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Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease
Structural and functional brain alterations during aging and disease depend on interactions between individual genetic bac...
Progressive alteration of dynamic functional connectivity patterns in subcortical ischemic vascular cognitive impairment patients
Subcortical ischemic vascular disease (SIVD) occurs frequently in elderly people and leads to cognitive deficits. Accordin...
Adulthood cognitive trajectories over 26 years and brain health at 70 years of age: findings from the 1946 British Birth Cohort
Volume 122, February 2023, Pages 22-32Author links open overlay panel…AbstractFew studies can address how adulthood cognit...
Genetic landscape of ALS in Malta based on a quinquennial analysis
Available online 23 November 2022Author links open overlay panelHighlights•Genetic isolates like Malta provide a unique op...
Age and Sex Drive Differential Behavioral and Neuroimmune Phenotypes During Postoperative Pain
The US census bureau predicts that our geriatric population, 65 years and older, will increase by almost 30% by 2050 (Robe...
Racial differences in white matter hyperintensity burden in older adults
Cerebrovascular disease (CVD) is a known risk factor for cognitive decline and dementia and may result in pathological bra...
TREX1 p.A129fs and p.Y305C variants in a large multi-ethnic cohort of CADASIL-like unrelated patients.
C.S, M.F, S.B, R.G generated the dataC.S, R.G, J.B, K.P, K. W, I.A, M.C.M, A.S.M, A.G.V, G.S, I.S, S.M, L.K, J.S, M.P, L.M...
Neural signature of mobility-related everyday function in older adults at-risk of cognitive impairment
Assessment of everyday activities is central to the diagnosis of pre-dementia and dementia (Petersen et al., 2018). Emergi...
Brain metabolic correlates of Locus Coeruleus degeneration in Alzheimer's disease: a multimodal neuroimaging study
The Locus Coeruleus (LC) is the main noradrenergic (NA) nucleus of the brain, densely innervating to the whole cortical ma...
Association of longitudinal cognitive decline with diffusion MRI in Gray Matter, Amyloid, and Tau deposition
Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly population in developed countries (Al...
Association of homocysteine-related subcortical brain atrophy with white matter lesion volume and cognition in healthy aging
Elevated plasma homocysteine (Hcy) levels have been implicated as a vascular risk factor in healthy aging and have been re...
Predicting time-to-conversion for dementia of Alzheimer's type using multi-modal deep survival analysis
Alzheimer's disease (AD) or clinically defined Dementia of Alzheimer's Type (DAT) is a progressive neurodegenerative condi...
Inhibition of cellular senescence hallmarks by mitochondrial transplantation in senescence-induced ARPE-19 cells
Cellular senescence is characterized by a permanent state of cell cycle arrest, which can be triggered in normal cells in ...
Plasma neurofilament light as blood marker for poor brain white matter integrity among middle-aged urban adults
Recent technological advances have led to substantial interest in utilizing blood-based markers of neuroaxonal damage to m...
Amyloid β oligomers disrupt piriform cortical output via a serotonergic pathway
There are over 50 million cases of dementia worldwide, with 60%–70% attributable to Alzheimer's disease (AD) (Dement, 2021...
Do age-related differences in aperiodic neural activity explain differences in resting EEG alpha?
Aging is associated with various physical, biological, and cognitive changes that can greatly impact one's physical and me...
Physical activity levels and brain structure in middle-aged and older adults: a bidirectional longitudinal population-based study
Physical activity has been suggested as modifiable factor that might contribute to improving cognitive and brain function ...
Depressive symptoms are associated with reduced positivity preferences in episodic memory in aging
While emotional content is often better remembered than neutral content across adulthood (LaBar and Cabeza, 2006), older a...
Cerebral blood flow predicts multiple demand network activity and fluid intelligence across the adult lifespan
Volume 121, January 2023, Pages 1-14Highlights•The impact of CBF on maintaining cognitive ability across the lifespan is u...
CSF peptides from VGF and other markers enhance prediction of MCI to AD progression using the ATN framework
Volume 121, January 2023, Pages 15-27AbstractThe amyloid beta, tau, neurodegenerative markers framework has been proposed ...
Intermediate-length CGG repeat expansion in NOTCH2NLC is associated with pathologically confirmed Alzheimer's disease
Volume 120, December 2022, Pages 189-195Highlights•Intermediate-length CGG repeat expansion in NOTCH2NLC was identified in...
Unbiased metabolome screen links serum urate to risk of Alzheimer's disease
Volume 120, December 2022, Pages 167-176AbstractAlzheimer's disease (AD) is a progressive and fatal neurodegenerative dise...
Behavioral and fMRI evidence that arousal enhances bottom-up selectivity in young but not older adults
Volume 120, December 2022, Pages 149-166AbstractThe locus coeruleus-noradrenergic system integrates signals about arousal ...
Fast versus slow disease progression in amyotrophic lateral sclerosis–clinical and genetic factors at the edges of the survival spectrum
Volume 119, November 2022, Pages 117-126Highlights•Clinical parameters differ between ALS patients with short and long sur...
Association of liver disease with brain volume loss, cognitive decline, and plasma neurodegenerative disease biomarkers
Volume 120, December 2022, Pages 34-42AbstractAlthough liver dysfunction has been implicated in Alzheimer's disease (AD), ...
Age-related ultrastructural changes in the lateral cortex of the inferior colliculus
Volume 120, December 2022, Pages 43-59AbstractTemporal precision, a key component of sound and speech processing in the in...