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Motor learning revamps the myelin landscape
Motor learning revamps the myelin landscape
Learning requires new oligodendrogenesis, but how myelin patterns change during learning is unclear. Bacmeister et al. sho...
Motor learning drives dynamic patterns of intermittent myelination on learning-activated axons
Motor learning drives dynamic patterns of intermittent myelination on learning-activated axons
Myelin plasticity occurs when newly formed and pre-existing oligodendrocytes remodel existing patterns of myelination. Mye...
A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes
A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes
Environmental cues influence the highly dynamic morphology of microglia. Strategies to characterize these changes usually ...
Structure and origin of complex cortical activity during decision making
Structure and origin of complex cortical activity during decision making
Frontal cortex activity contains a mixture of signals for different behavioral and cognitive processes. Analysis of 20,000...
Complementary task representations in hippocampus and prefrontal cortex for generalizing the structure of problems
Complementary task representations in hippocampus and prefrontal cortex for generalizing the structure of problems
Humans and other animals effortlessly generalize prior knowledge to solve novel problems, by abstracting common structure ...
Awake perception is associated with dedicated neuronal assemblies in the cerebral cortex
Awake perception is associated with dedicated neuronal assemblies in the cerebral cortex
Neural activity in the sensory cortex combines stimulus responses and ongoing activity, but it remains unclear whether the...
Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice
Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice
Oligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes throughout life, but the functions of OPC...
The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease
The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease
To characterize the dysregulation of chromatin accessibility in Alzheimer’s disease (AD), we generated 636 ATAC-seq ...
Thalamus-driven functional populations in frontal cortex support decision-making
Thalamus-driven functional populations in frontal cortex support decision-making
Neurons in frontal cortex exhibit diverse selectivity representing sensory, motor and cognitive variables during decision-...
Developmental dynamics of RNA translation in the human brain
Developmental dynamics of RNA translation in the human brain
The precise regulation of gene expression is fundamental to neurodevelopment, plasticity and cognitive function. Although ...
GABA receptors near sodium channels facilitate spike propagation in myelinated axons
GABA receptors near sodium channels facilitate spike propagation in myelinated axons
Although axonal GABAA receptors are thought to cause presynaptic inhibition, we show that instead they often facilitate so...
GABA facilitates spike propagation through branch points of sensory axons in the spinal cord
GABA facilitates spike propagation through branch points of sensory axons in the spinal cord
Movement and posture depend on sensory feedback that is regulated by specialized GABAergic neurons (GAD2+) that form axo-a...
How to build a cognitive map
How to build a cognitive map
Learning and interpreting the structure of the environment is an innate feature of biological systems, and is integral to ...
Better viruses for targeting microglia
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MEG signature of sexual trauma
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Controlling the action
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Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Aggregation of alpha-synuclein (α-Syn) drives Parkinson’s disease (PD), although the initial stages of self-ass...
Fiber photometry in striatum reflects primarily nonsomatic changes in calcium
Fiber photometry in striatum reflects primarily nonsomatic changes in calcium
Fiber photometry enables recording of population neuronal calcium dynamics in awake mice. While the popularity of fiber ph...
Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders
Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders
Astrocytes negatively impact neuronal development in many models of neurodevelopmental disorders (NDs); however, how they ...
Inconvenient truths and the usefulness of identifying unknown unknowns
Inconvenient truths and the usefulness of identifying unknown unknowns
We studied how the sex of human experimenters affected mouse behaviors and brain functions under normal conditions and in ...
Author Correction: Wireless multilateral devices for optogenetic studies of individual and social behaviors
Department of Mechanical Engineering, Northwestern University, Evanston, IL, USAYiyuan Yang, Yujun Deng, Raudel Avila, Shu...
Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation
Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation
The development of technologies to protect or enhance memory in older people is an enduring goal of translational medicine...
Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis
Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis
The incorporation of new information into the hippocampal network is likely to be constrained by its innate architecture a...
A multifaceted gradient in human cerebellum of structural and functional development
A multifaceted gradient in human cerebellum of structural and functional development
The organization of the basic tissue and functional properties of the cerebellum across development is unknown. Combining ...
Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking
Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking
Repeated exposure to opioids causes tolerance, which limits their analgesic utility and contributes to overdose and abuse ...
Addressing the opportunity gap in the Latin American neuroscience community
Addressing the opportunity gap in the Latin American neuroscience community
Although issues surrounding diversity and inclusion in science are global, distinctive region-specific socioeconomic facto...
Publisher Correction: Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans
These authors contributed equally: Douglas Vormstein-Schneider, Jessica D. Lin.Stanley Center for Psychiatric Research, Br...
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underly...
Salience in the raphe
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How sound soothes
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