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Intrinsic activity development unfolds along a sensorimotor–association cortical axis in youth
Intrinsic activity development unfolds along a sensorimotor–association cortical axis in youth
Animal studies of neurodevelopment have shown that recordings of intrinsic cortical activity evolve from synchronized and ...
Emergence of consciousness from anesthesia through ubiquitin degradation of KCC2 in the ventral posteromedial nucleus of the thalamus
Emergence of consciousness from anesthesia through ubiquitin degradation of KCC2 in the ventral posteromedial nucleus of the thalamus
The emergence of consciousness from anesthesia, once assumed to be a passive process, is now considered as an active and c...
A consensus protocol for functional connectivity analysis in the rat brain
A consensus protocol for functional connectivity analysis in the rat brain
Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena un...
Krishna V. Shenoy (1968–2023)
Krishna V. Shenoy (1968–2023)
Krishna Vaughn Shenoy died on 21 January 2023 at the age of 54. He had lived for over a decade after a di...
Abnormal lipid metabolism shapes astrocyte reactivity in patients with epilepsy
Abnormal lipid metabolism shapes astrocyte reactivity in patients with epilepsy
In the brains of patients with epilepsy, apolipoprotein E-mediated lipid transfer from hyperactive neurons to astrocytes r...
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy
Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epil...
Panoramic visual statistics shape retina-wide organization of receptive fields
Panoramic visual statistics shape retina-wide organization of receptive fields
Statistics of natural scenes are not uniform—their structure varies dramatically from ground to sky. It remains unkn...
Ascending neurons convey behavioral state to integrative sensory and action selection brain regions
Ascending neurons convey behavioral state to integrative sensory and action selection brain regions
Knowing one’s own behavioral state has long been theorized as critical for contextualizing dynamic sensory cues and ...
Bonding without OXT receptors
Prairie voles form enduring bonds with their mating partners, and both females and males show parental behaviors. This con...
Single-synapse sequencing
Single-cell transcriptomic technology has enabled a flurry of neuroscientific discoveries, but the ability to sequence the...
Brain organoids fill the gap
The brain has a very limited capacity to repair itself, and there is an urgent need for therapies to improve neurological ...
Neurons in the caudal ventrolateral medulla mediate descending pain control
Neurons in the caudal ventrolateral medulla mediate descending pain control
Supraspinal brain regions modify nociceptive signals in response to various stressors including stimuli that elevate pain ...
Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder
Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder
The mechanisms underlying phenotypic heterogeneity in autism spectrum disorder (ASD) are not well understood. Using a larg...
Developmental trajectory of transmission speed in the human brain
Developmental trajectory of transmission speed in the human brain
The structure of the human connectome develops from childhood throughout adolescence to middle age, but how these structur...
Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice
Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice
Myelin degeneration occurs in neurodegenerative diseases and aging. In these conditions, resident oligodendrocyte progenit...
Intermediate acoustic-to-semantic representations link behavioral and neural responses to natural sounds
Intermediate acoustic-to-semantic representations link behavioral and neural responses to natural sounds
Recognizing sounds implicates the cerebral transformation of input waveforms into semantic representations. Although past ...
Tracking neural activity from the same cells during the entire adult life of mice
Tracking neural activity from the same cells during the entire adult life of mice
Stably recording the electrical activity of the same neurons over the adult life of an animal is important to neuroscience...
A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans
A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans
Advances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries wit...
Author Correction: Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD
Author Correction: Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD
Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USALindsey D. Good...
Recording single-neuron activity during walking in humans
Recording single-neuron activity during walking in humans
We developed a wearable platform (the Neuro-stack) for recording single-neuron and local field potentials in freely moving...
The human brain biases integration of information passed through social networks
The human brain biases integration of information passed through social networks
Despite extensive studies on how social networks affect behavior at the population level, little is known about how the hu...
A framework for integrated cardio-behavioral defensive states
A framework for integrated cardio-behavioral defensive states
The defense response to threat involves complex behavioral and autonomic adjustments. We identified integrated, short-last...
Integrated cardio-behavioral responses to threat define defensive states
Integrated cardio-behavioral responses to threat define defensive states
Fear and anxiety are brain states that evolved to mediate defensive responses to threats. The defense reaction includes mu...
A TREM2 antibody energizes microglia
A TREM2 antibody energizes microglia
Loss-of-function variants of TREM2 increase risk for Alzheimer’s disease. A new study presents a therapeutic candida...
Precise mapping of molecular and cellular brain changes in Alzheimer’s disease
Precise mapping of molecular and cellular brain changes in Alzheimer’s disease
STARmap PLUS is a new spatial gene mapping method combined with histological staining. With STARmap PLUS, we created high-...
Neurocomputational mechanism of real-time distributed learning on social networks
Neurocomputational mechanism of real-time distributed learning on social networks
Social networks shape our decisions by constraining what information we learn and from whom. Yet, the mechanisms by which ...
Perivascular signals drive microglial appetite
Perivascular signals drive microglial appetite
Microglial synapse engulfment precedes brain amyloid plaque formation and probably contributes to early cognitive decline ...
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by synaptic loss, which can result from dysfunctional microglial phagocyto...
Commensals boost nerve regeneration
Skin-resident T cells that respond to commensal microbes can facilitate skin repair after injury. A study in Cell now show...
The brain gets SLYMed
The CNS is lined with meninges, which are canonically divided into three layers: the dura, arachnoid, and pia mater. Using...
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