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Lead-induced cardiomyocytes apoptosis by inhibiting gap junction intercellular communication via modulating the PKCα/Cx43 signaling pathway
Lead (Pb) is widely used in industrial production and easy to pollute the environment. It is one of the most common heavy ...
Capsaicin attenuates excitotoxic-induced neonatal brain injury and brain mast cell-mediated neuroinflammation in newborn rats
Perinatal brain injury (PBI) is one of the most critical neurological conditions in preterm and term infants. Surviving in...
Ursonic acid from Artemisia montana exerts anti-diabetic effects through anti-glycating properties, and by inhibiting PTP1B and activating the PI3K/Akt signaling pathway in insulin-resistant C2C12 cells
Diabetes mellitus (DM) is predicted to affect more than 642 million people worldwide by 2040 [1,2]. DM is a chronic metabo...
Resveratrol alleviates doxorubicin-induced damage in mice ovary
The impact of chemotherapy on the ovaries depends not only on the dosage and chemical properties of each drug but also on ...
Kidney tea ameliorates hyperuricemia in mice via altering gut microbiota and restoring metabolic profile
Uric acid (UA) is formed from the oxidation of hypoxanthine and xanthine catalyzed by xanthine oxidase (XOD), of which two...
Resveratrol inhibits glioblastoma cells and chemoresistance progression through blockade P-glycoprotein and targeting AKT/PTEN signaling pathway
Glioma is the most prevalent and aggressive tumor of the Central Nervous System (CNS). According to the investigations on ...
Structure-based virtual screening of chemical libraries as potential MELK inhibitors and their therapeutic evaluation against breast cancer
Breast cancer is one of the most common malignancies having high incidences and mortality rates. Among different subtypes,...
Sipeimine attenuates PM2.5-induced lung toxicity via suppression of NLRP3 inflammasome-mediated pyroptosis through activation of the PI3K/AKT pathway
Air pollution is the leading environment-related risk factor for human health and fourth in terms of global mortality [1,2...
Trimetazidine alleviates paclitaxel-induced peripheral neuropathy through modulation of TLR4/p38/NFκB and klotho protein expression
Paclitaxel (PTX), the parent of taxanes, is included among first line treatments of a plethora of common cancers such as b...
Cellular uptake of biotransformed graphene oxide into lung cells
Since its first mechanical exfoliation in 2004, graphene has attracted enormous attention as a material with broad potenti...
Modulation of cytochrome P450 1A (CYP1A) enzymes by monomethylmonothioarsonic acid (MMMTAV) in vivo and in vitro
Arsenic is a naturally occurring element that poses a major health threat to millions of people around the globe [1]. Arse...
In vitro models to measure effects on intestinal deconjugation and transport of mixtures of bile acids
Bile acid metabolism and transport are critical to maintain bile acid homeostasis and host health. In this study, it was i...
Assessment of suberoylanilide hydroxamic acid on a Alzheimer's disease model induced by β-amyloid(1-42) in aged female mice: Neuromodulatory and epigenetic effect
Alzheimer's disease (AD) is a pathology of multifactorial etiology that affects million people per years [1]. AD was first...
NMDA receptor-mediated modulation on glutamine synthetase and glial glutamate transporter GLT-1 is involved in the antidepressant-like and neuroprotective effects of guanosine
Major depressive disorder (MDD) is a common and prevalent psychiatric illness that comprises the most significant contribu...
Cnr1−/− has minimal impact on chlorpyrifos-mediated effects in the mouse endocannabinoid system, but it does alter lipopolysaccharide-induced cytokine levels in splenocytes
The organophosphate (OP) pesticide chlorpyrifos (CPF) has been registered for agricultural purposes in the United States s...
Thymol regulates the Endothelin-1 at gene expression and protein synthesis levels in septic rats
Thymol (5-methyl-2-isopropylphenol) is a phenolic compound and classified among the monoterpene group compounds [1]. Origa...
Systems-level multi-omics characterization provides novel molecular insights into indomethacin toxicity
Non-steroidal anti-inflammatory drugs (NSAIDs) are often the first-line approach to the treatment of pain and inflammatory...
Chrysin loaded nanovesicles ameliorated diabetic peripheral neuropathy. Role of NGF/AKT/GSK-3β pathway
Diabetes mellitus (DM) is a broad term that refers to a variety of metabolic disorders characterized by the occurrence of ...
Boron enhances adaptive responses and biological performance via hormetic mechanisms
Comprehensive and mechanistically focused dose-time response relationships are reported infrequently in the biomedical lit...
Hepatocyte ferroptosis contributes to anti-tuberculosis drug-induced liver injury: Involvement of the HIF-1α/SLC7A11/GPx4 axis
Tuberculosis (TB), a chronic respiratory infection caused by Mycobacterium tuberculosis, is the leading cause of death fro...
The role of mitochondrial dynamics imbalance in hexavalent chromium-induced apoptosis and autophagy in rat testis
Chromium (Cr), a harmful heavy metal pollutant, is widely distributed in soil, water, and air [1]. Cr has many valence sta...
Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain
Cadmium (Cd) produces cognition decline following single and repeated treatment, although the complete mechanisms are stil...
Rosmarinic acid decreases viability, inhibits migration and modulates expression of apoptosis-related CASP8/CASP3/NLRP3 genes in human metastatic melanoma cells
Cutaneous melanoma (CM) is an aggressive and difficult-to-treat skin cancer subtype that originates from malignant mutatio...
Quantum dots are time bomb: Multiscale toxicological study
Nanotechnology and nanoscience have become a lifesaver for the problems of today's generation, and have been reported in m...
Transcription factor B-MYB activates lncRNA CCAT1 and upregulates SOCS3 to promote chemoresistance in colorectal cancer
Colorectal cancer (CRC) is one the leading causes of mortality related to cancer worldwide [[1], [2], [3]]. There are seve...
Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells
Colorectal cancer (CRC) is the third most common cancer in the world and also the second leading cause of cancer death [1,...
Epirubicin toxicity in rat's ovary and uterus: A protective role of 3-Indolepropionic acid supplementation
The number of people diagnosed with cancer is rising across the globe. However, the cancer mortality rate has steadily dec...
Ratio-dependent effects of photoactivated hypericin and manumycin A on their genotoxic and mutagenic potential
Recently, the number of deaths related to cancer is growing worldwide [1]. The elevated tumor tissue resistance, as well a...
Laccaic acid restores epigenetic alterations responsible for high fat diet induced insulin resistance in C57BL/6J mice
Sedentary life style and unhealthy eating habits have resulted in obesity of pandemic proportions worldwide with the numbe...
Capsaicin toxicity to the yeast Saccharomyces cerevisiae is not due to oxidative stress but to disruption of membrane structure
Capsaicin (8-methyl-N-vanillyl-6-nonenamide; CAP; Fig. 1A), a pungent ingredient in various red peppers of the genus Capsi...
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