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Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease
Background: Heat shock proteins (HSPs) are involved in innate and adaptive immune responses, especially inflammatory respo...
Neutrophil Extracellular Traps Formation and Citrullinated Histones 3 Levels in Patients with Kawasaki Disease
Background: Kawasaki disease (KD) is a vasculitis associated with vascular injury and autoimmune response. Inflammatory fa...
Senescent CD153+ T Lymphocytes Increase in the Peripheral Blood of Patients with Thromboangiitis Obliterans
Background: Buerger’s disease, also known as Thromboangiitis Obliterans (TAO), is a progressive, inflammatory vascular dis...
Vol 20, Supplementary Issue, 16th International Congress of Immunology and Allergy
We are delighted to share the Abstract Book of the "16th International Congress of Immunology and Allergy". The ...
IJI, Vol 20, Supplementary Issue, 16th International Congress of Immunology and Allergy
We are delighted to share the Abstract Book of the "16th International Congress of Immunology and Allergy". The ...
Effects of Blocking NLRP3 Inflammasome on Type II Innate Lymphoid Cell Response in Allergic Rhinitis
Background: Type 2 innate lymphoid cells (ILC2s) and NLRP3 inflammasome are related to allergic and inflammatory responses...
Implications of Complement Imbalance in COVID-19: A Molecular Mechanistic Discussion on the Importance of Complement Balance
Two central questions in COVID-19 treatment which should be considered are: “How does the imbalance of the complement syst...
Angiopoietin-like 4 (ANGPTL4) Suppression Ameliorates Lupus Nephritis in MRL/lpr Mice by Inactivating NLRP3 Inflammasome and Inhibiting Inflammatory Response
Background: Lupus nephritis (LN) refers to the injury caused by systemic lupus erythematosus (SLE) involving the kidneys. ...
Impact of Echinococcus granulosus Antigens on Monocyte Development and Dendritic Cell Differentiation
Background: Different subtypes of dendritic cells (DCs) can induce different types of immune responses. Our previous study...
CD39 Expression in Peripheral T Cells is Associated with Clinicopathological Characteristics in Patients with Cervical Cancer
Background: CD39 is an inhibitory checkpoint exerting rate-limiting effects on the ATP-adenosine pathway. It can be target...
SPIB Knockdown Inhibits the Immune Escape of Ovarian Cancer Cells by Reducing PD-L1 (CD274) Expression and Inactivating the JAK/STAT Pathway
Background: Spi-B transcription factor (SPIB) is an E-twenty-six (ETS) transcription factor associated with tumor immunity...
Synthesized Anti-HER2 Trastuzumab-MCC-DM1 Conjugate: An Evaluation of Efficacy and Cytotoxicity
Background: Trastuzumab is a humanized monoclonal antibody that targets site-specifically human epidermal growth factor-2 ...
Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D
Background: The initial inflammatory reaction starts following occlusion in ischemic stroke (IS). Interleukin-1β (IL-1β) i...
Evaluation of SARS-CoV-2 Specific Antibodies in Recovered Patients by Different ELISA Kits
Background: The coronavirus disease 2019 (COVID-19) was first reported in December 2019 in Wuhan, Hubei Province of China....
The Anti-inflammatory Effect of Ginger Extract on the Animal Model of Multiple Sclerosis
Background: Experimental autoimmune encephalomyelitis (EAE), as an autoimmune disease in the central nervous system (CNS),...
The Upregulation of HLA-G1 and miRNA-34a in Lens Epithelial Cells of Diabetic Retinopathy Patients
Background: Retinopathy of diabetes is a chronic diabetes mellitus complication affecting retinal vessels, and some ocular...
Estrogen Receptor Alpha Gene (ESR1) Facilitates Th2-immune Response and Enhances Th2 Cytokines in Experimental Atopic Dermatitis Mice
Background: Molecular markers are involved in atopic dermatitis (AD) pathogenesis. The estrogen receptor (ESR)-1 gene, enc...
LKB1 Positively Regulates Dendritic Cell-induced T Cell Immunity and Suppresses Tumor Development
Background: The functions of dendritic cells (DCs) are influenced by their intracellular metabolism, in which liver kinase...
Pulmonary Arterial Hypertension Induced by Immune Checkpoint Inhibitor Combined Therapy in a Patient with Intrahepatic Cholangiocarcinoma: A Case Report
Immune Checkpoint Inhibitors (ICIs) have dramatically revolutionized the therapeutic approaches by which we treat a series...
Teucrium polium Extract Attenuates Inflammation in Asthma by Reducing RORγt Transcription and Increasing IL-10 Secretion in an Ovalbumin-induced Murine Asthma Model
Background: One of the inflammatory diseases of the respiratory system is asthma. Teucrium polium (TP) has anti-inflammato...
The Generation and Application of Monoclonal Antibodies to Detect SAPCD2 Expression in Precancerous and Malignant Gastric Lesions
Background: Suppressor APC domain containing 2 (SAPCD2) is involved in cell cycle regulation and its mRNA levels are highe...
Selective IgA Deficiency with Multiple Autoimmune Comorbidities: A Case Report and Literature Review
Individuals with Selective Immunoglobulin-A Deficiency (SIgAD) are often asymptomatic, and symptomatic SIgAD patients ofte...
Long-Term Effects of Low-Dose Naltrexone on Immunomodulatory Properties of Human Adipose-Derived Mesenchymal Stem Cells
Background: Low-dose naltrexone (LDN) is involved in the treatment of inflammatory and immune system diseases and can affe...
Novel Monoclonal Antibodies Specific for Human Ki67 and P53 Tumor Markers in Breast Cancer Tissue Samples
Background: Ki67 and P53 are important diagnostic and prognostic biomarkers expressed in several cancers. The current stan...
Leukocyte Reduction Filters Are Reliable and Economic Source for Natural Killer Cell Preparation
Background: An issue that hinders researchers’ access to Natural Killer (NK) cells is their low proportion in peripheral b...
Variations in Macrophage Activation Syndrome-associated Cardiac Diseases: A Report on Two Cases
Macrophage activation syndrome (MAS), a secondary hemophagocytic lymphohistiocytosis characterized by an excessive systemi...
Maternal Cold-Reacting Immunoglobulin G Anti-M of MNS Blood Group System Causing Hemolytic Disease of the Fetus
Several cases of the hemolytic disease of the fetus and newborn (HDFN) caused by immunoglobulin G (IgG) anti-M antibodies ...
Leukocyte Reduction Filters Are Reliable and Economic Source of Natural Killer Cells Preparation
Background: An issue that hinders researchers’ access to Natural Killer (NK) cells is their low proportion in peripheral b...
Evaluation of CD137 and CD137L Transcript Levels and the Serum sCD137 in Immune-mediated Polyneuropathy
Background: Abnormal humoral and cellular immune responses have been reported in immune-mediated polyneuropathies. CD137, ...
Anti-inflammatory Mechanisms of IL-38 in Chinese Patients with Allergic Rhinitis
Background: T-helper 17 (Th17) cell response is engaged in the onset of allergic rhinitis (AR). Moreover, interleukin (IL)...
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