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A top-down slow breathing circuit that alleviates negative affect in mice
A top-down slow breathing circuit that alleviates negative affect in mice
Although breathing is primarily automatic, its modulation by behavior and emotions suggests cortical inputs to brainstem r...
A revised view of the role of CaMKII in learning and memory
A revised view of the role of CaMKII in learning and memory
The Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) plays a fundamental role in learning and possibly also in m...
Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices
Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices
Seizures are made up of the coordinated activity of networks of neurons, suggesting that control of neurons in the patholo...
Emergence of a brainstem somatosensory tonotopic map for substrate vibration
Emergence of a brainstem somatosensory tonotopic map for substrate vibration
Perceiving substrate-borne vibrations is a fundamental component of tactile perception. How location (somatotopy) and freq...
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease
Astrocytes are crucial to brain homeostasis, yet their changes along the spatiotemporal progression of Alzheimer’s d...
TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model
TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model
Alzheimer’s disease is one of at least 26 diseases characterized by tau-positive accumulation in neurons, glia or bo...
Deep RNA sequencing of human dorsal root ganglion neurons reveals somatosensory mechanisms
Deep RNA sequencing of human dorsal root ganglion neurons reveals somatosensory mechanisms
We used single-soma deep RNA sequencing to generate a high-resolution atlas of human somatosensory dorsal root ganglion ne...
Smelling a concept
Although functional imaging studies have shown that odors activate the human piriform cortex, amygdala, entorhinal cortex ...
The fly’s neural blueprint
The fly’s neural blueprint
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Alcohol’s necessary accessory
Alcohol’s effects on the brain are mediated in part through its action as a positive allosteric modulator (PAM) at GABAA r...
Astrocytes facilitate brain metastases
Breast cancer cells that metastasize to the brain are often fatal, and few effective therapies are available. In a recent ...
Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation
Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation
The versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG) neurons. However, soma transcripto...
Mapping out multiple sclerosis with spatial transcriptomics
Mapping out multiple sclerosis with spatial transcriptomics
In this issue, Alsema, Wijering, Miedema, Kotah et al. and Lerma-Martin, Badia-i-Mompel et al. demonstrate the ever-growin...
Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions
Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Inflammation is gradually compart...
Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis
Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized by myelin loss and progress...
Ernest Arenas (1962–2024)
Ernest Arenas (1962–2024)
Ernest Arenas, Professor at the Karolinska Institutet, passed away on 15 September 2024 at the age of 62 in Stockholm, Swe...
Integration across biophysical scales identifies molecular and cellular correlates of person-to-person variability in human brain connectivity
Integration across biophysical scales identifies molecular and cellular correlates of person-to-person variability in human brain connectivity
Brain connectivity arises from interactions across biophysical scales, ranging from molecular to cellular to anatomical to...
A trainee-informed model for undergraduate neuroscience research programs serving marginalized students
A trainee-informed model for undergraduate neuroscience research programs serving marginalized students
Undergraduate research programs improve career outcomes for historically marginalized students in the US, but low retentio...
Integrating brainstem and cortical functional architectures
Integrating brainstem and cortical functional architectures
The brainstem is a fundamental component of the central nervous system, yet it is typically excluded from in vivo human br...
Rastermap: a discovery method for neural population recordings
Rastermap: a discovery method for neural population recordings
Neurophysiology has long progressed through exploratory experiments and chance discoveries. Anecdotes abound of researcher...
Integrated multimodal cell atlas of Alzheimer’s disease
Integrated multimodal cell atlas of Alzheimer’s disease
Alzheimer’s disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized ...
A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states
A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states
Human microglia play a pivotal role in neurological diseases, but we still have an incomplete understanding of microglial ...
The hippocampal CA2 region discriminates social threat from social safety
The hippocampal CA2 region discriminates social threat from social safety
The dorsal cornu ammonis 2 (dCA2) region of the hippocampus enables the discrimination of novel from familiar conspecifics...
Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines
Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines
Lewy bodies (LBs), α-synuclein-enriched intracellular inclusions, are a hallmark of Parkinson’s disease (PD) pa...
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes
Identifying genetic risk factors for highly heterogeneous disorders such as epilepsy remains challenging. Here we present,...
Maintaining and updating accurate internal representations of continuous variables with a handful of neurons
Maintaining and updating accurate internal representations of continuous variables with a handful of neurons
Many animals rely on persistent internal representations of continuous variables for working memory, navigation, and motor...
Oligodendrocytes need lymphatics, emphatically
The meningeal lymphatic system is known to regulate neuroimmune functions, but how it affects resident brain cells is less...
DNA methylation drives astrocyte stemness
Astrocytes in brain regions such as the ventricular–subventricular zone (vSVZ) act as neural stem cells (NSCs), despite sh...
Perturbing the line
The brain may use continuous attractor dynamics to encode behaviorally relevant variables, but direct evidence of their ci...
Beyond category-based object characterization
The human visual system has long been thought to rely on categorization for object recognition, as evidenced by the discov...
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