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Mapping the cellular etiology of schizophrenia and complex brain phenotypes
Mapping the cellular etiology of schizophrenia and complex brain phenotypes
Psychiatric disorders are multifactorial and effective treatments are lacking. Probable contributing factors to the challe...
Neural mechanisms of relational learning and fast knowledge reassembly in plastic neural networks
Neural mechanisms of relational learning and fast knowledge reassembly in plastic neural networks
Humans and animals have a striking ability to learn relationships between items in experience (such as stimuli, objects an...
Neural populations are dynamic but constrained
Neural populations are dynamic but constrained
Our brains evolved to help us rapidly learn new things. But anyone who has put in hours of practice to perfect their tenni...
Propagation of neuronal micronuclei regulates microglial characteristics
Propagation of neuronal micronuclei regulates microglial characteristics
Microglia—resident immune cells in the central nervous system—undergo morphological and functional changes in ...
Dynamical constraints on neural population activity
Dynamical constraints on neural population activity
The manner in which neural activity unfolds over time is thought to be central to sensory, motor and cognitive functions i...
Glioblastoma–neuron networks
Glioma cells can receive synaptic input from neurons, yet the spatial extent and diversity of synapse types of the neuron–...
AI beats neuroscientists’ predictions
Artificial intelligence (AI) is increasingly being leveraged to solve important scientific challenges. Given the ability o...
Together but opposites in reward
Dopamine and serotonin may oppositely modulate associative learning, yet their precise roles have not been examined simult...
A distinct hypothalamus–habenula circuit governs risk preference
A distinct hypothalamus–habenula circuit governs risk preference
Appropriate risk evaluation is essential for survival in complex, uncertain environments. Confronted with choosing between...
Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus
Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus
The mammalian dentate gyrus (DG) is involved in certain forms of learning and memory, and DG dysfunction has been implicat...
Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification
Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification
Huntington’s disease (HD) is caused by a CAG repeat expansion in the HTT gene, leading to altered gene expression. H...
Context-dependent decision-making in the primate hippocampal–prefrontal circuit
Context-dependent decision-making in the primate hippocampal–prefrontal circuit
What is good in one scenario may be bad in another. Despite the ubiquity of such contextual reasoning in everyday choice, ...
NOMPC ion channel hinge forms a gating spring that initiates mechanosensation
NOMPC ion channel hinge forms a gating spring that initiates mechanosensation
The sensation of mechanical stimuli is initiated by elastic gating springs that pull open mechanosensory transduction chan...
Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease
Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease
The central nervous system (CNS) is endowed with its own resident innate immune cells, the microglia. They constitute appr...
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus
Brain-resident macrophages, microglia, have been proposed to have an active role in synaptic refinement and maturation, in...
Negative self-experiences shape responses to others’ emotional states
Negative self-experiences shape responses to others’ emotional states
Mice react differently to others’ stress depending on their own past experience of the same (but not different) stre...
Neurocognitive dynamics of human cooperation unveiled by intracranial recordings
Neurocognitive dynamics of human cooperation unveiled by intracranial recordings
Simultaneous intracranial electroencephalographic recordings from individuals playing a dynamic cooperation game reveal un...
Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors
Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors
The cerebellum is activated by noxious stimuli and pathological pain but its role in noxious information processing remain...
Considering the interconnected nature of social identities in neuroimaging research
Considering the interconnected nature of social identities in neuroimaging research
Considerable heterogeneity exists in the expression of complex human behaviors across the cognitive, personality and menta...
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds
Tau pathology is a hallmark of several neurodegenerative diseases, including frontotemporal dementia and Alzheimer’s...
Transsynaptic labeling and transcriptional control of zebrafish neural circuits
Transsynaptic labeling and transcriptional control of zebrafish neural circuits
Deciphering the connectome, the ensemble of synaptic connections that underlie brain function, is a central goal of neuros...
Heat acclimation induces hypothalamic temperature sensitivity that promotes heat tolerance
Heat acclimation induces hypothalamic temperature sensitivity that promotes heat tolerance
After long-term heat exposure, a discrete group of hypothalamic neurons in the anterior ventromedial preoptic area become ...
A single-cell mass cytometry-based atlas of the developing mouse brain
A single-cell mass cytometry-based atlas of the developing mouse brain
Development of the mammalian brain requires precise molecular changes across diverse cell lineages. While single-cell RNA ...
Author Correction: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery
Helmholtz Pioneer Campus, Helmholtz Zentrum München, Neuherberg, GermanyBoyan BonevPhysiological Genomics, Biomedical Cent...
MeCP2 goes into unmethylated territories
MeCP2 goes into unmethylated territories
Methyl-CpG-binding protein 2 (MeCP2) is a chromatin regulator whose loss of function causes Rett syndrome. It has been unc...
Microglia as hunters or gatherers of brain synapses
Microglia as hunters or gatherers of brain synapses
Over a decade ago, it was discovered that microglia, the brain’s immune cells, engulf synaptic material in a process...
An RNA editing strategy rescues gene duplication in a mouse model of MECP2 duplication syndrome and nonhuman primates
An RNA editing strategy rescues gene duplication in a mouse model of MECP2 duplication syndrome and nonhuman primates
Duplication of methyl-CpG-binding protein 2 (MECP2) gene causes MECP2 duplication syndrome (MDS). To normalize the duplica...
Author Correction: Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain
F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Boston, MA, USASamuel E. Marsh, Alec J. Walker, Lasse Dissing-...
Simultaneous intracranial recordings of interacting brains reveal neurocognitive dynamics of human cooperation
Simultaneous intracranial recordings of interacting brains reveal neurocognitive dynamics of human cooperation
Cooperative interactions profoundly shape individual and collective behaviors of social animals. Successful cooperation re...
Amygdala intercalated cells form an evolutionarily conserved system orchestrating brain networks
Amygdala intercalated cells form an evolutionarily conserved system orchestrating brain networks
The amygdala attributes valence and emotional salience to environmental stimuli and regulates how these stimuli affect beh...
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