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Genomic Shift in Population Dynamics of mcr-1-positive Escherichia coli in Human Carriage
Available online 5 December 2022Author links open overlay panelAbstractEmergence of the colistin resistance gene, mcr-1, h...
Machine Learning Modeling of Protein-intrinsic Features Predicts Tractability of Targeted Protein Degradation
The datasets supporting the conclusions of this article are accessible at http://mapd.cistrome.org.© 2022 The Authors. Pub...
CNEReg Interprets Ruminant-specific Conserved Non-coding Elements by Developmental Gene Regulatory Network
Available online 7 December 2022Author links open overlay panelAbstractThe genetic information coded in DNA leads to trait...
Physical activity and risk of gallstone disease: A Mendelian randomization study
Physical activity and risk of gallstone disease: A Mendelian randomization study
Objective: Given the association between physical activity and the reduced risk of gallstone disease as suggested in obser...
Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer
Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a rare variant of breast cancer (BC) known to be aggressive and refractory. TNBC l...
A Wnt-related gene expression signature to improve the prediction of prognosis and tumor microenvironment in gastric cancer
A Wnt-related gene expression signature to improve the prediction of prognosis and tumor microenvironment in gastric cancer
Background: Most gastric cancer (GC) patients were diagnosed in the advanced stages without obvious symptoms, which result...
The risk of various types of cardiovascular diseases in mutation positive familial hypercholesterolemia; a review
The risk of various types of cardiovascular diseases in mutation positive familial hypercholesterolemia; a review
Familial hypercholesterolemia (FH) is a common, inherited disease characterized by high levels of low-density lipoprotein ...
Differentially expressed gene profiles and associated ceRNA network in ATG7-Deficient lens epithelial cells under oxidative stress
Differentially expressed gene profiles and associated ceRNA network in ATG7-Deficient lens epithelial cells under oxidative stress
Oxidation is an essential factor during cataract development. Autophagy, usually a cytoprotective process, is always found...
Pan-cancer analysis identifies DDX56 as a prognostic biomarker associated with immune infiltration and drug sensitivity
Pan-cancer analysis identifies DDX56 as a prognostic biomarker associated with immune infiltration and drug sensitivity
DDX56, a member of the RNA helicase family, is upregulated in colon adenocarcinoma, lung squamous cell carcinoma, and oste...
Characteristics of piRNAs and their comparative profiling in testes of sheep with different fertility
Characteristics of piRNAs and their comparative profiling in testes of sheep with different fertility
As a novel class of small RNAs, piRNAs are highly expressed in the animal gonads and their main known role is to inhibit t...
Initial characterization of immune microenvironment in pheochromocytoma and paraganglioma
Initial characterization of immune microenvironment in pheochromocytoma and paraganglioma
Due to fewer adverse events, faster onset of action, and longer durable responses compared to chemotherapy, immunotherapy ...
CMTM7 recognizes an immune-hot tumor microenvironment and predicts therapeutic response of immunotherapy in breast cancer well
CMTM7 recognizes an immune-hot tumor microenvironment and predicts therapeutic response of immunotherapy in breast cancer well
Breast cancer (BRCA) is a complex disease that leads to major mortalities and unsatisfactory clinical outcomes among women...
Analysis of miRNA rare variants in amyotrophic lateral sclerosis and in silico prediction of their biological effects
Analysis of miRNA rare variants in amyotrophic lateral sclerosis and in silico prediction of their biological effects
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and/or lower motor neurons ...
Case report: A heterozygous mutation in ZNF462 leads to growth hormone deficiency
Case report: A heterozygous mutation in ZNF462 leads to growth hormone deficiency
Weiss–Kruszka syndrome (WSKA) is a rare disease most often caused by mutations in the ZNF462 gene. To screen for hereditar...
Discovering novel reproductive genes in a non-model fly using de novo GridION transcriptomics
Discovering novel reproductive genes in a non-model fly using de novo GridION transcriptomics
Gene discovery has important implications for investigating phenotypic trait evolution, adaptation, and speciation. Male r...
Schizosaccharomyces pombe Grx4, Fep1, and Php4: In silico analysis and expression response to different iron concentrations
Schizosaccharomyces pombe Grx4, Fep1, and Php4: In silico analysis and expression response to different iron concentrations
Due to iron’s essential role in cellular metabolism, most organisms must maintain their homeostasis. In this regard, the f...
Increased diagnostic yield in a cohort of hearing loss families using a comprehensive stepwise strategy of molecular testing
Increased diagnostic yield in a cohort of hearing loss families using a comprehensive stepwise strategy of molecular testing
Hearing loss is one of the most common sensory disorders in humans. This study proposes a stepwise strategy of deafness ge...
Accurate determination of causalities in gene regulatory networks by dissecting downstream target genes
Accurate determination of causalities in gene regulatory networks by dissecting downstream target genes
Accurate determination of causalities between genes is a challenge in the inference of gene regulatory networks (GRNs) fro...
GWAS analysis to elucidate genetic composition underlying a photoperiod-insensitive rice population, North Korea
GWAS analysis to elucidate genetic composition underlying a photoperiod-insensitive rice population, North Korea
Heading date (Hd) is one of the main factors determining rice production and regional adaptation. To identify the genetic ...
Review: Genetic and protein variants of milk caseins in goats
Review: Genetic and protein variants of milk caseins in goats
The milk casein genes in goats, are highly polymorphic genes with numerous synonymous and non-synonymous mutations. So far...
A deep learning method to map tissue architecture
A deep learning method to map tissue architecture
A new study in Nature Methods describes a computational method named UTAG (unsupervised discovery of tissue architecture w...
What’s my age again?
Riccardo Marioni discusses how the publication of Horvath’s epigenetic clock has affected research into ageing, reju...
Navigating bottlenecks and trade-offs in genomic data analysis
Navigating bottlenecks and trade-offs in genomic data analysis
Genome sequencing and analysis allow researchers to decode the functional information hidden in DNA sequences as well as t...
Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
Intellectual disability is a well-known hallmark of Down Syndrome (DS) that results from the triplication of the critical ...
Relationship between leptin gene variants (–2548G>A and 19A>G) and obesity among north Indian Punjabi population
Relationship between leptin gene variants (–2548G>A and 19A>G) and obesity among north Indian Punjabi population
Leptin is an adipocyte-secreted hormone which is involved in the regulation of food intake and energy expenditure. To asce...