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Ferroptosis contributes to cyclophosphamide-induced hemorrhagic cystitis
Ferroptosis contributes to cyclophosphamide-induced hemorrhagic cystitis
Cystitis is a common condition characterized by urinary bladder inflammation, which can significantly impact the quality o...
Multi-omics profiling reveals cellular pathways and functions regulated by ALDH1B1 in colon cancer cells
Multi-omics profiling reveals cellular pathways and functions regulated by ALDH1B1 in colon cancer cells
By 2030, it is expected that the global burden of colon cancer will increase by 60%, with 2.2 million new cases and 1.1 mi...
Rottlerin impairs early and late steps of Toxoplasma gondii infection in human trophoblast cells and villous explants
Rottlerin impairs early and late steps of Toxoplasma gondii infection in human trophoblast cells and villous explants
Toxoplasmosis, a serious food-borne illness mainly for congenitally-infected children and immunocompromised individuals, i...
Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis
Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis
Matrine (MT) is an alkaloid found in the leguminous plant Sophora flavescens and has a long history of use in China and mo...
A novel self-assembled nanoplatform based on retrofitting poloxamer 188 for triple-negative breast cancer targeting treatment
A novel self-assembled nanoplatform based on retrofitting poloxamer 188 for triple-negative breast cancer targeting treatment
Breast cancer is a major global health concern and is the second leading cause of cancer related deaths among women worldw...
Rosavin regulates bone homeostasis through HDAC1-induced epigenetic regulation of EEF2
Rosavin regulates bone homeostasis through HDAC1-induced epigenetic regulation of EEF2
Fractures resulting from osteoporosis (OP) become gradually prevalent in women aged over 55 years and men aged over 65 yea...
Molecular targets and mechanisms of anti-cancer effects of withanolides
Molecular targets and mechanisms of anti-cancer effects of withanolides
Cancer involves abnormal growth of cells with the potential to invade and metastasize to other parts of the body [1]. Nowa...
Risk assessment of parabens in a transcriptomics-based in vitro test
Risk assessment of parabens in a transcriptomics-based in vitro test
Parahydroxybenzoates, often named ‘parabens’, are esters of 4-hydroxybenzoic acid and are effective antimicrobials and ant...
Particle-induced osteolysis is mediated by endoplasmic reticulum stress-associated osteoblast apoptosis
Particle-induced osteolysis is mediated by endoplasmic reticulum stress-associated osteoblast apoptosis
Aseptic loosening of artificial joints is a common complication of joint replacement, which is also the main reason for th...
Metabolic characteristics of voriconazole – Induced liver injury in rats
Metabolic characteristics of voriconazole – Induced liver injury in rats
Voriconazole (VOR) is a broad – spectrum antifungal agent, which is commonly used to treat invasive fungal infections caus...
Insights into the mechanisms of telbivudine-induced myopathy associated with mitochondrial dysfunction
Insights into the mechanisms of telbivudine-induced myopathy associated with mitochondrial dysfunction
Hepatitis B is a viral infection caused by the hepatitis B virus (HBV). It is a major public health concern, with an estim...
Assessment of cellular damage with cytome assay among environmental/occupational triazole
Assessment of cellular damage with cytome assay among environmental/occupational triazole
In recent years, Brazil has become one of the main consumers of pesticides in the world, particularly in the agricultural ...
Indole alkaloids from marine resources: Understandings from therapeutic point of view to treat cancers
Indole alkaloids from marine resources: Understandings from therapeutic point of view to treat cancers
Cancer is the leading cause of morbidity and mortality worldwide [1,2]. The hallmark characteristic of malignancies is the...
How do different bile acid derivatives affect rat macrophage function – Friends or foes?
How do different bile acid derivatives affect rat macrophage function – Friends or foes?
Bile acids (BAs) are amphiphilic steroid molecules formed as end products of cholesterol metabolism. They are essential in...
Astaxanthin ameliorates oxidative stress in lens epithelial cells by regulating GPX4 and ferroptosis
Astaxanthin ameliorates oxidative stress in lens epithelial cells by regulating GPX4 and ferroptosis
Age-related cataract (ARC) is a growing global public health problem that can lead to reduced vision and impaired visual f...
Butyrylcholinesterase and lipid metabolism: Possible dual role in metabolic disorders
Butyrylcholinesterase and lipid metabolism: Possible dual role in metabolic disorders
This study aims to compare three body mass index (BMI)-based classification systems of childhood obesity: the French, the ...
TUG1 protects against ferroptosis of hepatic stellate cells by upregulating PDK4-mediated glycolysis
TUG1 protects against ferroptosis of hepatic stellate cells by upregulating PDK4-mediated glycolysis
Liver fibrosis, an ongoing wound-healing process, results in the aberrant accumulation of extracellular matrix proteins an...
Discovery of acylated isoquercitrin derivatives as potent anti-neuroinflammatory agents in vitro and in vivo
Discovery of acylated isoquercitrin derivatives as potent anti-neuroinflammatory agents in vitro and in vivo
Neuroinflammation refers to an inflammatory response within the central nervous system (CNS) that is induced by activated ...
The ESTHER database on alpha/beta hydrolase fold proteins - An overview of recent developments
The ESTHER database on alpha/beta hydrolase fold proteins - An overview of recent developments
Neuroinflammation is considered as an important pathological mechanism in neurodegenerative diseases. The natural isoquerc...
Solvents and detergents compatible with enzyme kinetic studies of cholinesterases
Solvents and detergents compatible with enzyme kinetic studies of cholinesterases
Cholinesterases are serine hydrolase enzymes that are integral to a variety of physiological functions [1]. Acetylcholines...