×
Close
註冊
登入
主页
用户
博客
照片
视频
医学图书S馆
医学图书M馆
医学图书D馆
医学术语
群组
活动
用户工具
用户指南
问答
谁看过我
反馈
语言
English
中文
推广
×
Close
CN1699 Our Business - Guide for Agents
分类
Biochemistry & Molecular Biology
27231
Global Medical University
4529
Allergy
1700
Anatomy & Morphology
1452
Andrology
414
Anesthesia & Intensive Care
1078
Anesthesiology
4975
Audiology & Speech-Language Pathology
311
Behavioral Sciences
100
Biochemical Research Methods
6146
Biodiversity Conservation
255
Biology
7464
Biophysics
7327
Biotechnology & Applied Microbiology
7463
Cardiac & Cardiovascular Systems
28686
Cardiovascular & Respiratory Systems
1293
Cell & Tissue Engineering
596
Cell Biology
10174
Chemistry, Analytical
3943
Chemistry, Applied
10436
Chemistry, Medicinal
8025
Chemistry, Multidisciplinary
17582
Clinical Immunology & Infectious Disease
397
Clinical Medicine
8391
Clinical Neurology
15073
Clinical Psychology & Psychiatry
1151
Critical Care Medicine
2840
Dentistry, Oral Surgery & Medicine
11841
Dermatology
7376
Developmental Biology
6540
Ecology
627
Education, Scientific Disciplines
1706
Emergency Medicine
3602
Endocrinology, Metabolism & Nutrition
21651
Engineering, Biomedical
3288
Entomology
392
Environmental Medicine & Public Health
4288
Evolutionary Biology
232
Gastroenterology & Hepatology
10831
General & Internal Medicine
6430
Genetics & Heredity
13597
Geriatrics & Gerontology
4637
Gerontology
314
Health Care Sciences & Services
14280
Health Policy & Services
542
Hematology
5108
Immunology
22980
Infectious Diseases
12671
Integrative & Complementary Medicine
2478
Medical Ethics
1028
Medical Informatics
1876
Medical Laboratory Technology
433
Medicine, General & Internal
41814
Medicine, Legal
426
Medicine, Research & Experimental
16140
Microbiology
21150
Mycology
0
Nanoscience & Nanotechnology
4607
Neuroimaging
1133
Neurology
4001
Neurosciences
35885
Nursing
8510
Nutrition & Dietetics
7462
Obstetrics & Gynecology
7478
Oncology
48343
Ophthalmology
8688
Optics
3623
Orthopedics
10330
Orthopedics, Rehabilitation & Sports Medicine
1576
Otolaryngology
1406
Otorhinolaryngology
4485
Parasitology
945
Pathology
4473
Pediatrics
19585
Peripheral Vascular Disease
4216
Pharmacology & Pharmacy
30973
Pharmacology/Toxicology
11320
Physiology
8460
Polymer Science
496
Primary Health Care
737
Psychiatry
17332
Psychology
4644
Psychology, Applied
74
Psychology, Biological
295
Psychology, Clinical
710
Psychology, Developmental
204
Psychology, Educational
116
Psychology, Experimental
103
Psychology, Mathematical
0
Psychology, Multidisciplinary
1469
Psychology, Psychoanalysis
41
Psychology, Social
101
Public Health & Health Care Science
2073
Public, Environmental & Occupational Health
25429
Quantum Science & Technology
0
Radiology, Nuclear Medicine & Imaging
11015
Radiology, Nuclear Medicine & Medical Imaging
7248
Rehabilitation
2795
Remote Sensing
0
Reproductive Biology
2513
Reproductive Medicine
1058
Research/Laboratory Medicine & Medical Technology
3584
Respiratory System
6468
Rheumatology
5243
Social Sciences, Biomedical
1109
Substance Abuse
2489
Surgery
30619
Toxicology
3979
Transplantation
878
Tropical Medicine
314
Urology & Nephrology
11732
Veterinary Sciences
35
Virology
2233
Zoology
0
渠道
CHEMICAL BIOLOGY & DRUG DESIGN
164
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
223
ANTIOXIDANTS
2594
BIOMOLECULES
2187
BIOORGANIC CHEMISTRY
1480
CELL AND BIOSCIENCE
442
CELLULAR & MOLECULAR BIOLOGY LETTERS
201
CELLULAR AND MOLECULAR LIFE SCIENCES
1067
COLLOIDS AND SURFACES B-BIOINTERFACES
1349
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
1199
CYTOKINE
563
CYTOKINE & GROWTH FACTOR REVIEWS
119
FREE RADICAL BIOLOGY AND MEDICINE
895
GENOME RESEARCH
383
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
20
INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY
247
JOURNAL OF BIOLOGICAL CHEMISTRY
2142
JOURNAL OF CELLULAR BIOCHEMISTRY
110
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
143
JOURNAL OF GENETICS AND GENOMICS
397
JOURNAL OF INORGANIC BIOCHEMISTRY
623
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
101
JOURNAL OF LIPID RESEARCH
33
JOURNAL OF MOLECULAR BIOLOGY
650
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
359
MOLECULAR BIOLOGY
196
MOLECULAR CARCINOGENESIS
63
NATURE CHEMICAL BIOLOGY
571
NATURE PROTOCOLS
327
NEUROCHEMISTRY INTERNATIONAL
323
PROGRESS IN LIPID RESEARCH
0
REDOX BIOLOGY
1
SCIENCE SIGNALING
181
SIGNAL TRANSDUCTION AND TARGETED THERAPY
906
BIOCHEMISTRY AND CELL BIOLOGY
144
BIOMEDICAL JOURNAL
0
BIOORGANIC & MEDICINAL CHEMISTRY
1
BIOPHYSICAL CHEMISTRY
0
BIOPOLYMERS
28
BIOTECHNIQUES
324
BMC BIOCHEMISTRY
117
CELL BIOCHEMISTRY AND FUNCTION
55
CHEMBIOCHEM
352
CURRENT ISSUES IN MOLECULAR BIOLOGY
565
FRONTIERS IN MOLECULAR BIOSCIENCES
2545
JOURNAL OF FOOD BIOCHEMISTRY
259
JOURNAL OF MOLECULAR RECOGNITION
35
LIPIDS
23
NEUROCHEMICAL RESEARCH
555
PHYSICAL BIOLOGY
95
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
6
PROTEIN SCIENCE
152
LIPIDS IN HEALTH AND DISEASE
382
VITAMINS AND HORMONES
222
BIOCHEMISTRY INSIGHTS
8
BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY
57
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
180
PROTEOMES
63
MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS
45
REVIEWS OF PHYSIOLOGY BIOCHEMISTRY AND PHARMACOLOGY
64
GENES & GENOMICS
344
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
284
JOURNAL OF BIOMOLECULAR NMR
67
SCI时时刷
search
全部
推荐
+
Identification of selective mtbDHFR inhibitors by virtual screening and experimental approaches
Abstract mtbDHFR targeting inhibition has become a promising approach for tuberculosis treatment. In the current research,...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Identification of Novel Nematode SDH Inhibitors: Virtual Screening Based on Ligand‐Pocket Interactions
ABSTRACT To discover new nematicidal succinate dehydrogenase (SDH) inhibitors with novel structures, we conducted a virtua...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Study the mechanism of peimisine derivatives on NF‐κB inflammation pathway on mice with acute lung injury induced by lipopolysaccharide
Abstract Peimisine is one of the alkaloids in Fritillariae ussuriensis Bulbus, which has anti-acute lung injury effect. In...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Structure‐activity trend analysis between amino‐acids and minimal inhibitory concentration of antimicrobial peptides
Abstract Antimicrobial peptides (AMPs) provide large structural libraries of molecules with high variability of constituti...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Antitrypanosomal activity of new semi‐synthetic bergenin derivatives
Abstract Bergenin and 11-O-(4'-O-methyl galloyl)-bergenin, previously isolated from Crassula capitella extract, were used ...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Discovery of a novel and orally active Farnesoid X receptor agonist for the protection of acetaminophen‐induced hepatotoxicity
Abstract Acetaminophen (APAP) overdose is a leading cause of acute hepatic failure and liver transplantation, while the ex...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Structure‐based discovery of (S)‐2‐amino‐6‐(4‐fluorobenzyl)‐5,6,11,11a‐tetrahydro‐1H‐imidazo[1',5':1,6]pyrido[3,4‐b]indole‐1,3(2H)‐dione as low nanomolar, orally bioavailable autotaxin inhibitor
Abstract Inhibition of extracellular secreted enzyme autotaxin (ATX) represents an attractive strategy for the development...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Design, Synthesis and Molecular Modeling of Quinoline Based Derivatives as Anti‐Breast Cancer Agents Targeting EGFR/AKT Signaling Pathway
Abstract Two series of quinoline-thiazole and quinoline-thiazolidinone hybrids were designed, synthesized and evaluated fo...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Some important inhibitors and mechanisms of rheumatoid arthritis
Abstract Rheumatoid arthritis is a chronic disease that seriously affects human health and quality of life, and it is one ...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Synthesis and biological activities of butyrylcholinesterase inhibitors
Abstract Acetylcholinesterase (AChE) inhibitor is the first choice for the treatment of Alzheimer's disease (AD), but it h...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Discovery of a novel and orally active FXR agonist for the protection of APAP‐induced hepatotoxicity
Abstract Acetaminophen (APAP) overdose is a leading cause of acute hepatic failure and liver transplantation, while the ex...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Study the Mechanism of Peimisine Derivatives on NF‐κB Inflammation Pathway on Mice with Acute Lung Injury Induced by LPS
Abstract Peimisine is one of the alkaloids in Fritillariae ussuriensis Bulbus, which has anti-acute lung injury effect. In...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Radiolabeling, characterization and preclinical evaluation of plazomicin: a potential tracer for bacterial infection
Abstract In this study, 99mTc–plazomicin, a new radio-antibiotic complex, was prepared specifically for bacterial i...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Impact of different protonation states on virtual screening performance against cruzain
Abstract The cysteine protease cruzain is a Chagas disease target, exploited in computational studies. However, there is n...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Dimerization of 600 Da Branched Polyethyleneimine Improves β‐lactam Antibiotic Potentiation against Antibiotic Resistant Staphylococcus epidermidis and Pseudomonas aeruginosa
Abstract Antibiotic resistance is a growing concern in the medical field. Drug susceptible infections are often treated wi...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Identification of Tripeptides against Tyrosine Kinase Domain of EGFR for Lung Cancer Cell Inhibition by In silico and In vitro Studies
Abstract Epidermal growth factor receptor tyrosine kinase domain (EGFR-TK) has been one of the prominent targets for thera...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Discovery of novel Ketamine‐inspired derivatives as a protective agent against renal ischemic/reperfusion injury in Wistar rats
Abstract Renal ischemia-reperfusion (I/R) injury is a limiting factor for the success of renal grafts and is deemed greatl...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Synthesis of Ring‐opening of Evodiamine Derivatives and Evaluation on Their Biological Activity
Abstract As a main bioactive component extracted from Evodiae fructus, evodiamine has a variety of pharmacological activit...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Development of chimeric receptor activator of nuclear factor‐kappa B with glutathione S‐transferase in the extracellular domain: Artificial switch in a membrane receptor
Abstract Various chimeric receptors have been developed and used for biological experiments. In the present study, we cons...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Pyrimidine: An elite heterocyclic leitmotif in drug discovery‐synthesis and biological activity
Abstract Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important cla...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Active site‐based analysis of structural proteins for drug targets in different human Coronaviruses
ABSTRACT Seven types of Coronaviruses (CoVs) have been identified that can cause infection in humans, including HCoV-229E,...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Irreversible inhibitors of the proline racemase (PRAC) unveil innovative mechanism of action as antibacterial against Clostridioides difficile
Abstract Proline racemases (PRAC), catalyzing the L-proline and D-proline interconversion, are essential factors in eucary...
Chemical Biology & Drug Design
comment
0
thumb_up
0
The Multiple Function of lncRNA MALAT1 in Cancer Occurrence and Progression
Abstract Long non-coding RNAs (lncRNAs) have received particular attention in the last decade due to its engaging in carci...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Development of chimeric RANK with GST in the extracellular domain: Artificial switch in a membrane receptor
Abstract Various chimeric receptors have been developed and used for biological experiments. In the present study, we cons...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Bioisosteric modification on benzylidene‐carbonyl compounds improved the drug‐likeness and maintained the antifungal activity against Sporothrix brasiliensis
Abstract Considering the emergence of antifungal resistance on Sporothrix brasiliensis, we aimed to assess new benzylidene...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Chalcone‐inspired rA1/A2A adenosine receptor ligands: ring closure as an alternative to a reactive substructure
Abstract Over the past few years, great progress has been made in the development of high-affinity adenosine A1 and/or A2A...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Synthesis and antiviral activity of 2′‐deoxy‐6′‐substituted carbocyclic nucleosides
Abstract A series of 2'-deoxy carbocyclic nucleosides characterized by various 6'-substitutions were synthesized and evalu...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Synthesis and biological evaluation of novel 5,6‐dihydrobenzo[h]quinazoline derivatives as FLT3 inhibitors
Abstract Fms-like tyrosine kinase 3 (FLT3) is widely expressed and often mutated in acute myeloid leukemia (AML), which ma...
Chemical Biology & Drug Design
comment
0
thumb_up
0
The role of FoxO1 and its modulation with small molecules in the development of diabetes mellitus: A review
Abstract Diabetes mellitus type 2 (T2D) is one of the metabolic disorders suffered by a global human being. Certain factor...
Chemical Biology & Drug Design
comment
0
thumb_up
0
Theoretical study of Myriocin binding mechanism targeting Serine Palmitoyltransferase
Abstract Sphingolipids (SLs) are vital for cells as forming membrane and transducing signals. The first step for de novo b...
Chemical Biology & Drug Design
comment
0
thumb_up
0
阅读更多
Modal title
×
Modal title
×
分享
登入
Global News and Health Forum
Join Now!
馬上登入
記住我
忘記密碼?
或者使用
Linkedin