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Hippo pathway in non-small cell lung cancer: mechanisms, potential targets, and biomarkers
Hippo pathway in non-small cell lung cancer: mechanisms, potential targets, and biomarkers
Lung cancer is the primary contributor to cancer-related deaths globally, and non-small cell lung cancer (NSCLC) constitut...
Heterogeneity of hepatocellular carcinoma: from mechanisms to clinical implications
Heterogeneity of hepatocellular carcinoma: from mechanisms to clinical implications
Hepatocellular Carcinoma (HCC) is one of the most common types of primary liver cancer. Current treatment options have lim...
Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT
Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT
Androgen receptor (AR) splice variant 7 (AR-V7) is capable to enter nucleus and activate downstream signaling without liga...
MISEV2023: Shaping the Future of EV Research by Enhancing Rigour, Reproducibility and Transparency
Extracellular vesicles (EVs) are an area of growing interest due to their strong potential as biomark...
The pleiotropic nature of NONO, a master regulator of essential biological pathways in cancers
The pleiotropic nature of NONO, a master regulator of essential biological pathways in cancers
NONO is a member of the Drosophila behavior/human splicing (DBHS) family of proteins. NONO is a multifunctional protein th...
Romidepsin exhibits anti-esophageal squamous cell carcinoma activity through the DDIT4-mTORC1 pathway
Romidepsin exhibits anti-esophageal squamous cell carcinoma activity through the DDIT4-mTORC1 pathway
Esophageal squamous cell carcinoma (ESCC) is one of the most common human malignancies worldwide and is associated with hi...
Heparanase interacting BCLAF1 to promote the development and drug resistance of ICC through the PERK/eIF2α pathway
Heparanase interacting BCLAF1 to promote the development and drug resistance of ICC through the PERK/eIF2α pathway
Intrahepatic cholangiocarcinoma (ICC) is a primary epithelial carcinoma known for its aggressive nature, high metastatic p...
Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy
Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy
Use of immune checkpoint inhibitors (ICIs) as cancer immunotherapy has advanced rapidly in the clinic. We recently reporte...
Identification of EGR4 as a prospective target for inhibiting tumor cell proliferation and a novel biomarker in colorectal cancer
Identification of EGR4 as a prospective target for inhibiting tumor cell proliferation and a novel biomarker in colorectal cancer
EGR4 (Early Growth Response 4) is a member of the EGR family, involving in tumorigenesis. However, the function and action...
CAR T therapies in multiple myeloma: unleashing the future
CAR T therapies in multiple myeloma: unleashing the future
In recent years, the field of cancer treatment has witnessed remarkable breakthroughs that have revolutionized the landsca...
Single-cell atlas reveals the immunosuppressive microenvironment and Treg cells landscapes in recurrent Glioblastoma
Single-cell atlas reveals the immunosuppressive microenvironment and Treg cells landscapes in recurrent Glioblastoma
Patients diagnosed with glioblastoma (GBM) have the most aggressive tumor progression and lethal recurrence. Research on t...
Genetic mutation patterns among glioblastoma patients in the Taiwanese population – insights from a single institution retrospective study
Genetic mutation patterns among glioblastoma patients in the Taiwanese population – insights from a single institution retrospective study
This study utilized Next-Generation Sequencing (NGS) to explore genetic determinants of survival duration in Glioblastoma ...
Dual-inhibition of NAMPT and PAK4 induces anti-tumor effects in 3D-spheroids model of platinum-resistant ovarian cancer
Dual-inhibition of NAMPT and PAK4 induces anti-tumor effects in 3D-spheroids model of platinum-resistant ovarian cancer
Ovarian cancer follows a characteristic progression pattern, forming multiple tumor masses enriched with cancer stem cells...
A guardian turned rogue: TP53 promoter translocations rewire stress responses to oncogenic effectors in osteosarcoma
A guardian turned rogue: TP53 promoter translocations rewire stress responses to oncogenic effectors in osteosarcoma
Osteosarcoma is the most prevalent malignant bone tumour in children, adolescents and young adults. Despite a multitude of...
Recent progress of CDK4/6 inhibitors’ current practice in breast cancer
Recent progress of CDK4/6 inhibitors’ current practice in breast cancer
Dysregulated cellular proliferation represents a hallmark feature across all cancers. Aberrant activation of the cyclin-de...
Transactivation of Met signaling by oncogenic Gnaq drives the evolution of melanoma in Hgf-Cdk4 mice
Transactivation of Met signaling by oncogenic Gnaq drives the evolution of melanoma in Hgf-Cdk4 mice
Recent pan-cancer genomic analyses have identified numerous oncogenic driver mutations that occur in a cell-type and tissu...
Cancer-associated fibroblast exosomes promote prostate cancer metastasis through miR-500a-3p/FBXW7/HSF1 axis under hypoxic microenvironment
Cancer-associated fibroblast exosomes promote prostate cancer metastasis through miR-500a-3p/FBXW7/HSF1 axis under hypoxic microenvironment
Metastasis is the main cause of deaths in prostate cancer (PCa). However, the exact mechanisms underlying PCa metastasis a...
Emerging role of RNA modification and long noncoding RNA interaction in cancer
Emerging role of RNA modification and long noncoding RNA interaction in cancer
RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the...
Modification of the tumor microenvironment enhances immunity with plasmid gene therapy
Modification of the tumor microenvironment enhances immunity with plasmid gene therapy
Local intratumor delivery with electroporation of low levels of plasmids encoding molecules, induces an antitumor effect w...
Detection of (pre)cancerous colorectal lesions in Lynch syndrome patients by microsatellite instability liquid biopsy
Detection of (pre)cancerous colorectal lesions in Lynch syndrome patients by microsatellite instability liquid biopsy
Lynch syndrome (LS) is an inherited condition characterized by an increased risk of developing cancer, in particular color...
Divergent transcriptomic signatures from putative mesenchymal stimuli in glioblastoma cells
Divergent transcriptomic signatures from putative mesenchymal stimuli in glioblastoma cells
In glioblastoma, a mesenchymal phenotype is associated with especially poor patient outcomes. Various glioblastoma microen...
Roles of circRNAs in the progression of colorectal cancer: novel strategies for detection and therapy
Roles of circRNAs in the progression of colorectal cancer: novel strategies for detection and therapy
Endogenous noncoding RNAs with a covalently closed loop are known as circular RNAs (circRNAs). Recently, published works h...
Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer
Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer
Thyroid cancer is a prevalent endocrine malignancy with increasing incidence in recent years. Although most thyroid cancer...
Role of MARK2 in the nervous system and cancer
Role of MARK2 in the nervous system and cancer
Microtubule-Affinity Regulating Kinase 2 (MARK2), a member of the serine/threonine protein kinase family, phosphorylates m...
Schwann cell derived pleiotrophin stimulates fibroblast for proliferation and excessive collagen deposition in plexiform neurofibroma
Schwann cell derived pleiotrophin stimulates fibroblast for proliferation and excessive collagen deposition in plexiform neurofibroma
Neurofibromatosis type 1 associated plexiform neurofibroma (pNF) is characterized by abundant fibroblasts and dense collag...