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Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis
Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis
Papillary thyroid microcarcinoma (PTMC), although frequently indolent, could be aggressive in a few patients, leading to l...
CEACAM6 facilitates gastric cancer progression through upregulating SLC27A2
CEACAM6 facilitates gastric cancer progression through upregulating SLC27A2
Gastric cancer (GC) is one of the most lethal cancers. However, the underlying mechanisms are not yet fully understood. He...
Ammonia death: a novel potential strategy to augment immunotherapy in cancer
Ammonia death: a novel potential strategy to augment immunotherapy in cancer
The efficacy of immunotherapy is diminished by the low survival rate of effector CD8 + T cells after they have...
BAIAP2L2 promotes the malignancy of hepatocellular carcinoma via GABPB1-mediated reactive oxygen species imbalance
BAIAP2L2 promotes the malignancy of hepatocellular carcinoma via GABPB1-mediated reactive oxygen species imbalance
Hepatocellular carcinoma (HCC) is a common type of cancer worldwide and ranks as the fourth leading cause of cancer-relate...
Role of non-coding RNA in lineage plasticity of prostate cancer
Role of non-coding RNA in lineage plasticity of prostate cancer
The treatment of prostate cancer (PCa) has made great progress in recent years, but treatment resistance always develops a...
Novel pharmacologic inhibition of lysine-specific demethylase 1 as a potential therapeutic for glioblastoma
Novel pharmacologic inhibition of lysine-specific demethylase 1 as a potential therapeutic for glioblastoma
Lysine-specific demethylase 1 (LSD1/KDM1A) is a pivotal epigenetic enzyme that contributes to several malignancies includi...
Overexpression of Pin1 regulated by TOP2A, which subsequently stabilizes Pyk2 to promote bortezomib resistance in multiple myeloma
Overexpression of Pin1 regulated by TOP2A, which subsequently stabilizes Pyk2 to promote bortezomib resistance in multiple myeloma
Multiple myeloma (MM), a hematological malignancy of plasma cells, has remained largely incurable owing to drug resistance...
Baicalein inhibits cell proliferation and induces apoptosis in brain glioma cells by downregulating the LGR4-EGFR pathway
Baicalein inhibits cell proliferation and induces apoptosis in brain glioma cells by downregulating the LGR4-EGFR pathway
Patients diagnosed with brain glioma have a poor prognosis and limited therapeutic options. LGR4 is overexpressed in brain...
Correction: Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα–JNK pathway
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 ...
SEMA7A-mediated juxtacrine stimulation of IGFBP-3 upregulates IL-17RB at pancreatic cancer invasive front
SEMA7A-mediated juxtacrine stimulation of IGFBP-3 upregulates IL-17RB at pancreatic cancer invasive front
Tumor invasion is the hallmark of tumor malignancy. The invasive infiltration pattern of tumor cells located at the leadin...
Intraperitoneal administration of adeno-associated virus encoding microRNA-29b for the treatment of peritoneal metastasis
Intraperitoneal administration of adeno-associated virus encoding microRNA-29b for the treatment of peritoneal metastasis
This study explores a novel therapeutic approach for peritoneal metastasis (PM) using AAV-mediated delivery of tumor suppr...
γ-Glutamylcyclotransferase is transcriptionally regulated by c-Jun and controls proliferation of glioblastoma stem cells through Notch1 levels
γ-Glutamylcyclotransferase is transcriptionally regulated by c-Jun and controls proliferation of glioblastoma stem cells through Notch1 levels
Glioblastoma stem cells (GSCs) have been reported to cause poor prognosis of glioblastoma by contributing to therapy resis...
AMIGO2 enhances the invasive potential of colorectal cancer by inducing EMT
AMIGO2 enhances the invasive potential of colorectal cancer by inducing EMT
In our previous studies, we identified amphoterin-inducible gene and open reading frame 2 (AMIGO2) as a driver gene for li...
Systemic delivery of tannic acid-ferric-masked oncolytic adenovirus reprograms tumor microenvironment for improved therapeutic efficacy in glioblastoma
Systemic delivery of tannic acid-ferric-masked oncolytic adenovirus reprograms tumor microenvironment for improved therapeutic efficacy in glioblastoma
Glioblastoma (GBM) represents the most aggressive primary brain tumor, and urgently requires effective treatments. Oncolyt...
AAV-mediated combination gene therapy of inducible Caspase 9 and miR-199a-5p is therapeutic in hepatocellular carcinoma
AAV-mediated combination gene therapy of inducible Caspase 9 and miR-199a-5p is therapeutic in hepatocellular carcinoma
Advanced-stage hepatocellular carcinoma (HCC) remains an untreatable disease with an overall survival of less than one yea...
PARD6A promotes lung adenocarcinoma cell proliferation and invasion through Serpina3
PARD6A promotes lung adenocarcinoma cell proliferation and invasion through Serpina3
Par6α encoded by PARD6A is a member of the PAR6 family and is reported to promote cancer initiation and progression. ...
Correction: PARD6A promotes lung adenocarcinoma cell proliferation and invasion through Serpina3
These authors contributed equally: Lanlin Hu, Mingxin Liu, Bo Tang.These authors jointly supervised this work: Sijia Liu, ...
Targeting CREB-binding protein (CBP) abrogates colorectal cancer stemness through epigenetic regulation of C-MYC
Targeting CREB-binding protein (CBP) abrogates colorectal cancer stemness through epigenetic regulation of C-MYC
Colorectal cancer (CRC) is a common cancer worldwide with an increasing annual incidence. Cancer stem cells (CSCs) play im...
Microbiota in tumors: new factor influencing cancer development
Microbiota in tumors: new factor influencing cancer development
Tumor microbiota research is a new field in oncology. With the advancement of high-throughput sequencing, there is growing...
Multifaceted role of microRNA-301a in human cancer: from biomarker potential to therapeutic targeting
Multifaceted role of microRNA-301a in human cancer: from biomarker potential to therapeutic targeting
With the growing data on microRNA (miRNA) expression in tissues and circulation, there is increasing evidence for the pote...
Emerging roles of bases modifications and DNA repair proteins in onco-miRNA processing: novel insights in cancer biology
Emerging roles of bases modifications and DNA repair proteins in onco-miRNA processing: novel insights in cancer biology
Onco-microRNAs (onco-miRNAs) are essential players in the post-transcriptional regulation of gene expression and exert a c...
BAG2, MAD2L1, and MDK are cancer-driver genes and candidate targets for novel therapies in malignant pleural mesothelioma
BAG2, MAD2L1, and MDK are cancer-driver genes and candidate targets for novel therapies in malignant pleural mesothelioma
Malignant pleural mesothelioma (MPM) is an aggressive cancer with a poor prognosis and the identification of novel druggab...
PRAD6A promotes lung adenocarcinoma cell proliferation and invasion through Serpina3
PRAD6A promotes lung adenocarcinoma cell proliferation and invasion through Serpina3
Par6α encoded by PARD6A is a member of the PAR6 family and is reported to promote cancer initiation and progression. ...
Extracellular vesicle-based anti-HOXB7 CD8+ T cell-specific vaccination strengthens antitumor effects induced by vaccination against Her2/neu
Extracellular vesicle-based anti-HOXB7 CD8+ T cell-specific vaccination strengthens antitumor effects induced by vaccination against Her2/neu
We previously developed an innovative strategy to induce CD8+ T lymphocyte-immunity through in vivo engineering of extrace...
Chronic stress promotes non-small cell lung cancer (NSCLC) progression through circMBOAT2 upregulation mediated by CTCF
Chronic stress promotes non-small cell lung cancer (NSCLC) progression through circMBOAT2 upregulation mediated by CTCF
Circular RNA (circRNA) has been demonstrated to play a pivotal role in tumor development. This study aimed to investigate ...
HN1-mediated activation of lipogenesis through Akt-SREBP signaling promotes hepatocellular carcinoma cell proliferation and metastasis
HN1-mediated activation of lipogenesis through Akt-SREBP signaling promotes hepatocellular carcinoma cell proliferation and metastasis
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide, with more than 800,000 deat...
Caveolin-1 knockout mitigates breast cancer metastasis to the lungs via integrin α3 dysregulation in 4T1-induced syngeneic breast cancer model
Caveolin-1 knockout mitigates breast cancer metastasis to the lungs via integrin α3 dysregulation in 4T1-induced syngeneic breast cancer model
Caveolin-1 (Cav-1) is a critical lipid raft protein playing dual roles as both a tumor suppressor and promoter. While its ...
The Exon Junction Complex component EIF4A3 plays a splicing-linked oncogenic role in pancreatic ductal adenocarcinoma
The Exon Junction Complex component EIF4A3 plays a splicing-linked oncogenic role in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, underscoring the urgent need for in-depth biolo...
NF-κB-activated oncogene inhibition strategy for cancer gene therapy
NF-κB-activated oncogene inhibition strategy for cancer gene therapy
NF-κB is a promising target for cancer treatment because of its overactivation in almost all cancers but countless NF...
ZNF460-mediated upregulation of APCDD1L-DT promotes cholangiocarcinoma development by inhibiting the ubiquitin-mediated degradation of DVL2
ZNF460-mediated upregulation of APCDD1L-DT promotes cholangiocarcinoma development by inhibiting the ubiquitin-mediated degradation of DVL2
Cholangiocarcinoma (CCA), known for its aggressive nature, poses a formidable challenge in the current medical landscape, ...
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