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Towards a personalized prediction, prevention and therapy of insomnia: gut microbiota profile can discriminate between paradoxical and objective insomnia in post-menopausal women
Towards a personalized prediction, prevention and therapy of insomnia: gut microbiota profile can discriminate between paradoxical and objective insomnia in post-menopausal women
Insomnia persists as a prevalent sleep disorder among middle-aged and older adults, significantly impacting quality of lif...
Unraveling progression subtypes in people with Huntington’s disease
Unraveling progression subtypes in people with Huntington’s disease
Huntington’s disease (HD) is a progressive neurodegenerative disease caused by a CAG trinucleotide expansion in the ...
Rhodiola rosea: a review in the context of PPPM approach
Rhodiola rosea: a review in the context of PPPM approach
A natural “medicine and food” plant, Rhodiola rosea (RR) is primarily made up of organic acids, phenolic compo...
Clinically relevant immune subtypes based on alternative splicing landscape of immune-related genes for lung cancer advanced PPPM approach
Clinically relevant immune subtypes based on alternative splicing landscape of immune-related genes for lung cancer advanced PPPM approach
Alternative splicing (AS) occurs in the process of gene post-transcriptional process, which is very important for the corr...
Digital biomarkers: 3PM approach revolutionizing chronic disease management — EPMA 2024 position
Digital biomarkers: 3PM approach revolutionizing chronic disease management — EPMA 2024 position
Non-communicable chronic diseases (NCDs) have become a major global health concern. They constitute the leading cause of d...
Multi-risk factors joint prediction model for risk prediction of retinopathy of prematurity
Multi-risk factors joint prediction model for risk prediction of retinopathy of prematurity
Retinopathy of prematurity (ROP) is a retinal vascular proliferative disease common in low birth weight and premature infa...
Social determinants of health and their relation to suboptimal health status in the context of 3PM: a latent profile analysis
Social determinants of health and their relation to suboptimal health status in the context of 3PM: a latent profile analysis
Suboptimal health is identified as a reversible phase occurring before chronic diseases manifest, emphasizing the signific...
Multi-omic profiling reveals potential biomarkers of hepatocellular carcinoma prognosis and therapy response among mitochondria-associated cell death genes in the context of 3P medicine
Multi-omic profiling reveals potential biomarkers of hepatocellular carcinoma prognosis and therapy response among mitochondria-associated cell death genes in the context of 3P medicine
Cancer cell growth, metastasis, and drug resistance are major challenges in treating liver hepatocellular carcinoma (LIHC)...
Immune-related gene methylation prognostic instrument for stratification and targeted treatment of ovarian cancer patients toward advanced 3PM approach
Immune-related gene methylation prognostic instrument for stratification and targeted treatment of ovarian cancer patients toward advanced 3PM approach
DNA methylation is an important mechanism in epigenetics, which can change the transcription ability of genes and is close...
The Emergency Medical Team Operating System — a vision for field hospital data management in following the concepts of predictive, preventive, and personalized medicine
The Emergency Medical Team Operating System — a vision for field hospital data management in following the concepts of predictive, preventive, and personalized medicine
In times where sudden-onset disasters (SODs) present challenges to global health systems, the integration of predictive, p...
Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation
Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation
Despite their subordination in humans, to a great extent, mitochondria maintain their independent status but tightly coope...
Mediterranean diet in the targeted prevention and personalized treatment of chronic diseases: evidence, potential mechanisms, and prospects
Mediterranean diet in the targeted prevention and personalized treatment of chronic diseases: evidence, potential mechanisms, and prospects
The prevalence of chronic diseases is currently a major public health issue worldwide and is exploding with the population...
Energy metabolism as the hub of advanced non-small cell lung cancer management: a comprehensive view in the framework of predictive, preventive, and personalized medicine
Energy metabolism as the hub of advanced non-small cell lung cancer management: a comprehensive view in the framework of predictive, preventive, and personalized medicine
Energy metabolism is a hub of governing all processes at cellular and organismal levels such as, on one hand, reparable vs...
Clinically relevant stratification of lung squamous carcinoma patients based on ubiquitinated proteasome genes for 3P medical approach
Clinically relevant stratification of lung squamous carcinoma patients based on ubiquitinated proteasome genes for 3P medical approach
The proteasome is a crucial mechanism that regulates protein fate and eliminates misfolded proteins, playing a significant...
The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation
The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation
Worldwide stroke is the second leading cause of death and the third leading cause of death and disability combined. The es...
Promoting advanced medical services in the framework of 3PM—a proof-of-concept by the “Centro” Region of Portugal
Promoting advanced medical services in the framework of 3PM—a proof-of-concept by the “Centro” Region of Portugal
Multidisciplinary team from three universities based in the “Centro” Region of Portugal developed diverse appr...
Cancer screening in hospitalized ischemic stroke patients: a multicenter study focused on multiparametric analysis to improve management of occult cancers
Cancer screening in hospitalized ischemic stroke patients: a multicenter study focused on multiparametric analysis to improve management of occult cancers
The reciprocal promotion of cancer and stroke occurs due to changes in shared risk factors, such as metabolic pathways and...
Automated detection of nine infantile fundus diseases and conditions in retinal images using a deep learning system
Automated detection of nine infantile fundus diseases and conditions in retinal images using a deep learning system
We developed an Infant Retinal Intelligent Diagnosis System (IRIDS), an automated system to aid early diagnosis and monito...
Frailty mediating the causality between leucocyte telomere length and mortality: a cohort study of 440,551 UK Biobank participants
Frailty mediating the causality between leucocyte telomere length and mortality: a cohort study of 440,551 UK Biobank participants
Previous studies reported leucocyte telomere length (LTL) and frailty were associated with mortality, but it remains uncle...
The mediating effect of perceived stress on the relationship between big five personality traits and suboptimal health status in Chinese population: a nationwide survey in the framework of predictive, preventive, and personalized medicine
The mediating effect of perceived stress on the relationship between big five personality traits and suboptimal health status in Chinese population: a nationwide survey in the framework of predictive, preventive, and personalized medicine
The effects of psychological factors on suboptimal health status (SHS) have been widely described; however, mechanisms beh...
Nitroproteomics is instrumental for stratification and targeted treatments of astrocytoma patients: expert recommendations for advanced 3PM approach with improved individual outcomes
Nitroproteomics is instrumental for stratification and targeted treatments of astrocytoma patients: expert recommendations for advanced 3PM approach with improved individual outcomes
Protein tyrosine nitration is a selectively and reversible important post-translational modification, which is closely rel...
Impacts of a multipurpose outpatient hospital pharmacy in the framework of 3P medicine
Impacts of a multipurpose outpatient hospital pharmacy in the framework of 3P medicine
In recent years, we have been witnessing a change in the performance of hospital pharmacists, aimed at increasing their pa...
Diabetes, glycemic control and arterial stiffness: a real-world cohort study in the context of predictive, preventive, and personalized medicine
Diabetes, glycemic control and arterial stiffness: a real-world cohort study in the context of predictive, preventive, and personalized medicine
Arterial stiffness is a major contributor to morbidity and mortality worldwide. Although several metabolic markers associa...
The predictive, preventive, and personalized medicine of insomnia: gut microbiota and inflammation
The predictive, preventive, and personalized medicine of insomnia: gut microbiota and inflammation
The human gut microbiota (GM) has been recognized as a significant factor in the development of insomnia, primarily throug...
Emerging frontiers of artificial intelligence and machine learning in ischemic stroke: a comprehensive investigation of state-of-the-art methodologies, clinical applications, and unraveling challenges
Emerging frontiers of artificial intelligence and machine learning in ischemic stroke: a comprehensive investigation of state-of-the-art methodologies, clinical applications, and unraveling challenges
At present, stroke remains the second highest cause of death globally and a leading cause of disability. From 1990 to 2019...
Predicting 1-, 3-, 5-, and 8-year all-cause mortality in a community-dwelling older adult cohort: relevance for predictive, preventive, and personalized medicine
Predicting 1-, 3-, 5-, and 8-year all-cause mortality in a community-dwelling older adult cohort: relevance for predictive, preventive, and personalized medicine
Population aging is a global public health issue involving increased prevalence of age-related diseases, and concomitant b...
Conceptualised psycho-medical footprint for health status outcomes and the potential impacts for early detection and prevention of chronic diseases in the context of 3P medicine
Conceptualised psycho-medical footprint for health status outcomes and the potential impacts for early detection and prevention of chronic diseases in the context of 3P medicine
The Suboptimal Health Status Questionnaire-25 (SHSQ-25) is a distinctive medical psychometric diagnostic tool designed for...
Artificial intelligence to improve ischemia prediction in Rubidium Positron Emission Tomography—a validation study
Artificial intelligence to improve ischemia prediction in Rubidium Positron Emission Tomography—a validation study
Patients are referred to functional coronary artery disease (CAD) testing based on their pre-test probability (PTP) to sea...
Causal relationship between gut Prevotellaceae and risk of sepsis: a two-sample Mendelian randomization and clinical retrospective study in the framework of predictive, preventive, and personalized medicine
Causal relationship between gut Prevotellaceae and risk of sepsis: a two-sample Mendelian randomization and clinical retrospective study in the framework of predictive, preventive, and personalized medicine
Gut microbiota is closely related to sepsis. Recent studies have suggested that Prevotellaceae could be associated with in...
Development and validation of a short-form suboptimal health status questionnaire
Development and validation of a short-form suboptimal health status questionnaire
Suboptimal health status (SHS) is a reversible, borderline state between optimal health and disease. Although this conditi...
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