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Carotenoids as modulators of the PI3K/Akt/mTOR pathway: innovative strategies in cancer therapy
Carotenoids as modulators of the PI3K/Akt/mTOR pathway: innovative strategies in cancer therapy
Cancer progression is primarily driven by the uncontrolled activation of cellular signaling pathways, with the PI3K/Akt/mT...
Dissecting the epigenetic orchestra of HDAC isoforms in breast cancer development: a review
Dissecting the epigenetic orchestra of HDAC isoforms in breast cancer development: a review
Epigenetic modulators have recently emerged as potential targets in cancer therapy. Breast cancer, the second leading caus...
Self-assembled nanoparticles of alginate and paclitaxel-triphenylphosphonium for mitochondrial apoptosis targeting
Self-assembled nanoparticles of alginate and paclitaxel-triphenylphosphonium for mitochondrial apoptosis targeting
Paclitaxel (PTX), an antimitotic drug from the taxanes group, prevents the proliferation of breast cancer cells through mi...
siRNA-based strategies to combat drug resistance in gastric cancer
siRNA-based strategies to combat drug resistance in gastric cancer
Chemotherapy is a key treatment option for gastric cancer, but over 50% of patients develop either inherent or acquired re...
Transforming cancer detection and treatment with nanoflowers
Transforming cancer detection and treatment with nanoflowers
Nanoflowers, an innovative class of nanoparticles with a distinctive flower-like structure, have garnered significant inte...
Personalized oncology in pheochromocytomas and paragangliomas: integrating genetic analysis with machine learning
Personalized oncology in pheochromocytomas and paragangliomas: integrating genetic analysis with machine learning
Pheochromocytomas and paragangliomas (PCCs/PGLs) are uncommon neuroendocrine tumors with a significant genetic tendency. A...
Current evidence on patient precautions for reducing breast cancer-related lymphedema manifestation and progression risks
Current evidence on patient precautions for reducing breast cancer-related lymphedema manifestation and progression risks
Risk management and self-management strategies for breast cancer-related lymphedema (BCRL) must balance best-evidence guid...
Essential components of the maintenance phase of complex decongestive therapy
Essential components of the maintenance phase of complex decongestive therapy
Complex decongestive therapy is the current gold standard for non-surgical clinical lymphedema management and consists of ...
The effect of compression therapies and therapeutic modalities on lymphedema secondary to cancer: a rapid review and evidence map
The effect of compression therapies and therapeutic modalities on lymphedema secondary to cancer: a rapid review and evidence map
The identification of effective therapeutic modalities to manage lymphedema secondary to cancer is a high priority among p...
Recent advancements in cGAS-STING activation, tumor immune evasion, and therapeutic implications
Recent advancements in cGAS-STING activation, tumor immune evasion, and therapeutic implications
The cGAS-STING signaling pathway is indeed a pivotal component of the immune system and serve as a crucial link between in...
The influence of non-cancer-related risk factors on the development of cancer-related lymphedema: a rapid review
The influence of non-cancer-related risk factors on the development of cancer-related lymphedema: a rapid review
Extensive research supports an evidence-base for cancer treatment-related risk factors, including extent of lymph node dis...
Targeting telomerase with MST-312 leads to downregulation of CCND1, MDM2, MYC, and HSP90AA1 and induce apoptosis in Jurkat cell line
Targeting telomerase with MST-312 leads to downregulation of CCND1, MDM2, MYC, and HSP90AA1 and induce apoptosis in Jurkat cell line
Acute lymphoblastic leukemia is a challenging disease to treat, especially in older adults who are most commonly diagnosed...
Polydatin inhibits histone deacetylase 1 and shows an anti-angiogenic action in head and neck squamous cell carcinoma
Polydatin inhibits histone deacetylase 1 and shows an anti-angiogenic action in head and neck squamous cell carcinoma
Polydatin, a natural derivative of resveratrol, has shown many anticancer properties. However, the underlying mechanisms o...
Glycolytic pathway analysis and gene expression profiles of combination of aloe vera and paclitaxel on non-small cell lung cancer and breast cancer
Glycolytic pathway analysis and gene expression profiles of combination of aloe vera and paclitaxel on non-small cell lung cancer and breast cancer
The purpose of this study is to enhance the effectiveness of known anticancer medications using natural compounds. The stu...
The role of kinesin superfamily proteins in hepatocellular carcinoma
The role of kinesin superfamily proteins in hepatocellular carcinoma
The most prevalent form of primary liver cancer, hepatocellular carcinoma (HCC) poses a significant global health challeng...
PARP1 acetylation at K119 is essential in regulating the progression and proliferation of cervical cancer cells
PARP1 acetylation at K119 is essential in regulating the progression and proliferation of cervical cancer cells
Cervical cancer, CC, is one of the malignant cancers in women worldwide. Many studies about the genesis and progression of...
YBX1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma via transcriptional regulation of PLRG1
YBX1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma via transcriptional regulation of PLRG1
Hepatocellular carcinoma (HCC) ranks as the sixth most prevalent cancer worldwide. The epithelial-mesenchymal transition (...
Consensus statement on non-cancer-related risk factors for development of secondary lymphedema
Consensus statement on non-cancer-related risk factors for development of secondary lymphedema
Non-cancer-related risk factors for secondary lymphedema were defined across four categories: co-morbidity, social d...
Modulation of the tumor microenvironment in non-muscle-invasive bladder cancer by OncoTherad® (MRB-CFI-1) nanoimmunotherapy: effects on tumor-associated macrophages, tumor-infiltrating lymphocytes, and monoamine oxidases
Modulation of the tumor microenvironment in non-muscle-invasive bladder cancer by OncoTherad® (MRB-CFI-1) nanoimmunotherapy: effects on tumor-associated macrophages, tumor-infiltrating lymphocytes, and monoamine oxidases
Non-muscle-invasive bladder cancer (NMIBC) presents management challenges due to its high recurrence rate and a complex tu...
DNA fragmentation factor 40-based therapeutic approaches for cancer: a review article
DNA fragmentation factor 40-based therapeutic approaches for cancer: a review article
DNA Fragmentation Factor (DFF) is a heterodimer protein involved in DNA fragmentation during apoptosis, which acts as a tr...
Regulation of autophagy by non-coding RNAs in human glioblastoma
Regulation of autophagy by non-coding RNAs in human glioblastoma
Glioblastoma, a lethal form of brain cancer, poses substantial challenges in treatment due to its aggressive nature and re...
DDX3X dynamics, glioblastoma's genetic landscape, therapeutic advances, and autophagic interplay
DDX3X dynamics, glioblastoma's genetic landscape, therapeutic advances, and autophagic interplay
Glioblastoma is one of the most aggressive and deadly forms of cancer, posing significant challenges for the medical commu...
Comparative evaluation of anticancer potential of Spilanthes paniculata leaf and flower essential oil using annexin V and orosphere formation in oral cancer cell line
Comparative evaluation of anticancer potential of Spilanthes paniculata leaf and flower essential oil using annexin V and orosphere formation in oral cancer cell line
Spilanthes paniculata, a member of the Asteraceae family, is predominantly used as a traditional remedy in addressing oral...
The impact of Trifolium pratense extract on apoptosis and autophagy in NALM-6 cells: implications for B-ALL intervention
The impact of Trifolium pratense extract on apoptosis and autophagy in NALM-6 cells: implications for B-ALL intervention
B-cell acute lymphoblastic leukemia (B-ALL), a prevalent malignancy predominantly affecting children, poses challenges suc...
Centromeres in cancer: Unraveling the link between chromosomal instability and tumorigenesis
Centromeres in cancer: Unraveling the link between chromosomal instability and tumorigenesis
Centromeres are critical structures involved in chromosome segregation, maintaining genomic stability, and facilitating th...
Unraveling the role of EPHA2 in regulating migration and immunomodulation processes in cervical cancer: exploring the synergic effect of 17β-estradiol on cancer progression
Unraveling the role of EPHA2 in regulating migration and immunomodulation processes in cervical cancer: exploring the synergic effect of 17β-estradiol on cancer progression
Cervical cancer remained among the most prevalent cancers in women. Erythropoietin-producing hepatocellular A2 (EPHA2) is ...
Gamma-butyrobetaine hydroxylase (BBOX1) exerts suppressive effects on HepG2 hepatoblastoma cells
Gamma-butyrobetaine hydroxylase (BBOX1) exerts suppressive effects on HepG2 hepatoblastoma cells
Gamma-butyrobetaine hydroxylase (BBOX1) plays a pivotal role in catalyzing the final stage of L-carnitine biosynthesis. Re...
Personalized treatment approach for HER2-positive metastatic breast cancer
Personalized treatment approach for HER2-positive metastatic breast cancer
Breast cancer (BC) is a leading global concern for women, with 30% being HER2-positive cases linked to poorer outcomes. Ta...
Analysis of the mechanisms underlying the anticancer and biological activity of retinoic acid and chitosan nanoparticles containing retinoic acid
Analysis of the mechanisms underlying the anticancer and biological activity of retinoic acid and chitosan nanoparticles containing retinoic acid
Retinoic acid (RA) has been shown in earlier investigations to have anticancer properties in various cancer cells. RA̵...
The role of molecular biomarkers in recurrent glioblastoma trials: an assessment of the current trial landscape of genome-driven oncology
The role of molecular biomarkers in recurrent glioblastoma trials: an assessment of the current trial landscape of genome-driven oncology
For glioblastoma patients, the efficacy-targeted therapy is limited to date. Most of the molecular therapies previously st...
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