SCI时时刷

search
In conversation with Fernando de Castro Soubriet
In conversation with Fernando de Castro Soubriet
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the f...
Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain
Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain
Alzheimer’s disease (AD) and dementia in general are age-related diseases with multiple contributing factors, includ...
Larry J. Young (1967–2024)
Larry J. Young (1967–2024)
Larry J. Young (1967–2024) passed away in Tsukuba, Japan in March 2024 in the days leading up to the ...
Author Correction: Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment
Smurfit Institute of Genetics, Trinity College Dublin, Dublin, IrelandChris Greene, Eoin O’Keeffe, Jeffrey O’Callaghan, Be...
Advancing the neuroscience of human pregnancy
Advancing the neuroscience of human pregnancy
The study of the female brain during pregnancy and motherhood is gaining traction, and holds the potential to address the ...
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration
In neurons, RNA granules are transported along the axon for local translation away from the soma. Recent studies indicate ...
Widespread changes in alternative splicing in developing and adult mouse brain
Widespread changes in alternative splicing in developing and adult mouse brain
In the first comprehensive mRNA isoform atlas of the developing and adult mouse brain, we discover that region and age inf...
Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain
Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain
RNA isoforms influence cell identity and function. However, a comprehensive brain isoform map was lacking. We analyze sing...
Restoring sensation to prosthetics
Amputees often experience paresthesia and difficulties using prosthetic limbs because of impaired sensorimotor processing....
HDAC3 stokes microglia in stroke
Microglia play a complex role in the response to brain injury, with past work showing that these cells can both aid in the...
Pushing the bounds on dimensionality
Low-dimensional representations can capture structure in neural dynamics data, but it is unclear whether additional struct...
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
Learning and memory require activity-induced changes in dendritic translation, but which mRNAs are involved and how they a...
Climbing fibers provide essential instructive signals for associative learning
Climbing fibers provide essential instructive signals for associative learning
Supervised learning depends on instructive signals that shape the output of neural circuits to support learned changes in ...
Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus
Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus
An essential feature of neurons is their ability to centrally integrate information from their dendrites. The activity of ...
TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models
TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models
Human genetics implicate defective myeloid responses in the development of late-onset Alzheimer disease. A decline in peri...
Retraction Note: Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression
Takushi ShimomuraPresent address: Division of Biophysics and Neurobiology, Department of Molecular Physiology, National In...
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology
Microglia are central players in Alzheimer’s disease pathology but analyzing microglial states in human brain sample...
Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis
Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis
The generation of new myelin-forming oligodendrocytes in the adult central nervous system is critical for cognitive functi...
Pervasive environmental chemicals impair oligodendrocyte development
Pervasive environmental chemicals impair oligodendrocyte development
Exposure to environmental chemicals can impair neurodevelopment, and oligodendrocytes may be particularly vulnerable, as t...
Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation
Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation
Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals generated by fluid flow into bio...
Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development
Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development
The mammalian telencephalon contains distinct GABAergic projection neuron and interneuron types, originating in the germin...
A precision functional atlas of personalized network topography and probabilities
A precision functional atlas of personalized network topography and probabilities
Although the general location of functional neural networks is similar across individuals, there is vast person-to-person ...
A systems identification approach using Bayes factors to deconstruct the brain bases of emotion regulation
A systems identification approach using Bayes factors to deconstruct the brain bases of emotion regulation
Cognitive reappraisal is fundamental to cognitive therapies and everyday emotion regulation. Analyses using Bayes factors ...
Recommendations for the responsible use and communication of race and ethnicity in neuroimaging research
Recommendations for the responsible use and communication of race and ethnicity in neuroimaging research
The growing availability of large-population human biomedical datasets provides researchers with unique opportunities to c...
Co-dependent excitatory and inhibitory plasticity accounts for quick, stable and long-lasting memories in biological networks
Co-dependent excitatory and inhibitory plasticity accounts for quick, stable and long-lasting memories in biological networks
The brain’s functionality is developed and maintained through synaptic plasticity. As synapses undergo plasticity, t...
Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis
Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis
Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination of the central nervous system (CNS). Autol...
Natural language instructions induce compositional generalization in networks of neurons
Natural language instructions induce compositional generalization in networks of neurons
A fundamental human cognitive feat is to interpret linguistic instructions in order to perform novel tasks without explici...
The dynamic state of a prefrontal–hypothalamic–midbrain circuit commands behavioral transitions
The dynamic state of a prefrontal–hypothalamic–midbrain circuit commands behavioral transitions
Innate behaviors meet multiple needs adaptively and in a serial order, suggesting the existence of a hitherto elusive brai...
Local origin of excitatory–inhibitory tuning equivalence in a cortical network
Local origin of excitatory–inhibitory tuning equivalence in a cortical network
The interplay between excitation and inhibition determines the fidelity of cortical representations. The receptive fields ...
Identification of a cold sensor in peripheral somatosensory neurons
Identification of a cold sensor in peripheral somatosensory neurons
Cold sensor identities in peripheral somatosensory neurons remain obscure. We show that GluK2, a kainate-type glutamate-se...