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In conversation with Theanne Griffith
In conversation with Theanne Griffith
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the f...
Adaptor protein AP-3 produces synaptic vesicles that release at high frequency by recruiting phospholipid flippase ATP8A1
Adaptor protein AP-3 produces synaptic vesicles that release at high frequency by recruiting phospholipid flippase ATP8A1
Neural systems encode information in the frequency of action potentials, which is then decoded by synaptic transmission. H...
A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model
A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model
Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we lack a comprehensive unders...
Navigating T cell brain entry in MS
Navigating T cell brain entry in MS
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is driven by autoreactive lymphocytes....
In conversation with Freda Miller
In conversation with Freda Miller
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the f...
GluN2A mediates ketamine-induced rapid antidepressant-like responses
GluN2A mediates ketamine-induced rapid antidepressant-like responses
Ketamine was thought to induce rapid antidepressant responses by inhibiting GluN2B-containing N-methyl-d-aspartic acid (NM...
Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice
Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice
Oligodendrocytes, the myelinating cells of the central nervous system (CNS), are generated from oligodendrocyte precursor ...
Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols
Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols
Macroglia (astrocytes and oligodendrocytes) are required for normal development and function of the central nervous system...
Interoceptive rhythms in the brain
Interoceptive rhythms in the brain
Sensing internal bodily signals, or interoception, is fundamental to maintain life. However, interoception should not be v...
Author Correction: Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
These authors contributed equally: Alexandre Jourdon, Feinan Wu, Jessica Mariani.Child Study Center, Yale University Schoo...
Publisher Correction: Glymphatic influx and clearance are accelerated by neurovascular coupling
Author notesThese authors contributed equally: Stephanie Holstein-Rønsbo, Yiming Gan.Authors and AffiliationsCenter for Tr...
Dissociating the contributions of sensorimotor striatum to automatic and visually guided motor sequences
Dissociating the contributions of sensorimotor striatum to automatic and visually guided motor sequences
The ability to sequence movements in response to new task demands enables rich and adaptive behavior. However, such flexib...
The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish
The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish
The mesencephalic locomotor region (MLR) is a brain stem area whose stimulation triggers graded forward locomotion. How ML...
Myelination-independent functions of oligodendrocyte precursor cells in health and disease
Myelination-independent functions of oligodendrocyte precursor cells in health and disease
Oligodendrocyte precursor cells (OPCs) are a population of tissue-resident glial cells found throughout the CNS, constitut...
Prominent in vivo influence of single interneurons in the developing barrel cortex
Prominent in vivo influence of single interneurons in the developing barrel cortex
Spontaneous synchronous activity is a hallmark of developing brain circuits and promotes their formation. Ex vivo, synchro...
A very sexy circuit
Bayless, Davis, Yang et al. have mapped the circuit for mating behavior in male mice. They show that neurons that express ...
TRIMming Tau away
Tauopathies are a group of neurodegenerative diseases characterized by the presence of intracellular neurofibrillary tangl...
Modelling microglial states
Microglia can exist in various states depending on their environment and pathological conditions. Understanding the roles ...
Propagation of activity through the cortical hierarchy and perception are determined by neural variability
Propagation of activity through the cortical hierarchy and perception are determined by neural variability
Brains are composed of anatomically and functionally distinct regions performing specialized tasks, but regions do not ope...
Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing
Division of Genetics and Genomics, Manton Center for Orphan Disease Research, and Howard Hughes Medical Institute, Boston ...
Author Correction: Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia
Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USAXiaowei Zhu, Bo Zhou, Reenal Patt...
T cell–microglia signaling exacerbates neuropathology in an Alzheimer’s disease model
T cell–microglia signaling exacerbates neuropathology in an Alzheimer’s disease model
We developed a 3D human neuroimmune axis model to study the interplay of brain innate immune cells and peripheral adaptive...
High-precision mapping reveals the structure of odor coding in the human brain
High-precision mapping reveals the structure of odor coding in the human brain
Odor perception is inherently subjective. Previous work has shown that odorous molecules evoke distributed activity patter...
Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model
Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model
Brain infiltration of peripheral immune cells and their interactions with brain-resident cells may contribute to Alzheimer...
High-speed multiplane confocal microscopy for voltage imaging in densely labeled neuronal populations
High-speed multiplane confocal microscopy for voltage imaging in densely labeled neuronal populations
Genetically encoded voltage indicators (GEVIs) hold immense potential for monitoring neuronal population activity. To date...
Optimal routing to cerebellum-like structures
Optimal routing to cerebellum-like structures
The vast expansion from mossy fibers to cerebellar granule cells (GrC) produces a neural representation that supports func...
A stable and replicable neural signature of lifespan adversity in the adult brain
A stable and replicable neural signature of lifespan adversity in the adult brain
Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to ...
Orbitofrontal cortex control of striatum leads economic decision-making
Orbitofrontal cortex control of striatum leads economic decision-making
Animals must continually evaluate stimuli in their environment to decide which opportunities to pursue, and in many cases ...
In conversation with Marguerite Matthews
In conversation with Marguerite Matthews
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the f...
In conversation with Richard Tsien
In conversation with Richard Tsien
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the f...
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