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Strategic advancement of E3 ubiquitin ligase in the management of hepatocellular carcinoma
Strategic advancement of E3 ubiquitin ligase in the management of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) presents a significant global health challenge due to its high incidence, poor prognosis, a...
Multifaceted effects of LRP6 in cancer: exploring tumor development, immune modulation and targeted therapies
Multifaceted effects of LRP6 in cancer: exploring tumor development, immune modulation and targeted therapies
Low-density lipoprotein receptor (LDLR)-related protein 6 (LRP6), a member of the LDLR superfamily of cell surface recepto...
MLKL regulates radiation-induced death in breast cancer cells: an interplay between apoptotic and necroptotic signals
MLKL regulates radiation-induced death in breast cancer cells: an interplay between apoptotic and necroptotic signals
Resistance to caspase-dependent apoptosis is often responsible for treatments failure in cancer. Necroptosis is a type of ...
Resveratrol nanoparticles induce apoptosis in oral cancer stem cells by disrupting the interaction between β-catenin and GLI-1 through p53-independent activation of p21
Resveratrol nanoparticles induce apoptosis in oral cancer stem cells by disrupting the interaction between β-catenin and GLI-1 through p53-independent activation of p21
Cancer stem cells (CSCs) are mainly responsible for tumorigenesis, chemoresistance, and cancer recurrence. CSCs growth and...
Focused cancer pathway analysis revealed unique therapeutic targets in retinoblastoma
Focused cancer pathway analysis revealed unique therapeutic targets in retinoblastoma
Retinoblastoma (RB) is a pediatric cancer of the eye that occurs in 1/15000 live births worldwide. Albeit RB is initiated ...
p200CUX1-regulated BMP8B inhibits the progression of acute myeloid leukemia via the MAPK signaling pathway
p200CUX1-regulated BMP8B inhibits the progression of acute myeloid leukemia via the MAPK signaling pathway
The full-length p200CUX1 protein encoded by the homology frame CUT-like protein (CUX1) plays an important role in tumors a...
The recent update and advancements of natural products in targeting the Wnt/β-Catenin pathway for cancer prevention and therapeutics
The recent update and advancements of natural products in targeting the Wnt/β-Catenin pathway for cancer prevention and therapeutics
The Wnt/β-Catenin pathway (Wnt/β-CatP) is implicated in accelerating carcinogenesis and cancer progression, cont...
Insights into Nimbolide molecular crosstalk and its anticancer properties
Insights into Nimbolide molecular crosstalk and its anticancer properties
Nimbolide, one of the main ingredients constituent of Azadirachta indica (neem) leaf extract, has garnered attention for i...
Role of m6A modifications in immune evasion and immunotherapy
Role of m6A modifications in immune evasion and immunotherapy
RNA modification has garnered increasing attention in recent years due to its pivotal role in tumorigenesis and immune sur...
Tumor microenvironment and clinical efficacy of first line immunotherapy-based combinations in metastatic renal cell carcinoma
Tumor microenvironment and clinical efficacy of first line immunotherapy-based combinations in metastatic renal cell carcinoma
The impact of tumor microenvironment (TME) in influencing clinical response to first-line immune checkpoint inhibitor (ICI...
IL-6 regulates epithelial ovarian cancer EMT, invasion, and metastasis by modulating Let-7c and miR-200c through the STAT3/HIF-1α pathway
IL-6 regulates epithelial ovarian cancer EMT, invasion, and metastasis by modulating Let-7c and miR-200c through the STAT3/HIF-1α pathway
Interleukin-6 (IL-6) and hypoxia-inducible factor-1α (HIF-1α) play important roles in epithelial-mesenchymal tra...
Rhein suppresses esophageal cancer development by regulating cell cycle through DNMT3B gene
Rhein suppresses esophageal cancer development by regulating cell cycle through DNMT3B gene
The mechanism by which DNMT3B facilitates esophageal cancer (ESCA) progression is currently unknown, despite its associati...
Ethanolic extract of Euphorbia royleana Boiss. reduces metastasis of breast cancer cells and inhibits tumor progression in vivo
Ethanolic extract of Euphorbia royleana Boiss. reduces metastasis of breast cancer cells and inhibits tumor progression in vivo
Metastasis is the most devastating attribute of breast cancer (BC) that leads to high mortality. It is a complex process o...
NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression
NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression
Colorectal cancer (CRC) is a prevalent and aggressive malignancy with high mortality rates and significant risks to human ...
Drug-loaded polymer-coated silver nanoparticles for lung cancer theranostics
Drug-loaded polymer-coated silver nanoparticles for lung cancer theranostics
Lung cancer is the leading cause of death in cancer across the globe. To minimize these deaths, the replacement of traditi...
In silico and network pharmacology analysis of fucosterol: a potent anticancer bioactive compound against HCC
In silico and network pharmacology analysis of fucosterol: a potent anticancer bioactive compound against HCC
The Fucaceae family of marine brown algae includes Ascophyllum nodosum. Fucosterol (FSL) is a unique bioactive component t...
Role of the STING pathway in myeloid neoplasms: a prospero-registered systematic review of principal hurdles of STING on the road to the clinical practice
Role of the STING pathway in myeloid neoplasms: a prospero-registered systematic review of principal hurdles of STING on the road to the clinical practice
Myeloid neoplasms are a group of bone marrow diseases distinguished by disruptions in the molecular pathways that regulate...
Anti-cancer potential of zerumbone in cancer and glioma: current trends and future perspectives
Anti-cancer potential of zerumbone in cancer and glioma: current trends and future perspectives
Plant-derived immunomodulators and antitumor factors have appealed lots of attention from natural product scientists for t...
Challenges and strategies in relation to effective CAR-T cell immunotherapy for solid tumors
Challenges and strategies in relation to effective CAR-T cell immunotherapy for solid tumors
Chimeric Antigen Receptor T cell (CAR-T) therapy has revolutionized cancer treatment, but its application to solid tumors ...
Comprehensive review of the repositioning of non-oncologic drugs for cancer immunotherapy
Comprehensive review of the repositioning of non-oncologic drugs for cancer immunotherapy
Drug repositioning or repurposing has gained worldwide attention as a plausible way to search for novel molecules for the ...
Ferroptosis is an effective strategy for cancer therapy
Ferroptosis is an effective strategy for cancer therapy
Ferroptosis is a form of intracellular iron-dependent cell death that differs from necrosis, autophagy and apoptosis. Intr...
N-methyl-D-aspartate receptors and thymoquinone induce apoptosis and alteration in mitochondria in colorectal cancer cells
N-methyl-D-aspartate receptors and thymoquinone induce apoptosis and alteration in mitochondria in colorectal cancer cells
Colon cancer is on the rise in both men and women. In addition to traditional treatment methods, herbal treatments from co...
A new vision of the efficacy of both CAR-NK and CAR-T cells in treating cancers and autoimmune diseases
A new vision of the efficacy of both CAR-NK and CAR-T cells in treating cancers and autoimmune diseases
Chimeric Antigen Receptor (CAR) based therapies are becoming increasingly important in treating patients. CAR-T cells have...
FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner
FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner
Gastric cancer (GC) is a serious malignant tumour with a high mortality rate and a poor prognosis. Recently, emerging evid...
Liver cancer wars: plant-derived polyphenols strike back
Liver cancer wars: plant-derived polyphenols strike back
Liver cancer currently represents the leading cause of cancer-related death worldwide. The majority of liver cancer arises...
Exploring the immunomodulatory potential of Brahmi (Bacopa monnieri) in the treatment of invasive ductal carcinoma
Exploring the immunomodulatory potential of Brahmi (Bacopa monnieri) in the treatment of invasive ductal carcinoma
Bacopa monnieri (L) Wettst, commonly known as Brahmi, stands as a medicinal plant integral to India’s traditional me...
Dual function of activated PPARγ by ligands on tumor growth and immunotherapy
Dual function of activated PPARγ by ligands on tumor growth and immunotherapy
As one of the peroxisome-proliferator-activated receptors (PPARs) members, PPARγ is a ligand binding and activated nu...
A novel α,β-unsaturated ketone inhibits leukemia cell growth as PARP1 inhibitor
A novel α,β-unsaturated ketone inhibits leukemia cell growth as PARP1 inhibitor
Leukemia is a malignant disease of the hematopoietic system, in which clonal leukemia cells accumulate and inhibit normal ...
Coadministration of doxorubicin with vitamin D3, Lactobacillus acidophilus, and Lactobacillus casei in the 4T1 mouse model of breast cancer: anticancer and enteroprotective effects
Coadministration of doxorubicin with vitamin D3, Lactobacillus acidophilus, and Lactobacillus casei in the 4T1 mouse model of breast cancer: anticancer and enteroprotective effects
The use of doxorubicin (Dox) in the treatment of breast cancer negatively affects the intestines and other tissues. Many s...
Increased V-ATPase activity can lead to chemo-resistance in oral squamous cell carcinoma via autophagy induction: new insights
Increased V-ATPase activity can lead to chemo-resistance in oral squamous cell carcinoma via autophagy induction: new insights
Oral squamous cell carcinoma (OSCC) is a cancer type with a high rate of recurrence and a poor prognosis. Tumor chemo-resi...
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