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Repair and tolerance of DNA damage at the replication fork: A structural perspective
The replisome frequently encounters DNA damage, aberrant DNA structures, and transcription machinery that stall the replic...
Application of message passing neural networks for molecular property prediction
Deep learning-based approaches have made substantial progress in molecular property prediction and de novo drug discovery ...
Expansion microscopy: A chemical approach for super-resolution microscopy
Super-resolution microscopy is a series of imaging techniques that bypass the diffraction limit of resolution. Since the 1...
Organization of transcription and 3D genome as revealed by live-cell imaging
The human body is composed of 30 trillion cells, including more than 200 cell types. Each cell type acquires cell type-spe...
RPA-like single-stranded DNA-binding protein complexes including CST serve as specialized processivity factors for polymerases
Telomere maintenance and replication are highly coordinated processes regulated by a suite of proteins to ensure proper te...
The CMG DNA helicase and the core replisome
Eukaryotic DNA replication is performed by the replisome, a large and dynamic multi-protein machine endowed with the requi...
Hybrid computational methods combining experimental information with molecular dynamics
Techniques like X-ray crystallography [1] provide an exquisite picture of the average structure of stable conformations. B...
Reprogramming of three-dimensional chromatin organization in the early embryo
To fit inside the nucleus of a eukaryotic cell, the genome must be highly compacted. This compaction is a barrier to proce...
Recent breakthroughs in computational structural biology harnessing the power of sequences and structures
High placebo response rates in clinical trials of ulcerative colitis (UC) have been reported previously. However, data fro...
Cell-permeable chameleonic peptides: Exploiting conformational dynamics in de novo cyclic peptide design
Membrane-traversing peptides offer opportunities for targeting intracellular proteins and oral delivery. Despite progress ...
Emerging maps of allosteric regulation in cellular networks
KeywordsAllosteryDeep mutagenesisCellular signalingRegulationProtein networksHigh-throughput biochemistryEvolution of regu...
Combining on-line spectroscopy with synchrotron and X-ray free electron laser crystallography
The mechanism of enzymatic reactions and the associated kinetics are commonly studied using spectroscopic methods in solut...
At the core of nucleotide excision repair
Our genetic information is constantly challenged by endogenous and exogenous perturbances. Highly efficient preservation m...
Protein structure-based evaluation of missense variants: Resources, challenges and future directions
We provide an overview of the methods that can be used for protein structure-based evaluation of missense variants. The al...
The next wave of interactomics: Mapping the SLiM-based interactions of the intrinsically disordered proteome
Short linear motifs (SLiMs) are a unique and ubiquitous class of protein interaction modules that perform key regulatory f...
Protein structure dynamics by crosslinking mass spectrometry
Volume 80, June 2023, 102599Author links open overlay panel, AbstractCrosslinking mass spectrometry captures protein struc...
Structural biology of SMC complexes across the tree of life
Structural maintenance of chromosomes (SMC) complexes guard and organize the three-dimensional structure of chromosomal DN...
Phase transitions in heterochromatin organization
Heterochromatin formation has been proposed to involve phase transitions on the level of the three-dimensional folding of ...
CryoEM of V-ATPases: Assembly, disassembly, and inhibition
In eukaryotic cells, the internal pH of membrane-bounded compartments is tightly regulated. This control is crucial for th...
Structural insights into assembly of TRAPPII and its activation of Rab11/Ypt32
The nobel prize in physiology or medicine 2013 was awarded jointly to three scientists for their discoveries of machinery ...
Protein dynamics by the combination of high-speed AFM and computational modeling
Understanding how proteins function, a major goal in biophysics, can be facilitated by the direct observation of individua...
Paramagnetic NMR restraints for the characterization of protein structural rearrangements
Conformational rearrangements in proteins are often key steps of functional regulation. These rearrangements often require...
Multifaceted interactions mediated by intrinsically disordered regions play key roles in alpha synuclein aggregation
More than 50 human diseases, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Hu...
Progress at protein structure prediction, as seen in CASP15
In Dec 2020, the results of AlphaFold version 2 were presented at CASP14, sparking a revolution in the field of protein st...
Rocking the MBOAT: Structural insights into the membrane bound O-acyltransferase family
The membrane-bound O-acyltransferase (MBOAT) superfamily catalyses the transfer of acyl chains to substrates implicated in...
In silico toxicity studies of traditional Chinese herbal medicine: A mini review
The use of traditional Chinese medicine (TCM) has steadily increased every year. In China, TCM accounts for 40% of its pha...
Navigating large chemical spaces in early-phase drug discovery
The size of actionable chemical spaces is surging, owing to a variety of novel techniques, both computational and experime...
Towards the accurate alignment of over a million protein sequences: Current state of the art
Multiple sequence alignment (MSA) methods explicitly model the relationships between evolutionarily related sequences at r...
Deep generative models for 3D molecular structure
Deep generative models have gained recent popularity for chemical design. Many of these models have historically operated ...
The confluence of machine learning and multiscale simulations
The time- and length-scales accessible to any given type of modeling and simulation technique are limited. Despite consist...
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