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Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder
Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder
Social behavior emerges early in development, a time marked by the onset of neurodevelopmental disorders featuring social ...
Analgesia by intrathecal delta-9-tetrahydrocannabinol is dependent on Cav3.2 calcium channels
Analgesia by intrathecal delta-9-tetrahydrocannabinol is dependent on Cav3.2 calcium channels
Delta-9-tetrahydrocannabinol (Δ9-THC) is known to produce systemic analgesia that involves CB1 and CB2 cannabinoid re...
Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses
Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses
High frequency burst firing is critical in summation of back-propagating action potentials (APs) in dendrites, which may g...
Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency
Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency
Glycine receptors (GlyRs) are ligand-gated chloride channels comprising alpha (α1–4) and β subunits. The G...
Interneuronal GluK1 kainate receptors control maturation of GABAergic transmission and network synchrony in the hippocampus
Interneuronal GluK1 kainate receptors control maturation of GABAergic transmission and network synchrony in the hippocampus
Kainate type glutamate receptors (KARs) are strongly expressed in GABAergic interneurons and have the capability of modula...
Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila
Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila
Dysregulation of HDAC4 expression and/or nucleocytoplasmic shuttling results in impaired neuronal morphogenesis and long-t...
Enhanced primary ciliogenesis via mitochondrial oxidative stress activates AKT to prevent neurotoxicity in HSPA9/mortalin-depleted SH-SY5Y cells
Enhanced primary ciliogenesis via mitochondrial oxidative stress activates AKT to prevent neurotoxicity in HSPA9/mortalin-depleted SH-SY5Y cells
The primary cilium, an antenna-like structure on the cell surface, acts as a mechanical and chemical sensory organelle. Pr...
Modifiable risk factors that mediate the effect of educational attainment on the risk of stroke: a network Mendelian randomization study
Modifiable risk factors that mediate the effect of educational attainment on the risk of stroke: a network Mendelian randomization study
Stroke is a common cerebrovascular disease with great danger to public health. Educational inequality is a universal issue...
A new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice
A new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice
Cooperation is a social behavior crucial for the survival of many species, including humans. Several experimental paradigm...
Towards multiplexed immunofluorescence of 3D tissues
Towards multiplexed immunofluorescence of 3D tissues
Profiling molecular expression in situ allows the integration of biomolecular and cellular features, enabling an in-depth ...
Tibial fracture surgery in elderly mice caused postoperative neurocognitive disorder via SOX2OT lncRNA in the hippocampus
Tibial fracture surgery in elderly mice caused postoperative neurocognitive disorder via SOX2OT lncRNA in the hippocampus
Increasing evidence indicates the major role of mitochondrial function in neurodegenerative disease. However, it is unclea...
Increased social interaction in Shank2-deficient mice following acute social isolation
Increased social interaction in Shank2-deficient mice following acute social isolation
Autism spectrum disorder (ASD) is neuropsychiatric disorder with a gender specific risk. Although social impairment in ASD...
Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice
Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice
The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission. Mice genetically...
Diurnal variation in declarative memory and the involvement of SCOP in cognitive functions in nonhuman primates
Diurnal variation in declarative memory and the involvement of SCOP in cognitive functions in nonhuman primates
Cognitive functions depend on the time of day in various organisms. Previously, we found that 24-h recognition memory perf...
Experience-dependent changes in affective valence of taste in male mice
Experience-dependent changes in affective valence of taste in male mice
Taste plays an essential role in the evaluation of food quality by detecting potential harm and benefit in what animals ar...
Correction: Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles
Correction: Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Spatiotemporal expression patterns of genes coding for plasmalemmal chloride transporters and channels in neurological diseases
Spatiotemporal expression patterns of genes coding for plasmalemmal chloride transporters and channels in neurological diseases
Neuronal voltage changes which are dependent on chloride transporters and channels are involved in forming neural function...
The gut microbiota and metabolite profiles are altered in patients with spinal cord injury
The gut microbiota and metabolite profiles are altered in patients with spinal cord injury
Metabolites secreted by the gut microbiota may play an essential role in microbiota–gut–central nervous system...
Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation
Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation
The prenylation of proteins is involved in a variety of biological functions. However, it remains unknown whether it plays...
Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide
Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide
The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However...
Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus
Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus
A growing body of evidence suggests that excess stress could aggravate tumor progression. The paraventricular nucleus (PVN...
Cancer aggravation due to persistent pain signals with the increased expression of pain-related mediators in sensory neurons of tumor-bearing mice
Cancer aggravation due to persistent pain signals with the increased expression of pain-related mediators in sensory neurons of tumor-bearing mice
A growing body of evidence suggests that intractable pain reduces both the quality of life and survival in cancer patients...
Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus
Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus
Mutations in the Presenilin genes (PSEN1 and PSEN2) are the major cause of familial Alzheimer’s disease (AD), highli...
G-protein coupled estrogen receptor (GPER1) activation promotes synaptic insertion of AMPA receptors and induction of chemical LTP at hippocampal temporoammonic-CA1 synapses
G-protein coupled estrogen receptor (GPER1) activation promotes synaptic insertion of AMPA receptors and induction of chemical LTP at hippocampal temporoammonic-CA1 synapses
It is well documented that 17β estradiol (E2) regulates excitatory synaptic transmission at hippocampal Shaffer-colla...
Role of Calcr expressing neurons in the medial amygdala in social contact among females
Role of Calcr expressing neurons in the medial amygdala in social contact among females
Social animals become stressed upon social isolation, proactively engaging in affiliative contacts among conspecifics afte...
Circadian rhythms in the blood–brain barrier: impact on neurological disorders and stress responses
Circadian rhythms in the blood–brain barrier: impact on neurological disorders and stress responses
Circadian disruption has become more prevalent in society due to the increase in shift work, sleep disruption, blue light ...
Knee osteoarthritis accelerates amyloid beta deposition and neurodegeneration in a mouse model of Alzheimer’s disease
Knee osteoarthritis accelerates amyloid beta deposition and neurodegeneration in a mouse model of Alzheimer’s disease
Knee osteoarthritis (OA) is characterized by knee cartilage degeneration and secondary bone hyperplasia, resulting in pain...
Acute social defeat stress activated neurons project to the claustrum and basolateral amygdala
Acute social defeat stress activated neurons project to the claustrum and basolateral amygdala
We recently reported that a neuronal population in the claustrum (CLA) identified under exposure to psychological stressor...
Chronic skin ultraviolet irradiation induces transcriptomic changes associated with microglial dysfunction in the hippocampus
Chronic skin ultraviolet irradiation induces transcriptomic changes associated with microglial dysfunction in the hippocampus
Recent evidence indicates that ultraviolet (UV) exposure of the skin can affect brain functions such as learning and memor...
Object location learning in mice requires hippocampal somatostatin interneuron activity and is facilitated by mTORC1-mediated long-term potentiation of their excitatory synapses
Object location learning in mice requires hippocampal somatostatin interneuron activity and is facilitated by mTORC1-mediated long-term potentiation of their excitatory synapses
Hippocampus-dependent learning and memory originate from long-term synaptic changes in hippocampal networks. The activity ...
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