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p53 protein expression patterns associated with TP53 mutations in breast carcinoma
p53 protein expression patterns associated with TP53 mutations in breast carcinoma
The importance of a TP53 mutation has been demonstrated in several tumor types, including breast cancer (BC). However, the...
SCARB2 associates with tumor-infiltrating neutrophils and predicts poor prognosis in breast cancer
SCARB2 associates with tumor-infiltrating neutrophils and predicts poor prognosis in breast cancer
The tumor microenvironment (TME) plays a crucial role in various aspects of breast cancer development and metastasis. Neve...
Assessment of efficacy and safety of dose-dense doxorubicin and cyclophosphamide (ddAC) in combination with immunotherapy in early-stage triple-negative breast cancer
Assessment of efficacy and safety of dose-dense doxorubicin and cyclophosphamide (ddAC) in combination with immunotherapy in early-stage triple-negative breast cancer
This study aimed to assess safety and efficacy of a modified KEYNOTE 522 protocol, which incorporated pembrolizumab every ...
Clinical breast exam contribution to breast cancer diagnosis in BRCA mutation carriers vs. average to intermediate risk women
Clinical breast exam contribution to breast cancer diagnosis in BRCA mutation carriers vs. average to intermediate risk women
The contribution of clinical breast exam (CBE) to breast cancer diagnosis in average risk women undergoing regular screeni...
The Ki67 dilemma: investigating prognostic cut-offs and reproducibility for automated Ki67 scoring in breast cancer
The Ki67 dilemma: investigating prognostic cut-offs and reproducibility for automated Ki67 scoring in breast cancer
Quantification of Ki67 in breast cancer is a well-established prognostic and predictive marker, but inter-laboratory varia...
Long-term outcomes of neoadjuvant trastuzumab emtansine + pertuzumab (T-DM1 + P) and docetaxel + carboplatin + trastuzumab + pertuzumab (TCbHP) for HER2-positive primary breast cancer: results of the randomized phase 2 JBCRG20 study (Neo-peaks)
Long-term outcomes of neoadjuvant trastuzumab emtansine + pertuzumab (T-DM1 + P) and docetaxel + carboplatin + trastuzumab + pertuzumab (TCbHP) for HER2-positive primary breast cancer: results of the randomized phase 2 JBCRG20 study (Neo-peaks)
The randomized phase 2 Neo-peaks study examined usefulness of neoadjuvant trastuzumab emtansine + pertuzumab (...
Risk of first recurrence after treatment in a population-based cohort of young women with breast cancer
Risk of first recurrence after treatment in a population-based cohort of young women with breast cancer
Breast cancer (BC) in women under 45 is rare yet often aggressive. We aim to analyze loco-regional recurrences (LR), dista...
Pre-surgical cryoablation in ≤ 2 cm ER + /HER2-tumors. Prognostic factors for the presence of residual invasive carcinoma
Pre-surgical cryoablation in ≤ 2 cm ER + /HER2-tumors. Prognostic factors for the presence of residual invasive carcinoma
Breast cancer remains the most commonly diagnosed cancer in women. Breast-conserving surgery (BCS) is the standard approac...
Demographic and clinical characteristics of patients with metastatic breast cancer and leptomeningeal disease: a single center retrospective cohort study
Demographic and clinical characteristics of patients with metastatic breast cancer and leptomeningeal disease: a single center retrospective cohort study
Leptomeningeal disease (LMD) is a devastating complication of metastatic breast cancer (MBC). It is critical to better und...
Measuring serum oestrogen levels in breast cancer survivors using vaginal oestrogens: a systematic review
Measuring serum oestrogen levels in breast cancer survivors using vaginal oestrogens: a systematic review
Vaginal oestrogens can be used to treat genitourinary symptoms in women with early breast cancer. Studies evaluating vagin...
Lifestyle interventions with dietary strategies after breast cancer diagnosis: a systematic review
Lifestyle interventions with dietary strategies after breast cancer diagnosis: a systematic review
Obesity can increase mortality and morbidity in breast cancer survivors. Healthy lifestyle factors such as diet can help m...
Ten-year trend analysis of breast cancer, oncoplastic, and reconstructive breast surgery in a single institution (2010–2019), what has not changed?
Ten-year trend analysis of breast cancer, oncoplastic, and reconstructive breast surgery in a single institution (2010–2019), what has not changed?
There has been a UK national directive to ensure that patients are offered reconstructive surgical options. We aimed to as...
Patient-reported outcomes and quality of life after breast-conserving surgery, mastectomy, and breast reconstruction assessed using the BREAST-Q questionnaire
Patient-reported outcomes and quality of life after breast-conserving surgery, mastectomy, and breast reconstruction assessed using the BREAST-Q questionnaire
Breast-conserving surgery is the preferred treatment for breast cancer; however, its associated risk of local recurrence i...
Incidence of local breast cancer recurrence with delayed radiation therapy
Incidence of local breast cancer recurrence with delayed radiation therapy
The purpose of this research was to examine the probability of ipsilateral breast cancer recurrence in individuals whose R...
Pedigree analysis exploring the inconsistency between diverse phenotypes and testing criteria for germline TP53 mutations in Chinese women with breast cancer
Pedigree analysis exploring the inconsistency between diverse phenotypes and testing criteria for germline TP53 mutations in Chinese women with breast cancer
In the present study, we addressed the inconsistency between the testing criteria and diverse phenotypes for germline TP53...
Clinical implications of non-breast cancer related findings on FDG-PET/CT scan prior to neoadjuvant chemotherapy in patients with breast cancer
Clinical implications of non-breast cancer related findings on FDG-PET/CT scan prior to neoadjuvant chemotherapy in patients with breast cancer
Breast cancer (BC) patients undergoing FDG-PET/CT scans for neoadjuvant chemotherapy (NAC) may have additional non-BC rela...
The contribution of second primary cancers to the mortality of patients with a first primary breast cancer
The contribution of second primary cancers to the mortality of patients with a first primary breast cancer
Second primary cancers (SPCs) are estimated to affect nearly 5% of patients with breast cancer within 10 years of their di...
Comprehensive genomic profiling of ESR1, PIK3CA, AKT1, and PTEN in HR(+)HER2(−) metastatic breast cancer: prevalence along treatment course and predictive value for endocrine therapy resistance in real-world practice
Comprehensive genomic profiling of ESR1, PIK3CA, AKT1, and PTEN in HR(+)HER2(−) metastatic breast cancer: prevalence along treatment course and predictive value for endocrine therapy resistance in real-world practice
The treatment landscape for HR(+)HER2(−) metastatic breast cancer (MBC) is evolving for patients with ESR1 mutations...
Spectrum of germline pathogenic variants in Brazilian hereditary breast/ovarian cancer cases
Spectrum of germline pathogenic variants in Brazilian hereditary breast/ovarian cancer cases
To define the spectrum of germline pathogenic variants (PVs) and copy number variant (CNV) in cancer susceptibility genes ...
The REMAR (Rhein-Main-Registry) real-world study: prospective evaluation of the 21-gene breast recurrence score® assay in addition to Ki-67 for adjuvant treatment decisions in early-stage breast cancer
The REMAR (Rhein-Main-Registry) real-world study: prospective evaluation of the 21-gene breast recurrence score® assay in addition to Ki-67 for adjuvant treatment decisions in early-stage breast cancer
Ki-67 is recommended by international/national guidelines for risk stratification in early breast cancer (EBC), particular...
UM171 suppresses breast cancer progression by inducing KLF2
UM171 suppresses breast cancer progression by inducing KLF2
Breast cancer is the most frequent cancer in women with significant death rate. Morbidity is associated with drug resistan...
Tamoxifen modulates nutrition deprivation-induced ER stress through AMPK-mediated ER-phagy in breast cancer cells
Tamoxifen modulates nutrition deprivation-induced ER stress through AMPK-mediated ER-phagy in breast cancer cells
Rapid proliferation and nutrition starvation in the tumor microenvironment pose significant challenges to cellular protein...
Ferroptosis as a promising targeted therapy for triple negative breast cancer
Ferroptosis as a promising targeted therapy for triple negative breast cancer
Triple negative breast cancer (TNBC) is a challenging subtype characterized by the absence of estrogen receptor (ER), prog...
Adherence to guideline recommendations for follow-up in patients with DCIS at a large teaching hospital in the Netherlands
Adherence to guideline recommendations for follow-up in patients with DCIS at a large teaching hospital in the Netherlands
Ductal-carcinoma in situ (DCIS) is a pre-invasive form of breast cancer with good prognosis. Follow-up guidelines in the N...
De-escalating indications for excision when breast core needle biopsy returns fibroepithelial lesion—not further characterized
De-escalating indications for excision when breast core needle biopsy returns fibroepithelial lesion—not further characterized
Surgical excision is often performed to exclude phyllodes tumor (PT) when Core Needle Biopsy (CNB) of the breast returns f...
Choosing breast-conserving therapy or mastectomy and subpectoral implant breast reconstruction: implications for pectoralis major function
Choosing breast-conserving therapy or mastectomy and subpectoral implant breast reconstruction: implications for pectoralis major function
An increasing number of women are choosing mastectomy and subpectoral implant (SI) breast reconstruction over breast-conse...
Burden and trajectory of social needs after breast cancer diagnosis at a safety-net hospital
Burden and trajectory of social needs after breast cancer diagnosis at a safety-net hospital
Unmet social needs pose barriers to cancer care, contributing to adverse outcomes and health inequities. A better understa...
Revolutionizing breast cancer Ki-67 diagnosis: ultrasound radiomics and fully connected neural networks (FCNN) combination method
Revolutionizing breast cancer Ki-67 diagnosis: ultrasound radiomics and fully connected neural networks (FCNN) combination method
This study aims to assess the diagnostic value of ultrasound habitat sub-region radiomics feature parameters using a fully...
Frequency and characteristics of errors by artificial intelligence (AI) in reading screening mammography: a systematic review
Frequency and characteristics of errors by artificial intelligence (AI) in reading screening mammography: a systematic review
Artificial intelligence (AI) for reading breast screening mammograms could potentially replace (some) human-reading and im...
Second primary non-breast cancers in young breast cancer survivors
Second primary non-breast cancers in young breast cancer survivors
We evaluated the incidence, timing, and risk factors for second primary non-breast cancers (SPNBC) among young breast canc...
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