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The Clinical Application of Optimized AT(N) Classification in Alzheimer’s Clinical Syndrome (ACS) and non-ACS Conditions
AbbreviationsACSAlzheimer’s clinical syndromeCAAcerebral amyloid angiopathyDMTdisease modifying therapyFTLDfrontotemporal ...
Aging induces cell loss and a decline in phagosome processing in the mouse retinal pigment epithelium
Age related macular degeneration (AMD) is a leading cause of irreversible vision loss. Changes in the retinal pigment epit...
Reconfiguration of brain network dynamics underlying spatial deficits in subjective cognitive decline
Brain dynamics and the associations with spatial navigation in individuals with subjective cognitive decline (SCD) remain ...
Annualized changes in rate of amyloid deposition and neurodegeneration are greater in participants who become amyloid positive than those who remain amyloid negative
Cleavage of the amyloid precursor protein, an essential element of the cell membrane, results in amyloid-beta (Aβ) peptide...
Multi-omic characterization of brain changes in the vascular endothelial growth factor family during aging and Alzheimer's disease
Volume 126, June 2023, Pages 25-33Author links open overlay panel, , , , , , , , , , , , , , , Highlights•Vascular endothe...
Peripheral apolipoprotein E proteins and their binding to LRP1 antagonize Alzheimer’s disease pathogenesis in the brain during peripheral chronic inflammation
Apolipoprotein E4 (ApoE4) is the major genetic risk factor for late-onset Alzheimer’s disease (AD) (Strittmatter et al., 1...
NPC1 variants are not associated with Parkinson’s disease, REM-sleep behaviour disorder or Dementia with Lewy bodies in European cohorts
Alpha synucleinopathies are a group of neurodegenerative disorders characterized by alpha synuclein and Lewy body accumula...
Inflammatory Biomarkers and MRI visible Perivascular Spaces: the Framingham Heart Study
Perivascular spaces (PVS) visible on brain magnetic resonance imaging (MRI) are cerebrospinal fluid-filled spaces surround...
Loss of amyotrophic lateral sclerosis risk factor SCFD1 causes motor dysfunction in Drosophila
Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease characterised by progressive loss of motor function culmina...
Independent role of Alzheimer's disease genetics and C-reactive protein on cognitive ability in aging
Available online 22 February 2023Author links open overlay panel, , , , , Highlights•APOE ε4 was associated with more pron...
Chronic BMAA exposure combined with TDP-43 mutation elicits motor neuron dysfunction phenotypes in mice
Available online 23 February 2023Author links open overlay panel, , , , , , , Highlights•L-BMAA combined with TDP-43−Q331K...
The clock gene Per1 is necessary in the retrosplenial cortex—but not in the suprachiasmatic nucleus—for incidental learning in young and aging male mice
Circadian rhythms regulate many physiological and behavioral processes, including the formation of memory (Davies et al., ...
Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the Study of Latinos- Investigation of Neurocognitive Aging Magnetic Resonance Imaging (SOL-INCA MRI)
Hispanic/Latino adults are a growing segment of the older US population yet are underrepresented in brain aging research. ...
Age Differences in Cortical Thickness and their Association with Cognition in Chimpanzee (Pan troglodytes)
One remarkable feature of humans is our lifespan; humans can live more than 100 years compared to approximately 50 to 60 y...
Characterization of apathy-like behaviors in the 5xFAD mouse model of Alzheimer’s disease
Alcohol (ethanol) is among the most popularly consumed beverages globally. Ethanol was earlier demonstrated to elicit cogn...
Body fat and components of sarcopenia relate to inflammation, brain volume and neurometabolism in older adults
Available online 2 March 2023Author links open overlay panel, , , , , , , , , , Highlights•Body fat % is negatively associ...
Age- and sex-related differences in baboon (Papio anubis) gray matter covariation
Both humans and nonhuman primates show changes in cognition, brain morphology, and behavior with age, both as a part of no...
Sex differences in brain metabolic connectivity architecture in probable dementia with Lewy bodies
Several sex differences in brain structure and function exist in healthy participants (Ingalhalikar et al., 2014; Ruigrok ...
Enlarged perivascular space burden associations with arterial stiffness and cognition
Small vessel disease (SVD) exists in almost 75% of autopsy-confirmed Alzheimer's disease cases (Kapasi et al., 2017) and h...
Lost – and Found – in Translation
Volume 124, April 2023, Pages 98-99Author links open overlay panelMolly V. Wagster a, Jonathan W. King bShow morePrevious ...
A framework for concepts of reserve and resilience in aging
Volume 124, April 2023, Pages 100-103Author links open overlay panel, , , , , AbstractThe study of factors, across species...
Selective spatial attention in lateralized multi-talker speech perception: EEG correlates and the role of age
Understanding speech in multi-talker environments poses a remarkable challenge to our basic hearing and higher cognitive a...
Rare Genetic Variants Correlate with Better Processing Speed
Human cognitive functions change with age, both normally and pathologically. Some cognitive abilities, such as vocabulary,...
ANXA1 mutation analysis in Italian patients with early onset PD
Available online 29 January 2023Author links open overlay panel, , , , , , , , , , ABSTRACTRecently, a novel pathogenic va...
Chronic Gq activation of ventral hippocampal neurons and astrocytes differentially affects memory and behavior
Cellular disturbances in the inhibitory and excitatory balance of brain circuits have been implicated in various neurodege...
Robust differences in cortical cell type proportions across healthy human aging inferred through cross-dataset transcriptome analyses
Brain aging refers to the changes in cognitive, sensory, and motor function experienced along the natural lifespan. These ...
Age-related Differences in the Social Associative Learning of Trust Information
Available online 1 February 2023Author links open overlay panel, , , , Highlights•Older adults learn to trust differently ...
Retinal Photoreceptor Layer Thickness has Disease Specificity and Distinguishes Predicted FTLD-Tau from Biomarker Determined Alzheimer's Disease
FTLD-Tau is a neuropathologic diagnosis for patients with frontal temporal lobar degeneration from a tauopathy. These pati...
Age-dependent dysregulation of locus coeruleus firing in a transgenic rat model of Alzheimer's disease
Accumulation of hyperphosphorylated tau within subcortical nuclei and subsequent dysfunction of these neurons is a nearly ...
Cognitive Reserve Moderates the Association Between Cerebral Blood Flow and Language Performance in Older Adults with Mild Cognitive Impairment
Higher cognitive reserve (CR) may offer protection from cognitive changes associated with reduced cerebral blood flow (CBF...
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