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The role of cuticle in fruit shelf-life
Ensuring the availability of high-quality fresh fruits requires the development of strategies to maintain prolonged shelf-...
Mathematical modeling and process analytical technology for continuous chromatography of biopharmaceutical products
Column chromatography is undeniably the industry standard for the purification of biotherapeutics beginning with the produ...
Phage biocontrol for reducing bacterial foodborne pathogens in produce and other foods
Bacteriophages (also known as phages) are bacterial viruses that specifically infect and kill bacteria. Use of phages to c...
Building mutational bridges between carbohydrate-active enzymes
To support the central role that carbohydrates and their derivatives play in the living world, Nature has evolved a large ...
Progress toward rapid, at-line N-glycosylation detection and control for recombinant protein expression
Proteins continue to represent a large fraction of the therapeutics market, reaching over a hundred billion dollars in mar...
Dissecting postharvest chilling injury through biotechnology
Paradoxically, refrigerating many fruits and vegetables destroys their quality, and may even accelerate their spoilage. Th...
Biotechnological approaches for reducing fruit losses caused by pathogenic infection
Volume 78, December 2022, 102795Fruit loss due to disease occurs in both the field and postharvest. Knowledge of host immu...
The double life of CRISPR–Cas13
Since the discovery of RNA-programmable nucleases from the prokaryotic adaptive immune system CRISPR–Cas, these proteins h...
Virus-like particles for drug delivery: a review of methods and applications
Virus-like particles (VLPs) are self-assembling protein nanoparticles, typically derived from the capsid protein of nonenv...
Production of recombinant and therapeutic proteins in microalgae
Protein-based therapeutics continue to be the leading product of many pharmaceutical companies. In 2020, the global market...
Mycotoxin risks are lower in biotech corn
Mycotoxins are toxic secondary metabolites of fungi (molds) that infect food crops. Not all fungi that infect foods produc...
Continuous biomanufacturing with microbes — upstream progresses and challenges
Biomanufacturing is to use a biological system that consists of enzyme(s), microorganisms, or more advanced biological cel...
Natural products in antibiotic development: is the success story over?
Resistant bacterial infections are a significant threat to human health with drastic socioeconomic implications for our fu...
Biotechnological approaches for controlling postharvest fruit softening
Main determinants of ‘Hass’ avocado quality and consumer acceptance are mesocarp firmness and skin color. Relevant produci...
THE JOURNEY OF A LIFETIME – DEVELOPMENT OF PFIZER’S COVID-19 VACCINE
It would be apt to say that one of the greatest accomplishments in modern medicine has been the development of vaccines ag...
Monoclonal Antibody Therapies for COVID-19: Lessons Learned and Implications for the Development of Future Products
Available online 2 September 2022, 102798Several companies were authorized to treat COVID-19 patients with monoclonal anti...
Design and engineering of genetically encoded protein biosensors for small molecules
Biosensors, which transduce an input signal into a measurable output response, have been developed for a wide range of mol...
Biotechnology approaches for natural product discovery, engineering, and production based on Burkholderia bacteria
Natural products (NPs) of bacterial origin continue to provide an abundant source of novel chemical entities with applicat...
Manufactured extracellular vesicles as human therapeutics: challenges, advances, and opportunities
Volume 77, October 2022, 102776Highlights•EVs come in two classes: native or engineered with defined therapeutic entity.•A...
Sustainability in food-waste reduction biotechnology: a critical review
Reduction of the $2.625 trillion USD global food-waste problem is a critical goal in combatting climate change and world h...
Editorial overview: Analytical biotechnology for healthcare, strain engineering, biosensing and synthetic biology
Peng Xu is an associate professor at Guangdong Technion-Israel Institute of Technology. He received his BS and MS degree i...
Mannosylerythritol lipids: production, downstream processing, and potential applications
Biosurfactants are often more environmentally friendly, exhibit reduced toxicity, unique biological properties, and strong...
The potential of amoeba-based processes for natural product syntheses
Volume 77, October 2022, 102766Highlights•The amoeba D. discoideum is a specialist for natural product biosynthesis.•Activ...
Engineered living bioassemblies for biomedical and functional material applications
Volume 77, October 2022, 102756Recent breakthroughs in biofabrication of bioasemblies, consisting of the engineered struct...
Current research approaches in downstream processing of pharmaceutically relevant proteins
Volume 77, October 2022, 102768Highlights•Process intensification enables more efficient biopharmaceutical downstream proc...
Engineering phototrophic bacteria for the production of terpenoids
Volume 77, October 2022, 102764Ilka Axmann and Thomas Drepper dedicate this review article to Prof. Dr. Karl-Erich Jaeger ...
Emerging concepts in the semisynthetic and mutasynthetic production of natural products
Volume 77, October 2022, 102761Natural products have greatly influenced the development of drugs to combat infectious dise...