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Prenatal Ruxolitinib Treatment Improved Muscle Strength but Showed No Impact on the Neurobehavioral and Electrophysiological Traits in Adult Mice
Prenatal Ruxolitinib Treatment Improved Muscle Strength but Showed No Impact on the Neurobehavioral and Electrophysiological Traits in Adult Mice
The JAK/STAT signalling pathway is essential for cell communication and gene expression, particularly in brain development...
Noscapine Down-Regulates LPS-Induced Neuroinflammation in BV-2 Microglia Cells via Modulation of MAPK and NF-κB Signaling Pathways
Noscapine Down-Regulates LPS-Induced Neuroinflammation in BV-2 Microglia Cells via Modulation of MAPK and NF-κB Signaling Pathways
Noscapine is widely used to prevent stroke, glioblastoma, and anxiety. The aim of this study was to investigate the anti-n...
Clinical Value of lncRNA MALAT1 and miR-154-5p in the Severity and Prognosis of Convulsive Status Epilepticus
Clinical Value of lncRNA MALAT1 and miR-154-5p in the Severity and Prognosis of Convulsive Status Epilepticus
Convulsive status epilepticus (CSE) is a common pediatric emergency that can lead to irreversible brain damage and high mo...
Establishment of Neurofilament Light Chain in Plasma-Derived Neuronal Extracellular Vesicles as a Biomarker for Disease Progression in Multiple Sclerosis Patients
Establishment of Neurofilament Light Chain in Plasma-Derived Neuronal Extracellular Vesicles as a Biomarker for Disease Progression in Multiple Sclerosis Patients
Multiple sclerosis (MS) is a complex neurological disorder. Neurofilament light chain (NfL) is a marker of axonal injury. ...
S100B, GFAP and NSE: The Role of Neuro Biomarkers for Early Predictors of Cerebral Vaso-Occlusive Manifestations of Sickle Cell Disease
S100B, GFAP and NSE: The Role of Neuro Biomarkers for Early Predictors of Cerebral Vaso-Occlusive Manifestations of Sickle Cell Disease
Hemoglobinopathies are commonly occurring genetic disorders worldwide. The aim of this study is to determine the biochemic...
Evaluation of the Low-Energy Ultrashort Pulsed Electron Beam Irradiation-Induced Oxidative Stress and Adaptive Response of Select Enzymes in a Rat Brain
Evaluation of the Low-Energy Ultrashort Pulsed Electron Beam Irradiation-Induced Oxidative Stress and Adaptive Response of Select Enzymes in a Rat Brain
The aim of this study is to evaluate the dynamics of oxidative stress (OS) development, as well as adaptive response of se...
Exploring Mitochondrial Quality in Aging and Neurodegenerative Diseases
Exploring Mitochondrial Quality in Aging and Neurodegenerative Diseases
Aging is a gradual process characterized by a decline in cellular and tissue function, significantly contributing to the d...
The Correlation between NLR and PLR and the Occurrence and Prognosis of PHI in Patients with Traumatic Brain Injury
The Correlation between NLR and PLR and the Occurrence and Prognosis of PHI in Patients with Traumatic Brain Injury
The purpose of this retrospective study was to investigate the risk factors associated with progressive hemorrhagic injury...
Possible Mechanism for Perception of Auditory-Verbal Hallucinations in Schizophrenia and Approaches to Their Weakening
Possible Mechanism for Perception of Auditory-Verbal Hallucinations in Schizophrenia and Approaches to Their Weakening
We put forward a hypothesis that the processing and perception of auditory-verbal hallucinations in schizophrenia such as ...
A Systematic Review on the Effectiveness of Trigonelline, Safranal and Chamomile in Cure and Prevention of Alzheimer’s Disease and Dementia
A Systematic Review on the Effectiveness of Trigonelline, Safranal and Chamomile in Cure and Prevention of Alzheimer’s Disease and Dementia
Alzheimer’s disease and dementia are neurodegenerative conditions characterized by memory loss and diminished capaci...
Exploring the Role of TRP Channels and Neurotrophic Factors in Epileptogenesis: Insights from Diverse Seizure Models
Exploring the Role of TRP Channels and Neurotrophic Factors in Epileptogenesis: Insights from Diverse Seizure Models
Epilepsy affects many people globally and results from disrupted neuron balance, causing abnormal central nervous system e...
miR-92b-3p Regulates Cell Progression and Drug Resistance through Upregulation of CXCL5 in Glioma
miR-92b-3p Regulates Cell Progression and Drug Resistance through Upregulation of CXCL5 in Glioma
As malignant central nervous system tumors, glioma have strong aggressiveness and drug resistance, which reduces the survi...
Comparison of Methods for Isolation of Extracellular Vesicles from Human Serum
Comparison of Methods for Isolation of Extracellular Vesicles from Human Serum
Extracellular vesicles (EVs) have recently become an important object of studies. It seems that, in the body, intercellula...
Safranal’s Neurological Nexus: Unveiling Therapeutic Potential through Molecular Docking
Safranal’s Neurological Nexus: Unveiling Therapeutic Potential through Molecular Docking
Safranal, a bioactive compound derived from saffron, has emerged as a subject of growing interest in the quest for novel t...
Regulation of miR-590-5p on Neurological Inflammation and Oxidative Stress and Its Biomarker Role in Parkinson’s Disease
Regulation of miR-590-5p on Neurological Inflammation and Oxidative Stress and Its Biomarker Role in Parkinson’s Disease
Parkinson’s disease (PD) is a common neurological degradation disease involving inflammation and oxidative stress. A...
Impact of Intensive Insulin Therapy on Clinical Outcomes of Traumatic Brain Injury Patients with Pre-Existing Diabetes
Impact of Intensive Insulin Therapy on Clinical Outcomes of Traumatic Brain Injury Patients with Pre-Existing Diabetes
To determine the effect of intensive insulin therapy on blood glucose control in diabetes patients with traumatic brain in...
Brain Mechanisms Involved in Post COVID Syndrome: A Narrative Review
Brain Mechanisms Involved in Post COVID Syndrome: A Narrative Review
Potentially, patients with COVID-19 can experience long-term disturbances after the acute infection period, even people wi...
Therapeutic Effects of Citral Nanoliposome on Parkinson’s Treatment in a Rat Model: Modulation via Neurochemical, Inflammatory and Antioxidant Pathways
Therapeutic Effects of Citral Nanoliposome on Parkinson’s Treatment in a Rat Model: Modulation via Neurochemical, Inflammatory and Antioxidant Pathways
Parkinson’s disease is the most common neurodegenerative movement disorder, the pathogenesis of which is partly rela...
Changes in the Level of Neurotransmitters and Markers of Neurodegeneration in the Brain of Rats with Experimental Parkinson’s Disease after Therapy with Steroid Glycoalkaloids
Changes in the Level of Neurotransmitters and Markers of Neurodegeneration in the Brain of Rats with Experimental Parkinson’s Disease after Therapy with Steroid Glycoalkaloids
Abstract—Parkinson’s disease is a chronic neurodegenerative disease, one of the pathobiochemical manifestation...
Activation of P2Y2 Receptors Promotes Neuromuscular Junction Formation during Muscle Reinnervation
Activation of P2Y2 Receptors Promotes Neuromuscular Junction Formation during Muscle Reinnervation
Extracellular adenosine 5′-triphosphate (ATP), as neurotransmitter, is known to be an activity-dependent signaling m...
Comparison of Coblation versus Traditional Tonsillectomy for Patients with Chronic Tonsillitis: Impact on Serum Stress Indicators, Inflammatory Mediator Levels, Postoperative Pain, and Complications
Comparison of Coblation versus Traditional Tonsillectomy for Patients with Chronic Tonsillitis: Impact on Serum Stress Indicators, Inflammatory Mediator Levels, Postoperative Pain, and Complications
This study aims to compare the clinical efficacy of coblation tonsillectomy with that of conventional tonsillectomy for th...
Effect of Noopept on the Content of Neurotransmitter Amino Acids in the Hippocampus in Alcoholized Rats Using In Vivo Microdialysis
Effect of Noopept on the Content of Neurotransmitter Amino Acids in the Hippocampus in Alcoholized Rats Using In Vivo Microdialysis
Abstract—The aim of the present work was to study the dynamics of neurotransmitter amino acids after acute Noopept (...
The Anti-Convulsant Effects of Carvacrol in Penicillin- and Pentylenetetrazole-Induced Rat Models of Epilepsy
The Anti-Convulsant Effects of Carvacrol in Penicillin- and Pentylenetetrazole-Induced Rat Models of Epilepsy
Epileptic seizures are caused by abnormal neuronal excitation. It is well established that carvacrol, a monoterpenoid phen...
The Study of the State of Monoaminergic Systems in the Brain Structures of the Offsprings of Female BALB/c Mice at Different Stages of Formation of Autism Spectrum Disorders
The Study of the State of Monoaminergic Systems in the Brain Structures of the Offsprings of Female BALB/c Mice at Different Stages of Formation of Autism Spectrum Disorders
Abstract—The study of the status of norepinephrine-, dopamine- and serotonergic neurotransmitter systems of BALB/C m...
miR-885-5p Predicts the Risk and Development of Intracranial Hemorrhage in Traumatic Brain Injury and Regulates Inflammation in Microglia
miR-885-5p Predicts the Risk and Development of Intracranial Hemorrhage in Traumatic Brain Injury and Regulates Inflammation in Microglia
Intracranial hemorrhage (ICH) is the most critical secondary lesion of traumatic brain injury (TBI). Identifying novel bio...
Unveiling the Protective Potential of Sugammadex against PTZ-Induced Epileptic Seizures in Mice: A Comprehensive Study on Oxidative Stress, Apoptosis, and Autophagy
Unveiling the Protective Potential of Sugammadex against PTZ-Induced Epileptic Seizures in Mice: A Comprehensive Study on Oxidative Stress, Apoptosis, and Autophagy
Sugammadex (SUG) is a modified γ-cyclodextrin molecule used in patients under general anesthesia to reverse the effec...
Caspase-3 Activity and Autophagy Intensity in the Development of Neuronal Resistance to Glutamate Toxicity
Caspase-3 Activity and Autophagy Intensity in the Development of Neuronal Resistance to Glutamate Toxicity
Two periods of autophagy activation with a different significance for the development of resistance were demonstrated in t...
Effects of 5-HT1A Receptor Antagonist and 5-HT2A Receptor Agonist on Morphine Withdrawal
Effects of 5-HT1A Receptor Antagonist and 5-HT2A Receptor Agonist on Morphine Withdrawal
Chronic administration of morphine causes physical dependence, possibly through serotonin 5‑HT1A receptor (5-HT1AR) ...
Decreased Volumes of Selected Cortical and Limbic Structures of the Brain Are Associated with Post-Stroke Cognitive and Affective Disorders: Multiple Hit Scenarios?
Decreased Volumes of Selected Cortical and Limbic Structures of the Brain Are Associated with Post-Stroke Cognitive and Affective Disorders: Multiple Hit Scenarios?
Post-stroke depressive disorders (PSD) and post-stroke cognitive impairments (PCI) are frequent consequences of ischemic s...
Knockdown of PRR11 Induces Autophagy in Glioma Cells by Inhibiting Akt/mTOR Signaling Pathway
Knockdown of PRR11 Induces Autophagy in Glioma Cells by Inhibiting Akt/mTOR Signaling Pathway
Glioma is the most common type of primary craniocerebral tumor. Understanding the molecular mechanisms of glioma occurrenc...
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