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The Pro-inflammatory Functions of Type 1 CD 8+ T Cells and Interleukin-17-producing Cluster of Differentiation 8+ T Cells are Exhausted by Cholesterol in Atherosclerosis
Background: CD8+ T cells have been found to accumulate in atherosclerotic plaques. However, the specific role of CD8+ T ce...
Design and Cytotoxicity Evaluation of a Cancer-targeting Immunotoxin Based on a Camelid Nanobody-PE Fusion Protein
Background: Developing effective targeted treatment approaches to overcome drug resistance remains a crucial goal in cance...
Blood Cytokine Profile in Breast Cancer: Focusing on Differences among Molecular Subtypes
Background: Breast cancer is the leading cause of cancer-related deaths in women. Cytokines have been linked to various ca...
Differences in blood cytokines as a function of breast cancer molecular subtype
Background: Breast cancer is the primary contributor to cancer-related deaths in women. Cytokines have been linked to vari...
Effects of Intrauterine Infusion of G-CSF and HCG on Peripheral Blood Treg and Pregnancy Outcome in Patients with Thin Endometrium Undergoing Frozen-thawed Embryo Transfer
Background: Patients with thin endometrium undergoing frozen-thawed embryo transfer often encounter challenges with pregna...
Antitumor Activity and Immunostimulant Properties of Liposomes Containing Rosemary Extract on a Mouse Model of Colorectal Cancer
Background: Rosemary (Ros) is a member of the Lamiaceae family known for its antitumor properties. However, its low water ...
Evaluation of Metastasis Inhibition by ABD-IL-2 Compared to Human IL-2 in a Breast Cancer Mouse Model
Background: Interleukin-2 (IL-2) is a well-known cytokine that plays a crucial role in stimulating immune cells, including...
Analysis of the Blood Levels of NK and NKT Cells in Patients with Severe SARS-CoV-2 Infection
Background: Clinical manifestations SARS-CoV-2 infection are variable, ranging from asymptomatic to pneumonia, and differe...
Gamma-delta T Cells in Bladder Cancer Draining Lymph Nodes
Background: Gamma-delta (γδ) T cells are a distinct subset of T cells with a receptor composed of γ and δ chains. Their ab...
Prognostic Value of CD14 Expression in Peripheral Blood Mononuclear Cell Membrane in Patients with Severe COPD Complicated with Pulmonary Infection
Background: Severe chronic obstructive pulmonary disease (COPD) patients with pulmonary infections face higher morbidity a...
JAK/STAT Signaling Pathway Mediates Anti-Tumor Immunity of CD8+ T Cells in Renal Cancer
Background: CD8+ T cells play a crucial role in immune responses, and have significant potential in tumor immunotherapy. T...
The Impact of Wharton’s Jelly-derived Exosomes on the Production of Inflammatory Mediators from HIG-82 Synoviocytes
Background: Osteoarthritis (OA) is the most common joint disease worldwide. Routine treatment options are limited, and tot...
Modulation of M1/M2 Cytokines and Inflammatory Enzymes by Persicaria Species Leaf Extracts in Lipopolysaccharide-stimulated RAW 264.7 Cell Macrophages
Background: Investigating the impacts of plant-based substances on the regulation of pro-inflammatory M1 and anti-inflamma...
IgG4-Related Disease in a 90-Year-Old Man with an 18-Year Disease Course: A Case Report
IgG4-related disease (IgG4-RD) is a multi-organ inflammatory immune-mediated illness caused by IgG4-secreting plasma cells...
miR-196b-5p Affects Macrophage Polarization and Inflammation in Endometriosis
Background: miR-196b-5p was found to be significantly reduced in endometriosis, but its function and the mechanisms involv...
Comments on "Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice"
Saffaei, A., Amani, J., Salimian, J., Alishiri, G., Abolghasemi, H. (2024). 'Comments on "Com...
Outcome of Cyclophosphamide Treatment Following Hematopoietic Stem Cell Transplantation in a Thalassemia Patient: A Case Study
Hematopoietic stem cell transplantation (HSCT) is the only curative therapy for β-thalassemia major in children. However, ...
Evaluation of Monocyte Subpopulations in Patients with Systemic Sclerosis and its Association with Clinical Manifestations of the Disease: a Cross-sectional Controlled Study
Background: Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized not only by fibrosis and vasculopathy ...
The Protective Role of IL-17 and IL-22 in COVID-19 Infection
Background: The development of a cytokine storm in Coronavirus Disease 2019 (COVID-19) infection can make the disease fata...
Evaluation of PD-1 Gene Expression Profile and Methylation of the Regulatory Regions in Patients with Ankylosing Spondylitis
Background: Ankylosing spondylitis (AS) is a chronic autoimmune disorder characterized by the fusion of vertebral joints ...
Letter to the Editor Regarding “Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice”
Dear EditorWe are writing to discuss the article titled “Comparative Immunogenicity and Neutralization Potency of Four App...
Glycyrrhiza Glabra Extract Modulates Type 1 T Helper (TH1) and Regulatory T Cell-Related Immune Responses in an Animal Model of Breast Cancer
Background: It is well-known that TH1 and Treg cells exert anti- and pro-tumorigenic activity, respectively. Thus, TH1 cel...
Functional Property and Regulatory Mechanism of Macrophages in Complementary and Alternative Medicine: From Bench to Clinic
Complementary and alternative medicine (CAM) includes a wide range of treatments that are gaining acceptance among the pub...
The Effect of Interferon Beta and Natalizumab on miR-20b Expression in Patients with Relapsing-Remitting Multiple Sclerosis is Potentially Mediated by Modulation of the Jak–STAT Signaling Pathway: A Case-control Study
Background: The mechanisms of the function of interferon beta (IFN-β) and natalizumab (NTZ) in multiple sclerosis (MS) pat...
Natural Killer Cell Subsets in Tumor Draining Lymph Nodes of Patients with Bladder Cancer and Their Clinical Implications
Background: Natural killer (NK) cells are crucial innate components in anti-tumor immunity. However, the clinical impacts ...
Letter to the Editor Regarding “Antibody Production after COVID-19 Vaccination in Patients with Inborn Errors of Immunity”
Dear Editor I am writing in response to the recently published study titled "Antibody Production after COVID-19 Vacc...
Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice
Background: Since the outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), several vaccine ...
Immunohistochemical Evaluation of NKP46 Receptor Expression and the Number of NK Cells in the Endometrium of Patients with Endometriosis
Background: Endometriosis is a medical condition that can cause infertility in women. Women with endometriosis experience ...
Serum Interleukin-38 and Tumor-Infiltrating Lymphocytes in Primary Brain Tumors
Background: Tumor-infiltrating lymphocytes (TILs) and brain stromal cells produce immunosuppressive cytokines, contributin...
IL-27 Levels in Bronchoalveolar Lavage Fluid in Children with Post-infectious Bronchiolitis Obliterans
Background: Pulmonary neutrophils may play a crucial role in the development of bronchiolitis obliterans (BO) following me...
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