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Anti-angiogenesis and anti-immunosuppression gene therapy through targeting COUP-TFII in an in situ glioblastoma mouse model
Anti-angiogenesis and anti-immunosuppression gene therapy through targeting COUP-TFII in an in situ glioblastoma mouse model
Glioblastoma (GBM) is the most common and aggressive primary brain cancer; angiogenesis and immunosuppression exacerbate G...
Correction: H3.3-G34W in giant cell tumor of bone functionally aligns with the exon choice repressor hnRNPA1L2
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Correction: TRIM58 downregulation maintains stemness via MYH9-GRK3-YAP axis activation in triple-negative breast cancer stem cells
Correction: TRIM58 downregulation maintains stemness via MYH9-GRK3-YAP axis activation in triple-negative breast cancer stem cells
Author notesThese authors contributed equally: Xujun Li, Jing Jiang.Authors and AffiliationsDepartment of Oncology, Ningbo...
Extracellular vesicles from type-2 macrophages increase the survival of chronic lymphocytic leukemia cells ex vivo
Extracellular vesicles from type-2 macrophages increase the survival of chronic lymphocytic leukemia cells ex vivo
The resistance of Chronic Lymphocytic Leukemia (CLL) B-cells to cell death is mainly attributed to interactions within the...
Gut microbiota-mediated activation of GSDMD ignites colorectal tumorigenesis
Gut microbiota-mediated activation of GSDMD ignites colorectal tumorigenesis
Activation of Gasdermin D (GSDMD) results in its cleavage, oligomerization, and subsequent formation of plasma membrane po...
Lower ratio of IMPDH1 to IMPDH2 sensitizes gliomas to chemotherapy
Lower ratio of IMPDH1 to IMPDH2 sensitizes gliomas to chemotherapy
Gliomas are the most common primary tumors of the central nervous system, with approximately half of patients presenting w...
ScRNA-seq revealed the tumor microenvironment heterogeneity related to the occurrence and metastasis in upper urinary tract urothelial carcinoma
ScRNA-seq revealed the tumor microenvironment heterogeneity related to the occurrence and metastasis in upper urinary tract urothelial carcinoma
Metastasis is the greatest clinical challenge for UTUCs, which may have distinct molecular and cellular characteristics fr...
Deciphering the role of post-translational modifications in fanconi anemia proteins and their influence on tumorigenesis
Deciphering the role of post-translational modifications in fanconi anemia proteins and their influence on tumorigenesis
Fanconi anemia (FA) is an autosomal or X-linked human disease, characterized by bone marrow failure, cancer susceptibility...
Human adipose-derived stem cells genetically programmed to induce necroptosis for cancer immunotherapy
Human adipose-derived stem cells genetically programmed to induce necroptosis for cancer immunotherapy
Herein, we present human adipose-derived stem cells (ADSCs) inserted with the receptor-interacting protein kinase-3 (RIP3)...
RhoJ: an emerging biomarker and target in cancer research and treatment
RhoJ: an emerging biomarker and target in cancer research and treatment
RhoJ is a Rho GTPase that belongs to the Cdc42 subfamily and has a molecular weight of approximately 21 kDa. It can ...
Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia
Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by genomic aberrations in oncogenes, cytogenetic abn...
Retraction Note: miR-182 regulates trastuzumab resistance by targeting MET in breast cancer cells
Authors and AffiliationsDepartment of Immunology, China Medical University, Shenyang, ChinaDan YueLaboratory Medicine Depa...
Regulatory roles of N6-methyladenosine (m6A) methylation in RNA processing and non-communicable diseases
Regulatory roles of N6-methyladenosine (m6A) methylation in RNA processing and non-communicable diseases
Post-transcriptional RNA modification is an emerging epigenetic control mechanism in cells that is important in many diffe...
Integrating system biology and intratumor gene therapy by trans-complementing the appropriate co-stimulatory molecule as payload in oncolytic herpes virus
Integrating system biology and intratumor gene therapy by trans-complementing the appropriate co-stimulatory molecule as payload in oncolytic herpes virus
Systems biology has been applied at the multi-scale level within the cancer field, improving cancer prevention, diagnosis ...
Manipulating the tumour immune microenvironment by N6-methyladenosine RNA modification
Manipulating the tumour immune microenvironment by N6-methyladenosine RNA modification
N6-methyladenosine (m6A), a posttranscriptional regulatory mechanism, is the most common epigenetic modification in mammal...
H3.3-G34W in giant cell tumor of bone functionally aligns with the exon choice repressor hnRNPA1L2
H3.3-G34W in giant cell tumor of bone functionally aligns with the exon choice repressor hnRNPA1L2
RNA processing is an essential post-transcriptional phenomenon that provides the necessary complexity of transcript divers...
Unveiling mitochondrial and ribosomal gene deregulation and tumor microenvironment dynamics in acute myeloid leukemia
Unveiling mitochondrial and ribosomal gene deregulation and tumor microenvironment dynamics in acute myeloid leukemia
Acute myeloid leukemia (AML) is a malignant clonal hematopoietic disease with a poor prognosis. Understanding the interact...
CircPKN2 promotes ferroptosis in bladder cancer by promoting the ubiquitination of Stearoyl-CoA Desaturase 1
CircPKN2 promotes ferroptosis in bladder cancer by promoting the ubiquitination of Stearoyl-CoA Desaturase 1
Bladder cancer (BC) is one of the most common malignancies in the male urinary system and currently lacks an optimal treat...
Hsa_circ_0007590/PTBP1 complex reprograms glucose metabolism by reducing the stability of m6A-modified PTEN mRNA in pancreatic ductal adenocarcinoma
Hsa_circ_0007590/PTBP1 complex reprograms glucose metabolism by reducing the stability of m6A-modified PTEN mRNA in pancreatic ductal adenocarcinoma
The role of circular RNAs (circRNAs) in glucose metabolism in pancreatic duct adenocarcinoma (PDAC) remains elusive. Throu...
IGF2BP2-modified circular RNA circCHD7 promotes endometrial cancer progression via stabilizing PDGFRB and activating JAK/STAT signaling pathway
IGF2BP2-modified circular RNA circCHD7 promotes endometrial cancer progression via stabilizing PDGFRB and activating JAK/STAT signaling pathway
Circular RNAs (circRNAs) represent a class of covalently closed, single-stranded RNAs and have been linked to cancer progr...
Targeting KRASG12D mutation in non-small cell lung cancer: molecular mechanisms and therapeutic potential
Targeting KRASG12D mutation in non-small cell lung cancer: molecular mechanisms and therapeutic potential
Lung malignant tumors are a type of cancer with high incidence and mortality rates worldwide. Non-small cell lung cancer (...
Dickkopf-1 (DKK1) drives growth and metastases in castration-resistant prostate cancer
Dickkopf-1 (DKK1) drives growth and metastases in castration-resistant prostate cancer
Metastatic castration-resistant prostate cancer (mCRPC) is associated with a poor prognosis and remains an incurable fatal...
Phosphoglycerate mutase 1 promotes breast cancer progression through inducing immunosuppressive M2 macrophages
Phosphoglycerate mutase 1 promotes breast cancer progression through inducing immunosuppressive M2 macrophages
Immunosuppressive tumor microenvironment (TME) contributes to tumor progression and causes major obstacles for cancer ther...
TRIM58 downregulation maintains stemness via MYH9-GRK3-YAP axis activation in triple-negative breast cancer stem cells
TRIM58 downregulation maintains stemness via MYH9-GRK3-YAP axis activation in triple-negative breast cancer stem cells
TRIM58 is a member of the TRIM protein family, which possess with E3 ubiquitin ligase activities. Studies have revealed th...
Editorial Expression of Concern: Herpes simplex virus thymidine kinase/ganciclovir–induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells
Authors and AffiliationsICRF Molecular Oncology Unit, Imperial College School of Medicine, Hammersmith Hospital, London, W...
miR-451a was selectively sorted into exosomes and promoted the progression of esophageal squamous cell carcinoma through CAB39
miR-451a was selectively sorted into exosomes and promoted the progression of esophageal squamous cell carcinoma through CAB39
Exosomes are emerging mediators of cell-cell communication, which are secreted from cells and may be delivered into recipi...
Mesenchymal stem cells as therapeutic vehicles for glioma
Mesenchymal stem cells as therapeutic vehicles for glioma
Glioma is a disease with a poor prognosis despite the availability of multimodality treatments, and the development of nov...
Cleavage and polyadenylation machinery as a novel targetable vulnerability for human cancer
Cleavage and polyadenylation machinery as a novel targetable vulnerability for human cancer
The role of alternative polyadenylation of mRNA in sustaining aggressive features of tumors is quite well established, as ...
Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression
Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression
Novel therapeutic strategies are urgently required for osteosarcoma, given the early age at onset and persistently high mo...
CRISPR-Cas gene knockouts to optimize engineered T cells for cancer immunotherapy
CRISPR-Cas gene knockouts to optimize engineered T cells for cancer immunotherapy
While CAR-T and tgTCR-T therapies have exhibited noteworthy and promising outcomes in hematologic and solid tumors respect...
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