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Novel targeted protein degradation technologies as a therapeutic strategy for neurodegenerative diseases
Novel targeted protein degradation technologies as a therapeutic strategy for neurodegenerative diseases
**Author for correspondence: E-mail Address: zjf298257@163.comDepartment of Pharmacy, Chengdu Fifth People's Hospital, Che...
Truth and lies about the use of old drugs against COVID-19: have we learned the lesson?
Truth and lies about the use of old drugs against COVID-19: have we learned the lesson?
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial intere...
Carbenoxolone disodium suppresses the migration of gastric cancer by targeting HDAC6
Carbenoxolone disodium suppresses the migration of gastric cancer by targeting HDAC6
Aim: Because of the severe morbidity and mortality of gastric cancer, discovering new candidate drugs has been an urgent i...
Structure modification: a successful tool for prodrug design
Structure modification: a successful tool for prodrug design
Prodrug strategy is critical for innovative drug development. Structural modification is the most straightforward and effe...
Investigation of halogenated furanones as inhibitors of quorum sensing-regulated bioluminescence in Vibrio harveyi
Investigation of halogenated furanones as inhibitors of quorum sensing-regulated bioluminescence in Vibrio harveyi
Aim: Vibrio harveyi is a Gram-negative marine bacterium that is a model system in the study of quorum sensing (QS). V. har...
Machine learning study: from the toxicity studies to tetrahydrocannabinol effects on Parkinson's disease
Machine learning study: from the toxicity studies to tetrahydrocannabinol effects on Parkinson's disease
Aim: Investigating molecules having toxicity and chemical similarity to find hit molecules. Methods: The machine learning ...
Inhibition of α-glucosidase enzyme by ‘click'-inspired pharmacophore framework 1,3,4-thiadiazole–1,2,3-triazole hybrids
Inhibition of α-glucosidase enzyme by ‘click'-inspired pharmacophore framework 1,3,4-thiadiazole–1,2,3-triazole hybrids
Aim: α-Glucosidase inhibitors are important oral antidiabetic drugs that are used alone or in combination therapy. Materia...
Antimicrobial, anticancer and immunomodulatory potential of new quinazolines bearing benzenesulfonamide moiety
Antimicrobial, anticancer and immunomodulatory potential of new quinazolines bearing benzenesulfonamide moiety
Sulfonamides are privileged candidates with potent anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and co...
Human sirtuin 2 inhibitors, their mechanisms and binding modes
Human sirtuin 2 inhibitors, their mechanisms and binding modes
The silent information regulator (sirtuin) is a family of enzymes involved in epigenetic processes with lysine deacetylase...
Chitosan–maleic acid conjugate as potential excipient candidate for oral drug delivery?
Chitosan–maleic acid conjugate as potential excipient candidate for oral drug delivery?
Aim: To develop and evaluate chitosan–maleic acid conjugate. Methods: Maleic anhydride was attached to chitosan backbone v...
Improving the antimicrobial activity of old antibacterial drug mafenide: Schiff bases and their bioactivity targeting resistant pathogens
Improving the antimicrobial activity of old antibacterial drug mafenide: Schiff bases and their bioactivity targeting resistant pathogens
Background: Increasing rates of acquired resistance have justified the critical need for novel antimicrobial drugs. One vi...
Investigation of 2-phenylimidazo[1,2-a]quinolines as potential antiproliferative agents
Investigation of 2-phenylimidazo[1,2-a]quinolines as potential antiproliferative agents
Background: It has been demonstrated that the lead compound 2-phenylimidazo[1,2-a]quinoline 1a selectively inhibits CYP1 e...
Generative kinase inhibitor modeling viewed from a medicinal chemistry perspective
Generative kinase inhibitor modeling viewed from a medicinal chemistry perspective
The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest...
Potential strategies for the management of adenocarcinoma: a perspective
Potential strategies for the management of adenocarcinoma: a perspective
This study was supported by a research grant from the Department of Science and Technology–Science and Engineering Researc...
Propargylamine: an important moiety in drug discovery
Propargylamine: an important moiety in drug discovery
Propargylamine is a chemical moiety whose properties have made it a widely distributed group within the fields of medicina...
Synthetic benzofuran-linked chalcones with dual actions: a potential therapeutic approach to manage diabetes mellitus
Synthetic benzofuran-linked chalcones with dual actions: a potential therapeutic approach to manage diabetes mellitus
Background: Identification of molecules having dual capabilities to reduce postprandial hyperglycemia and oxidative stress...
Novel anthraquinone derivatives trigger endoplasmic reticulum stress response and induce apoptosis
Novel anthraquinone derivatives trigger endoplasmic reticulum stress response and induce apoptosis
Background: Endoplasmic reticulum (ER) stress is a therapeutic target in cancer given its regulation of bioenergetics and ...
Discovery of reversible selective monoamine oxidase B inhibitors with anti-acetylcholinesterase activity derived from 4-oxo-N-4-diphenyl butanamides
Discovery of reversible selective monoamine oxidase B inhibitors with anti-acetylcholinesterase activity derived from 4-oxo-N-4-diphenyl butanamides
Aim: Multitargeted drugs are essential for the treatment of various neurodegenerative disorders, because of their complex ...
An update on the recent advances and discovery of novel tubulin colchicine binding inhibitors
An update on the recent advances and discovery of novel tubulin colchicine binding inhibitors
Microtubules, formed by α- and β-tubulin heterodimer, are considered as a major target to prevent the proliferation of tum...
Challenging breast cancer through novel sulfonamide–pyridine hybrids: design, synthesis, carbonic anhydrase IX inhibition and induction of apoptosis
Challenging breast cancer through novel sulfonamide–pyridine hybrids: design, synthesis, carbonic anhydrase IX inhibition and induction of apoptosis
Background: Among the important key modulators of the tumor microenvironment and hypoxia is a family of enzymes named carb...
Our New Year's (re)solution: welcome to the 15th volume of Future Medicinal Chemistry
Our New Year's (re)solution: welcome to the 15th volume of Future Medicinal Chemistry
Michael Bell is an employee of Future Science Ltd. The author has no relevant affiliations or financial involvement with a...
The connection between PARP14 and SARS-CoV-2
The connection between PARP14 and SARS-CoV-2
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial intere...
Chemical language models for applications in medicinal chemistry
Chemical language models for applications in medicinal chemistry
A Yoshimori is CEO of the Institute for Theoretical Medicine, Inc. (ITM), which provides services and scientific software ...
Synergistic effect of bovine cateslytin-loaded nanoparticles combined with ultrasound against Candida albicans biofilm
Synergistic effect of bovine cateslytin-loaded nanoparticles combined with ultrasound against Candida albicans biofilm
Purpose: To investigate the synergistic effect of bovine cateslytin-loaded nanoparticles (bCAT-NPs) combined with ultrasou...
Pyrazoline scaffold: hit identification to lead synthesis and biological evaluation as antidiabetic agents
Pyrazoline scaffold: hit identification to lead synthesis and biological evaluation as antidiabetic agents
Background: Mining of novel scaffolds as potential DPP-IV inhibitors for future development of potential candidates as ant...
Design and synthesis of selective FLT3 inhibitors via exploration of back pocket II
Design and synthesis of selective FLT3 inhibitors via exploration of back pocket II
Aim: The clinical benefits of FLT3 inhibitors against acute myeloid leukemia (AML) have been limited by selectivity and re...
Design, synthesis and bio-evaluation of indolin-2-ones as potential antidiabetic agents
Design, synthesis and bio-evaluation of indolin-2-ones as potential antidiabetic agents
Background: Diabetes mellitus is a serious global health concern, and this is expected to impact more than 300 million peo...
Latest advances in specific inhibition of tumor-associated carbonic anhydrases
Latest advances in specific inhibition of tumor-associated carbonic anhydrases
Research from the author's laboratory was financed by the Italian Ministry for University and Research (MIUR), grants PRIN...
An introduction to the newest member of our editorial board, Associate Professor Fiorella Meneghetti
An introduction to the newest member of our editorial board, Associate Professor Fiorella Meneghetti
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Tetrahydroquinoline: an efficient scaffold as mTOR inhibitor for the treatment of lung cancer
Tetrahydroquinoline: an efficient scaffold as mTOR inhibitor for the treatment of lung cancer
Efforts have been made to find an efficient scaffold (and its substitution) that can be used for the treatment of lung can...
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