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A CTCF-dependent mechanism underlies the Hox timer: relation to a segmented body plan
A CTCF-dependent mechanism underlies the Hox timer: relation to a segmented body plan
During gastrulation, Hox genes are activated in a time-sequence that follows the order of the genes along their clusters. ...
Recent advances in polygenic scores: translation, equitability, methods and FAIR tools
Recent advances in polygenic scores: translation, equitability, methods and FAIR tools
Polygenic scores (PGS) can be used for risk stratification by quantifying individuals’ genetic predisposition to dis...
Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis
Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis
Drug resistance in tuberculosis (TB) poses a major ongoing challenge to public health. The recent inclusion of bedaquiline...
Analytical characterization of full, intermediate, and empty AAV capsids
Analytical characterization of full, intermediate, and empty AAV capsids
Manufacturing of recombinant adeno-associated virus (AAV) vectors produces three types of capsids: full, intermediate, and...
The origin and evolution of Wnt signalling
The origin and evolution of Wnt signalling
The Wnt signal transduction pathway has essential roles in the formation of the primary body axis during development, cell...
Plant pangenomes for crop improvement, biodiversity and evolution
Plant pangenomes for crop improvement, biodiversity and evolution
Plant genome sequences catalogue genes and the genetic elements that regulate their expression. Such inventories further r...
GSCIT: smart Hash Table-based mapping equipped genome sequence coverage inspection
GSCIT: smart Hash Table-based mapping equipped genome sequence coverage inspection
Andrews S, Krueger F, Segonds-Pichon A, Biggins L, Krueger C, Wingett S (2010) FastQCuppercase, a quality control tool for...
DKC1 aggravates gastric cancer cell migration and invasion through up-regulating the expression of TNFAIP6
DKC1 aggravates gastric cancer cell migration and invasion through up-regulating the expression of TNFAIP6
Gastric cancer (GC) is one hackneyed malignancy tumor accompanied by high death rate. DKC1 has been discovered to serve as...
Typological thinking in human genomics research contributes to the production and prominence of scientific racism
Typological thinking in human genomics research contributes to the production and prominence of scientific racism
<p>Public genomic datasets like the 1000 Genomes project (1KGP), Human Genome Diversity Project (HGDP), and the Adol...
Using genetics to investigate the association between lanosterol and cataract
Using genetics to investigate the association between lanosterol and cataract
<p><bold>Background:</bold> Cataract is one of the most prevalent causes of blindness worldwide. Whilst ...
Influential factors on urine EV DNA methylation detection and its diagnostic potential in prostate cancer
Influential factors on urine EV DNA methylation detection and its diagnostic potential in prostate cancer
<p>The value of Extracellular vesicles (EVs) diagnostic markers is widely recognized. However, current research on E...
A comprehensive review on Gossypium hirsutum resistance against cotton leaf curl virus
A comprehensive review on Gossypium hirsutum resistance against cotton leaf curl virus
<p>Cotton (<italic>Gossypium hirsutum</italic> L.) is a significant fiber crop. Being a major contributo...
The role of microRNAs in defining LSECs cellular identity and in regulating F8 gene expression
The role of microRNAs in defining LSECs cellular identity and in regulating F8 gene expression
<p><bold>Introduction:</bold> Coagulation Factor VIII (FVIII) plays a pivotal role in the coagulation ca...
Classifying breast cancer using multi-view graph neural network based on multi-omics data
Classifying breast cancer using multi-view graph neural network based on multi-omics data
<p><bold>Introduction:</bold> As the evaluation indices, cancer grading and subtyping have diverse clini...
Cold exposure impacts DNA methylation patterns in cattle sperm
Cold exposure impacts DNA methylation patterns in cattle sperm
<p>DNA methylation is influenced by various exogenous factors such as nutrition, temperature, toxicants, and stress....
Research progress of SWI/SNF complex in breast cancer
Research progress of SWI/SNF complex in breast cancer
In the past decade, numerous epigenetic mechanisms have been discovered to be associated with cancer. The mammalian SWI/SN...
Leigh syndrome with developmental regression and ataxia due to a novel splicing variant in the PMPCB gene
Leigh syndrome with developmental regression and ataxia due to a novel splicing variant in the PMPCB gene
Only five children with pathogenic PMPCB gene variants have been described and all carried missense variants. Clinical fea...
Heterozygous CAPZA2 mutations cause global developmental delay, hypotonia with epilepsy: a case report and the literature review
Heterozygous CAPZA2 mutations cause global developmental delay, hypotonia with epilepsy: a case report and the literature review
CAPZA2 encodes the α2 subunit of CAPZA, which is vital for actin polymerization and depolymerization in humans. Howev...
Clinical, genetic profile and therapy evaluation of 11 Chinese pediatric patients with Fanconi-Bickel syndrome
Clinical, genetic profile and therapy evaluation of 11 Chinese pediatric patients with Fanconi-Bickel syndrome
Fanconi-Bickel syndrome (FBS) is a rare autosomal recessive disorder characterized by impaired glucose and galactose utili...
Incidence and medical costs of lupus in Spanish hospitals: a retrospective database analysis
Incidence and medical costs of lupus in Spanish hospitals: a retrospective database analysis
This study aimed to assess the comorbidity profile, use of healthcare resources and medical costs of patients with systemi...
The male-to-female ratio in late-onset multiple acyl-CoA dehydrogenase deficiency: a systematic review and meta-analysis
The male-to-female ratio in late-onset multiple acyl-CoA dehydrogenase deficiency: a systematic review and meta-analysis
Late-onset multiple acyl-CoA dehydrogenase deficiency (MADD) is the most common lipid storage myopathy. There are sex diff...
Identification of TACSTD2 as novel therapeutic targets for cisplatin-induced acute kidney injury by multi-omics data integration
Identification of TACSTD2 as novel therapeutic targets for cisplatin-induced acute kidney injury by multi-omics data integration
Cisplatin-induced acute kidney injury (CP-AKI) is a common complication in cancer patients. Although ferroptosis is believ...
Assessing the efficacy of target adaptive sampling long-read sequencing through hereditary cancer patient genomes
Assessing the efficacy of target adaptive sampling long-read sequencing through hereditary cancer patient genomes
Innovations in sequencing technology have led to the discovery of novel mutations that cause inherited diseases. However, ...