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Translatability scoring in prospective and retrospective COVID drug development cases
Translatability scoring in prospective and retrospective COVID drug development cases
The ongoing pandemic of severe acute respiratory syndrome coronavirus 2 has led to an enormous surge of clinical research....
A clinical pharmacokinetic drug-drug interaction study between dextromethorphan and emvododstat, a potent anti-SARS-CoV-2 dihydroorotate dehydrogenase inhibitor
A clinical pharmacokinetic drug-drug interaction study between dextromethorphan and emvododstat, a potent anti-SARS-CoV-2 dihydroorotate dehydrogenase inhibitor
A therapeutic agent that targets both viral replication and the hyper-reactive immune response would offer a highly desira...
Avoiding incompatible drug pairs in central-venous catheters of patients receiving critical care: an algorithm-based analysis and a staff survey
Avoiding incompatible drug pairs in central-venous catheters of patients receiving critical care: an algorithm-based analysis and a staff survey
In a critical care setting, we aimed to identify and solve physico-chemical drug incompatibilities in central-venous cathe...
External validation of population pharmacokinetic models of vancomycin in postoperative neurosurgical patients
External validation of population pharmacokinetic models of vancomycin in postoperative neurosurgical patients
Vancomycin is commonly used in the prevention and treatment of intracranial infections in postoperative neurosurgical pati...
Population pharmacokinetic analyses of tacrolimus in non-transplant patients: a systematic review
Population pharmacokinetic analyses of tacrolimus in non-transplant patients: a systematic review
Tacrolimus (TAC) has been increasingly used in patients with non-transplant settings. Because of its large between-subject...
Nitrofurantoin for the treatment of uncomplicated urinary tract infection in female patients: the impact of dosing regimen, age, and renal function on drug exposure
Nitrofurantoin for the treatment of uncomplicated urinary tract infection in female patients: the impact of dosing regimen, age, and renal function on drug exposure
The aim of this study is to determine nitrofurantoin exposure in female patients with different age and renal function wit...
Failure to predict amikacin elimination in critically ill patients with cancer based on the estimated glomerular filtration rate: applying PBPK approach in a therapeutic drug monitoring study
Failure to predict amikacin elimination in critically ill patients with cancer based on the estimated glomerular filtration rate: applying PBPK approach in a therapeutic drug monitoring study
The aim of this work was to integrate the Therapeutic Drug Monitoring (TDM) with the model-informed precision dosing (MIPD...
Imprecision in vaccine adverse event reporting and a methodological analysis of reporting systems to improve pharmacovigilance and public health
Imprecision in vaccine adverse event reporting and a methodological analysis of reporting systems to improve pharmacovigilance and public health
This study documents imprecision in Japanese reports of adverse events following immunization (AEFI). In doing so, it pres...
Seronegative acute encephalitis following COVID-19 vaccines: a case series of an overlooked diagnosis with literature review
Seronegative acute encephalitis following COVID-19 vaccines: a case series of an overlooked diagnosis with literature review
Autoimmune encephalitis is a neurological emergency of new-onset altered mental status, caused by an exaggerated immune-me...
Correction to: Potentially inappropriate medications and cognitive performance: cross‑sectional results from the ELSA–Brasil study
Correction to: Potentially inappropriate medications and cognitive performance: cross‑sectional results from the ELSA–Brasil study
Deparment of Internal Medicine, University of Sao Paulo Medical School, São Paulo, BrazilAdriana Nancy Medeiros dos Santos...
Remdesivir treatment and clinical outcome in non-severe hospitalized COVID-19 patients: a propensity score matching multicenter Italian hospital experience
Remdesivir treatment and clinical outcome in non-severe hospitalized COVID-19 patients: a propensity score matching multicenter Italian hospital experience
Remdesivir exerts positive effects on clinical improvement, even though it seems not to affect mortality among CO...
Alogliptin: a DPP-4 inhibitor modulating adipose tissue insulin resistance and atherogenic lipid
Alogliptin: a DPP-4 inhibitor modulating adipose tissue insulin resistance and atherogenic lipid
The purpose of this study is to investigate the regulation of adipose tissue insulin resistance with DPP-4 inhibitors in t...
Safety of SGLT2 inhibitors in patients with different glomerular diseases treated with immunosuppressive therapies
Safety of SGLT2 inhibitors in patients with different glomerular diseases treated with immunosuppressive therapies
Despite the known effects of sodium-glucose-cotransporter 2 (SGLT2) inhibitors in halting chronic kidney disease (CKD) pro...
Lenvatinib in the treatment of unresectable hepatocellular carcinoma: a systematic review of economic evaluations
Lenvatinib in the treatment of unresectable hepatocellular carcinoma: a systematic review of economic evaluations
This aim of this study was to conduct a systematic review of economic evaluations comparing lenvatinib to other vascular e...
Potentially inappropriate medications and cognitive performance: cross-sectional results from the ELSA–Brasil study
Potentially inappropriate medications and cognitive performance: cross-sectional results from the ELSA–Brasil study
Potentially inappropriate medications (PIM), especially those with potential effects on the central nervous system, can in...
Prevalence and bleeding risk associated with the concomitant use of direct oral anticoagulants and antiarrhythmic drugs in patients with atrial fibrillation, based on the French healthcare insurance database
Prevalence and bleeding risk associated with the concomitant use of direct oral anticoagulants and antiarrhythmic drugs in patients with atrial fibrillation, based on the French healthcare insurance database
Pharmacokinetic interactions exist between apixaban or rivaroxaban, and CYP3A4 and P-glycoprotein inhibitors such as amiod...
Linezolid-associated serotonin toxicity: a systematic review
Linezolid-associated serotonin toxicity: a systematic review
This systematic review aims to evaluate the existing evidence associating linezolid to serotonin toxicity when used as mon...
A collaborative study of the impact of N-nitrosamines presence and ARB recall on ARB utilization – results from IQVIA™ Disease Analyzer Germany
A collaborative study of the impact of N-nitrosamines presence and ARB recall on ARB utilization – results from IQVIA™ Disease Analyzer Germany
Regulators are increasingly concerned with  the impact of recalls on drug adherence. In 2018, N-nitrosam...
Effects of sodium-glucose cotransporter 2 inhibitors on renal risk factors in patients with abnormal glucose metabolism: a meta-analysis of randomized controlled trials
Effects of sodium-glucose cotransporter 2 inhibitors on renal risk factors in patients with abnormal glucose metabolism: a meta-analysis of randomized controlled trials
Several trials have assessed the antihyperglycemic effects of sodium-glucose cotransporter 2 inhibitors (SGLT2Is) in patie...
Dapagliflozin reduces risk of heart failure rehospitalization in diabetic acute myocardial infarction patients: a propensity score-matched analysis
Dapagliflozin reduces risk of heart failure rehospitalization in diabetic acute myocardial infarction patients: a propensity score-matched analysis
The aim of this study was to investigate the effect of dapagliflozin (DAPA) on the rate of heart failure rehospitalization...
The pharmacokinetics and safety of lidocaine in liver cancer patients undergoing hepatic resection
The pharmacokinetics and safety of lidocaine in liver cancer patients undergoing hepatic resection
The purpose of this study was to explore the pharmacokinetics (PK) characteristics and safety of continuous lidocaine infu...
The role of time interval elimination on pain control of preterm infants by sucrose administration
The role of time interval elimination on pain control of preterm infants by sucrose administration
The 2-min time interval of sucrose administration given before minor painful procedures in preterm infants is based on a f...
Drug repositioning in the COVID-19 pandemic: fundamentals, synthetic routes, and overview of clinical studies
Drug repositioning in the COVID-19 pandemic: fundamentals, synthetic routes, and overview of clinical studies
Drug repositioning is a strategy to identify a new therapeutic indication for molecules that have been approved for other ...
Could carbamazepine-acetazolamide interaction lead to a severe hepatocellular liver injury? an interaction that needs to be uncovered
Could carbamazepine-acetazolamide interaction lead to a severe hepatocellular liver injury? an interaction that needs to be uncovered
Patsalos PN, Zugman M, Lake C, James A, Ratnaraj N, Sander JW (2017) Serum protein binding of 25 antiepileptic drugs in a ...
Drug information sources in professional work—a questionnaire study on physicians’ usage and preferences (the drug information study)
Drug information sources in professional work—a questionnaire study on physicians’ usage and preferences (the drug information study)
This study aimed to explore physicians’ use of drug information in professional work, with special focus on those wo...
Results from a first-in-human study of dersimelagon, an investigational oral selective MC1R agonist
Results from a first-in-human study of dersimelagon, an investigational oral selective MC1R agonist
To describe outcomes from the first-in-human study of dersimelagon, an investigational oral selective MC1R agonist, under ...
A cocktail probe approach to evaluate the effect of hormones on the expression and activity of CYP enzymes in human hepatocytes with conditions simulating late stage of pregnancy
A cocktail probe approach to evaluate the effect of hormones on the expression and activity of CYP enzymes in human hepatocytes with conditions simulating late stage of pregnancy
Pregnancy-mediated physiological and biochemical changes contribute to alterations in the pharmacokinetics of certain drug...
Population plasma and urine pharmacokinetics and the probability of target attainment of fosfomycin in healthy male volunteers
Population plasma and urine pharmacokinetics and the probability of target attainment of fosfomycin in healthy male volunteers
A population pharmacokinetic model of fosfomycin was developed in healthy volunteers after intravenous administration, and...
Risk factors for acute kidney injury after high-dose methotrexate therapy: a single-center study and narrative review
Risk factors for acute kidney injury after high-dose methotrexate therapy: a single-center study and narrative review
To assess the risk factors associated with high-dose methotrexate (HDMTX) (≥ 1 g/m2) treatment-induce...
Analysis of clinical characteristics and automatic monitoring of drug-induced arrhythmias in 167,546 inpatients
Analysis of clinical characteristics and automatic monitoring of drug-induced arrhythmias in 167,546 inpatients
The purpose of this study was to analyze the occurrence characteristics, clinical manifestations, medication distribution,...
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