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The cerebellum modulates thirst
The cerebellum modulates thirst
The cerebellum, a phylogenetically ancient brain region, has long been considered strictly a motor control structure. Rece...
Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice
Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice
Perineuronal nets (PNNs) are densely packed extracellular matrices that cover the cell body of fast-spiking inhibitory neu...
Nested compressed co-representations of multiple sequential experiences during sleep
Nested compressed co-representations of multiple sequential experiences during sleep
Animals encounter and remember multiple experiences daily. During sleep, hippocampal neuronal ensembles replay past experi...
Higher-order interactions between hippocampal CA1 neurons are disrupted in amnestic mice
Higher-order interactions between hippocampal CA1 neurons are disrupted in amnestic mice
Across systems, higher-order interactions between components govern emergent dynamics. Here we tested whether contextual t...
Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling
Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling
Independent of its appetite- and body weight-modulating effects, the hormone asprosin activates its receptor PTPRD at cere...
A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior
A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior
The most robust and reliable signatures of brain states are enriched in rhythms between 0.1 and 20 Hz. Here we addre...
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Neuropeptides are ubiquitous in the nervous system. Research into neuropeptides has been limited by a lack of experimental...
Morphine maladaptively modulates myelination
Myelin plasticity is involved in several forms of learning in mice. Yalçın et al. now show that it also contributes to mal...
Real control in virtual rats
How neural activity controls naturalistic behavior is a fundamental question in neuroscience. Using deep reinforcement lea...
Author Correction: Meta-reinforcement learning via orbitofrontal cortex
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
A sensory–motor theory of the neocortex
A sensory–motor theory of the neocortex
Recent neurophysiological and neuroanatomical studies suggest a close interaction between sensory and motor processes acro...
Control and recalibration of path integration in place cells using optic flow
Control and recalibration of path integration in place cells using optic flow
Hippocampal place cells are influenced by both self-motion (idiothetic) signals and external sensory landmarks as an anima...
T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis
T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis
Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer’s disease remains uncerta...
Dissecting the epigenetic regulation of human brain organoid development in single cells
Dissecting the epigenetic regulation of human brain organoid development in single cells
We present a developmental atlas that offers insight into sequential epigenetic changes underlying early human brain devel...
A high-density 1,024-channel probe for brain-wide recordings in non-human primates
A high-density 1,024-channel probe for brain-wide recordings in non-human primates
Large-scale neural population recordings with single-cell resolution across the primate brain remain challenging. Here we ...
Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems
Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems
Cell fate progression of pluripotent progenitors is strictly regulated, resulting in high human cell diversity. Epigenetic...
Author Correction: A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, KoreaShinwon Park, Hanbyul Cho, Bo-yon...
Astrocytes at the border of repair
Astrocytes at the border of repair
Astrocytes have important roles in the repair of the CNS. However, the underlying mechanisms involved remain incompletely ...
Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice
Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice
Central nervous system (CNS) lesions become surrounded by neuroprotective borders of newly proliferated reactive astrocyte...
Apolipoprotein E in Alzheimer’s disease trajectories and the next-generation clinical care pathway
Apolipoprotein E in Alzheimer’s disease trajectories and the next-generation clinical care pathway
Alzheimer’s disease (AD) is a complex, progressive primary neurodegenerative disease. Since pivotal genetic studies ...
Reward prediction error neurons implement an efficient code for reward
Reward prediction error neurons implement an efficient code for reward
We use efficient coding principles borrowed from sensory neuroscience to derive the optimal neural population to encode a ...
Author Correction: Brain clearance is reduced during sleep and anesthesia
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Medial entorhinal cortex mediates learning of context-dependent interval timing behavior
Medial entorhinal cortex mediates learning of context-dependent interval timing behavior
Episodic memory requires encoding the temporal structure of experience and relies on brain circuits in the medial temporal...
A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
The cortical patterning principle has been a long-standing question in neuroscience, yet how this translates to macroscale...
Spatiotemporally selective astrocytic ATP dynamics encode injury information sensed by microglia following brain injury in mice
Spatiotemporally selective astrocytic ATP dynamics encode injury information sensed by microglia following brain injury in mice
Injuries to the brain result in tunable cell responses paired with stimulus properties, suggesting the existence of intrin...
Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala
Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala
The lateral amygdala (LA) encodes fear memories by potentiating sensory inputs associated with threats and, in the process...
One cubic millimeter of human cortex, solved
Shapson-Coe, Januszewski, Berger et al. recently reported in Science a major milestone in neuroanatomy and connectomics, r...
Sleeping with the zebrafishes
Researchers have speculated that sleep facilitates synaptic pruning to rebalance neuronal connections formed during waking...
Voluntary imaging goes magnetic
Multi-photon cellular imaging of neural activity in rodents typically requires head fixation. In this paper, the authors d...
Boosting children’s cognitive control does not result in behavioral or neural changes
Boosting children’s cognitive control does not result in behavioral or neural changes
Cognitive control is crucial for present and future success and therefore is a frequent target of interventions. This stud...
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