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Statin-Associated Muscle Symptoms: Identification and Recommendations for Management
Statin-Associated Muscle Symptoms: Identification and Recommendations for Management
Statins are first-line pharmacotherapy for the treatment of elevated low-density lipoprotein cholesterol and are generally...
Inhibition of the ANGPTL3/8 Complex for the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
Inhibition of the ANGPTL3/8 Complex for the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
Dyslipidemia is a casual risk factor for atherosclerotic cardiovascular disease (ASCVD). There is an unmet need for more e...
The Emerging Potential of Apolipoprotein C-III Inhibition for ASCVD Prevention: A State-of-the-Art Review
The Emerging Potential of Apolipoprotein C-III Inhibition for ASCVD Prevention: A State-of-the-Art Review
Multiple agents are being developed that inhibit apolipoprotein (apo) C-III. This state-of-the-art review examines their p...
Erosion of the Atheroma: Wicked T Cells at the Culprit Site
Erosion of the Atheroma: Wicked T Cells at the Culprit Site
There is a growing recognition of plaque erosion as a cause of acute coronary syndrome. This review aims to examine the po...
Do Statins Affect Cognitive Health? A Narrative Review and Critical Analysis of the Evidence
Do Statins Affect Cognitive Health? A Narrative Review and Critical Analysis of the Evidence
Statins are the first-line treatment for hypercholesterolemia and play a key role in the prevention of cardiovascular dise...
The Role of Iron in Atherosclerosis and its Association with Related Diseases
The Role of Iron in Atherosclerosis and its Association with Related Diseases
This review aims to elucidate the multifaceted role of iron in the pathogenesis of atherosclerosis. The primary objective ...
Targeting Inflammatory Pathways in Atherosclerosis: Exploring New Opportunities for Treatment
Targeting Inflammatory Pathways in Atherosclerosis: Exploring New Opportunities for Treatment
This review discusses the molecular mechanisms involved in the immuno-pathogenesis of atherosclerosis, the pleiotropic ant...
Pericoronary Fat Attenuation: Diagnosis and Clinical Implications
Pericoronary Fat Attenuation: Diagnosis and Clinical Implications
The purpose of this review is to evaluate the current state of knowledge regarding the technical challenges associated wit...
PCSK9 Monoclonal Antibodies Have Come a Long Way
PCSK9 Monoclonal Antibodies Have Come a Long Way
This review examines the pivotal role of monoclonal antibodies against PCSK9 in lipid-lowering therapy, emphasizing their ...
Beyond the Guidelines: Perspectives on Management of Pediatric Patients with Hypertriglyceridemia
Beyond the Guidelines: Perspectives on Management of Pediatric Patients with Hypertriglyceridemia
To provide a comprehensive overview of hypertriglyceridemia (HTG) in youth, identifying gaps in categorizing triglyceride ...
Health Data Sciences and Cardiovascular Disease in Africa: Needs and the Way Forward
Health Data Sciences and Cardiovascular Disease in Africa: Needs and the Way Forward
The rising burden of cardiovascular disease (CVD) in Africa is of great concern. Health data sciences is a rapidly develop...
Health Data Sciences and Cardiovascular Diseases in South Asia: Innovations and Challenges in Digital Health
Health Data Sciences and Cardiovascular Diseases in South Asia: Innovations and Challenges in Digital Health
Health data sciences can help mitigate high burden of cardiovascular disease (CVD) management in South Asia by increasing ...
Should We Use Aspirin or P2Y12 Inhibitor Monotherapy in Stable Ischemic Heart Disease?
Should We Use Aspirin or P2Y12 Inhibitor Monotherapy in Stable Ischemic Heart Disease?
To summarize the recent evidence and guideline recommendations on aspirin or P2Y12 inhibitor monotherapy in patients with ...
PCSK9 and Coronary Artery Plaque—New Opportunity or Red Herring?
PCSK9 and Coronary Artery Plaque—New Opportunity or Red Herring?
Although the clinical benefit of reducing low-density lipoprotein cholesterol (LDLc) in patients with coronary artery dise...
Obicetrapib—the Rebirth of CETP Inhibitors?
Obicetrapib—the Rebirth of CETP Inhibitors?
To provide perspective on the current development status, and potential future role, of obicetrapib, a third-generation ch...
Targeting Macrophage Phenotypes and Metabolism as Novel Therapeutic Approaches in Atherosclerosis and Related Cardiovascular Diseases
Targeting Macrophage Phenotypes and Metabolism as Novel Therapeutic Approaches in Atherosclerosis and Related Cardiovascular Diseases
Macrophage accumulation and activation function as hallmarks of atherosclerosis and have complex and intricate dynamics th...
A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease
A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease
Major Depressive Disorder (MDD) is characterized by persistent symptoms such as fatigue, loss of interest in activities, f...
Cholesterol Lowering in Older Adults: Should We Wait for Further Evidence?
Cholesterol Lowering in Older Adults: Should We Wait for Further Evidence?
Current guidelines for primary and secondary prevention of cardiovascular events in adults up to age 75 years are...
Cardiovascular Risk Estimation and Stratification Among Individuals with Hypercholesterolemia
Cardiovascular Risk Estimation and Stratification Among Individuals with Hypercholesterolemia
This review aims to assess the variability in considering hypercholesterolemia for cardiovascular risk stratification in t...
Social Phenotyping for Cardiovascular Risk Stratification in Electronic Health Registries
Social Phenotyping for Cardiovascular Risk Stratification in Electronic Health Registries
Evaluation of social influences on cardiovascular care requires a comprehensive analysis encompassing economic, societal, ...
The Role of Social Determinants of Health in Atherosclerotic Cardiovascular Disease
The Role of Social Determinants of Health in Atherosclerotic Cardiovascular Disease
This review seeks to provide important information on each of the major domains of social determinants of health (SDOH) in...
Therapeutic Monoclonal Antibodies for Metabolic Disorders: Major Advancements and Future Perspectives
Therapeutic Monoclonal Antibodies for Metabolic Disorders: Major Advancements and Future Perspectives
Globally, the prevalence of metabolic disorders is rising. Elevated low-density lipoprotein (LDL) cholesterol is a hallmar...
The Emerging Specialty of Cardio-Rheumatology
The Emerging Specialty of Cardio-Rheumatology
In this review, we aimed to summarize the different aspects of the field of cardio-rheumatology, the role of the cardio-rh...
The Role of Reverse Cascade Screening in Children with Familial Hypercholesterolemia: A Literature Review and Analysis
The Role of Reverse Cascade Screening in Children with Familial Hypercholesterolemia: A Literature Review and Analysis
Familial Hypercholesterolemia (FH) is a common genetic disorder characterized by lifelong elevation of severely elevated p...
Unraveling the miRNA Puzzle in Atherosclerosis: Revolutionizing Diagnosis, Prognosis, and Therapeutic Approaches
Unraveling the miRNA Puzzle in Atherosclerosis: Revolutionizing Diagnosis, Prognosis, and Therapeutic Approaches
To eradicate atherosclerotic diseases, novel biomarkers, and future therapy targets must reveal the burden of early athero...
Lipoprotein (a)-Related Inflammatory Imbalance: A Novel Horizon for the Development of Atherosclerosis
Lipoprotein (a)-Related Inflammatory Imbalance: A Novel Horizon for the Development of Atherosclerosis
The primary objective of this review is to explore the pathophysiological roles and clinical implications of lipoprotein(a...
Myocardial Bridge and Atherosclerosis, an Intimal Relationship
Myocardial Bridge and Atherosclerosis, an Intimal Relationship
This review investigates the relationship between myocardial bridges (MBs), intimal thickening in coronary arteries, and A...
Hypercholesterolemia and the Increased Risk of Vascular Dementia: a Cholesterol Perspective
Hypercholesterolemia and the Increased Risk of Vascular Dementia: a Cholesterol Perspective
Vascular dementia (VaD) is the second most prevalent type of dementia after Alzheimer's disease.Hypercholesterolemia m...
Stress, Vascular Smooth Muscle Cell Phenotype and Atherosclerosis: Novel Insight into Smooth Muscle Cell Phenotypic Transition in Atherosclerosis
Stress, Vascular Smooth Muscle Cell Phenotype and Atherosclerosis: Novel Insight into Smooth Muscle Cell Phenotypic Transition in Atherosclerosis
Our work is to establish more distinct association between specific stress and vascular smooth muscle cells (VSMCs) phenot...
GLP-1 Receptor Agonists and Cardiovascular Disease: What Do Clinicians Need to Know?
GLP-1 Receptor Agonists and Cardiovascular Disease: What Do Clinicians Need to Know?
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are gaining importance due to their effects on cardiovascular paramet...
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