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Liver cancer wars: plant-derived polyphenols strike back
Liver cancer wars: plant-derived polyphenols strike back
Liver cancer currently represents the leading cause of cancer-related death worldwide. The majority of liver cancer arises...
Exploring the immunomodulatory potential of Brahmi (Bacopa monnieri) in the treatment of invasive ductal carcinoma
Exploring the immunomodulatory potential of Brahmi (Bacopa monnieri) in the treatment of invasive ductal carcinoma
Bacopa monnieri (L) Wettst, commonly known as Brahmi, stands as a medicinal plant integral to India’s traditional me...
Dual function of activated PPARγ by ligands on tumor growth and immunotherapy
Dual function of activated PPARγ by ligands on tumor growth and immunotherapy
As one of the peroxisome-proliferator-activated receptors (PPARs) members, PPARγ is a ligand binding and activated nu...
A novel α,β-unsaturated ketone inhibits leukemia cell growth as PARP1 inhibitor
A novel α,β-unsaturated ketone inhibits leukemia cell growth as PARP1 inhibitor
Leukemia is a malignant disease of the hematopoietic system, in which clonal leukemia cells accumulate and inhibit normal ...
Increased V-ATPase activity can lead to chemo-resistance in oral squamous cell carcinoma via autophagy induction: new insights
Increased V-ATPase activity can lead to chemo-resistance in oral squamous cell carcinoma via autophagy induction: new insights
Oral squamous cell carcinoma (OSCC) is a cancer type with a high rate of recurrence and a poor prognosis. Tumor chemo-resi...
Recent developments in targeting breast cancer stem cells (BCSCs): a descriptive review of therapeutic strategies and emerging therapies
Recent developments in targeting breast cancer stem cells (BCSCs): a descriptive review of therapeutic strategies and emerging therapies
Despite recent advancements in the diagnosis and treatment of breast cancer (BC), patient outcomes in terms of survival, r...
Combination of IFN-gamma with STING agonist and PD-1 immune checkpoint blockade: a potential immunotherapy for gastric cancer
Combination of IFN-gamma with STING agonist and PD-1 immune checkpoint blockade: a potential immunotherapy for gastric cancer
Suppression of the cGAS-STING pathway is an immune escape mechanism in cancer cells. The critical role of this pathway in ...
Study of the effect of sFRP1 protein on molecules involved in the regulation of DNA methylation in CML cell line
Study of the effect of sFRP1 protein on molecules involved in the regulation of DNA methylation in CML cell line
Wnt-signaling pathway plays a crucial role in the pathogenesis and progression of Chronic Myeloid Leukemia (CML). sFRP1 is...
Unlocking the potential: phenylboronic acid as a nuclear-targeting boron agent for neutron capture therapy
Unlocking the potential: phenylboronic acid as a nuclear-targeting boron agent for neutron capture therapy
It has been proposed that boron neutron capture therapy (BNCT) holds promise as a treatment modality for melanoma. However...
Probiotic-derived silver nanoparticles target mTOR/MMP-9/BCL-2/dependent AMPK activation for hepatic cancer treatment
Probiotic-derived silver nanoparticles target mTOR/MMP-9/BCL-2/dependent AMPK activation for hepatic cancer treatment
Recent advances in nanotechnology have offered novel ways to combat cancer. By utilizing the reducing capabilities of Lact...
Regulation of hippo signaling mediated apoptosis by Rauvolfia tetraphylla in triple-negative breast cancer
Regulation of hippo signaling mediated apoptosis by Rauvolfia tetraphylla in triple-negative breast cancer
Rauvolfia tetraphylla is an essential medicinal plant that has been widely used in traditional medicine for various diseas...
Exploring the combined anti-cancer effects of sodium butyrate and celastrol in glioblastoma cell lines: a novel therapeutic approach
Exploring the combined anti-cancer effects of sodium butyrate and celastrol in glioblastoma cell lines: a novel therapeutic approach
Glioblastoma, a highly aggressive and lethal brain cancer, lacks effective treatment options and has a poor prognosis. In ...
Regulation of cancer progression by CK2: an emerging therapeutic target
Regulation of cancer progression by CK2: an emerging therapeutic target
Casein kinase II (CK2) is an enzyme with pleiotropic kinase activity that catalyzes the phosphorylation of lots of substra...
Plumbagin as a preferential lead molecule to combat EGFR-driven matrix abundance and migration of cervical carcinoma cells
Plumbagin as a preferential lead molecule to combat EGFR-driven matrix abundance and migration of cervical carcinoma cells
The handshake between the complex networks of matrix components in the tumor micro-environment (TME) is considered as a cr...
High expression of CD9 and Epidermal Growth Factor Receptor promotes the development of tongue cancer
High expression of CD9 and Epidermal Growth Factor Receptor promotes the development of tongue cancer
Tongue cancer is distinguished by aggressive behavior, a high risk of recurrence, lymph, and distant metastases. Hypoxia-I...
Role of interferon-induced transmembrane protein family in cancer progression: a special focus on pancreatic cancer
Role of interferon-induced transmembrane protein family in cancer progression: a special focus on pancreatic cancer
Human interferon-induced transmembrane protein family (IFITMs) consists of five main proteins. IFITM1, IFITM2, and IFITM3 ...
The cytotoxic effects of prazosin, chlorpromazine, and haloperidol on hepatocellular carcinoma and immortalized non-tumor liver cells
The cytotoxic effects of prazosin, chlorpromazine, and haloperidol on hepatocellular carcinoma and immortalized non-tumor liver cells
Liver cancer annually accounts for over 800,000 cases and 700,000 deaths worldwide. Hepatocellular carcinoma is responsibl...
Emerging therapeutic strategies in cancer therapy by HDAC inhibition as the chemotherapeutic potent and epigenetic regulator
Emerging therapeutic strategies in cancer therapy by HDAC inhibition as the chemotherapeutic potent and epigenetic regulator
In developing new cancer medications, attention has been focused on novel epigenetic medicines called histone deacetylase ...
Venetoclax with decitabine or azacitidine in relapsed or refractory acute myeloid leukemia
Venetoclax with decitabine or azacitidine in relapsed or refractory acute myeloid leukemia
Relapsed or refractory acute myeloid leukemia (AML) is associated with poor outcomes and resistance to therapy. The additi...
Insights into lenvatinib resistance: mechanisms, potential biomarkers, and strategies to enhance sensitivity
Insights into lenvatinib resistance: mechanisms, potential biomarkers, and strategies to enhance sensitivity
Lenvatinib is a multitargeted tyrosine kinase inhibitor capable of promoting apoptosis, suppressing angiogenesis, inhibiti...
Estrogen-related receptor alpha (ERRα) promotes the migration, invasion and angiogenesis of breast cancer stem cell-like cells
Estrogen-related receptor alpha (ERRα) promotes the migration, invasion and angiogenesis of breast cancer stem cell-like cells
Breast cancer progression, metastasis and recurrence are largely driven by breast cancer stem cells (BCSCs), which constit...
Evaluation of TRIM63 RNA in situ hybridization (RNA-ISH) as a potential biomarker for alveolar soft-part sarcoma (ASPS)
Evaluation of TRIM63 RNA in situ hybridization (RNA-ISH) as a potential biomarker for alveolar soft-part sarcoma (ASPS)
Alveolar soft-part sarcoma (ASPS) is a rare soft tissue tumor with a broad morphologic differential diagnosis. While histo...
Clinical significance of blocking novel immune checkpoint B7-H4 in urothelial carcinoma of bladder as a potential therapeutic target
Clinical significance of blocking novel immune checkpoint B7-H4 in urothelial carcinoma of bladder as a potential therapeutic target
Urothelial Carcinoma of Bladder is complex disease with high mortality and recurrence rates. Current standard regimes have...