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“Anti-inflammatory Therapies in Atherosclerosis – Where are we going?”
“Anti-inflammatory Therapies in Atherosclerosis – Where are we going?”
Inflammation has been commonly known for the past decade as a part of the pathophysiology of atherosclerosis, along with l...
Risk Factors Favoring Plaque Erosion
Risk Factors Favoring Plaque Erosion
Plaque erosion is the second leading cause of coronary thrombosis following plaque rupture and represents a key pathophysi...
Statin Use in Children and Adolescents – Dos, Don’ts and Practical Tips
Statin Use in Children and Adolescents – Dos, Don’ts and Practical Tips
We review treatment criteria in the pediatric population, provide practical advice on how and when to prescribe statins, a...
Sticky Business: Correlating Oligomeric Features of Class B Scavenger Receptors to Lipid Transport
Sticky Business: Correlating Oligomeric Features of Class B Scavenger Receptors to Lipid Transport
Atherosclerotic plaques result from imbalanced lipid metabolism and maladaptive chronic immune responses. Class B scavenge...
Impact of Climate Change on Cardiovascular Health
Impact of Climate Change on Cardiovascular Health
Climate change is profoundly impacting cardiovascular disease through rising temperatures, more extreme weather events, an...
Ezetimibe: Integrating Established Use with New Evidence - A Comprehensive Review
Ezetimibe: Integrating Established Use with New Evidence - A Comprehensive Review
To consolidate key information on the efficacy and safety of ezetimibe, with a focus on the latest evidence. While ezetimi...
Statin Therapy for Primary and Secondary Prevention in Older Adults
Statin Therapy for Primary and Secondary Prevention in Older Adults
Although statin therapy is well established to prevent atherosclerotic vascular disease (ASCVD) events in adults 40 to 75 ...
IL-6 and Cardiovascular Risk: A Narrative Review
IL-6 and Cardiovascular Risk: A Narrative Review
The objective of this narrative review is to summarize data from recently published prospective observational studies that...
Role of RNA-binding Proteins in Regulating Cell Adhesion and Progression of the Atherosclerotic Plaque and Plaque Erosion
Role of RNA-binding Proteins in Regulating Cell Adhesion and Progression of the Atherosclerotic Plaque and Plaque Erosion
RNA-binding proteins (RBPs) have emerged as crucial regulators of post-transcriptional processes, influencing the fate of ...
Bridging the Gap: How Accounting for Social Determinants of Health Can Improve Digital Health Equity in Cardiovascular Medicine
Bridging the Gap: How Accounting for Social Determinants of Health Can Improve Digital Health Equity in Cardiovascular Medicine
In this review, we discuss the importance of digital health equity and how social determinants of health (and intersection...
Lp(a): A Rapidly Evolving Therapeutic Landscape
Lp(a): A Rapidly Evolving Therapeutic Landscape
Elevated lipoprotein(a) (Lp[a]) is a genetically determined cardiovascular risk factor, causally linked to both atheroscle...
Statin-Associated Muscle Symptoms: Identification and Recommendations for Management
Statin-Associated Muscle Symptoms: Identification and Recommendations for Management
Statins are first-line pharmacotherapy for the treatment of elevated low-density lipoprotein cholesterol and are generally...
Inhibition of the ANGPTL3/8 Complex for the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
Inhibition of the ANGPTL3/8 Complex for the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
Dyslipidemia is a casual risk factor for atherosclerotic cardiovascular disease (ASCVD). There is an unmet need for more e...
The Emerging Potential of Apolipoprotein C-III Inhibition for ASCVD Prevention: A State-of-the-Art Review
The Emerging Potential of Apolipoprotein C-III Inhibition for ASCVD Prevention: A State-of-the-Art Review
Multiple agents are being developed that inhibit apolipoprotein (apo) C-III. This state-of-the-art review examines their p...
Erosion of the Atheroma: Wicked T Cells at the Culprit Site
Erosion of the Atheroma: Wicked T Cells at the Culprit Site
There is a growing recognition of plaque erosion as a cause of acute coronary syndrome. This review aims to examine the po...
Do Statins Affect Cognitive Health? A Narrative Review and Critical Analysis of the Evidence
Do Statins Affect Cognitive Health? A Narrative Review and Critical Analysis of the Evidence
Statins are the first-line treatment for hypercholesterolemia and play a key role in the prevention of cardiovascular dise...
The Role of Iron in Atherosclerosis and its Association with Related Diseases
The Role of Iron in Atherosclerosis and its Association with Related Diseases
This review aims to elucidate the multifaceted role of iron in the pathogenesis of atherosclerosis. The primary objective ...
Targeting Inflammatory Pathways in Atherosclerosis: Exploring New Opportunities for Treatment
Targeting Inflammatory Pathways in Atherosclerosis: Exploring New Opportunities for Treatment
This review discusses the molecular mechanisms involved in the immuno-pathogenesis of atherosclerosis, the pleiotropic ant...
Pericoronary Fat Attenuation: Diagnosis and Clinical Implications
Pericoronary Fat Attenuation: Diagnosis and Clinical Implications
The purpose of this review is to evaluate the current state of knowledge regarding the technical challenges associated wit...
PCSK9 Monoclonal Antibodies Have Come a Long Way
PCSK9 Monoclonal Antibodies Have Come a Long Way
This review examines the pivotal role of monoclonal antibodies against PCSK9 in lipid-lowering therapy, emphasizing their ...
Beyond the Guidelines: Perspectives on Management of Pediatric Patients with Hypertriglyceridemia
Beyond the Guidelines: Perspectives on Management of Pediatric Patients with Hypertriglyceridemia
To provide a comprehensive overview of hypertriglyceridemia (HTG) in youth, identifying gaps in categorizing triglyceride ...
Health Data Sciences and Cardiovascular Disease in Africa: Needs and the Way Forward
Health Data Sciences and Cardiovascular Disease in Africa: Needs and the Way Forward
The rising burden of cardiovascular disease (CVD) in Africa is of great concern. Health data sciences is a rapidly develop...
Health Data Sciences and Cardiovascular Diseases in South Asia: Innovations and Challenges in Digital Health
Health Data Sciences and Cardiovascular Diseases in South Asia: Innovations and Challenges in Digital Health
Health data sciences can help mitigate high burden of cardiovascular disease (CVD) management in South Asia by increasing ...
Should We Use Aspirin or P2Y12 Inhibitor Monotherapy in Stable Ischemic Heart Disease?
Should We Use Aspirin or P2Y12 Inhibitor Monotherapy in Stable Ischemic Heart Disease?
To summarize the recent evidence and guideline recommendations on aspirin or P2Y12 inhibitor monotherapy in patients with ...
PCSK9 and Coronary Artery Plaque—New Opportunity or Red Herring?
PCSK9 and Coronary Artery Plaque—New Opportunity or Red Herring?
Although the clinical benefit of reducing low-density lipoprotein cholesterol (LDLc) in patients with coronary artery dise...
Obicetrapib—the Rebirth of CETP Inhibitors?
Obicetrapib—the Rebirth of CETP Inhibitors?
To provide perspective on the current development status, and potential future role, of obicetrapib, a third-generation ch...
Targeting Macrophage Phenotypes and Metabolism as Novel Therapeutic Approaches in Atherosclerosis and Related Cardiovascular Diseases
Targeting Macrophage Phenotypes and Metabolism as Novel Therapeutic Approaches in Atherosclerosis and Related Cardiovascular Diseases
Macrophage accumulation and activation function as hallmarks of atherosclerosis and have complex and intricate dynamics th...
A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease
A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease
Major Depressive Disorder (MDD) is characterized by persistent symptoms such as fatigue, loss of interest in activities, f...
Cholesterol Lowering in Older Adults: Should We Wait for Further Evidence?
Cholesterol Lowering in Older Adults: Should We Wait for Further Evidence?
Current guidelines for primary and secondary prevention of cardiovascular events in adults up to age 75 years are...
Cardiovascular Risk Estimation and Stratification Among Individuals with Hypercholesterolemia
Cardiovascular Risk Estimation and Stratification Among Individuals with Hypercholesterolemia
This review aims to assess the variability in considering hypercholesterolemia for cardiovascular risk stratification in t...
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