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Thermodynamics of benzoquinone-induced conformational changes in nucleic acids and human serum albumin
Incomplete combustion of polycyclic aromatic hydrocarbons (PAHs) during coal combustion, biomass burning, and automobile e...
Modulation of the miR-122/Sirt-6/ACE2 axis on experimentally-induced myocardial infarction
Myocardial infarction (MI) is a progressive disorder of myocardial necrosis due to an acute disturbance of the coronary bl...
Amygdalin alleviated TGF-β-induced epithelial-mesenchymal transition in bronchial epithelial cells
Asthma is one of the most common chronic respiratory diseases in the world, characterized by recurrent wheezing, coughing,...
Thymoquinone-treated mouse mesenchymal stem cells-derived conditioned medium inhibits human breast cancer cells in vitro
Stem cells can be used to affect the biology of tumors and to deliver anti-tumor drugs for the treatment of cancers [1,2]....
Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism
Persistent chronic stress nowadays emerges as a critical culprit contributor to the enhanced progression of many diseases,...
Trabectedin induces ferroptosis via regulation of HIF-1α/IRP1/TFR1 and Keap1/Nrf2/GPX4 axis in non-small cell lung cancer cells
Lung cancer is the leading cause of cancer-related death worldwide, with over 1 million new cases diagnosed each year [1]....
High-fat diet and palmitate inhibits FNDC5 expression via AMPK-Zfp57 pathway in mouse muscle cells
Modern lifestyles, including high-calorie diets and prevalent sedentary behavior, significantly contribute to the high inc...
Artificial neural networks in contemporary toxicology research
Artificial neural networks (ANNs) represent a variety of information technology–based algorithms and systems designed with...
Adverse effects of 2-Methoxyestradiol on mouse oocytes during reproductive aging
Accumulating evidence suggests that oxidative stress is the leading cause of oocyte aging, and involved in ovarian toxicit...
Human cell-based estrogen receptor beta dimerization assay
Estrogen is not only responsible for important functions in the human body, such as cell growth, reproduction, differentia...
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells
CQ, 5-chloro-7-iodo-8-quinolinol, entered the market as an external antimicrobial agent for skin as early as 1899, and sub...
Anti-proliferating and apoptosis-inducing activity of chemical compound FTI-6D in association with p53 in human cancer cell lines
Indole alkaloids are considered important as natural resources in the medicinal chemistry field because of their potential...
Sodium acetate ameliorates cisplatin-induced kidney injury in vitro and in vivo
Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is the first-line chemotherapeutic agent that is extensively used for t...
Long-term copper exposure caused hepatocytes autophagy in broiler via miR-455-3p-OXSR1 axis
Copper (Cu) is widely used in animal husbandry [1], serving as a growth promoter [2], resisting bacteria [3], and enhancin...
Low doses of fumonisin B1 exacerbate ochratoxin A-induced renal injury in mice and the protective roles of heat shock protein 70
Mycotoxins are the secondary metabolites from different fungi species, belonging to genera of Aspergillus, Fusarium and Pe...
Non-targeting siRNA-mediated responses are associated with apoptosis in chemotherapy-induced senescent skin cancer cells
Post-transcriptional gene silencing (RNA interference, RNAi), based on double-stranded (ds)RNA-mediated (small interfering...
Triphenyl phosphate induces clastogenic effects potently in mammalian cells, human CYP1A2 and 2E1 being major activating enzymes
Triphenyl phosphate (TPP) is an organic phosphorus flame retardant (OPFRs), which has been polluting the environment world...
Pseurotin D inhibits delayed type IV hypersensitivity response
Dysregulated control of the immune system has major health consequences and is behind the development of numerous diseases...
Isosilybin regulates lipogenesis and fatty acid oxidation via the AMPK/SREBP-1c/PPARα pathway
Non-alcoholic fatty liver disease (NAFLD) is a growing worldwide epidemic which has become the main cause of chronic liver...