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Leukocyte Reduction Filters Are Reliable and Economic Source for Natural Killer Cell Preparation
Background: An issue that hinders researchers’ access to Natural Killer (NK) cells is their low proportion in peripheral b...
Variations in Macrophage Activation Syndrome-associated Cardiac Diseases: A Report on Two Cases
Macrophage activation syndrome (MAS), a secondary hemophagocytic lymphohistiocytosis characterized by an excessive systemi...
Maternal Cold-Reacting Immunoglobulin G Anti-M of MNS Blood Group System Causing Hemolytic Disease of the Fetus
Several cases of the hemolytic disease of the fetus and newborn (HDFN) caused by immunoglobulin G (IgG) anti-M antibodies ...
Leukocyte Reduction Filters Are Reliable and Economic Source of Natural Killer Cells Preparation
Background: An issue that hinders researchers’ access to Natural Killer (NK) cells is their low proportion in peripheral b...
Evaluation of CD137 and CD137L Transcript Levels and the Serum sCD137 in Immune-mediated Polyneuropathy
Background: Abnormal humoral and cellular immune responses have been reported in immune-mediated polyneuropathies. CD137, ...
Anti-inflammatory Mechanisms of IL-38 in Chinese Patients with Allergic Rhinitis
Background: T-helper 17 (Th17) cell response is engaged in the onset of allergic rhinitis (AR). Moreover, interleukin (IL)...
Methylation Profile of Cancer Testis Antigens in Colorectal Cancer
Background: Cancer testis antigens (CTAs) are a class of immune-stimulating antigens often overexpressed in many types of ...
Effect of the Previous History of the SARS-CoV-2 Infections on Antibody Levels among Sputnik V Vaccinated Healthcare Workers
Background: Measuring the level of antibodies produced post-vaccination in response to the SARS-CoV-2 spike protein is con...
Exploring the Influence of Hepatitis B Immunoglobulin on the Immune Response to the Hepatitis B Vaccine in a Mouse Model
Background: The extent to which maternal antibodies against the hepatitis B surface antigen (HBsAb) acquired transplacenta...
Immunogenicity of the Non-toxic Form of Staphylococcus Aureus α-Hemolysin Using a Chimeric Fusion in Mice
Background: Staphylococcus aureus is an opportunistic pathogen responsible for various infections with diverse clinical pr...
Methyl-cpg-binding Domain Protein 2 Silencing Inhibits Th17 Differentiation of CD4+T cells Induced by Ovalbumin
Background: Little is known about MBD2’s epigenetic regulation in the immune pathogenesis of CD4+T cell differentiation.Ob...
rMBP-NAP Suppresses OXA-induced Allergic Dermatitis by Regulating the Th1/Th2 Balance
Background: Allergic dermatitis (AD) is an inflammatory skin disease that arises from abnormal T lymphocyte activation. A ...
The Evaluation of the Effect of Tolerogenic Probiotics on the Maturation of Healthy Dendritic Cells versus Immature Dendritic Cells
Background: Dendritic cells, (DCs) as one of the important immune cell populations, are responsible for the initiation, de...
Activation of β2-adrenergic Receptor Alleviates Collagen-induced Arthritis by Ameliorating Th17/Treg Imbalance
Background: Recent research in our laboratory shows that CD4+ T cells express the β2 adrenergic receptor (β2-AR), and the ...
Vaccine Adjuvants: Selection Criteria, Mechanism of Action Associated with Immune Responses and Future Directions
The most effective method to minimize the prevalence of infectious diseases is vaccination. Vaccines enhance immunity and ...
Introducing a New Method for Purification of Human IL-4 by Substitution of a Single Amino Acid in IL-4 Protein Sequence
Background: It is advantageous to develop an effective purification procedure to produce recombinant protein drugs (rPDs)...
Letter to the Editor in Response to the "Comparison of the Antibody Responses Following Vaccination with AstraZeneca and Sinopharm"
Mungmunpuntipantip, R., Wiwanitkit, V. (2022). 'Letter to the Editor in Response to the "Comp...
Introducing a New Method for Purification of Human IL-4 by Substitution of a Single Amino Acid in IL-4 Protein Sequences
Background: It is advantageous to develop an effective purification procedure to produce recombinant protein drugs (rPDs)...
The Effect of Oral Administration of Silymarin on Serum Levels of Tumor Necrosis Factor-α and Interleukin-1ß in Patients with Rheumatoid Arthritis
Shavandi, M., Yazdani, Y., Asar, S., Mohammadi, A., Mohammadi-noori, E., Kiani, A. (2022). 'T...
Niclosamide Modulates the Cellular and Humoral Immune Response in Balb/c Mice
Background: Niclosamide, a STAT3 inhibitor, is widely under investigation due to its anti-cancer properties. STAT3 also ex...
The Impact of HLA-G and HLA-E Polymorphisms on CMV Reinfection in Liver Transplant Recipients
Background: Cytomegalovirus (CMV) reinfection in transplant patients has been associated with graft loss and decreased pa...
Predictive Value of the Serum Diamine Oxidase Level in the Diagnosis of Seasonal Allergic Rhinitis
Background: Allergic rhinitis (AR) is characterized by the increased sensitivity of the nasal mucosa to allergens and has...
Enzyme-Assisted Extraction of Narirutin from Citri Reticulatae Pericarpium and Anti-allergic Asthma Activity
Background: Asthma is a heterogeneous disorder of the airways related to inflammation; it affects millions of people worl...
Changes in Maternal Serum Levels of C3 and C4 complement Components in Different Delivery Methods and Postpartum Hemorrhage
Background: Activation of the complement system may play a role in the pathophysiology of human labor. Yet no unanimous c...
Evaluation of CD3+ T Cell Percentage, Function and its Relationship with Serum Vitamin D Levels in Women with Recurrent Spontaneous Abortion and Recurrent Implantation Failure
Background: Women afflicted with recurrent spontaneous abortion (RSA) and repeated implantation failure (RIF) may have im...
Identification of the CD16low CD56low CD38pos Natural Killer Cell as a Key Subset in Patients with Multiple Myeloma
Background: Natural killer (NK) cells are classified as innate immune cells which can directly recognize and kill tumor c...
LncRNA-GAS5 and its Promoter Region Polymorphism Associate with Helper Th17 Polarization and Predict Postoperative Pain and the Prognosis of the Patients with Hepatocellular Carcinoma Undergoing Hepatectomy
Background: The relationship between genetic polymorphism and postoperative pain and the prognosis of patients with hepat...
Evaluation of Innate Lymphoid Cells (ILCs) Population in the Mouse Model of Colorectal Cancer
Background: Innate Lymphoid Cells (ILCs) promote tissue homeostasis, contribute to the immune defense mechanisms, and pla...
Letter to the Editor Regarding "An Overview on Serology and Molecular Tests for COVID-19: An Important Challenge of the Current Century (doi: 10.22034/iji.2021.88660.1894.)"
Recently in a review article by Mansourabadi et al. published in the Iranian Journal of Immunology, the authors described ...
Labor Could Increase Systemic Inflammation and Cause or Deteriorate Cytokine Storm in COVID-19
Pregnant women with coronavirus disease 2019 (COVID-19) have a higher risk of morbidity and mortality compared with the ge...
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