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Mutant Fam20c knock-in mice recapitulate both lethal and non-lethal human Raine Syndrome
Mutant Fam20c knock-in mice recapitulate both lethal and non-lethal human Raine Syndrome
Inactivation or mutations of FAM20C causes human Raine Syndrome, which manifests as lethal osteosclerosis bone dysplasia o...
Functional significance of some common oxytocin receptor SNPs involved in complex human traits
Functional significance of some common oxytocin receptor SNPs involved in complex human traits
Oxytocin function is associated with a range of human traits and is often indexed by common polymorphisms of the receptor ...
Transcriptome and DNA methylation profiling during the NSN to SN transition in mouse oocytes
Transcriptome and DNA methylation profiling during the NSN to SN transition in mouse oocytes
During the latter stages of their development, mammalian oocytes under dramatic chromatin reconfiguration, transitioning f...
Designing multi-epitope vaccines against Echinococcus granulosus: an in-silico study using immuno-informatics
Designing multi-epitope vaccines against Echinococcus granulosus: an in-silico study using immuno-informatics
Cystic echinococcosis (CE) is a worldwide zoonotic public health issue. The reasons for this include a lack of specific th...
Convergent evolution of type I antifreeze proteins from four different progenitors in response to global cooling
Convergent evolution of type I antifreeze proteins from four different progenitors in response to global cooling
Alanine-rich, alpha-helical type I antifreeze proteins (AFPs) in fishes are thought to have arisen independently in the la...
Single-cell RNA sequencing identifies the expression of hemoglobin in chondrocyte cell subpopulations in osteoarthritis
Single-cell RNA sequencing identifies the expression of hemoglobin in chondrocyte cell subpopulations in osteoarthritis
In recent years, chondrocytes have been found to contain hemoglobin, which might be an alternative strategy for adapting t...
LEP O-GlcNAcylation inactivates NF-κB pathway by suppressing LEP protein level and thus mediates cellular senescence and osteogenic differentiation in mouse mesenchymal stem cells
LEP O-GlcNAcylation inactivates NF-κB pathway by suppressing LEP protein level and thus mediates cellular senescence and osteogenic differentiation in mouse mesenchymal stem cells
Cellular senescence is a key driver of decreased bone formation and osteoporosis. Leptin (LEP) has been implicated in cell...
Correction: Glycogen Synthase Kinase-3 regulates IGFBP-1 gene transcription through the Thymine-rich Insulin Response Element
Correction: Glycogen Synthase Kinase-3 regulates IGFBP-1 gene transcription through the Thymine-rich Insulin Response Element
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Role of layilin in regulating mitochondria-mediated apoptosis: a study on B cell lymphoma (BCL)-2 family proteins
Role of layilin in regulating mitochondria-mediated apoptosis: a study on B cell lymphoma (BCL)-2 family proteins
Malignant gliomas exhibit rapid tumor progression and resistance to treatment, leading to high lethality. One of the cause...
Induction of chronic asthma up regulated the transcription of senile factors in male rats
Induction of chronic asthma up regulated the transcription of senile factors in male rats
The main characteristic of asthma is chronic inflammation. We examined cellular senescence by histology and molecular assa...
Neuroprotective effect of ciclopirox olamine in retinal ischemia/reperfusion injury
Neuroprotective effect of ciclopirox olamine in retinal ischemia/reperfusion injury
Retinal ischemia–reperfusion (IR) injury is a basic pathological procedure in clinic and associated with various isc...
Evaluation of antibacterial and anticancer properties of secondary metabolites isolated from soil Bacillus spp focusing on two strains of Bacillus licheniformis and Bacillus siamensis
Evaluation of antibacterial and anticancer properties of secondary metabolites isolated from soil Bacillus spp focusing on two strains of Bacillus licheniformis and Bacillus siamensis
Bacillus strains are well recognized for their inherent production of bioactive compounds that exhibit antibacterial and a...
Optimisation of cryopreservation conditions, including storage duration and revival methods, for the viability of human primary cells
Optimisation of cryopreservation conditions, including storage duration and revival methods, for the viability of human primary cells
Cryopreservation is a crucial procedure for safeguarding cells or other biological constructs, showcasing considerable pot...
Differential methylation patterns in paternally imprinted gene promoter regions in sperm from hepatitis B virus infected individuals
Differential methylation patterns in paternally imprinted gene promoter regions in sperm from hepatitis B virus infected individuals
Hepatitis B virus (HBV) infection poses a substantial threat to human health, impacting not only infected individuals but ...
Circulating microRNAs as potential biomarkers of physical activity in geriatric patients with HCV
Circulating microRNAs as potential biomarkers of physical activity in geriatric patients with HCV
Circulating microRNAs have been implicated in a diverse array of biological and pathological phenomena. Their potential ut...
Upregulated dual oxidase 1-induced oxidative stress and caspase-1-dependent pyroptosis reflect the etiologies of heart failure
Upregulated dual oxidase 1-induced oxidative stress and caspase-1-dependent pyroptosis reflect the etiologies of heart failure
Oxidative stress is implicated in the pathogenesis of heart failure. Dual oxidase 1 (DUOX1) might be important in heart fa...
Comparing chemical transfection, electroporation, and lentiviral vector transduction to achieve optimal transfection conditions in the Vero cell line
Comparing chemical transfection, electroporation, and lentiviral vector transduction to achieve optimal transfection conditions in the Vero cell line
Transfection is an important analytical method for studying gene expression in the cellular environment. There are some ba...
High-fat diet enhances cell proliferation and compromises intestinal permeability in a translational canine intestinal organoid model
High-fat diet enhances cell proliferation and compromises intestinal permeability in a translational canine intestinal organoid model
Emerging evidence underscores the responsiveness of the mammalian intestine to dietary cues, notably through the involveme...
Long non-coding RNA SOX2OT in tamoxifen-resistant breast cancer
Long non-coding RNA SOX2OT in tamoxifen-resistant breast cancer
Hormone receptor (HR)-positive breast cancer can become aggressive after developing hormone-treatment resistance. This stu...
mTOR signaling pathway regulation HIF-1 α effects on LPS induced intestinal mucosal epithelial model damage
mTOR signaling pathway regulation HIF-1 α effects on LPS induced intestinal mucosal epithelial model damage
Sepsis-induced small-intestinal injury is associated with increased morbidity and mortality. Our previous study and other ...
Mice lacking DIO3 exhibit sex-specific alterations in circadian patterns of corticosterone and gene expression in metabolic tissues
Mice lacking DIO3 exhibit sex-specific alterations in circadian patterns of corticosterone and gene expression in metabolic tissues
Disruption of circadian rhythms is associated with neurological, endocrine and metabolic pathologies. We have recently sho...
Optimization of seeding density of OP9 cells to improve hematopoietic differentiation efficiency
Optimization of seeding density of OP9 cells to improve hematopoietic differentiation efficiency
OP9 mouse stromal cell line has been widely used to induce differentiation of human embryonic stem cells (hESCs) into hema...
Development of an in vitro human alveolar epithelial air-liquid interface model using a small molecule inhibitor cocktail
Development of an in vitro human alveolar epithelial air-liquid interface model using a small molecule inhibitor cocktail
The alveolar epithelium is exposed to numerous stimuli, such as chemicals, viruses, and bacteria that cause a variety of p...
Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells
Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells
Hypertension-induced mechanical stress on vascular smooth muscle cells (VSMCs) is a known risk factor for vascular remodel...
Melatonin reduces lung injury in type 1 diabetic mice by the modulation of autophagy
Melatonin reduces lung injury in type 1 diabetic mice by the modulation of autophagy
In recent years, the role of autophagy has been highlighted in the pathogenesis of diabetes and inflammatory lung diseases...
TonEBP/NFAT5 expression is associated with cisplatin resistance and migration in macrophage-induced A549 cells
TonEBP/NFAT5 expression is associated with cisplatin resistance and migration in macrophage-induced A549 cells
Macrophages promote angiogenesis, metastasis, and drug resistance in several cancers. Similarly, TonEBP/NFAT5 induces meta...
Optimizing combination therapy in prostate cancer: mechanistic insights into the synergistic effects of Paclitaxel and Sulforaphane-induced apoptosis
Optimizing combination therapy in prostate cancer: mechanistic insights into the synergistic effects of Paclitaxel and Sulforaphane-induced apoptosis
Combination therapies in cancer treatment have demonstrated synergistic or additive outcomes while also reducing the devel...
CTC together with Shh and Nrf2 are prospective diagnostic markers for HNSCC
CTC together with Shh and Nrf2 are prospective diagnostic markers for HNSCC
The lack of appropriate prognostic biomarkers remains a significant obstacle in the early detection of Head and Neck Squam...
Prioritization of Trypanosoma brucei editosome protein interactions interfaces at residue resolution through proteome-scale network analysis
Prioritization of Trypanosoma brucei editosome protein interactions interfaces at residue resolution through proteome-scale network analysis
Trypanosoma brucei is the causative agent for trypanosomiasis in humans and livestock, which presents a growing challenge ...
Sumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function
Sumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function
Fas-associated factor 1 (FAF1) is a multidomain protein that interacts with diverse partners to affect numerous cellular p...
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