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Pre-treatment with IL-6 potentiates β-cell death induced by pro-inflammatory cytokines
Pre-treatment with IL-6 potentiates β-cell death induced by pro-inflammatory cytokines
Type I Diabetes mellitus (T1D) is characterized by a specific destruction of β-cells by the immune system. During thi...
Evolutionary relevance of single nucleotide variants within the forebrain exclusive human accelerated enhancer regions
Evolutionary relevance of single nucleotide variants within the forebrain exclusive human accelerated enhancer regions
Human accelerated regions (HARs) are short conserved genomic sequences that have acquired significantly more nucleotide su...
The DNA demethylation-regulated SFRP2 dictates the progression of endometriosis via activation of the Wnt/β-catenin signaling pathway
The DNA demethylation-regulated SFRP2 dictates the progression of endometriosis via activation of the Wnt/β-catenin signaling pathway
Endometriosis cause decreases in life quality and pelvic pain in reproductive-age women. Methylation abnormalities played ...
Role of the human solute carrier family 14 member 1 gene in hypoxia-induced renal cell carcinoma occurrence and its enlightenment to cancer nursing
Role of the human solute carrier family 14 member 1 gene in hypoxia-induced renal cell carcinoma occurrence and its enlightenment to cancer nursing
Hypoxia is considered a critical contributor to renal cell carcinoma progression, including invasion and metastasis. Howev...
Cyclic tensile force modifies calvarial osteoblast function via the interplay between ERK1/2 and STAT3
Cyclic tensile force modifies calvarial osteoblast function via the interplay between ERK1/2 and STAT3
Mechanical therapies, such as distraction osteogenesis, are widely used in dental clinics. During this process, the mechan...
Urine-derived mesenchymal stem cells-derived exosomes enhances survival and proliferation of aging retinal ganglion cells
Urine-derived mesenchymal stem cells-derived exosomes enhances survival and proliferation of aging retinal ganglion cells
This study was designed to investigate to test the effect of exosomes from urine-derived mesenchymal stem cells (USCs) on ...
Sperm capacitation and transcripts levels are altered by in vitro THC exposure
Sperm capacitation and transcripts levels are altered by in vitro THC exposure
Delta-9-tetrahydrocannabinol (THC) is the primary phytocannabinoid responsible for the psychoactive properties of cannabis...
RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy
RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy
Abnormal biogenesis and ribosome free function of ribosomal proteins (RPs) is important for tumorgenesis and development. ...
The dual role of Nrf2 in melanoma: a systematic review
The dual role of Nrf2 in melanoma: a systematic review
Melanoma is the most lethal type of skin cancer that originates from the malignant transformation of melanocytes. Although...
Hyperoxia exposure upregulates Dvl-1 and activates Wnt/β-catenin signaling pathway in newborn rat lung
Hyperoxia exposure upregulates Dvl-1 and activates Wnt/β-catenin signaling pathway in newborn rat lung
Bronchopulmonary dysplasia is a serious and lifelong pulmonary disease in premature neonates that influences around one-qu...
Circ-ATL1 silencing reverses the activation effects of SIRT5 on smooth muscle cellular proliferation, migration and contractility in intracranial aneurysm by adsorbing miR-455
Circ-ATL1 silencing reverses the activation effects of SIRT5 on smooth muscle cellular proliferation, migration and contractility in intracranial aneurysm by adsorbing miR-455
Alterations in vascular smooth muscle cells (VSMCs) contribute to the pathogenesis of intracranial aneurysms (IAs). Howeve...
HMGB1 mediates lipopolysaccharide-induced macrophage autophagy and pyroptosis
HMGB1 mediates lipopolysaccharide-induced macrophage autophagy and pyroptosis
Autophagy and pyroptosis of macrophages play important protective or detrimental roles in sepsis. However, the underlying ...
N-Acetyl-L-cysteine facilitates tendon repair and promotes the tenogenic differentiation of tendon stem/progenitor cells by enhancing the integrin α5/β1/PI3K/AKT signaling
N-Acetyl-L-cysteine facilitates tendon repair and promotes the tenogenic differentiation of tendon stem/progenitor cells by enhancing the integrin α5/β1/PI3K/AKT signaling
Tendon injury is associated with oxidative stress, leading to reactive oxygen species (ROS) production and inflammation. N...
The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates
The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates
Considering the high correlation between the functional decline in Alzheimer’s disease (AD) and the propagation of a...
microRNA-338-3p suppresses lipopolysaccharide-induced inflammatory response in HK-2 cells
microRNA-338-3p suppresses lipopolysaccharide-induced inflammatory response in HK-2 cells
Inflammation is the most common cause of kidney damage, and inflammatory responses in a number of diseases are mediated by...
Overexpression of lncRNA HOXA-AS2 promotes the progression of oral squamous cell carcinoma by mediating SNX5 expression
Overexpression of lncRNA HOXA-AS2 promotes the progression of oral squamous cell carcinoma by mediating SNX5 expression
Oral squamous cell carcinoma (OSCC) is one of the most common head and neck cancers. Long non-coding RNA HOXA-AS2 (lncRNA ...
CREB1 regulates KPNA2 by inhibiting mir-495-3p transcription to control melanoma progression
CREB1 regulates KPNA2 by inhibiting mir-495-3p transcription to control melanoma progression
Melanoma is a common type of skin cancer, and its incidence is increasing gradually. Exploring melanoma pathogenesis helps...
Overexpressed cold inducible RNA-binding protein improves cell viability and EGF expression in glial cells
Overexpressed cold inducible RNA-binding protein improves cell viability and EGF expression in glial cells
Cold inducible RNA-binding protein (CIRP) is a key protein in the hypothermic therapy. Highly expressed CIRP exerts a neur...
Metabolic analysis of the regulatory mechanism of sugars on secondary flowering in Magnolia
Metabolic analysis of the regulatory mechanism of sugars on secondary flowering in Magnolia
Magnolia, a traditional and important ornamental plant in urban greening, has been cultivated for about 2000 years i...
Exogenous 8-hydroxydeoxyguanosine attenuates doxorubicin-induced cardiotoxicity by decreasing pyroptosis in H9c2 cardiomyocytes
Exogenous 8-hydroxydeoxyguanosine attenuates doxorubicin-induced cardiotoxicity by decreasing pyroptosis in H9c2 cardiomyocytes
Doxorubicin (DOX), which is widely used in cancer treatment, can induce cardiomyopathy. One of the main mechanisms whereby...
Ceramide induces pyroptosis through TXNIP/NLRP3/GSDMD pathway in HUVECs
Ceramide induces pyroptosis through TXNIP/NLRP3/GSDMD pathway in HUVECs
Pyroptosis of endothelial cells is a new cause of endothelial dysfunction in multiple diseases. Ceramide acts as a potenti...
Comparison of adhesion of thawed and cultured synovial mesenchymal stem cells to the porcine meniscus and the relevance of cell surface microspikes
Comparison of adhesion of thawed and cultured synovial mesenchymal stem cells to the porcine meniscus and the relevance of cell surface microspikes
Placement of a cultured synovial mesenchymal stem cell (MSC) suspension on a repaired meniscus for 10 min accelerate...
RUNX3 mediates keloid fibroblast proliferation through deacetylation of EZH2 by SIRT1
RUNX3 mediates keloid fibroblast proliferation through deacetylation of EZH2 by SIRT1
Keloid is a benign proliferative fibrous disease featured by excessive fibroblast proliferation after skin injury. However...
Lncap-AI prostate cancer cell line establishment by Flutamide and androgen-free environment to promote cell adherent
Lncap-AI prostate cancer cell line establishment by Flutamide and androgen-free environment to promote cell adherent
To establish castration-resistant prostate cancer (CRPC) - Lncap androgen-independent (AI) cell line from Lncap androgen-d...
The role of the TGF-β/LIF signaling pathway mediated by SMADs during the cyst formation of Echinococcus in young children
The role of the TGF-β/LIF signaling pathway mediated by SMADs during the cyst formation of Echinococcus in young children
The present study aims to explore the correlation of the transforming growth factor β (TGF-β), drosophila mother...
CARD9 contributes to ovarian cancer cell proliferation, cycle arrest, and cisplatin sensitivity
CARD9 contributes to ovarian cancer cell proliferation, cycle arrest, and cisplatin sensitivity
Ovarian cancer recurrence and chemotherapy resistance are still urgent issues, and exploring the mechanisms of metastasis ...
Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway
Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway
Abnormal expression of ribosomal proteins has an important regulatory effect on the progression of cancer. RPL5 is involve...
High levels of follicular fluid testosterone could impair oocyte developmental competency via affecting aryl hydrocarbon receptor pathway in PCOS patients
High levels of follicular fluid testosterone could impair oocyte developmental competency via affecting aryl hydrocarbon receptor pathway in PCOS patients
Although hormonal and metabolic dysfunction have been recognized as a possible cause of polycystic ovarian syndrome (PCOS)...
Downregulation of miR-451 in cholangiocarcinoma help the diagnsosi and promotes tumor progression
Downregulation of miR-451 in cholangiocarcinoma help the diagnsosi and promotes tumor progression
Cholangiocarcinoma is a kind of invasive malignant tumor followed by hepatocellular carcinoma. miR-451 was suggested to fu...
CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways
CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways
Cervical cancer is an important malignant tumor threatening the physical and mental health of women in the world. As a new...
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