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A multitier virtual screening of antagonists targeting PD-1/PD-L1 interface for the management of triple-negative breast cancer
A multitier virtual screening of antagonists targeting PD-1/PD-L1 interface for the management of triple-negative breast cancer
Immunotherapies are promising therapeutic options for the management of triple-negative breast cancer because of its high ...
Involving stemness factors to improve CAR T-cell-based cancer immunotherapy
Involving stemness factors to improve CAR T-cell-based cancer immunotherapy
Treatment with chimeric antigen receptor (CAR) T cells indicated remarkable clinical responses with liquid cancers such as...
Solanum nigrum Linn.: Advances in anti-cancer activity and mechanism in digestive system tumors
Solanum nigrum Linn.: Advances in anti-cancer activity and mechanism in digestive system tumors
Cancer has currently become a serious public health issue in many countries worldwide, and tumors of the digestive system ...
Toxicity evaluation of synthetic glucocorticoids against breast cancer cell lines MDA-MB-231, MCF-7 and human embryonic kidney HEK293
Toxicity evaluation of synthetic glucocorticoids against breast cancer cell lines MDA-MB-231, MCF-7 and human embryonic kidney HEK293
In this study, we conducted a comprehensive assessment of the cytotoxicity of three glucocorticoids, namely Hydrocortisone...
Dysregulated ceramides metabolism via PTPN11 exposes a metabolic vulnerability to breast cancer metastasis
Dysregulated ceramides metabolism via PTPN11 exposes a metabolic vulnerability to breast cancer metastasis
Breast cancer is a prevalent malignant tumor, posing a significant threat to women's health globally due to its increa...
C2orf48 promotes the progression of nasopharyngeal carcinoma by regulating high mobility group AT-hook 2
C2orf48 promotes the progression of nasopharyngeal carcinoma by regulating high mobility group AT-hook 2
Recurrence and metastasis are the major factors affecting the survival of nasopharyngeal carcinoma (NPC), and the mechanis...
Deregulation of cytokine affecting oral neutrophil subsets in oral cancer
Deregulation of cytokine affecting oral neutrophil subsets in oral cancer
The most prevalent form of leukocytes in human blood, neutrophils, is regarded as an essential part of the innate immune s...
Role of tissue markers associated with tumor microenvironment in the progression and immune suppression of oral squamous cell carcinoma
Role of tissue markers associated with tumor microenvironment in the progression and immune suppression of oral squamous cell carcinoma
Head and neck cancers (HNC) continues to dominate major cancers contributing to  mortality worldwide. Squamous ce...
Label-free nLC-MS/MS proteomic analysis reveals significant differences in the proteome between colorectal cancer tissues and normal colon mucosa
Label-free nLC-MS/MS proteomic analysis reveals significant differences in the proteome between colorectal cancer tissues and normal colon mucosa
Despite the discovery of numerous driving and passenger genes that play key roles in cancer characteristics, progress in c...
Therapeutic approaches for HTLV-1-associated adult T-cell leukemia/lymphoma: a comprehensive review
Therapeutic approaches for HTLV-1-associated adult T-cell leukemia/lymphoma: a comprehensive review
Adult T-cell leukemia/lymphoma (ATLL), an infrequent malignancy resultant from human T-cell lymphotropic virus type I (HTL...
Identification of the therapeutic mechanism of the saffron crocus on glioma through network pharmacology and bioinformatics analysis
Identification of the therapeutic mechanism of the saffron crocus on glioma through network pharmacology and bioinformatics analysis
Saffron crocus is a herbal medicine of traditional Tibetan medicine (TTM). Saffron extract has been indicated to inhibit t...
Chitosan oligosaccharide suppresses osteosarcoma malignancy by inhibiting CEMIP via the PI3K/AKT/mTOR pathway
Chitosan oligosaccharide suppresses osteosarcoma malignancy by inhibiting CEMIP via the PI3K/AKT/mTOR pathway
Osteosarcoma is a malignant bone tumor that is prone to metastasize early and primarily affects children and adolescents. ...
GLDC promotes colorectal cancer metastasis through epithelial–mesenchymal transition mediated by Hippo signaling pathway
GLDC promotes colorectal cancer metastasis through epithelial–mesenchymal transition mediated by Hippo signaling pathway
Cancer metastasis remains a major cause of death in cancer patients, and epithelial–mesenchymal transition (EMT) pla...
Artificial intelligence and Italian culture: an understanding of how artificial intelligence can transform the radiation therapy landscape
Artificial intelligence and Italian culture: an understanding of how artificial intelligence can transform the radiation therapy landscape
The aim is to support the perception of artificial intelligence in the radiation therapy landscape.
The role of polyploidy in tumorigenesis: confusion versus reality
The role of polyploidy in tumorigenesis: confusion versus reality
This letter serves as a response to Dr. Vladimir F. Niculescu's latest letter, which continues to create misunderstand...
RNF149 confers cisplatin resistance in esophageal squamous cell carcinoma via destabilization of PHLPP2 and activating PI3K/AKT signalling
RNF149 confers cisplatin resistance in esophageal squamous cell carcinoma via destabilization of PHLPP2 and activating PI3K/AKT signalling
Chemo-resistance has been identified as a crucial factor contributing to tumor recurrence and a leading cause of worse pro...
RIG-I promotes cell proliferation in esophageal squamous cell carcinoma by facilitating p21 degradation
RIG-I promotes cell proliferation in esophageal squamous cell carcinoma by facilitating p21 degradation
Retinoic acid-inducible gene-I (RIG-I) is considered a key sensor for host recognition of RNA virus infections. Recent stu...
The NEDD8-activating enzyme E1 UBA3 orchestrates the immunosuppressive microenvironment in lung adenocarcinoma via the NF-кB pathway
The NEDD8-activating enzyme E1 UBA3 orchestrates the immunosuppressive microenvironment in lung adenocarcinoma via the NF-кB pathway
Immunosuppressive cells play important roles in generating an immunosuppressive tumor microenvironment and facilitating tu...
The apoptotic effect of the Lycopodium clavatum extracts on MCF-7 human breast cancer cells
The apoptotic effect of the Lycopodium clavatum extracts on MCF-7 human breast cancer cells
Breast cancer is a significant health problem worldwide, and the search for effective treatments is critical. Side effects...
Knockdown of SIX4 inhibits pancreatic cancer cells via apoptosis induction
Knockdown of SIX4 inhibits pancreatic cancer cells via apoptosis induction
Sine oculis homeobox 4 (SIX4), a critical transcription factor modulating organ development, potentially participates in t...
Reverse vaccinology and immunoinformatics approaches to design multi-epitope based vaccine against oncogenic KRAS
Reverse vaccinology and immunoinformatics approaches to design multi-epitope based vaccine against oncogenic KRAS
Mutant KRAS-induced tumorigenesis is highly involved in the progression of pancreatic, lung, and breast cancer. Comparativ...
Targeting MerTK decreases efferocytosis and increases anti-tumor immune infiltrate in prostate cancer
Targeting MerTK decreases efferocytosis and increases anti-tumor immune infiltrate in prostate cancer
The prostate cancer tumor microenvironment (TME) is comprised of many cell types that can contribute to and influence tumo...
EZH2 inhibitor Tazemetostat synergizes with JQ-1 in esophageal cancer by inhibiting c-Myc signaling pathway
EZH2 inhibitor Tazemetostat synergizes with JQ-1 in esophageal cancer by inhibiting c-Myc signaling pathway
EZH2, a highly conserved histone methyltransferase, plays an essential role in tumorigenesis and development. The inhibito...
Metformin as a promising target for DPP4 expression: computational modeling and experimental validation
Metformin as a promising target for DPP4 expression: computational modeling and experimental validation
Metformin is a regularly prescribed and low-cost generic medication. Metformin has been proposed as a target for Dipeptidy...
Chrysin and chrysin-loaded nanocarriers induced immunogenic cell death on B16 melanoma cells
Chrysin and chrysin-loaded nanocarriers induced immunogenic cell death on B16 melanoma cells
Induction of immunogenic cell death (ICD) is a promising strategy for cancer immunotherapy. Chrysin, which has potential a...
Role of plectin and its interacting molecules in cancer
Role of plectin and its interacting molecules in cancer
Plectin, as the cytolinker and scaffolding protein, are widely expressed and abundant in many tissues, and has involved in...
The mechanism of LSM2 in the progression of live hepatocellular carcinoma was analyzed based on bioinformatics
The mechanism of LSM2 in the progression of live hepatocellular carcinoma was analyzed based on bioinformatics
Comprehensive analysis of the expression and probable function of LSM2 in Live hepatocellular carcinoma (LIHC), and valida...
METTL3 regulatory TROAP can regulate the progression of non-small cell lung cancer through PI3K/AKT and EMT signaling pathway
METTL3 regulatory TROAP can regulate the progression of non-small cell lung cancer through PI3K/AKT and EMT signaling pathway
TROAP, interacts with trophinin and bystin, polys a key role in embryo implantation. TROAP is required for spindle assembl...
Revolutionizing cancer treatment: a comprehensive review of CAR-T cell therapy
Revolutionizing cancer treatment: a comprehensive review of CAR-T cell therapy
Chimeric antigen receptor (CAR)-T cell therapy is a promising new treatment for cancer that involves genetically modifying...
The potential of monoclonal antibodies for colorectal cancer therapy
The potential of monoclonal antibodies for colorectal cancer therapy
Conventional chemotherapy has significant limitations for colorectal cancer (CRC) treatment, especially those who have dev...
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