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High-clearance anti-amyloid immunotherapies in Alzheimer's disease. Part 1: Meta-analysis and review of efficacy and safety data, and medico-economical aspects
In 2021, aducanumab, an immunotherapy targeting amyloid-β, was approved for Alzheimer's disease (AD) by the US Food and Dr...
French recommendations for the management of adult & pediatric chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)
CIDP is a rare disease, with prevalence and incidence ranging from 1 to 8.9 per 100,000 population and 0.15 to 1.6 per 100...
Modelling mouse auditory response dynamics along a continuum of consciousness using a deep recurrent neural network
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Stable, long-term single-neuronal recording from the rat spinal cord with flexible carbon nanotube fiber electrodes
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Riemannian distance based channel selection and feature extraction combining discriminative time-frequency bands and Riemannian tangent space for MI-BCIs
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A new attention-based 3D densely connected cross-stage-partial network for motor imagery classification in BCI
Objective. The challenge for motor imagery (MI) in brain-computer interface (BCI) systems is finding a reliab...
Psychiatric Vulnerability, Mood, and Anxiety Disorders
Psychiatric Vulnerability, Mood, and Anxiety Disorders
This volume looks at classic and novel methods currently used by researchers to understand mood and anxiety disorders and ...
Integrating problem posing into the mathematics classroom: current advances and future directions of research
Providing students opportunities to engage in problem posing activities is advocated in the mathematics curriculum standar...
The developmental journey of therapies targeting purine receptors: from basic science to clinical trials
The developmental journey of therapies targeting purine receptors: from basic science to clinical trials
Since the discovery of ATP as an extracellular signalling molecule in 1972, purinergic signalling, mediated by extracellul...
Tramadol and Codeine Stacking/Boosting Dose Exposure Induced Neurotoxic Behaviors, Oxidative Stress, Mitochondrial Dysfunction, and Neurotoxic Genes in Adolescent Mice
Tramadol and Codeine Stacking/Boosting Dose Exposure Induced Neurotoxic Behaviors, Oxidative Stress, Mitochondrial Dysfunction, and Neurotoxic Genes in Adolescent Mice
In spite of the increasing epidemic of pharmaceutical opioids (codeine and tramadol) misuse and abuse among the adolescent...
MIR99AHG/miR-204-5p/TXNIP/Nrf2/ARE Signaling Pathway Decreases Glioblastoma Temozolomide Sensitivity
MIR99AHG/miR-204-5p/TXNIP/Nrf2/ARE Signaling Pathway Decreases Glioblastoma Temozolomide Sensitivity
Glioblastoma (GBM) is the most prevalent primary cerebral tumor in adults with high aggressiveness. Temozolomide (TMZ) is ...
Incorporation of spatial- and connectivity-based cortical brain region information in regularized regression: Application to Human Connectome Project data
Incorporation of spatial- and connectivity-based cortical brain region information in regularized regression: Application to Human Connectome Project data
Studying the association of the brain's structure and function with neurocognitive outcomes requires a comprehensive a...
Brain state transition analysis using ultra-fast fMRI differentiates MCI from cognitively normal controls
Brain state transition analysis using ultra-fast fMRI differentiates MCI from cognitively normal controls
PurposeConventional resting-state fMRI studies indicate that many cortical and subcortical regions have altered function i...
Background inhibited and speed-loss-free volumetric imaging in vivo based on structured-illumination Fourier light field microscopy
Background inhibited and speed-loss-free volumetric imaging in vivo based on structured-illumination Fourier light field microscopy
Benefiting from its advantages in fast volumetric imaging for recording biodynamics, Fourier light field microscopy (FLFM)...
miR-409-3p represses Cited2 to refine neocortical layer V projection neuron identity
miR-409-3p represses Cited2 to refine neocortical layer V projection neuron identity
The evolutionary emergence of the corticospinal tract and corpus callosum are thought to underpin the expansion of complex...
From Bayes-optimal to heuristic decision-making in a two-alternative forced choice task with an information-theoretic bounded rationality model
From Bayes-optimal to heuristic decision-making in a two-alternative forced choice task with an information-theoretic bounded rationality model
Bayes optimal and heuristic decision-making schemes are often considered fundamentally opposed to each other as a framewor...
Light-induced shifts in opsin gene expression in the four-eyed fish Anableps anableps
Light-induced shifts in opsin gene expression in the four-eyed fish Anableps anableps
The development of the vertebrate eye is a complex process orchestrated by several conserved transcriptional and signaling...
Early life nociceptive stimulus and fentanyl exposure increase hippocampal neurogenesis and anxiety but do not affect spatial learning and memory
Early life nociceptive stimulus and fentanyl exposure increase hippocampal neurogenesis and anxiety but do not affect spatial learning and memory
This study aimed to determine whether preemptive fentanyl administration in neonatal rats reduces the impact of a nocicept...
High phenylalanine concentrations induce demyelination and microglial activation in mouse cerebellar organotypic slices
High phenylalanine concentrations induce demyelination and microglial activation in mouse cerebellar organotypic slices
Phenylketonuria (PKU) is an inborn error of metabolism. Mutations in the enzyme phenylalanine hydroxylase (PAH)-encoding g...
Focal electrical stimulation on an alcohol disorder model using magnetic resonance imaging-compatible chronic neural monopolar carbon fiber electrodes
Focal electrical stimulation on an alcohol disorder model using magnetic resonance imaging-compatible chronic neural monopolar carbon fiber electrodes
Neuromodulation interventions, such as Deep Brain Stimulation (DBS) and repeated transcranial magnetic stimulation (rTMS),...
Reactive morphology of dividing microglia following kainic acid administration
Reactive morphology of dividing microglia following kainic acid administration
The microglial response to a pathological microenvironment is hallmarked by a change in cellular morphology. Following a p...
The study on the morphological changes of oropharynx in patients with complete unilateral cleft lip and palate after palatopharyngeal closure
The study on the morphological changes of oropharynx in patients with complete unilateral cleft lip and palate after palatopharyngeal closure
Cleft lip and palate can be treated as one of the most common craniofacial congenital malformations in humans. Such diseas...
Adaptive control of a wheelchair mounted robotic arm with neuromorphically integrated velocity readings and online-learning
Adaptive control of a wheelchair mounted robotic arm with neuromorphically integrated velocity readings and online-learning
Wheelchair-mounted robotic arms support people with upper extremity disabilities with various activities of daily living (...
Natural killer cells-related immune traits and amyotrophic lateral sclerosis: A Mendelian randomization study
Natural killer cells-related immune traits and amyotrophic lateral sclerosis: A Mendelian randomization study
BackgroundObservational studies have suggested that peripheral immune disorders are associated with amyotrophic lateral sc...
Proteomic and metabolomic profiling of acupuncture for migraine reveals a correlative link via energy metabolism
Proteomic and metabolomic profiling of acupuncture for migraine reveals a correlative link via energy metabolism
Migraine is a neurovascular disease with a high disability rate. Acupuncture treatment has emerged as a safe and viable al...
Evaluating the use of synthetic T1-w images in new T2 lesion detection in multiple sclerosis
Evaluating the use of synthetic T1-w images in new T2 lesion detection in multiple sclerosis
The assessment of disease activity using serial brain MRI scans is one of the most valuable strategies for monitoring trea...
EvtSNN: Event-driven SNN simulator optimized by population and pre-filtering
EvtSNN: Event-driven SNN simulator optimized by population and pre-filtering
Recently, spiking neural networks (SNNs) have been widely studied by researchers due to their biological interpretability ...
Structural gray matter features and behavioral preliterate skills predict future literacy – A machine learning approach
Structural gray matter features and behavioral preliterate skills predict future literacy – A machine learning approach
When children learn to read, their neural system undergoes major changes to become responsive to print. There seem to be n...
Distributed model-free formation control of networked fully-actuated autonomous surface vehicles
Distributed model-free formation control of networked fully-actuated autonomous surface vehicles
This paper presents a distributed constant bearing guidance and model-free disturbance rejection control method for format...
Efficient recognition of dynamic user emotions based on deep neural networks
Efficient recognition of dynamic user emotions based on deep neural networks
The key issue at this stage is how to mine the large amount of valuable user sentiment information from the massive amount...
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