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What is new in fibroblastic/myofibroblastic tumors in children
What is new in fibroblastic/myofibroblastic tumors in children
Fibroblastic and myofibroblastic neoplasms represent about 12% of pediatric soft tissue tumors. Most of these neoplasms in...
Sensitive and reliable detection of KIT p.D816V mutation in decalcified archival bone marrow trephines
Sensitive and reliable detection of KIT p.D816V mutation in decalcified archival bone marrow trephines
The majority of mastocytosis cases are characterized by an activating mutation in the KIT gene in codon 816. The detection...
Sclerosing mucoepidermoid carcinoma of salivary glands
Sclerosing mucoepidermoid carcinoma of salivary glands
Sclerosing mucoepidermoid carcinoma (SMEC) of the salivary glands is a rare variant of low-grade mucoepidermoid carcinoma ...
Primary osseous tumors of the orbit
Primary osseous tumors of the orbit
This review article focuses on the various primary osseous tumors of the orbit. Due to overlapping clinical, radiologic, a...
A clinicopathological and molecular series of five TFEB-altered renal cell carcinoma (RCC) cases: highlighting an aggressive subset of TFEB-rearranged RCC concomitant with TFEB amplification/gene copy number gains
A clinicopathological and molecular series of five TFEB-altered renal cell carcinoma (RCC) cases: highlighting an aggressive subset of TFEB-rearranged RCC concomitant with TFEB amplification/gene copy number gains
The classification of TFEB-altered renal cell carcinoma (RCC) has been revised to include TFEB-rearranged RCC and TFEB-amp...
Comparison of ante- and postmortem ventricular wall thickness using echocardiography and autopsy findings
Comparison of ante- and postmortem ventricular wall thickness using echocardiography and autopsy findings
In autopsy practice, the thickness of ventricular walls is one of the parameters used to identify cardiac hypertrophy. The...
Determination of Ki-67 indices in neuroendocrine tumours of the gastrointestinal tract: the past, the present, and the future
Determination of Ki-67 indices in neuroendocrine tumours of the gastrointestinal tract: the past, the present, and the future
Ki-67 index (Ki-67i) is integral to the grading of many tumours. There remains considerable variability across pathologist...
Multifocal vascular neoplasm with an EWSR1::NFATC2 gene fusion and progression to epithelioid angiosarcoma – a case report
Multifocal vascular neoplasm with an EWSR1::NFATC2 gene fusion and progression to epithelioid angiosarcoma – a case report
The study was approved by the Institutional Review Board (ID 8/21). A written permission to publ...
Chapter 13: What is new in fibroblastic/myofibroblastic tumors in children
Chapter 13: What is new in fibroblastic/myofibroblastic tumors in children
Fibroblastic and myofibroblastic neoplasms represent about 12% of pediatric soft tissue tumors. Most of these neoplasms in...
Spitz tumours and mimickers
Spitz tumours and mimickers
Since their initial description in 1948, Spitz tumours have always been a challenge in the field of dermatopathology and p...
Bronchial salivary gland-type mucinous adenocarcinoma harboring a GNAS mutation: a novel lung cancer entity? A case report
Bronchial salivary gland-type mucinous adenocarcinoma harboring a GNAS mutation: a novel lung cancer entity? A case report
The morphology of the current case was reminiscent of pancreatic IPMN with associated colloid carcinoma. Meanwhile, a GNAS...
Digital spatial profiling for pathologists
Digital spatial profiling for pathologists
The advent of “omics” technologies for high-depth tumor profiling has provided new information regarding cance...
Gastric-like (pseudopyloric and pseudofoveolar) metaplasia and Paneth cell hyperplasia—neglected histological features of chronic ileal inflammation
Gastric-like (pseudopyloric and pseudofoveolar) metaplasia and Paneth cell hyperplasia—neglected histological features of chronic ileal inflammation
Architectural distortion and basal plasmacytosis are the most widely recognized histologic features of chronic ileal infla...
The challenge of diagnosing neuroendocrine neoplasms: experience from a national reference center
The challenge of diagnosing neuroendocrine neoplasms: experience from a national reference center
Correctly diagnosing neuroendocrine neoplasm (NEN) has become increasingly challenging, given that more histomorphologic a...
Exploratory evidence maps for the WHO Classification of Tumours 5th edition for lung and thymus tumors
Exploratory evidence maps for the WHO Classification of Tumours 5th edition for lung and thymus tumors
The WHO Classification of Tumours (WCT) guides cancer diagnosis, treatment, and research. However, research evidence in pa...
Integrating single cell and bulk RNA sequencing data identifies RBM17 as a novel response biomarker for immunotherapy in bladder cancer
Integrating single cell and bulk RNA sequencing data identifies RBM17 as a novel response biomarker for immunotherapy in bladder cancer
Checkpoint inhibitors (CPIs) have been widely applied in the treatment of patients with bladder cancer (BLCA). However, th...
Primary central nervous system diffuse large B-cell lymphoma with MYC and BCL2 rearrangements associated with deep brain stimulation device
Primary central nervous system diffuse large B-cell lymphoma with MYC and BCL2 rearrangements associated with deep brain stimulation device
Author notesKirill A. Lyapichev and Sri Bharathi Kavuri contributed equally to this work.Authors and AffiliationsDepartmen...
Cyclin-D1 rearrangement as a secondary event in the large cell transformation of splenic marginal zone lymphoma with a TP53 deletion
Cyclin-D1 rearrangement as a secondary event in the large cell transformation of splenic marginal zone lymphoma with a TP53 deletion
IGH::CCND1 translocation has been implicated as a preliminary finding in mantle cell lymphoma (MCL) and plasma cell myelom...
Pseudomyogenic hemangioendothelioma presenting as a penile lesion
Pseudomyogenic hemangioendothelioma presenting as a penile lesion
Pseudomyogenic hemangioendothelioma (PHE) is a rare, usually multifocal neoplasm typically affecting individuals in the se...
Combined immunohistochemical profile CD10/LMO2/MYC is a useful tool to screen MYC rearrangements in aggressive large B-cell lymphomas
Combined immunohistochemical profile CD10/LMO2/MYC is a useful tool to screen MYC rearrangements in aggressive large B-cell lymphomas
Aggressive large B-cell lymphomas (LBCL) are a heterogeneous group of lymphomas with variable biological characteristics, ...
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): what do we need to know?
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): what do we need to know?
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a recently defined thyroid nodule...
Malignant epithelioid neoplasm with GLI1 gene rearrangement (PANX3::GLI1 transcript) and MDM2 gene amplification
Malignant epithelioid neoplasm with GLI1 gene rearrangement (PANX3::GLI1 transcript) and MDM2 gene amplification
We hereby report the case of an epithelioid neoplasm arising from pterygopalatine fossa in a 13-year-old child harboring P...
Apocrine variant of intraductal carcinoma of the parotid gland with sebaceous-like differentiation: expanding morphological and molecular spectrum of an enigmatic entity
Apocrine variant of intraductal carcinoma of the parotid gland with sebaceous-like differentiation: expanding morphological and molecular spectrum of an enigmatic entity
Delgado R, Klimstra D (1996) Albores-Saavedra J. Low grade salivary duct carcinoma. A distinctive variant with a low grade...
Relationships between tumor CD147 expression, tumor-infiltrating lymphocytes, and oncostatin M in hepatocellular carcinoma
Relationships between tumor CD147 expression, tumor-infiltrating lymphocytes, and oncostatin M in hepatocellular carcinoma
In hepatocellular carcinoma (HCC), CD147 expression contributes to tumor malignancy; however, its relationship with the tu...
FGFR3::TACC3 fusions in head and neck carcinomas: a study of nine cases highlighting phenotypic heterogeneity, frequent HPV association, and a morphologically distinct subset in favor of a putative entity
FGFR3::TACC3 fusions in head and neck carcinomas: a study of nine cases highlighting phenotypic heterogeneity, frequent HPV association, and a morphologically distinct subset in favor of a putative entity
The FGFR3::TACC3 fusion has been reported in subsets of diverse cancers including urothelial and squamous cell carcinomas ...
S100 and CD34 positive spindle cell tumors of the uterine cervix with EGFR mutation: a hitherto unrecognized neoplasm phenotypically and epigenetically overlapping with “NTRK-rearranged spindle cell neoplasms” of the uterus
S100 and CD34 positive spindle cell tumors of the uterine cervix with EGFR mutation: a hitherto unrecognized neoplasm phenotypically and epigenetically overlapping with “NTRK-rearranged spindle cell neoplasms” of the uterus
NTRK-rearranged spindle cell neoplasm represents an emerging entity included in the latest 5th edition of WHO classificati...
Tumor budding in pre-neoadjuvant biopsy and post-neoadjuvant resection specimens is associated with poor prognosis in intrahepatic cholangiocarcinoma—a cohort study of 147 cases by modified ITBCC criteria
Tumor budding in pre-neoadjuvant biopsy and post-neoadjuvant resection specimens is associated with poor prognosis in intrahepatic cholangiocarcinoma—a cohort study of 147 cases by modified ITBCC criteria
Tumor budding (TB) has been associated with poor survival in a variety of cancers including intrahepatic cholangiocarcinom...
Diagnostic utility of ESR1 mutation detection in liquid biopsy of metastatic breast cancer patients
Diagnostic utility of ESR1 mutation detection in liquid biopsy of metastatic breast cancer patients
Molecular analysis of circulating cell-free DNA (cfDNA) extracted from peripheral blood plasma samples of metastatic breas...
Uterine mesenchymal tumours harboring the KAT6B/A::KANSL1 gene fusion represent a distinct type of uterine sarcoma based on DNA methylation profiles
Uterine mesenchymal tumours harboring the KAT6B/A::KANSL1 gene fusion represent a distinct type of uterine sarcoma based on DNA methylation profiles
Uterine mesenchymal tumours harboring KAT6B/A::KANSL1 gene fusions typically exhibit histological and immunophenotypic ove...
Pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma: additional evidence to support they are a single disease with variation in the histologic spectrum
Pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma: additional evidence to support they are a single disease with variation in the histologic spectrum
Pediatric-type follicular lymphoma (PTFL) and pediatric nodal marginal zone lymphoma (PNMZL) are two rare indolent B-cell ...
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