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A meta-analysis and systematic review based on perioperative management of elderly patients: is ciprofol an alternative to propofol?
A meta-analysis and systematic review based on perioperative management of elderly patients: is ciprofol an alternative to propofol?
With the rising number of elderly surgical patients, selecting an appropriate anesthetic tailored to their specific needs ...
Risk prediction models for adverse drug reactions and adverse drug events in older adults—a systematic review and meta-analysis
Risk prediction models for adverse drug reactions and adverse drug events in older adults—a systematic review and meta-analysis
Adverse drug reactions (ADRs) are common and result in significant morbidity, mortality, and associated hospital costs. Mo...
Effectiveness of macrolides as add-on therapy to beta-lactams in community-acquired pneumonia: A meta-analysis of randomized controlled trials
Effectiveness of macrolides as add-on therapy to beta-lactams in community-acquired pneumonia: A meta-analysis of randomized controlled trials
This study aims to evaluate whether adding macrolides (MAC) to beta-lactam (BL) monotherapy in the treatment of community-...
Racial/ethnic differences in survival and treatment response with PD-1/PD-L1 inhibitors in resectable non-small cell lung cancer: a meta-analysis of randomized controlled trials
Racial/ethnic differences in survival and treatment response with PD-1/PD-L1 inhibitors in resectable non-small cell lung cancer: a meta-analysis of randomized controlled trials
The optimal treatment for resectable Non-Small Cell Lung Cancer (NSCLC) remains under investigation, particularly about it...
Towards streamlined product information: reporting of transporter-mediated drug interactions
Towards streamlined product information: reporting of transporter-mediated drug interactions
The purpose of this study is to investigate the reporting of risks associated with transporter-mediated drug-drug interact...
Sodium-glucose cotransporter 2 inhibitors and renal cancer in the US FDA adverse event reporting system
Sodium-glucose cotransporter 2 inhibitors and renal cancer in the US FDA adverse event reporting system
Recent evidence suggests an association between sodium-glucose cotransporter 2 (SGLT2) inhibitors and a higher risk of ren...
Preventive effects of first-generation antihistamine on emergence agitation or delirium: a systematic review
Preventive effects of first-generation antihistamine on emergence agitation or delirium: a systematic review
The effects of first-generation antihistamines in preventing postoperative emergence agitation or delirium are unclear. De...
Evaluation of the predictive performance of an online voriconazole dose calculator in children
Evaluation of the predictive performance of an online voriconazole dose calculator in children
The dosing of voriconazole is challenging in pediatrics. One approach to improve the dosing is through the use of Bayesian...
Efficacy and safety of ticagrelor monotherapy following a brief DAPT vs. prolonged 12-month DAPT in ACS patients post-PCI: a meta-analysis of RCTs
Efficacy and safety of ticagrelor monotherapy following a brief DAPT vs. prolonged 12-month DAPT in ACS patients post-PCI: a meta-analysis of RCTs
As per current guidelines, acute coronary syndrome (ACS) patients who undergo percutaneous coronary intervention (PCI) sho...
Olaparib-associated toxicity in cancer patients: a systematic review and meta-analysis
Olaparib-associated toxicity in cancer patients: a systematic review and meta-analysis
To investigate the characteristics of olaparib-associated adverse events (AEs) in cancer patients. Databases were searched...
Effects of olanzapine in the improvement of body weight and appetite in patients with cancer or receiving chemotherapy: a systematic review and meta-analysis
Effects of olanzapine in the improvement of body weight and appetite in patients with cancer or receiving chemotherapy: a systematic review and meta-analysis
We aimed to assess the effects of olanzapine in the improvement of body weight and appetite in patients with cancer or rec...
Use of dipyrone during pregnancy and risk of congenital anomalies: a systematic review
Use of dipyrone during pregnancy and risk of congenital anomalies: a systematic review
This study aimed to summarize the evidence on the teratogenic effects of dipyrone used during pregnancy. Databases (MEDLIN...
A critical review on approaches to generate and validate virtual population for physiologically based pharmacokinetic models: Methodologies, case studies and way forward
A critical review on approaches to generate and validate virtual population for physiologically based pharmacokinetic models: Methodologies, case studies and way forward
In silico modeling and simulation techniques such as physiologically based pharmacokinetic (PBPK) and physiologically base...
Comment on “Use of statins and risks of ovarian, uterine, and cervical diseases: a cohort study in the UK Biobank”
Comment on “Use of statins and risks of ovarian, uterine, and cervical diseases: a cohort study in the UK Biobank”
Cite this articleChung, PY., Liao, KF. & Lai, SW. Comment on “Use of statins and risks of ovarian, uterine, and cervic...
The impact of age and renal function on the pharmacokinetics and protein binding characteristics of fludarabine in paediatric and adult patients undergoing allogeneic haematopoietic stem cell transplantation conditioning
The impact of age and renal function on the pharmacokinetics and protein binding characteristics of fludarabine in paediatric and adult patients undergoing allogeneic haematopoietic stem cell transplantation conditioning
To evaluate the population pharmacokinetics of unbound F-Ara-A (the circulating metabolite of fludarabine) in 211 patients...
Pharmacokinetics-pharmacodynamics of first-line antitubercular drugs: a comparative study in tuberculosis patients with and without concomitant diabetes mellitus
Pharmacokinetics-pharmacodynamics of first-line antitubercular drugs: a comparative study in tuberculosis patients with and without concomitant diabetes mellitus
To observe the variability in the plasma concentrations and pharmacokinetic-pharmacodynamic (PK-PD) profiles of first-line...
Efficacy of cannabis-based medicine in the treatment of Tourette syndrome: a systematic review and meta-analysis
Efficacy of cannabis-based medicine in the treatment of Tourette syndrome: a systematic review and meta-analysis
Tourette syndrome (TS) is a neurodevelopmental disorder characterized by motor and phonic tics. It is a condition that aff...
Efficacy and safety of different pharmacological interventions in the treatment of tardive dyskinesia: a systematic review and network meta-analysis
Efficacy and safety of different pharmacological interventions in the treatment of tardive dyskinesia: a systematic review and network meta-analysis
The aim of this study is to indirectly compare and rank the different drugs that have been studied in randomized clinical ...
Dose reduction and discontinuation due to the combination of CDK4/6 inhibitors and endocrine drugs: a systematic review and meta-analysis
Dose reduction and discontinuation due to the combination of CDK4/6 inhibitors and endocrine drugs: a systematic review and meta-analysis
With the widespread use of CDK4/6 inhibitors, the number of discontinuations and reductions due to adverse events is incre...
Consumers’ knowledge and experiences of adverse drug reaction reporting in Australia: a national survey
Consumers’ knowledge and experiences of adverse drug reaction reporting in Australia: a national survey
This study aimed to investigate the current knowledge and experiences of consumers in Australia on adverse drug reaction (...
Correction to: Immune‑related serious adverse events with immune checkpoint inhibitors: systematic review and network meta‑analysis
Correction to: Immune‑related serious adverse events with immune checkpoint inhibitors: systematic review and network meta‑analysis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Impact of CYP2D6*2, CYP2D6*35, rs5758550, and related haplotypes on risperidone clearance in vivo
Impact of CYP2D6*2, CYP2D6*35, rs5758550, and related haplotypes on risperidone clearance in vivo
The CYP2D6 gene exhibits significant polymorphism, contributing to variability in responses to drugs metabolized by CYP2D6...
Time-course and dose-effect of omalizumab in treating chronic idiopathic urticaria/chronic spontaneous urticaria
Time-course and dose-effect of omalizumab in treating chronic idiopathic urticaria/chronic spontaneous urticaria
Several studies have shown that subcutaneous injections of omalizumab can treat chronic idiopathic/spontaneous urticaria (...
Real-world safety and effectiveness of pirfenidone and nintedanib in the treatment of idiopathic pulmonary fibrosis: a systematic review and meta-analysis
Real-world safety and effectiveness of pirfenidone and nintedanib in the treatment of idiopathic pulmonary fibrosis: a systematic review and meta-analysis
Multiple randomized controlled studies have shown that pirfenidone and nintedanib are effective and safe for treating idio...
Effects of active vitamin D analogs and calcimimetic agents on PTH and bone mineral biomarkers in hemodialysis patients with SHPT: a network meta-analysis
Effects of active vitamin D analogs and calcimimetic agents on PTH and bone mineral biomarkers in hemodialysis patients with SHPT: a network meta-analysis
Active vitamin D analogs and calcimimetic agents are primary drugs for patients with secondary hyperparathyroidism. Due to...
The cost-effectiveness analysis of semaglutide for the treatment of adult and adolescent patients with overweight and obesity: a systematic review
The cost-effectiveness analysis of semaglutide for the treatment of adult and adolescent patients with overweight and obesity: a systematic review
The present study aimed to systematically collect and synthesize available cost-effectiveness studies of semaglutide in pa...
Efficacy of tacrolimus versus cyclosporine after lung transplantation: an updated systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials
Efficacy of tacrolimus versus cyclosporine after lung transplantation: an updated systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials
Little data supports using tacrolimus versus cyclosporin for immunosuppression concerning acute rejection and bronchioliti...
Voriconazole therapeutic drug monitoring including analysis of CYP2C19 phenotype in immunocompromised pediatric patients with invasive fungal infections
Voriconazole therapeutic drug monitoring including analysis of CYP2C19 phenotype in immunocompromised pediatric patients with invasive fungal infections
Therapeutic drug monitoring (TDM) of voriconazole (VCZ) should be mandatory for all pediatric patients with invasive funga...
Therapeutic drug monitoring in tuberculosis
Therapeutic drug monitoring in tuberculosis
Therapeutic drug monitoring (TDM) is a standard clinical procedure that uses the pharmacokinetic and pharmacodynamic param...
Fixed parameters in the population pharmacokinetic modeling of valproic acid might not be suitable: external validation in Chinese adults with epilepsy or after neurosurgery
Fixed parameters in the population pharmacokinetic modeling of valproic acid might not be suitable: external validation in Chinese adults with epilepsy or after neurosurgery
This study aims to assess the predictive performance of published valproic acid (VPA) population pharmacokinetic (PPK) mod...
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