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Increased neural differentiation after a single session of aerobic exercise in older adults
Increased neural differentiation after a single session of aerobic exercise in older adults
The decline of cognitive and neural systems in older adults is a major risk factor for neurodegenerative diseases such as ...
The many faces of resilience
The many faces of resilience
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Toward a cosmopolitan appreciation of “resilience” in the world of aging research
Toward a cosmopolitan appreciation of “resilience” in the world of aging research
Y. Stern et al.A framework for concepts of reserve and resilience in agingNeurobiol Aging(2023)Y. Stern et al.Brain reserv...
Adapting the reserve and resilience framework for motor and other aging phenotypes
Adapting the reserve and resilience framework for motor and other aging phenotypes
Volume 131, November 2023, Pages 224-225Author links open overlay panel, References (33)A.S. Buchman et al.Different Combi...
Commentary on "A framework for concepts of reserve and resilience in aging"
Commentary on "A framework for concepts of reserve and resilience in aging"
Volume 131, November 2023, Pages 226-227Author links open overlay panelM. Natasha RajahShow moreReferences (15)There are m...
Comments on framework: The need to include socio-economic status.
Comments on framework: The need to include socio-economic status.
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A way to the future
A way to the future
We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of c...
Comorbid amyloid with cerebrovascular disease in domain-specific cognitive and neuropsychiatric disturbances: a cross-sectional memory clinic study
Comorbid amyloid with cerebrovascular disease in domain-specific cognitive and neuropsychiatric disturbances: a cross-sectional memory clinic study
Central to the pathogenesis of Alzheimer’s disease (AD) is the accumulation of cerebral beta-amyloid (Aβ), which has shown...
White matter hyperintensity load mediates the relationship between age and cognition
White matter hyperintensity load mediates the relationship between age and cognition
KeywordsWhite matter hyperintensitiesCognitionAgingSmall vessel diseaseData availabilityThe data that support the findings...
Gamma connectivity predicts response to intermittent theta burst stimulation in Alzheimer’s disease: a randomized controlled trial
Gamma connectivity predicts response to intermittent theta burst stimulation in Alzheimer’s disease: a randomized controlled trial
Alzheimer’s disease is a neurodegenerative cognitive disorder and the most common form of dementia. According to the World...
Multimodal imaging of microstructural cerebral alterations and loss of synaptic density in Alzheimer’s disease
Multimodal imaging of microstructural cerebral alterations and loss of synaptic density in Alzheimer’s disease
Concomitantly with an increase in average life expectancy, a major epidemiologic trend of the current century is the rise ...
Topological changes of fast large-scale brain dynamics in mild cognitive impairment predict early memory impairment: a resting-state, source reconstructed, magnetoencephalography study
Topological changes of fast large-scale brain dynamics in mild cognitive impairment predict early memory impairment: a resting-state, source reconstructed, magnetoencephalography study
AbbreviationsAALAutomatic Anatomical LabellingaMCIamnestic Mild Cognitive ImpairmentATMAvalanche Transition MatrixBDIBeck ...
White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer’s disease continuum
White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer’s disease continuum
Alzheimer’s disease (AD) is a multiplex condition characterized by neurotoxic amyloid and tau accumulation, neurodegenerat...
angptl4 gene expression as a marker of adaptive homeostatic response to social isolation across the lifespan in zebrafish
angptl4 gene expression as a marker of adaptive homeostatic response to social isolation across the lifespan in zebrafish
Volume 131, November 2023, Pages 209-221Author links open overlay panel, , , , , AbstractSocial isolation has detrimental ...
Grey matter volume and CSF biomarkers predict neuropsychological subtypes of MCI
Grey matter volume and CSF biomarkers predict neuropsychological subtypes of MCI
Mild cognitive impairment (MCI) is considered a transitional stage between normal aging and Alzheimer’s disease (AD). Ther...
An Alzheimer’s disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons
An Alzheimer’s disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons
A missense variant in the tetratricopeptide repeat domain 3 (TTC3) gene (rs377155188, p.S1038C, NM_003316.4:c 0.3113C>G...
A cognitive marker for Alzheimer disease pathology in primary progressive aphasia? A validation study in the clinical setting
A cognitive marker for Alzheimer disease pathology in primary progressive aphasia? A validation study in the clinical setting
Progressive nonfluent aphasia (PNFA), semantic dementia (SD), and logopenic variant PPA (lvPPA) (Gorno-Tempini et al., 201...
Biomarkers of Alzheimer’s disease in Black and/or African American Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants
Biomarkers of Alzheimer’s disease in Black and/or African American Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants
An overwhelming number of participants in studies of dementia identify as non-Hispanic White yet older Black adults (inclu...
Age differences in the neural correlates of recollection: transient versus sustained fMRI effects
Age differences in the neural correlates of recollection: transient versus sustained fMRI effects
Compared with young adults, older adults typically demonstrate reduced episodic memory performance, that is, a decline in ...
Moderating role of physical activity on hippocampal iron deposition and memory outcomes in typically aging older adults
Moderating role of physical activity on hippocampal iron deposition and memory outcomes in typically aging older adults
AbbreviationsCVLT-IICalifornia Verbal Learning Test, second editionDWIdiffusion weighted imagingMRIMagnetic resonance imag...
Characterising the covariance pattern between lifestyle factors and structural brain measures: a multivariable replication study of two independent ageing cohorts
Characterising the covariance pattern between lifestyle factors and structural brain measures: a multivariable replication study of two independent ageing cohorts
Modifiable lifestyle factors have been shown to promote healthy brain ageing. However, studies have typically focused on a...
Age differences in the neural processing of semantics, within and beyond the core semantic network
Age differences in the neural processing of semantics, within and beyond the core semantic network
Volume 131, November 2023, Pages 88-105Author links open overlay panel, Highlights•Right inferior frontal gyrus contribute...
Modifiable risk factors for dementia, cognition, and plasma phosphorylated tau 181 in a large-scale cohort of Australian older adults
Modifiable risk factors for dementia, cognition, and plasma phosphorylated tau 181 in a large-scale cohort of Australian older adults
Volume 131, November 2023, Pages 106-114Author links open overlay panel, , , , , , AbstractAlzheimer’s disease (AD), the m...
Age-related deficits in retinal autophagy following intraocular pressure elevation in autophagy reporter mouse model
Age-related deficits in retinal autophagy following intraocular pressure elevation in autophagy reporter mouse model
Glaucoma is a multifactorial optic neuropathy characterized by progressive retinal ganglion cell (RGC) degeneration (Quigl...
Clinical and neurochemical correlates of the APOE genotype in early-stage Parkinson’s disease
Clinical and neurochemical correlates of the APOE genotype in early-stage Parkinson’s disease
Volume 131, November 2023, Pages 24-28Author links open overlay panel, , , , , , , , , , , AbstractEmerging evidence indic...
Mediterranean diet is associated with lower white matter lesion volume in Mediterranean cities and lower cerebrospinal fluid Aβ42 in non-Mediterranean cities in the EPAD LCS cohort
Mediterranean diet is associated with lower white matter lesion volume in Mediterranean cities and lower cerebrospinal fluid Aβ42 in non-Mediterranean cities in the EPAD LCS cohort
The data sets analyzed for this study can be found via the EPAD website (ep-ad.org/open-access-data/overview), the data se...
Biologic that disrupts PDE11A4 homodimerization in hippocampus CA1 reverses age-related cognitive decline of social memories in mice
Biologic that disrupts PDE11A4 homodimerization in hippocampus CA1 reverses age-related cognitive decline of social memories in mice
Decreases in 3′,5′-cyclic nucleotide signaling in the aged and demented hippocampus contribute to cognitive decline (Bonka...
Extracellular matrix proteoglycans support aged hippocampus networks: a potential cellular-level mechanism of brain reserve
Extracellular matrix proteoglycans support aged hippocampus networks: a potential cellular-level mechanism of brain reserve
One often held misconception of brain aging is that neurodegenerative disease is inevitable; however, only 10%–14% of indi...
Inverse correlation between Alzheimer’s disease and cancer from the perspective of hypoxia
Inverse correlation between Alzheimer’s disease and cancer from the perspective of hypoxia
AbbreviationsANLSastroglia-neuron lactate shuttleAPPamyloid precursor proteinBDNFbrain-derived neurotrophic factorCAFscanc...
Dissociating effects of aging and genetic risk of sporadic Alzheimer’s disease on path integration
Spatial navigation in humans is a complex cognitive ability that allows individuals to orientate in space. Navigation is v...
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