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Immunohistochemical analysis of 147 cases of low-grade endometrial stromal sarcoma: refining the immunohistochemical profile of LG-ESS on a large, molecularly confirmed series
Immunohistochemical analysis of 147 cases of low-grade endometrial stromal sarcoma: refining the immunohistochemical profile of LG-ESS on a large, molecularly confirmed series
Low-grade endometrial stromal sarcoma (LG-ESS) can present diagnostic challenges, due to its overlapping morphological fea...
Atypical and worrisome histological features in pleomorphic adenoma: challenging and potentially significant diagnostic pitfall
Atypical and worrisome histological features in pleomorphic adenoma: challenging and potentially significant diagnostic pitfall
Pleomorphic adenoma (PA), the most prevalent salivary gland tumor, exhibits a diverse histological spectrum characterized ...
Congenital melanocytic neoplasms: clinical, histopathological and recent molecular developments
Congenital melanocytic neoplasms: clinical, histopathological and recent molecular developments
Salgado CM, Reyes-Múgica M, Adameyko I, Etchevers HC, Singh R (2022) Congenital naevi. In: WHO Classification of Tumours E...
Tumor-infiltrating plasma cells are a prognostic factor in penile squamous cell carcinoma
Tumor-infiltrating plasma cells are a prognostic factor in penile squamous cell carcinoma
Penile cancer (PeCa) is a rare disease with poor prognosis in the metastatic stage. Neither effective adjuvant nor palliat...
Updates on Langerhans cell histiocytosis and other histiocytosis in children: invited review—challenges and novelties in paediatric tumours
Updates on Langerhans cell histiocytosis and other histiocytosis in children: invited review—challenges and novelties in paediatric tumours
Langerhans cell histiocytosis (LCH), juvenile xanthogranuloma (JXG) family lesions, and Rosai-Dorfman-Destombes disease (R...
Paediatric renal tumours: an update on challenges and recent developments
Paediatric renal tumours: an update on challenges and recent developments
Paediatric renal tumours include a broad range of neoplasms which largely differ, but also overlap to a smaller extent, wi...
Germ cell tumors in children
Germ cell tumors in children
Pediatric germ cell tumors represent a rare but biologically diverse group of neoplasms arising from pluripotent primordia...
Obstacles and drivers in the adoption of Standardized Structured Reporting (SSR): insights from pathologists
Obstacles and drivers in the adoption of Standardized Structured Reporting (SSR): insights from pathologists
The adoption of Standardized Structured Reporting (SSR) in pathology offers significant potential to improve data consiste...
YAP1::TFE3 fusion in a case of malignant TFE3-rearranged PEComa of the lung: expanding the spectrum of pulmonary PEComa-like mesenchymal neoplasms
YAP1::TFE3 fusion in a case of malignant TFE3-rearranged PEComa of the lung: expanding the spectrum of pulmonary PEComa-like mesenchymal neoplasms
The family of PEComa encompasses a heterogeneous group of related mesenchymal neoplasms with myomelanocytic differentiatio...
Cystic masses of the pediatric lung: update on congenital pulmonary airway malformation and its differential diagnosis
Cystic masses of the pediatric lung: update on congenital pulmonary airway malformation and its differential diagnosis
Localized cystic lung lesions in pediatric patients encompass a spectrum of benign and rare malignant conditions that are ...
EGFR status assessment using reflex testing targeted next-generation sequencing for resected non-squamous non-small cell lung cancer
EGFR status assessment using reflex testing targeted next-generation sequencing for resected non-squamous non-small cell lung cancer
EGFR status assessment is mandatory for adjuvant decision-making of resected stage IB-IIIA non-squamous non-small cell lun...
S100-positive stroma in salivary gland basal cell adenomas: a neoplastic component with CTNNB1 mutations
S100-positive stroma in salivary gland basal cell adenomas: a neoplastic component with CTNNB1 mutations
Basal cell adenomas (BCAs) are benign epithelial tumors of the salivary gland, characterized by the proliferation of basal...
Prostatic amyloidosis: pathological features of an underdiagnosed condition
Prostatic amyloidosis: pathological features of an underdiagnosed condition
Amyloidosis is a rare disease that can affect genitourinary organs but the involvement of the prostate has been documented...
Pediatric lymphomas: overview and diagnostic challenges
Pediatric lymphomas: overview and diagnostic challenges
Only 10% of new lymphoma diagnoses in the USA occur in children < 15 years. Although the same ...
Rhabdomyosarcoma in children and young adults
Rhabdomyosarcoma in children and young adults
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood, accounting for 3% of all pediatric malignan...
Prognosis and tumor microenvironment in pseudohypoxic pheochromocytoma/paraganglioma
Prognosis and tumor microenvironment in pseudohypoxic pheochromocytoma/paraganglioma
Pheochromocytoma and paraganglioma (PPGL) are rare tumors that occur in the adrenal medulla and extra-adrenal tissues, res...
Aggressive renal cell carcinoma with somatic BRCA2 mutation—an emerging entity? A case report with literature review
Aggressive renal cell carcinoma with somatic BRCA2 mutation—an emerging entity? A case report with literature review
Role of BRCA2 gene mutation in renal tumorigenesis remains largely unclear. There are only two case reports of renal cell ...
GLI1::FOXO4-rearranged kidney tumors: a potentially distinct renal subtype within the spectrum of GLI1-altered tumors?
GLI1::FOXO4-rearranged kidney tumors: a potentially distinct renal subtype within the spectrum of GLI1-altered tumors?
Pathogenic alterations, namely, fusions and amplifications, of the GLI1 gene have been identified in various mesenchymal t...
Primary cutaneous rhabdomyosarcoma with EWSR1/FUS::TFCP2 fusion: four new cases with distinctive morphology, immunophenotypic, and genetic profile
Primary cutaneous rhabdomyosarcoma with EWSR1/FUS::TFCP2 fusion: four new cases with distinctive morphology, immunophenotypic, and genetic profile
EWSR1/FUS::TFCP2-rearranged rhabdomyosarcoma (RMS) is a rare tumor with an aggressive clinical course, a predilection for ...
Interstitial lipoid pneumonia—A complication of intravenous administration of lipid emulsions in critically ill patients
Interstitial lipoid pneumonia—A complication of intravenous administration of lipid emulsions in critically ill patients
Lipoid pneumonia is a rare entity most often associated with inhalation of foreign material (i.e. “fire-eater’...
Julius Hirschberg und die Geschichte der Augenheilkunde
Julius Hirschberg und die Geschichte der Augenheilkunde
Die Werke von Julius Hirschberg (1843–1925), insbesondere seine „Geschichte der Augenheilkunde“ sind bis...
Next-generation sequencing in the molecular classification of endometrial carcinomas: Experience with 270 cases suggesting a potentially more aggressive clinical behavior of multiple classifier endometrial carcinomas
Next-generation sequencing in the molecular classification of endometrial carcinomas: Experience with 270 cases suggesting a potentially more aggressive clinical behavior of multiple classifier endometrial carcinomas
Molecular classification of endometrial carcinomas (EC) divides these neoplasms into four distinct subgroups based on thei...
Diagnostic relevance of p53 and Rb status in neuroendocrine tumors G3 from different organs: an immunohistochemical study of 465 high-grade neuroendocrine neoplasms
Diagnostic relevance of p53 and Rb status in neuroendocrine tumors G3 from different organs: an immunohistochemical study of 465 high-grade neuroendocrine neoplasms
The double inactivation of TP53 and RB1 is considered typical of neuroendocrine carcinomas (NECs) but is assumed to be rar...
ERBB2/ERBB3-mutated S100/SOX10-positive uterine sarcoma: something new
ERBB2/ERBB3-mutated S100/SOX10-positive uterine sarcoma: something new
A distinctive subset of uterine mesenchymal tumors display recurrent genetic fusions involving receptor tyrosine kinases, ...
High interobserver variability of PTEN immunohistochemistry defining PTEN status in low- to intermediate-risk prostate cancer: results of the first German ring trial
High interobserver variability of PTEN immunohistochemistry defining PTEN status in low- to intermediate-risk prostate cancer: results of the first German ring trial
The prognostication of individual disease trajectory and selection of optimal therapy in patients with localized, low-grad...
Polarised light scanner for digital pathology
Polarised light scanner for digital pathology
Digital pathology is rapidly transforming diagnostic pathology by allowing remote work and integration of artificial intel...
Malignant epithelioid tumors with EWSR1::CREB fusion involving the kidney: a report of two cases
Malignant epithelioid tumors with EWSR1::CREB fusion involving the kidney: a report of two cases
Soft tissue tumors with EWSR1/FUS fusion to genes encoding the cyclic adenosine monophosphate response element-binding (CR...
Reappraisal of soft tissue myoepithelial tumors by DNA methylation profiling reveals an epigenetically distinct group of mostly fusion-driven neoplasms
Reappraisal of soft tissue myoepithelial tumors by DNA methylation profiling reveals an epigenetically distinct group of mostly fusion-driven neoplasms
Soft tissue myoepithelial tumors (METs) are diagnostically challenging tumors that require careful histologic and immunohi...
Tenosynovitis with psammomatous calcifications: Series of 18 cases and review of the literature emphasizing a common source of expert consultation and updated differential diagnosis
Tenosynovitis with psammomatous calcifications: Series of 18 cases and review of the literature emphasizing a common source of expert consultation and updated differential diagnosis
Tenosynovitis with psammomatous calcifications (TPC) is a rare, benign condition currently regarded as a pseudotumor possi...
YAP1::KMT2A-rearranged sarcomas harbor a unique methylation profile and are distinct from sclerosing epithelioid fibrosarcoma and low-grade fibromyxoid sarcoma
YAP1::KMT2A-rearranged sarcomas harbor a unique methylation profile and are distinct from sclerosing epithelioid fibrosarcoma and low-grade fibromyxoid sarcoma
Sclerosing epithelioid fibrosarcoma (SEF) was originally described as a peculiar variant of fibrosarcoma in 1995. Subseque...
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