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Diagnosis and insight into the unique lung microbiota of pediatric pulmonary tuberculosis patients by bronchoalveolar lavage using metagenomic next-generation sequencing
1 IntroductionTuberculosis (TB) remains a major public health problem for children and adolescents. In 2022, 7.5 million p...
Editorial: Factors associated with drug resistance and virulence of Mycobacterium tuberculosis
The standard treatment regime for drug-sensitive TB is two months of therapy with rifampicin (RIF), isoniazid (INH), pyraz...
Persistent microbial infections and idiopathic pulmonary fibrosis - an insight into non-typeable Haemophilus influenza pathogenesis
1 IntroductionIdiopathic Pulmonary Fibrosis (IPF) is an idiopathic, progressive, and chronic illness that causes an accumu...
Multi-epitope vaccines: a promising strategy against viral diseases in swine
1 IntroductionViral infections significantly impact the swine industry, particularly those affecting the respiratory, repr...
Intratumoral Lactobacillus iners as a poor prognostic biomarker and potential therapeutic target for cervical cancer
Cervical cancer is the fourth most common cancer among women worldwide, and its occurrence linked to a variety of factors,...
Comparative transcriptomic and molecular biology analyses to explore potential immune responses to Vibrio parahaemolyticus challenge in Eriocheir sinensis
1 IntroductionChinese mitten crabs (Eriocheir sinensis) are a valuable aquaculture species in East Asia (Sun et al., 2013;...
Increased in vitro antimicrobial resistance of Mycoplasma pneumoniae isolates obtained from children in Beijing, China, in 2023
1 IntroductionMycoplasmas are the smallest and simplest self-replicating prokaryotic organisms that often parasitize mucus...
Longitudinal ozone exposure and SARS-CoV-2 infection in late pregnancy: a retrospective cohort study
1 IntroductionThe global pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome ...
Rapid detection of Mycoplasma hyopneumoniae by recombinase-aided amplification combined with the CRISPR/Cas12a system
1 IntroductionMycoplasma hyopneumoniae (M. hyopneumoniae) is considered one of the smallest known bacteria and lacks a cel...
Polymorphonuclear myeloid-derived suppressor cells regulates immune recovery during HIV infection through PD-L1 and TGF-β pathways
1 BackgroundIn general, it is admitted that 10–40% of HIV-infected individuals on antiretroviral therapy (ART) may have in...
The clinical indexes and immunological status of HIV/AIDS patients undergoing different highly active antiretroviral treatments
1 IntroductionIn the last ten years, highly active antiretroviral therapy (HAART) has been used for the treatment of HIV-i...
Immunogenicity and safety of the fourth dose of quadrivalent human papillomavirus (HPV) vaccine in immunosuppressed women who did not seroconvert after three doses
1 IntroductionPeople living with human immunodeficiency virus (PLWH), solid organ transplant (SOT) recipients, and other i...
Gut microbiome and clinical and lifestyle host factors associated with recurrent positive RT-PCR for SARS-CoV-2
1 IntroductionCoronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV...
Preparation, characterization, and protective effects of Gardenia fructus carbon dots against oxidative damage induced by LPS in IPEC-J2 cells
1 IntroductionThe basis for swine farming for maintaining homeostasis is the proper raising of pigs, as oxidative stress f...
Prolonged fecal shedding of replication-competent virus, lasting immune activation, and intestinal inflammation in a rhesus macaque after experimental SARS-CoV-2 infection
1 IntroductionThe disease caused by SARS-CoV-2, COVID-19, was initially regarded as a respiratory syndrome. However, it so...
Characterization of glycogen-related glycoside hydrolase glgX and glgB from Klebsiella pneumoniae and their roles in biofilm formation and virulence
1 IntroductionExcessive glucose ingested by organisms is stored in the form of inactive polymers, with glycogen serving as...
Amoebae: beyond pathogens- exploring their benefits and future potential
1 IntroductionAmoebae, within the Protista kingdom, encompasses over 17,000 species, exhibiting diverse lifestyles from fr...
Transcriptomic profiling of “brain-eating amoeba” Naegleria fowleri infection in mice: the host and the protozoa perspectives
1 IntroductionProtozoan parasites represent a significant threat to health causing severe diseases in humans worldwide (Da...
Identification and characterization of a Relish-type NF-κB, DvRelish, in Dermacentor variabilis in response to Rickettsia rickettsii infection
IntroductionIxodid ticks cause harm to vertebrate hosts through blood feeding and the transmission of disease-causing agen...
Two genotypes of H3N2 swine influenza viruses identified in pigs from Shandong Province, China
1 IntroductionSwine influenza virus (SIV), a negative-sense, single-stranded RNA virus belonging to the genus Influenza A ...
Diagnostic and prognostic values of NSCLC patients with or without obstructive pneumonia after sleeve lobectomy
1 IntroductionThe incidence of lung cancer is increasing with increasing access to tobacco. Lung cancer is a leading cause...
New tools to monitor Pseudomonas aeruginosa infection and biofilms in vivo in C. elegans
1 IntroductionThe Gram-negative bacterium Pseudomonas aeruginosa, a common and opportunistic pathogen, causes disease in a...
Deciphering pathogenicity and virulence of the first Staphylococcus debuckii isolate from diabetic foot osteomyelitis
IntroductionDiabetic foot ulcers (DFUs) constitute a prevalent, deleterious, and costly complication of diabetes mellitus,...
Localized provoked vulvodynia as an immune-mediated inflammatory disease: rationale for a new line of research
Localized provoked vulvodynia (LPV) is defined as vulvar pain induced by touching the vulvar vestibular epithelium that ha...
Metabarcoding analysis of oral microbiome during pregnancy
IntroductionPregnancy represents a remarkable transformation for a woman’s body. A cascade of hormonal, immune, and metabo...
Helicobacter pylori resistance in Hainan Province, China: investigating phenotypes and genotypes through whole-genome sequencing
IntroductionHelicobacter pylori is a gram-negative bacterium that resides on the luminal surface of the gastric epithelium...
Alterations of the paired maternal vaginal microbiome and neonatal meconium microbiome in vulvovaginal candidiasis positive pregnant women
IntroductionThe vaginal microbiome during pregnancy is of considerable interest due to its impact on both maternal and neo...
Gestational diabetes-combined excess weight gain exacerbates gut microbiota dysbiosis in newborns, associated with reduced abundance of Clostridium, Coriobacteriaceae, and Collinsella
IntroductionGestational diabetes mellitus (GDM) is a condition characterized by glucose tolerance identified during pregna...
Immunoinflammatory markers SIRI and NAR as predictors of respiratory distress syndrome and secondary infections in premature infants
IntroductionPremature birth is an important challenge in perinatal medicine (Stevenson et al., 2024). The American College...
Connecting dots of long COVID-19 pathogenesis: a vagus nerve- hypothalamic-pituitary- adrenal-mitochondrial axis dysfunction
IntroductionLong COVID (LC) was redefined by the US National Academies of Sciences, Engineering, and Medicine as “an infec...
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