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Celastrol inhibits the migration and invasion and enhances the anti-cancer effects of docetaxel in human triple-negative breast cancer cells
Celastrol inhibits the migration and invasion and enhances the anti-cancer effects of docetaxel in human triple-negative breast cancer cells
The molecular mechanism of anti-metastatic effect of celastrol is not fully understood in breast cancer cells. Herein, we ...
Addressing artifacts of colorimetric anticancer assays for plant-based drug development
Addressing artifacts of colorimetric anticancer assays for plant-based drug development
Cancer has become the silent killer in less-developed countries and the most significant cause of morbidity worldwide. The...
Is anti-PD-1 immunotherapy a means for post-irradiation tumor clearance in head and neck cancer?
Is anti-PD-1 immunotherapy a means for post-irradiation tumor clearance in head and neck cancer?
Chemo-radiotherapy is the standard treatment for locally advanced head–neck cancer (LA-HNC). However, about 30% of t...
Coronary artery disease and cancer: a significant resemblance
Coronary artery disease and cancer: a significant resemblance
Cancer and coronary artery disease (CAD) are two of the most common causes of death, and they frequently coexist, especial...
The effect of ciprofloxacin on doxorubicin cytotoxic activity in the acquired resistance to doxorubicin in DU145 prostate carcinoma cells
The effect of ciprofloxacin on doxorubicin cytotoxic activity in the acquired resistance to doxorubicin in DU145 prostate carcinoma cells
The present study aimed to assess the influence of ciprofloxacin (CIP) against the doxorubicin (DOX)-resistant androgen-in...
A critical review on oligometastatic disease: a radiation oncologist’s perspective
A critical review on oligometastatic disease: a radiation oncologist’s perspective
Since the first definition by Hellman and Weichselbaum in 1995, the concept of OligoMetastatic Disease (OMD) is a growing ...
Exosomes carrying immune checkpoints, a promising therapeutic approach in cancer treatment
Exosomes carrying immune checkpoints, a promising therapeutic approach in cancer treatment
Exosomes are a subgroup of extracellular vesicles generated by distinct cells. Tumor-derived extracellular vesicles convey...
The potential therapeutic effect of klotho on cell viability in human colorectal adenocarcinoma HT-29 cells
The potential therapeutic effect of klotho on cell viability in human colorectal adenocarcinoma HT-29 cells
Klotho is an anti-aging, anti-inflammator, and anti-oxidative protein and has been shown to important role in tumorigenesi...
Exploring the inverse association of glioblastoma multiforme and Alzheimer’s disease via bioinformatics analysis
Exploring the inverse association of glioblastoma multiforme and Alzheimer’s disease via bioinformatics analysis
Glioblastoma multiforme (GBM) and Alzheimer’s disease (AD) are two major diseases in the nervous system with a simil...
Combination of AURKA inhibitor and HSP90 inhibitor to treat breast cancer with AURKA overexpression and TP53 mutations
Combination of AURKA inhibitor and HSP90 inhibitor to treat breast cancer with AURKA overexpression and TP53 mutations
Breast cancer is the most common cancer among women worldwide. Researches show that Aurora kinase A (AURKA) is highly expr...
Anti-EGF nanobodies enhance the antitumoral effect of osimertinib and overcome resistance in non-small cell lung cancer (NSCLC) cellular models
Anti-EGF nanobodies enhance the antitumoral effect of osimertinib and overcome resistance in non-small cell lung cancer (NSCLC) cellular models
Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that is effectiv...
Rad54L promotes bladder cancer progression by regulating cell cycle and cell senescence
Rad54L promotes bladder cancer progression by regulating cell cycle and cell senescence
Bladder cancer (BCa) is the most prevalent cancer of the urinary system, but its pathogenesis is still poorly understood. ...
Patient activation, self-efficacy and usage of complementary and alternative medicine in cancer patients
Patient activation, self-efficacy and usage of complementary and alternative medicine in cancer patients
Complementary and alternative medicine (CAM) is used by many cancer patients by themselves. Therefore, we conducted a surv...
ABT-737 suppresses aberrant Hedgehog pathway and overcomes resistance to smoothened antagonists by blocking Gli
ABT-737 suppresses aberrant Hedgehog pathway and overcomes resistance to smoothened antagonists by blocking Gli
Abnormally activated Hedgehog (Hh) pathway has been linked to multiple types of cancers including medulloblastoma (MB). Cu...
Radioprotective effects of gliclazide against irradiation-induced cardiotoxicity and lung injury through inhibiting oxidative stress
Radioprotective effects of gliclazide against irradiation-induced cardiotoxicity and lung injury through inhibiting oxidative stress
Radiotherapy is one of the main treatments for localized primary cancer in patients. Cardiotoxicity and lung injury are tw...
Epithelial-mesenchymal transition in cancer stemness and heterogeneity: updated
Epithelial-mesenchymal transition in cancer stemness and heterogeneity: updated
Epithelial-mesenchymal transition (EMT) as a trans-differentiation program and a key process in tumor progression is linke...
Isolation and characterization of human anti-CD20 single-chain variable fragment (scFv) from a Naive human scFv library
Isolation and characterization of human anti-CD20 single-chain variable fragment (scFv) from a Naive human scFv library
CD20 is a receptor expressed on B cells with anonymous functions. The receptor is the target of some food and drug adminis...
Assessment of mechanism involved in the apoptotic and anti-cancer activity of Quercetin and Quercetin-loaded chitosan nanoparticles
Assessment of mechanism involved in the apoptotic and anti-cancer activity of Quercetin and Quercetin-loaded chitosan nanoparticles
In prior studies, Quercetin was revealed to exhibit anti-cancer features in a variety of cancer cell lines. However, the i...
Chk1/2 inhibitor AZD7762 enhances the susceptibility of IDH-mutant brain cancer cells to temozolomide
Chk1/2 inhibitor AZD7762 enhances the susceptibility of IDH-mutant brain cancer cells to temozolomide
The IDH mutation initially exhibits chemosensitive properties, progression-free survival cannot be achieved in the later g...
The inhibitory effect of betulinic acid on epithelial–mesenchymal transition pathway in renal cell carcinoma
The inhibitory effect of betulinic acid on epithelial–mesenchymal transition pathway in renal cell carcinoma
Renal cancer is the most lethal urological cancer and characterized by high metastasis rate at initial diagnosis and drug ...
Pancreatic adenocarcinoma and pancreatic high-grade neuroendocrine carcinoma: two sides of the moon
Pancreatic adenocarcinoma and pancreatic high-grade neuroendocrine carcinoma: two sides of the moon
Pancreatic adenocarcinoma is the seventh leading cause of cancer death in the world and the most common type pf pancreatic...
Synthesis, characterization, antioxidant and anticancer activities of a new Schiff base and its M(II) complexes derived from 5-fluorouracil
Synthesis, characterization, antioxidant and anticancer activities of a new Schiff base and its M(II) complexes derived from 5-fluorouracil
In this study, Schiff base ligand was obtained from the condensation reaction of benzene-1,2-diamine and 5-fluoropyrimidin...
Matrine induces autophagy in human neuroblastoma cells via blocking the AKT-mTOR pathway
Matrine induces autophagy in human neuroblastoma cells via blocking the AKT-mTOR pathway
Neuroblastoma (NB) is one of the most common malignant solid tumors in children. Despite significant advances in the treat...
Regulation of the sensitivity of hepatocarcinoma cells by ORMDL3, to sorafenib by autophagy
Regulation of the sensitivity of hepatocarcinoma cells by ORMDL3, to sorafenib by autophagy
Serum orosomucoid1-like protein 3 (ORMDL3) is a membrane protein in the endoplasmic reticulum, known to regulate many impo...
SND1 confers chemoresistance to cisplatin-induced apoptosis by targeting GAS6-AKT in SKOV3 ovarian cancer cells
SND1 confers chemoresistance to cisplatin-induced apoptosis by targeting GAS6-AKT in SKOV3 ovarian cancer cells
Platinum-based (especially cisplatin) chemotherapy is the main treatment after surgery for ovarian cancer. Although the in...