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Cryo-electron ptychography: Applications and potential in biological characterisation
Cryo-electron ptychography: Applications and potential in biological characterisation
There is a clear need for developments in characterisation techniques that provide detailed information about structure–fu...
Automated pipelines for rapid evaluation during cryoEM data acquisition
Automated pipelines for rapid evaluation during cryoEM data acquisition
In recent years, cryo-electron microscopy (cryoEM), especially single particle analysis, has experienced an increase in po...
Protein disaggregation machineries in the human cytosol
Protein disaggregation machineries in the human cytosol
The process of folding is a seminal event in the life of a protein, converting a newly synthesized polypeptide into the fu...
Artificial intelligence-driven antimicrobial peptide discovery
Artificial intelligence-driven antimicrobial peptide discovery
Antimicrobial resistance, fueled by antibiotic overuse that drives the emergence of resistant strains, is recognized as a ...
Mechanical forces and the 3D genome
Mechanical forces and the 3D genome
Cells routinely integrate mechanical (stretch, compression, or shear) and biochemical signals (cytokines and growth factor...
3D genome organization and beyond!
3D genome organization and beyond!
Geneviève Almouzni, director of research at the CNRS (France), former director of the Research Center of Institut Curie (2...
B12-dependent radical SAM enzymes: Ever expanding structural and mechanistic diversity
B12-dependent radical SAM enzymes: Ever expanding structural and mechanistic diversity
With more than 600,000 proteins included in its current release, the radical S-adenosyl-l-methionine (SAM) superfamily con...
All over or overall – Do we understand allostery?
All over or overall – Do we understand allostery?
Allostery is probably the most important concept in the regulation of cellular processes. Models to explain allostery are ...
Structure–function relationships in protein homorepeats
Structure–function relationships in protein homorepeats
A large percentage of protein sequences are aperiodic, showing close to average amino acid composition. This subtle mixtur...
Distinguishing between concerted, sequential and barrierless conformational changes: Folding versus allostery
Distinguishing between concerted, sequential and barrierless conformational changes: Folding versus allostery
A classical approach in chemistry for obtaining insights into mechanisms of reactions is to identify and characterize thei...
Cell phenotypes can be predicted from propensities of protein conformations
Cell phenotypes can be predicted from propensities of protein conformations
Proteins exist as dynamic conformational ensembles. Here we suggest that the propensities of the conformations can be pred...
The new epoch of structural insights into radical SAM enzymology
The new epoch of structural insights into radical SAM enzymology
Radical SAM (RS) enzymes were first classified as a superfamily in 2001 and at that time were predicted to have around 600...
Recent developments in catalysis and inhibition of the Jumonji histone demethylases
Recent developments in catalysis and inhibition of the Jumonji histone demethylases
KeywordsJumonji histone demethylasesDomain crosstalkCatalysisPost-translational modificationsLysine demethylationOrthoster...
Catalysis and structure of nitrogenases
Catalysis and structure of nitrogenases
In providing bioavailable nitrogen as building blocks for all classes of biomacromolecules, biological nitrogen fixation i...
Editorial Overview: Protein-nucleic acid Interactions
Editorial Overview: Protein-nucleic acid Interactions
James Berger is a Professor of Biophysics and the Director of the Institute for Basic Biomedical Sciences at the Johns Hop...
Viral amyloids: New opportunities for antiviral therapeutic strategies
Viral amyloids: New opportunities for antiviral therapeutic strategies
Amyloidoses encompass a wide range of incurable animal diseases characterized by the deposition of amyloid fibrils either ...
Protein disorder and autoinhibition: The role of multivalency and effective concentration
Protein disorder and autoinhibition: The role of multivalency and effective concentration
Autoinhibition is a common method of self-regulation in proteins, where two or more domains interact to modulate the equil...
Folding and functions of knotted proteins
Folding and functions of knotted proteins
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Representing structures of the multiple conformational states of proteins
Representing structures of the multiple conformational states of proteins
Biomolecules exhibit dynamic behavior that single-state models of their structures cannot fully capture. We review some re...
Three-dimensional nuclear organisation and the DNA replication timing program
Three-dimensional nuclear organisation and the DNA replication timing program
In eukaryotic cells, genome duplication is temporally organised according to a program referred to as the replication-timi...
Approaches to characterize chromatin subcompartment organization in the cell nucleus
Approaches to characterize chromatin subcompartment organization in the cell nucleus
Distinct chromatin states partition the genome to locally enrich associated activities for transcription, DNA replication,...
Time resolved applications for Cryo-EM; approaches, challenges and future directions
Time resolved applications for Cryo-EM; approaches, challenges and future directions
Cryo-EM is well placed to study protein interactions and dynamics with the ability to separate and determine the structure...
Conformational entropy in molecular recognition of intrinsically disordered proteins
Conformational entropy in molecular recognition of intrinsically disordered proteins
Broad conformational ensembles make intrinsically disordered proteins or regions entropically intriguing. Although methodo...
Conformational inhibitors of protein aggregation
Conformational inhibitors of protein aggregation
Amyloidoses are a clinically diverse group of disorders characterized by the deposition of amyloid fibrils. Amyloid fibril...
Progressive computational approaches to facilitate decryption of allosteric mechanism and drug discovery
Progressive computational approaches to facilitate decryption of allosteric mechanism and drug discovery
Allostery, or allosteric regulation, is a fundamental biological concept that describes the phenomenon where the orthoster...
Computing allostery: from the understanding of biomolecular regulation and the discovery of cryptic sites to molecular design
Computing allostery: from the understanding of biomolecular regulation and the discovery of cryptic sites to molecular design
The concept of allostery has become a central tenet in the study of biological systems. In parallel, the discovery of allo...
Mass spectrometers as cryoEM grid preparation instruments
Mass spectrometers as cryoEM grid preparation instruments
Structure determination by single-particle cryoEM has matured into a core structural biology technique. Despite many metho...
Understanding the structure and function of Plasmodium aminopeptidases to facilitate drug discovery
Understanding the structure and function of Plasmodium aminopeptidases to facilitate drug discovery
Malaria continues to be the most widespread parasitic disease affecting humans globally. As parasites develop drug resista...
Nucleosomes unwrapped: Structural perspectives on transcription through chromatin
Nucleosomes unwrapped: Structural perspectives on transcription through chromatin
Volume 82, October 2023, 102690Author links open overlay panelAbstractTranscription of most protein-coding genes requires ...
Insights in bacterial genome folding
Insights in bacterial genome folding
Chromosomes in all domains of life are well-defined structural entities with complex hierarchical organization. The regula...
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