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New-onset Systemic Lupus Erythematosus in a Woman with Previous Lymphoma during Late Pregnancy: a Case Report and Literature Review
Background: Systemic lupus erythematosus (SLE) is most likely to occur during the first and second trimesters of pregnancy...
Case Report of a Female Patient with Adult-onset Still's Disease and Review of the Literature
Background: Adult-onset Still's disease (AOSD), which presents many non-specific symptoms, such as rash leukocytosis,...
IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes
Background: Obesity and diabetes are related to a chronic low-grade inflammation. As a pro-inflammatory cytokine, IL-18 st...
Fibroblast Growth Factor-2 Levels are Elevated in The Serum of Patients with Multiple Sclerosis
Background: Various factors contribute to the pathogenesis of Multiple Sclerosis (MS), one of which is Fibroblast Growth F...
Anti-Ro52 Antibody as a Protective Factor for Pulmonary Fibrosis in Primary Sjögren's Syndrome
Background: Pulmonary fibrosis is common in primary Sjögren's syndrome (pSS)-related interstitial lung disease (ILD)....
Association Between Polymorphisms of IL-23/IL-17 Pathway and Clinical Phenotypes of Autoimmune Thyroid Diseases
Background: Several autoimmune and inflammatory disorders, including autoimmune thyroid diseases (AITD), have been linked ...
Essential Transcription Factors and Functional Roles of Follicular Helper T Cells in Human Autoimmune Diseases
Follicular helper T (TFH) cells are a subset of effector CD4+ T cells that support the differentiation of antigen-specific...
Case Report of China/Tianjin's First Novel Coronavirus Variant Omicron
COVID-19 is a new acute respiratory infectious disease caused by a novel Coronavirus (2019-COV-2) infection. On November 2...
Relapsing Polychondritis Associated with Miscellaneous Ocular Symptoms and Increased IgA: a Case Report
A male patient had suffered miscellaneous ocular symptoms for 20 years with auricular dysmorphosis and was diagnosed with ...
Cytokine Gene Polymorphisms in Chinese Children with Idiopathic Nephrotic Syndrome
Background: Cytokines play a role in the progression of idiopathic-nephrotic syndrome (INS). Objectives: To investigate ...
Immunomodulatory Effects of Omega-3 Fatty Acids in Patients with Differentiated Thyroid Cancer Before or After Radioiodine Ablation
Background: Thyroid cancer and radioactive iodine (RAI) ablation for postsurgical management may lead to uncontrolled inf...
High Neutrophil-lymphocyte Ratio Predicts Serious Renal Insufficiency in Patients with Lupus Nephritis
Background: Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE).The neutr...
LPS Activated Macrophages Induced Hepatocyte Pyroptosis via P2X7R Activation of NLRP3 in Mice
Background: Pyroptosis is a programmed cell death related to caspase-1, accompanied by the secretion of pro-inflammatory ...
Follicular Helper T Cells in Pulmonary Tuberculosis: A Retrospective Study
Background: Follicular helper T lymphocyte (Tfh) promotes antibody production by B lymphocytes in various diseases, inclu...
Elevated IL-37 Serum Levels in Patients with Transitional Cell Carcinoma of Bladder
Background: Interleukin-37 (IL-37) is a recently described cytokine that emerges as a natural inhibitor of inflammatory an...
Evaluation of the Relationship between Pro-Inflammatory Cytokine Levels and Clinical Findings of Fibromyalgia Syndrome
Background: Immune system has an important effect on pain-related disorders such as fibromyalgia syndrome (FMS). There is ...
More Evidence of the Link of Interleukin-6 and Interleukin-10 with Critical COVID-19: A Report in Mexican Patients
Background: According to the World Health Organization, Mexico presents one of the highest mortality rates due to coronavi...
Upregulation of Interleukin-6 in HPV-Positive Breast Cancer Patients
Background: Interleukin-6 (IL-6) is a well-known proinflammatory cytokine with tumor promoting capacity in various forms o...
TLR9/NF-kB Pathway Regulates Brucella CpG DNA-mediated Cytokine Response in Human Peripheral Blood Mononuclear Cells
Background: It was reported that targeting the Toll-like receptor9(TLR9) signaling pathway can be a promising therapeutics...