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A Study Of the effect of Sex on drug dosing, concentrations, and pharmacogenomics in the Montreal Heart Institute Hospital Cohort (SOS-PGx): methodology and research progress
A Study Of the effect of Sex on drug dosing, concentrations, and pharmacogenomics in the Montreal Heart Institute Hospital Cohort (SOS-PGx): methodology and research progress
Women are underrepresented in drug development trials and there is no sex-tailored drug regimen for most medications. It h...
The quantity, reliability, transparency, reporting, and interpretation of pharmacovigilance signal detection studies in pregnancy: a meta-epidemiological study
The quantity, reliability, transparency, reporting, and interpretation of pharmacovigilance signal detection studies in pregnancy: a meta-epidemiological study
To systematically review the characteristics of the available pharmacovigilance signal detection studies in pregnancy, and...
Is nivolumab alone or in combination with ipilimumab more effective for treating lung cancer? a meta-analysis
Is nivolumab alone or in combination with ipilimumab more effective for treating lung cancer? a meta-analysis
Nivolumab and ipilimumab combination immunotherapy has become a standard treatment option for certain cancers. However, th...
Identification of the most cost-saving disease-modifying therapies and factors affecting the budget in the pharmacotherapy of multiple sclerosis: a systematic review
Identification of the most cost-saving disease-modifying therapies and factors affecting the budget in the pharmacotherapy of multiple sclerosis: a systematic review
Multiple sclerosis (MS) is an immune-mediated disease that has a considerable health-related quality of life interference....
Effects of drugs on the oxygen dissociation curve—a scoping review
Effects of drugs on the oxygen dissociation curve—a scoping review
The shape and position of the hemoglobin-oxygen dissociation curve (ODC) is of critical importance in medicine, as it dete...
Inpatient referrals to a specialist falls and syncope service: prevalence of STOPPFall FRIDs and review of deprescribing patterns
Inpatient referrals to a specialist falls and syncope service: prevalence of STOPPFall FRIDs and review of deprescribing patterns
Falls are the commonest cause of accidental death in older people and the most frequent reason for their presentation to h...
Evaluating the safety and effectiveness of tolvaptan in patients with heart failure and renal impairment: a systematic review and meta-analysis
Evaluating the safety and effectiveness of tolvaptan in patients with heart failure and renal impairment: a systematic review and meta-analysis
Patients with heart failure and concomitant renal impairment are often prescribed loop diuretics, such as furosemide, as t...
Association between sodium-glucose cotransporter-2 inhibitor and adverse events in patients with moderate to severe chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials
Association between sodium-glucose cotransporter-2 inhibitor and adverse events in patients with moderate to severe chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials
Although there is concern about the association of sodium-glucose cotransporter-2 inhibitor (SGLT2i) use with musculoskele...
Treatment appropriateness of direct oral anticoagulants in patients with atrial fibrillation for stroke prevention: A real-world prospective study
Treatment appropriateness of direct oral anticoagulants in patients with atrial fibrillation for stroke prevention: A real-world prospective study
Inappropriate use of direct oral anticoagulants (DOACs) is common, affecting up to 30% of atrial fibrillation (AF) populat...
A meta-analysis and systematic review based on perioperative management of elderly patients: is ciprofol an alternative to propofol?
A meta-analysis and systematic review based on perioperative management of elderly patients: is ciprofol an alternative to propofol?
With the rising number of elderly surgical patients, selecting an appropriate anesthetic tailored to their specific needs ...
Risk prediction models for adverse drug reactions and adverse drug events in older adults—a systematic review and meta-analysis
Risk prediction models for adverse drug reactions and adverse drug events in older adults—a systematic review and meta-analysis
Adverse drug reactions (ADRs) are common and result in significant morbidity, mortality, and associated hospital costs. Mo...
Effectiveness of macrolides as add-on therapy to beta-lactams in community-acquired pneumonia: A meta-analysis of randomized controlled trials
Effectiveness of macrolides as add-on therapy to beta-lactams in community-acquired pneumonia: A meta-analysis of randomized controlled trials
This study aims to evaluate whether adding macrolides (MAC) to beta-lactam (BL) monotherapy in the treatment of community-...
Racial/ethnic differences in survival and treatment response with PD-1/PD-L1 inhibitors in resectable non-small cell lung cancer: a meta-analysis of randomized controlled trials
Racial/ethnic differences in survival and treatment response with PD-1/PD-L1 inhibitors in resectable non-small cell lung cancer: a meta-analysis of randomized controlled trials
The optimal treatment for resectable Non-Small Cell Lung Cancer (NSCLC) remains under investigation, particularly about it...
Towards streamlined product information: reporting of transporter-mediated drug interactions
Towards streamlined product information: reporting of transporter-mediated drug interactions
The purpose of this study is to investigate the reporting of risks associated with transporter-mediated drug-drug interact...
Sodium-glucose cotransporter 2 inhibitors and renal cancer in the US FDA adverse event reporting system
Sodium-glucose cotransporter 2 inhibitors and renal cancer in the US FDA adverse event reporting system
Recent evidence suggests an association between sodium-glucose cotransporter 2 (SGLT2) inhibitors and a higher risk of ren...
Preventive effects of first-generation antihistamine on emergence agitation or delirium: a systematic review
Preventive effects of first-generation antihistamine on emergence agitation or delirium: a systematic review
The effects of first-generation antihistamines in preventing postoperative emergence agitation or delirium are unclear. De...
Evaluation of the predictive performance of an online voriconazole dose calculator in children
Evaluation of the predictive performance of an online voriconazole dose calculator in children
The dosing of voriconazole is challenging in pediatrics. One approach to improve the dosing is through the use of Bayesian...
Efficacy and safety of ticagrelor monotherapy following a brief DAPT vs. prolonged 12-month DAPT in ACS patients post-PCI: a meta-analysis of RCTs
Efficacy and safety of ticagrelor monotherapy following a brief DAPT vs. prolonged 12-month DAPT in ACS patients post-PCI: a meta-analysis of RCTs
As per current guidelines, acute coronary syndrome (ACS) patients who undergo percutaneous coronary intervention (PCI) sho...
Olaparib-associated toxicity in cancer patients: a systematic review and meta-analysis
Olaparib-associated toxicity in cancer patients: a systematic review and meta-analysis
To investigate the characteristics of olaparib-associated adverse events (AEs) in cancer patients. Databases were searched...
Effects of olanzapine in the improvement of body weight and appetite in patients with cancer or receiving chemotherapy: a systematic review and meta-analysis
Effects of olanzapine in the improvement of body weight and appetite in patients with cancer or receiving chemotherapy: a systematic review and meta-analysis
We aimed to assess the effects of olanzapine in the improvement of body weight and appetite in patients with cancer or rec...
Use of dipyrone during pregnancy and risk of congenital anomalies: a systematic review
Use of dipyrone during pregnancy and risk of congenital anomalies: a systematic review
This study aimed to summarize the evidence on the teratogenic effects of dipyrone used during pregnancy. Databases (MEDLIN...
A critical review on approaches to generate and validate virtual population for physiologically based pharmacokinetic models: Methodologies, case studies and way forward
A critical review on approaches to generate and validate virtual population for physiologically based pharmacokinetic models: Methodologies, case studies and way forward
In silico modeling and simulation techniques such as physiologically based pharmacokinetic (PBPK) and physiologically base...
Comment on “Use of statins and risks of ovarian, uterine, and cervical diseases: a cohort study in the UK Biobank”
Comment on “Use of statins and risks of ovarian, uterine, and cervical diseases: a cohort study in the UK Biobank”
Cite this articleChung, PY., Liao, KF. & Lai, SW. Comment on “Use of statins and risks of ovarian, uterine, and cervic...
The impact of age and renal function on the pharmacokinetics and protein binding characteristics of fludarabine in paediatric and adult patients undergoing allogeneic haematopoietic stem cell transplantation conditioning
The impact of age and renal function on the pharmacokinetics and protein binding characteristics of fludarabine in paediatric and adult patients undergoing allogeneic haematopoietic stem cell transplantation conditioning
To evaluate the population pharmacokinetics of unbound F-Ara-A (the circulating metabolite of fludarabine) in 211 patients...
Pharmacokinetics-pharmacodynamics of first-line antitubercular drugs: a comparative study in tuberculosis patients with and without concomitant diabetes mellitus
Pharmacokinetics-pharmacodynamics of first-line antitubercular drugs: a comparative study in tuberculosis patients with and without concomitant diabetes mellitus
To observe the variability in the plasma concentrations and pharmacokinetic-pharmacodynamic (PK-PD) profiles of first-line...
Efficacy of cannabis-based medicine in the treatment of Tourette syndrome: a systematic review and meta-analysis
Efficacy of cannabis-based medicine in the treatment of Tourette syndrome: a systematic review and meta-analysis
Tourette syndrome (TS) is a neurodevelopmental disorder characterized by motor and phonic tics. It is a condition that aff...
Efficacy and safety of different pharmacological interventions in the treatment of tardive dyskinesia: a systematic review and network meta-analysis
Efficacy and safety of different pharmacological interventions in the treatment of tardive dyskinesia: a systematic review and network meta-analysis
The aim of this study is to indirectly compare and rank the different drugs that have been studied in randomized clinical ...
Dose reduction and discontinuation due to the combination of CDK4/6 inhibitors and endocrine drugs: a systematic review and meta-analysis
Dose reduction and discontinuation due to the combination of CDK4/6 inhibitors and endocrine drugs: a systematic review and meta-analysis
With the widespread use of CDK4/6 inhibitors, the number of discontinuations and reductions due to adverse events is incre...
Consumers’ knowledge and experiences of adverse drug reaction reporting in Australia: a national survey
Consumers’ knowledge and experiences of adverse drug reaction reporting in Australia: a national survey
This study aimed to investigate the current knowledge and experiences of consumers in Australia on adverse drug reaction (...
Correction to: Immune‑related serious adverse events with immune checkpoint inhibitors: systematic review and network meta‑analysis
Correction to: Immune‑related serious adverse events with immune checkpoint inhibitors: systematic review and network meta‑analysis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
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