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Plasma H3Cit-DNA Discriminates Between Cancer and Inflammation in a Cohort of Patients with Unspecific Cancer Symptoms
Plasma H3Cit-DNA Discriminates Between Cancer and Inflammation in a Cohort of Patients with Unspecific Cancer Symptoms
Cancer detection is challenging, especially in patients with unspecific cancer symptoms. Biomarkers could identify patient...
Deficiency of Secreted Phosphoprotein 1 Alleviates Hyperoxia-induced Bronchopulmonary Dysplasia in Neonatal Mice
Deficiency of Secreted Phosphoprotein 1 Alleviates Hyperoxia-induced Bronchopulmonary Dysplasia in Neonatal Mice
Bronchopulmonary dysplasia (BPD) is a common chronic lung disorder characterized by impaired proximal airway and bronchoal...
Autophagy Regulation Attenuates Neuroinflammation and Cognitive Decline in an Alzheimer's Disease Mouse Model with Chronic Cerebral Hypoperfusion
Autophagy Regulation Attenuates Neuroinflammation and Cognitive Decline in an Alzheimer's Disease Mouse Model with Chronic Cerebral Hypoperfusion
This study investigates the role of autophagy regulation in modulating neuroinflammation and cognitive function in an Alzh...
Ginkgolide C attenuated Western diet-induced non-alcoholic fatty liver disease via increasing AMPK activation
Ginkgolide C attenuated Western diet-induced non-alcoholic fatty liver disease via increasing AMPK activation
Non-alcoholic steatohepatitis (NASH) is a metabolic dysregulation-related disorder that is generally characterized by lipi...
Peroxiredoxin 6 Protects Pulmonary Epithelial Cells From Cigarette-related Ferroptosis in Chronic Obstructive Pulmonary Disease
Peroxiredoxin 6 Protects Pulmonary Epithelial Cells From Cigarette-related Ferroptosis in Chronic Obstructive Pulmonary Disease
Peroxiredoxin 6 (PRDX6) has a protective effect on pulmonary epithelial cells against cigarette smoke (CS)-induced ferropt...
Targeting S100A12 to Improve Angiogenesis and Accelerate Diabetic Wound Healing
Targeting S100A12 to Improve Angiogenesis and Accelerate Diabetic Wound Healing
Long-term inflammation and impaired angiogenesis are thought to be the causes of delayed healing or nonhealing of diabetic...
Platr3/NUDT21/NF-κB Axis Mediates P. gingivalis-Suppressed Cementoblast Mineralization
Platr3/NUDT21/NF-κB Axis Mediates P. gingivalis-Suppressed Cementoblast Mineralization
Porphyromonas gingivalis (P. gingivalis) is one of the major pathogens causing periodontitis and apical periodontitis (AP)...
Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice
Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice
Despite intense efforts to develop efficient therapeutic regimes for asthma, there is a large demand for novel treatment s...
Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways
Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways
Methylprednisolone (MP) is a potent glucocorticoid that can effectively inhibit immune system inflammation and brain tissu...
Increased Tryptophan Catabolism Provides Predictive Value to Chronic Heart Failure Patients with Low-Grade Inflammation
Increased Tryptophan Catabolism Provides Predictive Value to Chronic Heart Failure Patients with Low-Grade Inflammation
Kynurenine to tryptophan ratio (KTR), which serves as an indicator for evaluating indoleamine-2,3-dioxygenase activity and...
YTHDF2 Regulates Advanced Glycation End Products-Induced Melanogenesis through Inhibiting A20 Expression in Human Dermal Fibroblasts
YTHDF2 Regulates Advanced Glycation End Products-Induced Melanogenesis through Inhibiting A20 Expression in Human Dermal Fibroblasts
Fibroblast A20 suppresses advanced glycation end products (AGEs)-induced melanogenesis by inhibiting NLRP3 inflammasome ac...
Biochanin A Ameliorates Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice by Modulating the NF-κB and MAPK Signaling Pathways
Biochanin A Ameliorates Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice by Modulating the NF-κB and MAPK Signaling Pathways
Psoriasis is a chronic skin inflammatory disorder characterized by the hyper-activation of the immune system and the over-...
Melatonin via MTNR1B regulates METTL3 to protect ileum cell differentiation
Melatonin via MTNR1B regulates METTL3 to protect ileum cell differentiation
Intestinal stem cells rapidly differentiate into various epithelial cells, playing a crucial role in maintaining intestina...
Deciphering Autoimmune Diseases: Unveiling the Diagnostic, Therapeutic, and Prognostic Potential of Immune Repertoire Sequencing
Deciphering Autoimmune Diseases: Unveiling the Diagnostic, Therapeutic, and Prognostic Potential of Immune Repertoire Sequencing
Autoimmune diseases (AIDs) are immune system disorders where the body exhibits an immune response to its own antigens, cau...
Crucial Roles of RSAD2/viperin in Immunomodulation, Mitochondrial Metabolism and Autoimmune Diseases
Crucial Roles of RSAD2/viperin in Immunomodulation, Mitochondrial Metabolism and Autoimmune Diseases
Autoimmune diseases are typically characterized by aberrant activation of immune system that leads to excessive inflammato...
Alloferon Mitigates LPS-Induced Endometritis by Attenuating the NLRP3/CASP1/IL-1β/IL-18 Signaling Cascade
Alloferon Mitigates LPS-Induced Endometritis by Attenuating the NLRP3/CASP1/IL-1β/IL-18 Signaling Cascade
Endometritis is an inflammatory reaction of the uterine lining that can lead to infertility. Alloferon, a linear non-glyco...
Prenatal Inflammatory Exposure Predisposes Offspring to Chronic Kidney Diseases Via the Activation of the eIF2α-ATF4 Pathway
Prenatal Inflammatory Exposure Predisposes Offspring to Chronic Kidney Diseases Via the Activation of the eIF2α-ATF4 Pathway
It has recently become more recognized that renal diseases in adults can originate from adverse intrauterine (maternal) en...
Non-Canonical STING-PERK Pathway Modulation of Cellular Senescence and Therapeutic Response in Sepsis-Associated Acute Kidney Injury
Non-Canonical STING-PERK Pathway Modulation of Cellular Senescence and Therapeutic Response in Sepsis-Associated Acute Kidney Injury
Abstract–This study explored the role of the non-canonical STING-PERK signaling pathway in sepsis-associated acute k...
The Implications of Brain-Derived Neurotrophic Factor in the Biological Activities of Platelet-Rich Plasma
The Implications of Brain-Derived Neurotrophic Factor in the Biological Activities of Platelet-Rich Plasma
Platelet-rich plasma (PRP) is a biological blood-derived therapeutic obtained from whole blood that contains higher levels...
AMPK Regulates M1 Macrophage Polarization through the JAK2/STAT3 Signaling Pathway to Attenuate Airway Inflammation in Obesity-Related Asthma
AMPK Regulates M1 Macrophage Polarization through the JAK2/STAT3 Signaling Pathway to Attenuate Airway Inflammation in Obesity-Related Asthma
Abstract—Obesity-related asthma is primarily characterized by nonallergic inflammation, with pathogenesis involving ...
The Role of Cobalamin in Multiple Sclerosis: An Update
The Role of Cobalamin in Multiple Sclerosis: An Update
Multiple sclerosis (MS) is a neurodegenerative condition that results in axonal and permanent damage to the central nervou...
Characteristics of Neutrophil Migration and Function in Acute Inflammation Induced by Zymosan and Carrageenan in the Mice Air Pouch Model
Characteristics of Neutrophil Migration and Function in Acute Inflammation Induced by Zymosan and Carrageenan in the Mice Air Pouch Model
Deciphering the complex and redundant process of acute inflammation remains challenging. The failure of numerous clinical ...
Gene Regulation of Neutrophils Mediated Liver and Lung Injury through NETosis in Acute Pancreatitis
Gene Regulation of Neutrophils Mediated Liver and Lung Injury through NETosis in Acute Pancreatitis
Acute pancreatitis (AP) is one of the most common gastrointestinal emergencies, often resulting in self-digestion, edema, ...
Celastrol Regulates the Hsp90-NLRP3 Interaction to Alleviate Rheumatoid Arthritis
Celastrol Regulates the Hsp90-NLRP3 Interaction to Alleviate Rheumatoid Arthritis
Previous studies have verified that celastrol (Cel) protects against rheumatoid arthritis (RA) by inhibiting the NLRP3 inf...