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Prognostic Value of CD14 Expression in Peripheral Blood Mononuclear Cell Membrane in Patients with Severe COPD Complicated with Pulmonary Infection
Background: Severe chronic obstructive pulmonary disease (COPD) patients with pulmonary infections face higher morbidity a...
JAK/STAT Signaling Pathway Mediates Anti-Tumor Immunity of CD8+ T Cells in Renal Cancer
Background: CD8+ T cells play a crucial role in immune responses, and have significant potential in tumor immunotherapy. T...
The Impact of Wharton’s Jelly-derived Exosomes on the Production of Inflammatory Mediators from HIG-82 Synoviocytes
Background: Osteoarthritis (OA) is the most common joint disease worldwide. Routine treatment options are limited, and tot...
Modulation of M1/M2 Cytokines and Inflammatory Enzymes by Persicaria Species Leaf Extracts in Lipopolysaccharide-stimulated RAW 264.7 Cell Macrophages
Background: Investigating the impacts of plant-based substances on the regulation of pro-inflammatory M1 and anti-inflamma...
IgG4-Related Disease in a 90-Year-Old Man with an 18-Year Disease Course: A Case Report
IgG4-related disease (IgG4-RD) is a multi-organ inflammatory immune-mediated illness caused by IgG4-secreting plasma cells...
miR-196b-5p Affects Macrophage Polarization and Inflammation in Endometriosis
Background: miR-196b-5p was found to be significantly reduced in endometriosis, but its function and the mechanisms involv...
Comments on "Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice"
Saffaei, A., Amani, J., Salimian, J., Alishiri, G., Abolghasemi, H. (2024). 'Comments on "Com...
Outcome of Cyclophosphamide Treatment Following Hematopoietic Stem Cell Transplantation in a Thalassemia Patient: A Case Study
Hematopoietic stem cell transplantation (HSCT) is the only curative therapy for β-thalassemia major in children. However, ...
Evaluation of Monocyte Subpopulations in Patients with Systemic Sclerosis and its Association with Clinical Manifestations of the Disease: a Cross-sectional Controlled Study
Background: Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized not only by fibrosis and vasculopathy ...
The Protective Role of IL-17 and IL-22 in COVID-19 Infection
Background: The development of a cytokine storm in Coronavirus Disease 2019 (COVID-19) infection can make the disease fata...
Evaluation of PD-1 Gene Expression Profile and Methylation of the Regulatory Regions in Patients with Ankylosing Spondylitis
Background: Ankylosing spondylitis (AS) is a chronic autoimmune disorder characterized by the fusion of vertebral joints ...
Letter to the Editor Regarding “Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice”
Dear EditorWe are writing to discuss the article titled “Comparative Immunogenicity and Neutralization Potency of Four App...
Glycyrrhiza Glabra Extract Modulates Type 1 T Helper (TH1) and Regulatory T Cell-Related Immune Responses in an Animal Model of Breast Cancer
Background: It is well-known that TH1 and Treg cells exert anti- and pro-tumorigenic activity, respectively. Thus, TH1 cel...
Functional Property and Regulatory Mechanism of Macrophages in Complementary and Alternative Medicine: From Bench to Clinic
Complementary and alternative medicine (CAM) includes a wide range of treatments that are gaining acceptance among the pub...
The Effect of Interferon Beta and Natalizumab on miR-20b Expression in Patients with Relapsing-Remitting Multiple Sclerosis is Potentially Mediated by Modulation of the Jak–STAT Signaling Pathway: A Case-control Study
Background: The mechanisms of the function of interferon beta (IFN-β) and natalizumab (NTZ) in multiple sclerosis (MS) pat...
Natural Killer Cell Subsets in Tumor Draining Lymph Nodes of Patients with Bladder Cancer and Their Clinical Implications
Background: Natural killer (NK) cells are crucial innate components in anti-tumor immunity. However, the clinical impacts ...
Letter to the Editor Regarding “Antibody Production after COVID-19 Vaccination in Patients with Inborn Errors of Immunity”
Dear Editor I am writing in response to the recently published study titled "Antibody Production after COVID-19 Vacc...
Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice
Background: Since the outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), several vaccine ...
Immunohistochemical Evaluation of NKP46 Receptor Expression and the Number of NK Cells in the Endometrium of Patients with Endometriosis
Background: Endometriosis is a medical condition that can cause infertility in women. Women with endometriosis experience ...
Serum Interleukin-38 and Tumor-Infiltrating Lymphocytes in Primary Brain Tumors
Background: Tumor-infiltrating lymphocytes (TILs) and brain stromal cells produce immunosuppressive cytokines, contributin...
IL-27 Levels in Bronchoalveolar Lavage Fluid in Children with Post-infectious Bronchiolitis Obliterans
Background: Pulmonary neutrophils may play a crucial role in the development of bronchiolitis obliterans (BO) following me...
MicroRNA-150 Deletion Reduces the Occurrence and Severity of Rheumatoid Arthritis by Inhibiting IL-17
Background: Understanding the effects of epigenetic factors on the pathogenesis of rheumatoid arthritis (RA) is important ...
Abnormal Changes in IL-13 and IL-17A Serum Levels in Children with Adenovirus Pneumonia and their Diagnostic Value
Background: Human adenovirus (HAdV) is an enveloped icosahedral DNA virus. HAdV infection can lead to immune system damage...
Sulforaphane Regulates Macrophage M1/M2 Polarization to Attenuate Macrophage-induced Caco-2 Cell Injury in an Inflammatory Environment
Background: The imbalance between M1 and M2 macrophage activation is closely associated with the pathogenesis of inflammat...
Intervention with ICOSL Antibodies Alleviates Inflammatory Infiltrations in Mice with Neutrophilic Asthma
Background: Neutrophilic asthma is characterized by the predominant infiltration of neutrophils in airway inflammation.Obj...
The Ratio of Peripheral Blood Natural Killer Cells is not a Solid Surrogate Immune Index in Unexplained Recurrent Miscarriage
Background: Immunotherapies targeting peripheral natural killer (pbNK) cells in unexplained recurrent miscarriage (uRM) re...
Letter to the Editor Regarding "Evaluation of SARS-CoV-2 Specific Antibodies in Recovered Patients by Different ELISA Kits"
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Harnessing the Power of CAR-NK Cells: A Promising Off-the-Shelf Therapeutic Strategy for CD38-Positive Malignancies
Background: CD38 is highly expressed on multiple myeloma (MM) cells and has been successfully targeted by different target...
Relationship between TIM3 Expression on Peripheral T Lymphocytes and Post-Stroke Depression
Background: T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is a regulatory molecule expressed on a var...
Human Umbilical Cord Mesenchymal Stem Cells and Their Extracellular Vesicles Modulate Pro- and Anti-Inflammatory Cytokines in Ligature-induced Periodontitis
Background: Periodontitis is a persistent inflammatory condition that impacts the tissues supporting the teeth, ultimately...
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