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Upregulated dual oxidase 1-induced oxidative stress and caspase-1-dependent pyroptosis reflect the etiologies of heart failure
Upregulated dual oxidase 1-induced oxidative stress and caspase-1-dependent pyroptosis reflect the etiologies of heart failure
Oxidative stress is implicated in the pathogenesis of heart failure. Dual oxidase 1 (DUOX1) might be important in heart fa...
Comparing chemical transfection, electroporation, and lentiviral vector transduction to achieve optimal transfection conditions in the Vero cell line
Comparing chemical transfection, electroporation, and lentiviral vector transduction to achieve optimal transfection conditions in the Vero cell line
Transfection is an important analytical method for studying gene expression in the cellular environment. There are some ba...
High-fat diet enhances cell proliferation and compromises intestinal permeability in a translational canine intestinal organoid model
High-fat diet enhances cell proliferation and compromises intestinal permeability in a translational canine intestinal organoid model
Emerging evidence underscores the responsiveness of the mammalian intestine to dietary cues, notably through the involveme...
Long non-coding RNA SOX2OT in tamoxifen-resistant breast cancer
Long non-coding RNA SOX2OT in tamoxifen-resistant breast cancer
Hormone receptor (HR)-positive breast cancer can become aggressive after developing hormone-treatment resistance. This stu...
mTOR signaling pathway regulation HIF-1 α effects on LPS induced intestinal mucosal epithelial model damage
mTOR signaling pathway regulation HIF-1 α effects on LPS induced intestinal mucosal epithelial model damage
Sepsis-induced small-intestinal injury is associated with increased morbidity and mortality. Our previous study and other ...
Mice lacking DIO3 exhibit sex-specific alterations in circadian patterns of corticosterone and gene expression in metabolic tissues
Mice lacking DIO3 exhibit sex-specific alterations in circadian patterns of corticosterone and gene expression in metabolic tissues
Disruption of circadian rhythms is associated with neurological, endocrine and metabolic pathologies. We have recently sho...
Optimization of seeding density of OP9 cells to improve hematopoietic differentiation efficiency
Optimization of seeding density of OP9 cells to improve hematopoietic differentiation efficiency
OP9 mouse stromal cell line has been widely used to induce differentiation of human embryonic stem cells (hESCs) into hema...
Development of an in vitro human alveolar epithelial air-liquid interface model using a small molecule inhibitor cocktail
Development of an in vitro human alveolar epithelial air-liquid interface model using a small molecule inhibitor cocktail
The alveolar epithelium is exposed to numerous stimuli, such as chemicals, viruses, and bacteria that cause a variety of p...
Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells
Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells
Hypertension-induced mechanical stress on vascular smooth muscle cells (VSMCs) is a known risk factor for vascular remodel...
Melatonin reduces lung injury in type 1 diabetic mice by the modulation of autophagy
Melatonin reduces lung injury in type 1 diabetic mice by the modulation of autophagy
In recent years, the role of autophagy has been highlighted in the pathogenesis of diabetes and inflammatory lung diseases...
TonEBP/NFAT5 expression is associated with cisplatin resistance and migration in macrophage-induced A549 cells
TonEBP/NFAT5 expression is associated with cisplatin resistance and migration in macrophage-induced A549 cells
Macrophages promote angiogenesis, metastasis, and drug resistance in several cancers. Similarly, TonEBP/NFAT5 induces meta...
Optimizing combination therapy in prostate cancer: mechanistic insights into the synergistic effects of Paclitaxel and Sulforaphane-induced apoptosis
Optimizing combination therapy in prostate cancer: mechanistic insights into the synergistic effects of Paclitaxel and Sulforaphane-induced apoptosis
Combination therapies in cancer treatment have demonstrated synergistic or additive outcomes while also reducing the devel...
CTC together with Shh and Nrf2 are prospective diagnostic markers for HNSCC
CTC together with Shh and Nrf2 are prospective diagnostic markers for HNSCC
The lack of appropriate prognostic biomarkers remains a significant obstacle in the early detection of Head and Neck Squam...
Prioritization of Trypanosoma brucei editosome protein interactions interfaces at residue resolution through proteome-scale network analysis
Prioritization of Trypanosoma brucei editosome protein interactions interfaces at residue resolution through proteome-scale network analysis
Trypanosoma brucei is the causative agent for trypanosomiasis in humans and livestock, which presents a growing challenge ...
Sumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function
Sumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function
Fas-associated factor 1 (FAF1) is a multidomain protein that interacts with diverse partners to affect numerous cellular p...
Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder
Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder
Chronic alcohol exposure increases liver damage such as lipid accumulation and hepatitis, resulting in hepatic cirrhosis. ...
Association between plasma L-carnitine levels and mitochondrial DNA copy number
Association between plasma L-carnitine levels and mitochondrial DNA copy number
Mitochondria are key cytoplasmic organelles in eukaryotic cells that generate adenosine triphosphate (ATP) through the ele...
Effect of Emi1 gene silencing on the proliferation and invasion of human breast cancer cells
Effect of Emi1 gene silencing on the proliferation and invasion of human breast cancer cells
Breast cancer is the most common malignant tumour in women. The early silk-splitting inhibitor protein 1 Emi1 is responsib...
TNFα induces Caspase-3 activity in hematopoietic progenitor cells CD34+, CD33+, and CD41 + of myelodysplastic syndromes
TNFα induces Caspase-3 activity in hematopoietic progenitor cells CD34+, CD33+, and CD41 + of myelodysplastic syndromes
Cytopenia is the primary feature of Myelodysplastic Syndrome, even in the presence of hypercellular bone marrow. TNFα...
Simple, low-cost, and well-performing method, the outgrowth technique, for the isolation of cells from nasal polyps
Simple, low-cost, and well-performing method, the outgrowth technique, for the isolation of cells from nasal polyps
Epithelial cells are an important part of the pathomechanism in chronic rhinosinusitis with nasal polyps. It is therefore ...
From network analysis to experimental validation: identification of regulators of non-muscle myosin II contractility using the folded-gastrulation signaling pathway
From network analysis to experimental validation: identification of regulators of non-muscle myosin II contractility using the folded-gastrulation signaling pathway
The morphogenetic process of apical constriction, which relies on non-muscle myosin II (NMII) generated constriction of ap...
Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats
Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats
Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to...
Mineral elements and adiposity-related consequences in adolescents with intellectual disabilities
Mineral elements and adiposity-related consequences in adolescents with intellectual disabilities
Patients with intellectual disabilities are shown to have a limited capacity for cooperation, communication,and other biol...
Glycyrrhizin inhibits LPS-induced inflammatory responses in goat ruminal epithelial cells in vitro
Glycyrrhizin inhibits LPS-induced inflammatory responses in goat ruminal epithelial cells in vitro
Inflammation plays a crucial role in the progression of Subacute Ruminal Acidosis (SARA). The experiment was designed to i...
D-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of mice
D-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of mice
Age-related hearing loss, known as presbycusis, is the result of auditory system degeneration. Numerous studies have sugge...
Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer
Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) regulates pre-mRNA processing and long non-coding RNA localization in t...
BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway
BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway
Bone morphogenetic protein 9 (BMP9) has been shown to regulate processes such as angiogenesis, endothelial dysfunction, an...
A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78
A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78
Cells can die through a process called apoptosis in both pathological and healthy conditions. Cancer development and progr...
Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance
Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance
Emodin and aloe-emodin are two anthraquinones having positive effects in wound healing. However, their mechanism of action...
Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress
Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress
Renal ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI). Dysfunction of E74-like ETS transcr...
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