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Screening and surveillance recommendations for central nervous system hemangioblastomas in pediatric patients with Von Hippel-Lindau disease
Screening and surveillance recommendations for central nervous system hemangioblastomas in pediatric patients with Von Hippel-Lindau disease
Von Hippel-Lindau (VHL) disease is an autosomal-dominantly inherited tumor predisposition syndrome. One of the most common...
Suberanilohydroxamic acid (SAHA), a HDAC inhibitor, suppresses the effect of Treg cells by targeting the c-Myc/CCL1 pathway in glioma stem cells and improves PD-L1 blockade therapy
Suberanilohydroxamic acid (SAHA), a HDAC inhibitor, suppresses the effect of Treg cells by targeting the c-Myc/CCL1 pathway in glioma stem cells and improves PD-L1 blockade therapy
A strong immunosuppressive tumor microenvironment (TME) represents the major barrier responsible for the failure of curren...
Intraoperative radiotherapy combined with spinal stabilization surgery—a novel treatment strategy for spinal metastases based on a first single-center experiences
Intraoperative radiotherapy combined with spinal stabilization surgery—a novel treatment strategy for spinal metastases based on a first single-center experiences
Current treatment of spinal metastases (SM) aims on preserving spinal stability, neurological status, and functional statu...
Genomic landscape of glioblastoma without IDH somatic mutation in 42 cases: a comprehensive analysis using RNA sequencing data
Genomic landscape of glioblastoma without IDH somatic mutation in 42 cases: a comprehensive analysis using RNA sequencing data
Glioblastoma is a malignant brain tumor with a poor prognosis. Genetic mutations associated with this disease are complex ...
Impact of concurrent antibody–drug conjugates and radiotherapy on symptomatic radiation necrosis in breast cancer patients with brain metastases: a multicenter retrospective study
Impact of concurrent antibody–drug conjugates and radiotherapy on symptomatic radiation necrosis in breast cancer patients with brain metastases: a multicenter retrospective study
We aimed to investigate the impact of concurrent antibody–drug conjugates (ADC) and radiotherapy on symptomatic radi...
National trends in the treatment of adult diffuse midline gliomas: a rare clinical scenario
National trends in the treatment of adult diffuse midline gliomas: a rare clinical scenario
Diffuse midline gliomas (DMG) include all midline gliomas with a point mutation to the histone H3 gene resulting in the su...
Personalized prognosis stratification of newly diagnosed glioblastoma applying a statistical decision tree model
Personalized prognosis stratification of newly diagnosed glioblastoma applying a statistical decision tree model
Glioblastoma (GBM) is the most frequent glioma in adults with a high treatment resistance resulting into limited survival....
Central nervous system embryonal tumors with EWSR1-PLAGL1 rearrangements reclassified as INI-1 deficient tumors at relapse
Central nervous system embryonal tumors with EWSR1-PLAGL1 rearrangements reclassified as INI-1 deficient tumors at relapse
Central nervous system (CNS) embryonal tumors are a diverse group of malignant tumors typically affecting pediatric patien...
Neuroradiological features of patients with bilateral macronodular adrenocortical disease and meningiomas associated or not with genetic variants of ARMC5– a case series
Neuroradiological features of patients with bilateral macronodular adrenocortical disease and meningiomas associated or not with genetic variants of ARMC5– a case series
Meningiomas are the most common primary brain and central nervous system tumors, accounting for approximately 40% of these...
Improved outcomes for triple negative breast cancer brain metastases patients after stereotactic radiosurgery and new systemic approaches
Improved outcomes for triple negative breast cancer brain metastases patients after stereotactic radiosurgery and new systemic approaches
Although ongoing studies are assessing the efficacy of new systemic therapies for patients with triple negative breast can...
Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines
Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines
Patients with pediatric low-grade gliomas (pLGGs), the most common primary brain tumors in children, can often benefit fro...
Exploring management and outcomes of elderly patients with glioblastoma using data from two randomised trials (GEINO1401/EX-TEM)
Exploring management and outcomes of elderly patients with glioblastoma using data from two randomised trials (GEINO1401/EX-TEM)
The impact of age on optimal management of glioblastoma remains unclear. A recent combined analysis of two randomised tria...
Comparative analysis of bevacizumab and LITT for treating radiation necrosis in previously radiated CNS neoplasms: a systematic review and meta-analysis
Comparative analysis of bevacizumab and LITT for treating radiation necrosis in previously radiated CNS neoplasms: a systematic review and meta-analysis
Radiation necrosis (RN) is a local inflammatory reaction that arises in response to radiation injury and may cause signifi...
Gamma knife radiosurgery for clival metastasis: case series and systematic review
Gamma knife radiosurgery for clival metastasis: case series and systematic review
Clival metastatic cancer is rare and has limited literature to guide management. We describe management of clival metastas...
Profile of miRNAs in small extracellular vesicles released from glioblastoma cells treated by boron neutron capture therapy
Profile of miRNAs in small extracellular vesicles released from glioblastoma cells treated by boron neutron capture therapy
Boron neutron capture therapy (BNCT) is a tumor cell-selective particle-radiation therapy. In BNCT, administered p-boronop...
Assessment of multimodal treatment options in recurrent and persistent acromegaly: a systematic review and meta-analysis
Assessment of multimodal treatment options in recurrent and persistent acromegaly: a systematic review and meta-analysis
In patients with acromegaly, secondary treatment options in cases of hormonal non-remission or tumor progression include r...
Intraoperative magnetic resonance imaging in glioma surgery: a single-center experience
Intraoperative magnetic resonance imaging in glioma surgery: a single-center experience
To investigate the effect of intraoperative magnetic resonance imaging (Io MRI) on overall and progression-free survival (...
Loss of methylthioadenosine phosphorylase immunoreactivity correlates with poor prognosis and elevated uptake of 11C-methionine in IDH-mutant astrocytoma
Loss of methylthioadenosine phosphorylase immunoreactivity correlates with poor prognosis and elevated uptake of 11C-methionine in IDH-mutant astrocytoma
The proximate localization of MTAP, which encodes methylthioadenosine phosphorylase, and CDKN2A/B on Chromosome 9q21 has a...
Maximal cardiopulmonary exercise testing in glioblastoma patients undergoing chemotherapy: assessment of feasibility, safety, and physical fitness status
Maximal cardiopulmonary exercise testing in glioblastoma patients undergoing chemotherapy: assessment of feasibility, safety, and physical fitness status
Maximal cardiopulmonary exercise testing (max. CPET) provides the most accurate measurement of cardiorespiratory fitness. ...
Machine learning-based pathomics signature of histology slides as a novel prognostic indicator in primary central nervous system lymphoma
Machine learning-based pathomics signature of histology slides as a novel prognostic indicator in primary central nervous system lymphoma
To develop and validate a pathomics signature for predicting the outcomes of Primary Central Nervous System Lymphoma (PCNS...
Sex differences in adverse events in Medicare individuals ≥ 66 years of age post glioblastoma treatment
Sex differences in adverse events in Medicare individuals ≥ 66 years of age post glioblastoma treatment
Glioblastoma (GB) is the most common primary malignant brain tumor with the highest incidence occurring in older adults wi...
Pediatric neurosurgical medulloblastoma outcomes in La Paz, Bolivia: How a Lower Middle-Income Country (LMIC) institution in South America compares to the United States
Pediatric neurosurgical medulloblastoma outcomes in La Paz, Bolivia: How a Lower Middle-Income Country (LMIC) institution in South America compares to the United States
How pediatric medulloblastoma patients fare in Lower Middle-Income Country (LMICs) in South America is not well understood...
Real-world cost- effectiveness analysis: Tumor Treating Fields for newly diagnosed glioblastoma in China
Real-world cost- effectiveness analysis: Tumor Treating Fields for newly diagnosed glioblastoma in China
Glioblastoma (GBM) stands as the most aggressive and prevalent primary brain malignancy. Tumor Treating Fields (T...
Repurposing mebendazole against triple-negative breast cancer CNS metastasis
Repurposing mebendazole against triple-negative breast cancer CNS metastasis
Triple-negative breast cancer (TNBC) often metastasizes to the central nervous system (CNS) and has the highest propensity...
A new updated prognostic index for patients with brain metastases (BMs) treated with palliative whole brain radiotherapy (WBRT) in the era of precision oncology. METASNCore project
A new updated prognostic index for patients with brain metastases (BMs) treated with palliative whole brain radiotherapy (WBRT) in the era of precision oncology. METASNCore project
Palliative WBRT is the main treatment for multiple BMs. Recent studies report no benefit in survival after WBRT compared t...
Hypofractionated re-irradiation with bevacizumab for relapsed chemorefractory glioblastoma after prior high dose radiotherapy: a feasible option for patients with large-volume relapse
Hypofractionated re-irradiation with bevacizumab for relapsed chemorefractory glioblastoma after prior high dose radiotherapy: a feasible option for patients with large-volume relapse
There remains no standard of care for patients with recurrent and chemorefractory glioblastoma. Re-irradiation (reRT) prov...
A systematic review of extraneural meningioma metastasis: timing, evolution and outlook
A systematic review of extraneural meningioma metastasis: timing, evolution and outlook
Extraneural meningioma metastasis is a rare occurrence and may pose a clinical challenge due to its unclear prognosis. In ...
Utility of molecular markers in predicting local control specific to lung cancer spine metastases treated with stereotactic body radiotherapy
Utility of molecular markers in predicting local control specific to lung cancer spine metastases treated with stereotactic body radiotherapy
We report outcomes following spine stereotactic body radiotherapy (SBRT) in metastatic non-small cell lung cancer (NSCLC) ...
Adjuvant re-irradiation vs. no early re-irradiation of resected recurrent glioblastoma: pooled comparative cohort analysis from two tertiary centers
Adjuvant re-irradiation vs. no early re-irradiation of resected recurrent glioblastoma: pooled comparative cohort analysis from two tertiary centers
The optimal management strategy for recurrent glioblastoma (rGBM) remains uncertain, and the impact of re-irradiation (Re-...
Palliative care for in-patient malignant glioma patients in Germany
Palliative care for in-patient malignant glioma patients in Germany
Malignant gliomas impose a significant symptomatic burden on patients and their families. Current guidelines recommend pal...
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