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Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology
Microglia are central players in Alzheimer’s disease pathology but analyzing microglial states in human brain sample...
Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis
Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis
The generation of new myelin-forming oligodendrocytes in the adult central nervous system is critical for cognitive functi...
Pervasive environmental chemicals impair oligodendrocyte development
Pervasive environmental chemicals impair oligodendrocyte development
Exposure to environmental chemicals can impair neurodevelopment, and oligodendrocytes may be particularly vulnerable, as t...
Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation
Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation
Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals generated by fluid flow into bio...
Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development
Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development
The mammalian telencephalon contains distinct GABAergic projection neuron and interneuron types, originating in the germin...
A precision functional atlas of personalized network topography and probabilities
A precision functional atlas of personalized network topography and probabilities
Although the general location of functional neural networks is similar across individuals, there is vast person-to-person ...
A systems identification approach using Bayes factors to deconstruct the brain bases of emotion regulation
A systems identification approach using Bayes factors to deconstruct the brain bases of emotion regulation
Cognitive reappraisal is fundamental to cognitive therapies and everyday emotion regulation. Analyses using Bayes factors ...
Recommendations for the responsible use and communication of race and ethnicity in neuroimaging research
Recommendations for the responsible use and communication of race and ethnicity in neuroimaging research
The growing availability of large-population human biomedical datasets provides researchers with unique opportunities to c...
Co-dependent excitatory and inhibitory plasticity accounts for quick, stable and long-lasting memories in biological networks
Co-dependent excitatory and inhibitory plasticity accounts for quick, stable and long-lasting memories in biological networks
The brain’s functionality is developed and maintained through synaptic plasticity. As synapses undergo plasticity, t...
Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis
Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis
Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination of the central nervous system (CNS). Autol...
Natural language instructions induce compositional generalization in networks of neurons
Natural language instructions induce compositional generalization in networks of neurons
A fundamental human cognitive feat is to interpret linguistic instructions in order to perform novel tasks without explici...
The dynamic state of a prefrontal–hypothalamic–midbrain circuit commands behavioral transitions
The dynamic state of a prefrontal–hypothalamic–midbrain circuit commands behavioral transitions
Innate behaviors meet multiple needs adaptively and in a serial order, suggesting the existence of a hitherto elusive brai...
Local origin of excitatory–inhibitory tuning equivalence in a cortical network
Local origin of excitatory–inhibitory tuning equivalence in a cortical network
The interplay between excitation and inhibition determines the fidelity of cortical representations. The receptive fields ...
Identification of a cold sensor in peripheral somatosensory neurons
Identification of a cold sensor in peripheral somatosensory neurons
Cold sensor identities in peripheral somatosensory neurons remain obscure. We show that GluK2, a kainate-type glutamate-se...
The kainate receptor GluK2 mediates cold sensing in mice
The kainate receptor GluK2 mediates cold sensing in mice
Thermosensors expressed in peripheral somatosensory neurons sense a wide range of environmental temperatures. While thermo...
Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics
Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics
Large-scale imaging of neuronal activities is crucial for understanding brain functions. However, it is challenging to ana...
In conversation with Igor Adameyko
In conversation with Igor Adameyko
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the f...
Liprin-α proteins are master regulators of human presynapse assembly
Liprin-α proteins are master regulators of human presynapse assembly
The formation of mammalian synapses entails the precise alignment of presynaptic release sites with postsynaptic receptors...
Learning with baby
The rate at which young children learn new words astounds care-givers and scientists alike. Most models of early language ...
The eyes have it
Many social species use eye contact to guide social behaviors. To study how visual cues shape social decision making, Fran...
Slowing human neurons
Human neurodevelopment is slower than that of other mammalian species, and this timescale appears to be intrinsic to human...
Population coding of strategic variables during foraging in freely moving macaques
Population coding of strategic variables during foraging in freely moving macaques
Until now, it has been difficult to examine the neural bases of foraging in naturalistic environments because previous app...
The silence of the reactive astrocytes
The silence of the reactive astrocytes
Astrocytes have important roles in disease and are difficult to modulate, owing to a paucity of known targets. Clayton et ...
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons
Dipeptide repeat proteins are a major pathogenic feature of C9orf72 amyotrophic lateral sclerosis (C9ALS)/frontotemporal d...
A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity
A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity
Disease, injury and aging induce pathological reactive astrocyte states that contribute to neurodegeneration. Modulating r...
Mapping the dysfunctome provides an avenue for targeted brain circuit therapy
Mapping the dysfunctome provides an avenue for targeted brain circuit therapy
Brain connections modulated by 534 deep-brain-stimulation electrodes revealed a gradient of circuits involved in dystonia,...
Leaky blood–brain barrier in long-COVID-associated brain fog
Leaky blood–brain barrier in long-COVID-associated brain fog
Long COVID has remained an on-going public health issue in the years following the global pandemic. Here, we report blood&...
Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation
Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation
Frontal circuits play a critical role in motor, cognitive and affective processing, and their dysfunction may result in a ...
Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment
Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment
Vascular disruption has been implicated in coronavirus disease 2019 (COVID-19) pathogenesis and may predispose to the neur...
Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories
Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories
To make adaptive decisions, we build an internal model of the associative relationships in an environment and use it to ma...