics of the CD11c+ microglial population in the mouse brain and spinal cord from developmental to adult stages
CD11c-positive (CD11c+) microglia have attracted considerable attention because of their potential implications in central...
A method for selective and efficient isolation of gray matter astrocytes from the spinal cord of adult mice
A method for selective and efficient isolation of gray matter astrocytes from the spinal cord of adult mice
A growing body of evidence indicates intra- and inter-regional heterogeneity of astrocytes in the brain. However, because ...
Moxibustion ameliorates chronic inflammatory visceral pain via spinal circRNA-miRNA-mRNA networks: a central mechanism study
Moxibustion ameliorates chronic inflammatory visceral pain via spinal circRNA-miRNA-mRNA networks: a central mechanism study
This study aimed to unveil the central mechanism of moxibustion treating chronic inflammatory visceral pain (CIVP) from th...
L-DOPA regulates neuroinflammation and Aβ pathology through NEP and ADAM17 in a mouse model of AD
L-DOPA regulates neuroinflammation and Aβ pathology through NEP and ADAM17 in a mouse model of AD
Dopamine plays important roles in cognitive function and inflammation and therefore is involved in the pathogenesis of neu...
Chronic pain enhances excitability of corticotropin-releasing factor-expressing neurons in the oval part of the bed nucleus of the stria terminalis
Chronic pain enhances excitability of corticotropin-releasing factor-expressing neurons in the oval part of the bed nucleus of the stria terminalis
We previously reported that enhanced corticotropin-releasing factor (CRF) signaling in the bed nucleus of the stria termin...
Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors
Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors
While the excessive inflammation in cancer cachexia is well-known to be induced by the overproduction of inflammatory medi...
Correction to: Toll-like receptor 4 deficiency ameliorates β2-microglobulin induced age-related cognition decline due to neuroinflammation in mice
Correction to: Toll-like receptor 4 deficiency ameliorates β2-microglobulin induced age-related cognition decline due to neuroinflammation in mice
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Differential contribution of canonical and noncanonical NLGN3 pathways to early social development and memory performance
Differential contribution of canonical and noncanonical NLGN3 pathways to early social development and memory performance
Neuroligin (NLGN) 3 is a postsynaptic cell adhesion protein organizing synapse formation through two different types of tr...
Spermidine treatment: induction of autophagy but also apoptosis?
Spermidine treatment: induction of autophagy but also apoptosis?
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a fatal neurodegenerative disease that cause...
Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
Synucleinopathies refer to a group of disorders characterized by SNCA/α-synuclein (α-Syn)-containing cytoplasmic...
Crucial role of TFAP2B in the nervous system for regulating NREM sleep
Crucial role of TFAP2B in the nervous system for regulating NREM sleep
The AP-2 transcription factors are crucial for regulating sleep in both vertebrate and invertebrate animals. In mice, loss...
TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway
TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway
Autism spectrum disorder (ASD) encompasses a diverse range of neurodevelopmental disorders, but the precise underlying pat...
A simple and reliable method for claustrum localization across age in mice
A simple and reliable method for claustrum localization across age in mice
The anatomical organization of the rodent claustrum remains obscure due to lack of clear borders that distinguish it from ...
Deleting IP6K1 stabilizes neuronal sodium–potassium pumps and suppresses excitability
Deleting IP6K1 stabilizes neuronal sodium–potassium pumps and suppresses excitability
Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reporte...
The brain cytokine orchestra in multiple sclerosis: from neuroinflammation to synaptopathology
The brain cytokine orchestra in multiple sclerosis: from neuroinflammation to synaptopathology
The central nervous system (CNS) is finely protected by the blood–brain barrier (BBB). Immune soluble factors such a...
Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state
Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state
Alzheimer’s disease (AD) is characterized by the loss of memory due to aggregation of misphosphorylated tau and amyl...
Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics
Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics
Unraveling the intricate relationship between mechanical factors and brain activity is a pivotal endeavor, yet the underly...
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