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Effects of two commonly used antidepressants amitriptyline and fluoxetine on the pharmacokinetics of abrocitinib in rats
Effects of two commonly used antidepressants amitriptyline and fluoxetine on the pharmacokinetics of abrocitinib in rats
Atopic dermatitis (AD), a form of dermatitis, has a prevalence of 5–10 % in adults and 10–15 % in children, resulting in a...
Systematic screening of synthetic organochalcogen compounds with anticancer activity using human lung adenocarcinoma spheroids
Systematic screening of synthetic organochalcogen compounds with anticancer activity using human lung adenocarcinoma spheroids
Lung adenocarcinomas stand as a predominant cause of global cancer-related mortality [1], posing a significant challenge d...
A water-soluble preparation for intravenous administration of isorhamnetin and its pharmacokinetics in rats
A water-soluble preparation for intravenous administration of isorhamnetin and its pharmacokinetics in rats
Many epidemiological and animal studies have found flavonoids to be promising compounds for the prevention or treatment of...
Cyclosporin A inhibits PDGF-BB induced hyaluronan synthesis in orbital fibroblasts
Cyclosporin A inhibits PDGF-BB induced hyaluronan synthesis in orbital fibroblasts
Orbital connective tissue changes are contributors to the pathogenesis in thyroid eye disease (TED). Activated fibroblasts...
Cytotoxicity of acridinium-based ionic liquids: Structure-activity relationship and mechanistic studies
Cytotoxicity of acridinium-based ionic liquids: Structure-activity relationship and mechanistic studies
Ionic liquids (ILs) are a class of low melting point salts with physicochemical properties suitable for a range of industr...
3D-QSAR and molecular docking studies of peptide-hybrids as dengue virus NS2B/NS3 protease inhibitors
3D-QSAR and molecular docking studies of peptide-hybrids as dengue virus NS2B/NS3 protease inhibitors
Dengue fever is a highly dangerous virus, causing 10,000 deaths and 100–400 million illnesses annually in over 120 countri...
Interaction of dinuclear Co(III) cylinders with higher-order DNA structures
Interaction of dinuclear Co(III) cylinders with higher-order DNA structures
Apart from a canonical Watson-Crick double helix (B-DNA), DNA can also adopt a broad range of alternative structures, incl...
Liensinine alleviates sepsis-induced acute liver injury by inhibiting the NF-κB and MAPK pathways in an Nrf2-dependent manner
Liensinine alleviates sepsis-induced acute liver injury by inhibiting the NF-κB and MAPK pathways in an Nrf2-dependent manner
Sepsis has been described as a systemic inflammatory response syndrome (SIRS) that develops as a result of microbial infec...
Hydroxygenkwanin suppresses peritoneal metastasis in colorectal cancer by modulating tumor-associated macrophages polarization
Hydroxygenkwanin suppresses peritoneal metastasis in colorectal cancer by modulating tumor-associated macrophages polarization
Colorectal cancer (CRC) is the third most common cancer globally and the second leading cause of cancer-related deaths, po...
Gelsenicine disrupted the intestinal barrier of Caenorhabditis elegans
Gelsenicine disrupted the intestinal barrier of Caenorhabditis elegans
Gelsemium elegans Benth. (G. elegans) is a traditional medicinal herb that has anti-inflammatory, analgesic, sedative, and...
Inhibition of human UDP-glucuronosyltransferase enzyme by entrectinib: Implications for drug-drug interactions
Inhibition of human UDP-glucuronosyltransferase enzyme by entrectinib: Implications for drug-drug interactions
Entrectinib is a multi-kinase inhibitor, targeting the c-ros oncogene 1 (ROS1), tropomyosin receptor kinases (Trk)A/B/C, a...
Interaction of exogenous acetylcholinesterase and butyrylcholinesterase with amyloid-β plaques in human brain tissue
Interaction of exogenous acetylcholinesterase and butyrylcholinesterase with amyloid-β plaques in human brain tissue
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are associated with amyloid-β (Aβ) plaques and exhibit altere...