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SMYD3 regulates gastric cancer progression and macrophage polarization through EZH2 methylation
SMYD3 regulates gastric cancer progression and macrophage polarization through EZH2 methylation
SET and MYND domain-containing protein 3 (SMYD3), a known histone methyltransferase, was reported to regulate cancer patho...
Retraction Note: BET inhibitor I-BET151 sensitizes GBM cells to temozolomide via PUMA induction
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
m6A-modified circFOXK2 targets GLUT1 to accelerate oral squamous cell carcinoma aerobic glycolysis
m6A-modified circFOXK2 targets GLUT1 to accelerate oral squamous cell carcinoma aerobic glycolysis
N6-methyladenosine (m6A) is an abundant nucleotide modification in mRNA, and its emerging roles have been gradually identi...
Lysine-40 succinylation of TAGLN2 induces glioma angiogenesis and tumor growth through regulating TMSB4X
Lysine-40 succinylation of TAGLN2 induces glioma angiogenesis and tumor growth through regulating TMSB4X
Protein lysine succinylation (Ksucc) represents an important regulatory mechanism of tumor development. In this work, the ...
A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer
A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer
The chromatin-modifying enzyme ATAD2 confers oncogenic competence and proliferative advantage in malignances. We previousl...
CCR3 blockage elicits polyploidization associated with the signatures of epithelial-mesenchymal transition in carcinoma cell lines
CCR3 blockage elicits polyploidization associated with the signatures of epithelial-mesenchymal transition in carcinoma cell lines
Malignant features such as the acquisition of metastatic ability, stemness of cells, and therapeutic resistance of cancer ...
Knock-out of 5-lipoxygenase in overexpressing tumor cells—consequences on gene expression and cellular function
Knock-out of 5-lipoxygenase in overexpressing tumor cells—consequences on gene expression and cellular function
5-Lipoxygenase (5-LO), the central enzyme in the biosynthesis of leukotrienes, is frequently expressed in human solid mali...
ECT2 promotes malignant phenotypes through the activation of the AKT/mTOR pathway and cisplatin resistance in cervical cancer
ECT2 promotes malignant phenotypes through the activation of the AKT/mTOR pathway and cisplatin resistance in cervical cancer
Epithelial cell transforming sequence 2 (ECT2) is expressed at high levels in various malignancies and contributes to mali...
Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT
Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT
TRAIP, as a 53 kDa E3 ubiquitin protein ligase, is involved in various cellular processes and closely related to the...
Overcoming biophysical barriers with innovative therapeutic delivery approaches
Overcoming biophysical barriers with innovative therapeutic delivery approaches
Cancer is often conceptualized as principally a cellular process, one initiated by genetic mutations in a progenitor cell ...
Potent bystander effect and tumor tropism in suicide gene therapy using stem cells from human exfoliated deciduous teeth
Potent bystander effect and tumor tropism in suicide gene therapy using stem cells from human exfoliated deciduous teeth
Herpes simplex virus thymidine kinase (HSVTK)/ganciclovir (GCV) suicide gene therapy has a long history of treating malign...
MCPIP1 Suppresses the NF-κB Signaling Pathway Through Negative Regulation of K63-Linked Ubiquitylation of TRAF6 in Colorectal Cancer
MCPIP1 Suppresses the NF-κB Signaling Pathway Through Negative Regulation of K63-Linked Ubiquitylation of TRAF6 in Colorectal Cancer
The abnormal activation of the nuclear factor-kappa B (NF-κB) signaling pathway is an important precipitating factor ...
High CAR intensity of expression confers enhanced antitumor effect against lymphoma without functional exhaustion
High CAR intensity of expression confers enhanced antitumor effect against lymphoma without functional exhaustion
Identifying factors that ameliorates clinical outcomes following CART therapy represents an unmet need. We hypothesized th...
Hidden patterns of gene expression provide prognostic insight for colorectal cancer
Hidden patterns of gene expression provide prognostic insight for colorectal cancer
Cancer tissue samples contain cancer cells and non-cancer cells with each biopsied site containing distinct proportions of...
Regulation of tumor metabolism by post translational modifications on metabolic enzymes
Regulation of tumor metabolism by post translational modifications on metabolic enzymes
Metabolic reprogramming is a hallmark of cancer development, progression, and metastasis. Several metabolic pathways such ...
CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages
CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages
We have demonstrated that CDK5RAP3 exerts a tumour suppressor effect in gastric cancer, but its role in regulating tumour-...
The cross-talk of cancer-associated fibroblasts assist in prognosis and immunotherapy in patients with breast carcinoma
The cross-talk of cancer-associated fibroblasts assist in prognosis and immunotherapy in patients with breast carcinoma
The association between cancer-associated fibroblasts (CAFs) and tumor microenvironment (TME) is a key factor in promoting...
Tumor-promoting properties of karyopherin β1 in melanoma by stabilizing Ras-GTPase-activating protein SH3 domain-binding protein 1
Tumor-promoting properties of karyopherin β1 in melanoma by stabilizing Ras-GTPase-activating protein SH3 domain-binding protein 1
The nuclear import receptor karyopherin β1 (KPNB1), a member of the Karyopherin protein family, is reported to be ove...
Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling
Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling
Although androgen receptor (AR) can influence bladder cancer (BCa) initiation and progression, its impact on tumor immune ...
CYP2E1-dependent upregulation of SIRT7 is response to alcohol mediated metastasis in hepatocellular carcinoma
CYP2E1-dependent upregulation of SIRT7 is response to alcohol mediated metastasis in hepatocellular carcinoma
Long-term alcohol use is a confirmed risk factor of liver cancer tumorigenesis and metastasis. Multiple mechanisms respons...
The combination of ruxolitinib and Bcl-2/Mcl-1 inhibitors has a synergistic effect on leukemic cells carrying a SPAG9::JAK2 fusion
The combination of ruxolitinib and Bcl-2/Mcl-1 inhibitors has a synergistic effect on leukemic cells carrying a SPAG9::JAK2 fusion
JAK2 rearrangements can occur in Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL). Here, we perform...
Gastrointestinal cancer-associated fibroblasts expressing Junctional Adhesion Molecule-A are amenable to infection by oncolytic reovirus
Gastrointestinal cancer-associated fibroblasts expressing Junctional Adhesion Molecule-A are amenable to infection by oncolytic reovirus
Gastrointestinal (GI) cancers are characterized by extensive tumor stroma that both promotes tumor progression and acts as...