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Region-specific and age-related differences in astrocytes in the human brain
Region-specific and age-related differences in astrocytes in the human brain
KeywordsAstrocyte heterogeneityMass spectrometry-based proteomicsAgingHuman brainData availabilityThe proteomic dataset su...
Isoform-specific effects of neuronal inhibition of AMPK catalytic subunit on LTD impairments in a mouse model of Alzheimer’s disease
Isoform-specific effects of neuronal inhibition of AMPK catalytic subunit on LTD impairments in a mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common cause of dementia syndrome in the elderly and a devastating neurodegenerative ...
Degree of multilingual engagement modulates resting state oscillatory activity across the lifespan
Degree of multilingual engagement modulates resting state oscillatory activity across the lifespan
Multilingualism has been demonstrated to lead to a more favorable trajectory of neurocognitive aging, yet our understandin...
Age- and sex- divergent translatomic responses of the mouse retinal pigmented epithelium
Age- and sex- divergent translatomic responses of the mouse retinal pigmented epithelium
AbbreviationsRPEretinal pigmented epitheliumAMDage-related macular degenerationTRAPTranslating Ribosome Affinity Purificat...
Slow wave activity disruptions and memory impairments in a mouse model of aging
Slow wave activity disruptions and memory impairments in a mouse model of aging
Volume 140, August 2024, Pages 12-21Author links open overlay panel, , , , , , , Highlights•Slow wave activity disruptions...
Reserve, resilience and maintenance of episodic memory and other cognitive functions in aging
Reserve, resilience and maintenance of episodic memory and other cognitive functions in aging
AbbreviationsAFQTArmed Forces Qualification TestAPOE-ɛ4apolipoprotein ɛ4CVLT-IICalifornia Verbal Learning Test–Second Edit...
High-fat diet and aging-associated memory impairments persist in the absence of microglia in female rats
High-fat diet and aging-associated memory impairments persist in the absence of microglia in female rats
Available online 1 May 2024Author links open overlay panel, , , , , , , , Highlights•Aging is associated with microglial p...
Age-related differences in functional connectivity associated with pain modulation
Age-related differences in functional connectivity associated with pain modulation
Growing evidence suggests that aging is associated with impaired endogenous pain modulation, and that this likely underlie...
Elevated protease-activated receptor 4 (PAR4) gene expression in Alzheimer’s disease predicts cognitive decline
Elevated protease-activated receptor 4 (PAR4) gene expression in Alzheimer’s disease predicts cognitive decline
Platelet activation of protease-activated receptor 4 (PAR4) and thrombin are at the top of a chain of events leading to fi...
The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging
The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging
Age-related neurocognitive disorders such as Alzheimer’s disease (AD) and mild cognitive impairment (MCI) involve widespre...
Association of APOE genotype with blood-brain barrier permeability in neurodegenerative disorders
Association of APOE genotype with blood-brain barrier permeability in neurodegenerative disorders
The blood-brain barrier (BBB), a highly dynamic interface between the central nervous system and the peripheral circulatio...
Brain oscillatory processes related to sequence memory in healthy older adults
Brain oscillatory processes related to sequence memory in healthy older adults
In addition to a general decline of memory functions, the ability to remember the order of events, i.e., sequence memory, ...
Trajectories of amyloid beta accumulation – unveiling the relationship with APOE genotype and cognitive decline
Trajectories of amyloid beta accumulation – unveiling the relationship with APOE genotype and cognitive decline
Amyloid beta (Aβ) follows a sigmoidal time function with varying accumulation rates. We studied how the position on this f...
Alterations in gamma frequency oscillations correlate with cortical tau deposition in Alzheimer’s disease
Alterations in gamma frequency oscillations correlate with cortical tau deposition in Alzheimer’s disease
Volume 139, July 2024, Pages 1-4Author links open overlay panel, , , , , , , Highlights•Relative gamma power is higher in ...
Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden
Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden
Cerebrovascular reactivity (CVR) deficits may contribute to small vessel disease, such as white matter hyperintensities (W...
Apolipoprotein E and Alzheimer’s disease pathology in African American older adults
Apolipoprotein E and Alzheimer’s disease pathology in African American older adults
Ann D. Cohen: Writing – review & editing, Supervision, Resources, Project administration, Methodology, Investigation, ...
Decomposing neurophysiological underpinnings of age-related decline in visual working memory
Decomposing neurophysiological underpinnings of age-related decline in visual working memory
Working memory (WM) is a complex cognitive function that is generally defined as the ability to temporarily store and mani...
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer’s disease progression
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer’s disease progression
Alzheimer’s disease (AD) is a neurodegenerative disorder with a dual proteinopathy as key markers of its pathology: accumu...
Preventive effect of propolis on cognitive decline in Alzheimer’s disease model mice
Preventive effect of propolis on cognitive decline in Alzheimer’s disease model mice
Alzheimer’s disease (AD) is an irreversible, progressive neurodegenerative disease characterized by memory loss and cognit...
CYTOKINE PROFILING IN SENESCENT AND REACTIVE ASTROCYTES: A SYSTEMATIC REVIEW.
CYTOKINE PROFILING IN SENESCENT AND REACTIVE ASTROCYTES: A SYSTEMATIC REVIEW.
In recent years, neuroinflammation has been accepted as one of the most important factors leading to age-associated cognit...
Associations between multidomain modifiable dementia risk factors with AD biomarkers and cognition in middle-aged and older adults
Associations between multidomain modifiable dementia risk factors with AD biomarkers and cognition in middle-aged and older adults
This study aimed to determine associations between modifiable dementia risk factors (MDRF), across domains mood symptomato...
Psychosis in Alzheimer’s disease is associated with specific changes in brain MRI volume, cognition and neuropathology
Psychosis in Alzheimer’s disease is associated with specific changes in brain MRI volume, cognition and neuropathology
Psychosis in Alzheimer’s Disease (AD) is defined as the presence of delusions, i.e. fixed false beliefs, or visual or audi...
Brain Age of Rhesus Macaques over the Lifespan
Brain Age of Rhesus Macaques over the Lifespan
Available online 9 March 2024Author links open overlay panel, , , , , , , , , , Highlights•Machine-learning based rhesus m...
The bidirectional relationship between brain structure and physical activity: A longitudinal analysis in the UK Biobank
The bidirectional relationship between brain structure and physical activity: A longitudinal analysis in the UK Biobank
All data analyzed herein (including IDPs) were provided by UK Biobank under project reference 68400, subject to a data tra...
LOWER ODDBALL EVENT-RELATED EEG DELTA AND THETA RESPONSES IN PATIENTS WITH DEMENTIA DUE TO PARKINSON'S AND LEWY BODY THAN ALZHEIMER'S DISEASE
LOWER ODDBALL EVENT-RELATED EEG DELTA AND THETA RESPONSES IN PATIENTS WITH DEMENTIA DUE TO PARKINSON'S AND LEWY BODY THAN ALZHEIMER'S DISEASE
Parkinson’s disease (PD) is defined by motor dysfunctions due to progressive neurodegeneration of nigrostriatal dopaminerg...