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Plausible mechanism of drug resistance and side-effects of COVID-19 therapeutics: a bottleneck for its eradication
Plausible mechanism of drug resistance and side-effects of COVID-19 therapeutics: a bottleneck for its eradication
COVID-19 pandemic has turned our world upside down by meddling with our normal lives. While there is no definitive drug ag...
Evaluating the effect of sodium alginate and sodium carboxymethylcellulose on pulmonary delivery of levofloxacin spray-dried microparticles
Evaluating the effect of sodium alginate and sodium carboxymethylcellulose on pulmonary delivery of levofloxacin spray-dried microparticles
Patients with cystic fibrosis commonly suffer from lung infections caused by Pseudomonas aeruginosa. Recently, the Levoflo...
Preparation of poly(vinyl alcohol) nanofibers containing disulfiram-copper complex by electrospinning: a potential delivery system against melanoma
Preparation of poly(vinyl alcohol) nanofibers containing disulfiram-copper complex by electrospinning: a potential delivery system against melanoma
Melanoma poses a significant threat to human health, making the development of a safe and effective treatment a crucial ch...
Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish
Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish
Several countries’ most incorrectly discarded medicines are acetaminophen (ACM), metamizole (MTZ), and nimesulide (N...
Structure-activity relationship of pharmacophores and toxicophores: the need for clinical strategy
Structure-activity relationship of pharmacophores and toxicophores: the need for clinical strategy
Sometimes clinical efficacy and potential risk of therapeutic and toxic agents are difficult to predict over a long period...
Repurposing metformin as a potential anticancer agent using in silico technique
Repurposing metformin as a potential anticancer agent using in silico technique
The focus on repurposing readily available, well-known drugs for new, creative uses has grown recently. One such medicatio...
Public interest in drug-related problems reflected in information search trends: an infodemiological study
Public interest in drug-related problems reflected in information search trends: an infodemiological study
The analysis of how people search and “navigate” the internet to obtain health-related information and how the...
Investigation of the relationship between inflammation and microbiota in the intestinal tissue of female and male rats fed with fructose: Modulatory role of metformin
Investigation of the relationship between inflammation and microbiota in the intestinal tissue of female and male rats fed with fructose: Modulatory role of metformin
It has been reported that High-Fructose (HF) consumption, considered one of the etiological factors of Metabolic Syndrome ...
Dry powder inhaler design and particle technology in enhancing Pulmonary drug deposition: challenges and future strategies
Dry powder inhaler design and particle technology in enhancing Pulmonary drug deposition: challenges and future strategies
The efficient delivery of drugs from dry powder inhaler (DPI) formulations is associated with the complex interaction betw...
Effect of the treatment of iron deficiency anemia on chronic drug-resistant cough: a rare case report
Effect of the treatment of iron deficiency anemia on chronic drug-resistant cough: a rare case report
A persistent difficult-to-treat cough can be exhausting. Iron is an essential element that plays an important role in regu...
Cost minimization analysis of subcutaneous trastuzumab versus intravenous biosimilar trastuzumab: policy recommendations for breast cancer treatment in Malaysia
Cost minimization analysis of subcutaneous trastuzumab versus intravenous biosimilar trastuzumab: policy recommendations for breast cancer treatment in Malaysia
Current clinical practice recommends switching innovator intravenous trastuzumab (IV-TZMi) to subcutaneous trastuzumab (SC...
Royal jelly and its hormonal effects in breast cancer: a literature review
Royal jelly and its hormonal effects in breast cancer: a literature review
Breast cancer is the most common cancer in women which can be cured in most individuals with early-stage non-metastatic di...
Targeting resistant breast cancer stem cells in a three-dimensional culture model with oleuropein encapsulated in methacrylated alginate microparticles
Targeting resistant breast cancer stem cells in a three-dimensional culture model with oleuropein encapsulated in methacrylated alginate microparticles
Cancer stem cells (CSCs) are a subpopulation of cancer cells that are believed to be responsible for tumor initiation, pro...
Evaluation of 1,10-phenanthroline-based hydroxamate derivative as dual histone deacetylases/ribonucleotide reductase inhibitor with antitumor activities
Evaluation of 1,10-phenanthroline-based hydroxamate derivative as dual histone deacetylases/ribonucleotide reductase inhibitor with antitumor activities
Aberrant expression of histone deacetylases (HDACs) and ribonucleotide reductase (RR) enzymes are commonly observed in var...
Evaluation of time-to-onset and outcome of cardiac adverse events related to pembrolizumab using post-marketing surveillance in Japanese patients
Evaluation of time-to-onset and outcome of cardiac adverse events related to pembrolizumab using post-marketing surveillance in Japanese patients
Pembrolizumab has been widely used in patients since its release, but information on cardiac Adverse Events (AEs) related ...
A rare case of phenobarbital-induced leukocytoclastic vasculitis
A rare case of phenobarbital-induced leukocytoclastic vasculitis
Drug hypersensitivity reactions (DHRs) manifested as vasculitis are rare. Antibiotics, non-steroidal anti-inflammatory dru...
Deciphering the similarities and disparities of molecular mechanisms behind respiratory epithelium response to HCoV-229E and SARS-CoV-2 and drug repurposing, a systems biology approach
Deciphering the similarities and disparities of molecular mechanisms behind respiratory epithelium response to HCoV-229E and SARS-CoV-2 and drug repurposing, a systems biology approach
Identifying the molecular mechanisms behind SARS-CoV-2 disparities and similarities will help find new treatments. The pre...
Developing an AI-based prediction model for anaphylactic shock from injection drugs using Japanese real-world data and chemical structure-based analysis
Developing an AI-based prediction model for anaphylactic shock from injection drugs using Japanese real-world data and chemical structure-based analysis
This study aims to develop an AI-based prediction model for injection drugs that cause anaphylactic shock using Japanese R...
New amide and diterpene alkaloids with anticholinesterase activity from Delphinium cyphoplectrum roots
New amide and diterpene alkaloids with anticholinesterase activity from Delphinium cyphoplectrum roots
The cholinergic hypothesis posits a robust correlation between the onset of Alzheimer’s disease and a pronounced def...
Educational interventions in pharmacovigilance to improve the knowledge, attitude and the report of adverse drug reactions in healthcare professionals: Systematic Review and Meta-analysis
Educational interventions in pharmacovigilance to improve the knowledge, attitude and the report of adverse drug reactions in healthcare professionals: Systematic Review and Meta-analysis
Underreporting of adverse drug reactions (ADRs) limits and delays the detection of signs. The aim of this systematic revie...
Freeze-drying of bupivacaine lipospheres: preparation, characterization, and evaluation of anti-microbial properties
Freeze-drying of bupivacaine lipospheres: preparation, characterization, and evaluation of anti-microbial properties
To prepare freeze-dried bupivacaine lipospheres intended for topical application in burn injuries. The aim was improving t...
Dexmedetomidine alleviates Hypoxia/reoxygenation-induced mitochondrial dysfunction in cardiomyocytes via activation of Sirt3/Prdx3 pathway
Dexmedetomidine alleviates Hypoxia/reoxygenation-induced mitochondrial dysfunction in cardiomyocytes via activation of Sirt3/Prdx3 pathway
Myocardial ischemia/reperfusion injury (MIRI) seriously threatens the health of people. The mitochondrial dysfunction in c...
Activity of zinc oxide and zinc borate nanoparticles against resistant bacteria in an experimental lung cancer model
Activity of zinc oxide and zinc borate nanoparticles against resistant bacteria in an experimental lung cancer model
Recent research indicates a prevalence of typical lung infections, such as pneumonia, in lung cancer patients. Klebsiella ...
Antimicrobial activity and mechanism of anti-MRSA of phloroglucinol derivatives
Antimicrobial activity and mechanism of anti-MRSA of phloroglucinol derivatives
In previous studies, authors have completed the total synthesis of several phloroglucinol natural products and synthesized...
A critical overview of challenging roles of medicinal plants in improvement of wound healing technology
A critical overview of challenging roles of medicinal plants in improvement of wound healing technology
Chronic diseases often hinder the natural healing process, making wound infections a prevalent clinical concern. In severe...
Oral regimen for high dose methotrexate urine alkalinization: a systematic review and meta-analysis
Oral regimen for high dose methotrexate urine alkalinization: a systematic review and meta-analysis
Urine alkalinization prevents nephrotoxicity in patients receiving high-dose methotrexate (HDMTX). While the standard appr...
Co-delivery of artemisinin and metformin via PEGylated niosomal nanoparticles: potential anti-cancer effect in treatment of lung cancer cells
Co-delivery of artemisinin and metformin via PEGylated niosomal nanoparticles: potential anti-cancer effect in treatment of lung cancer cells
Despite the advances in treatment, lung cancer is a global concern and necessitates the development of new treatments. Big...
Development of brimonidine niosomes laden contact lenses for extended release and promising delivery system in glaucoma treatment
Development of brimonidine niosomes laden contact lenses for extended release and promising delivery system in glaucoma treatment
Increased intraocular pressure is a common symptom of glaucoma. In severe circumstances, it may result in loss of eyesight...
Imiquimod as a new treatment in refractory idiopathic granulomatous mastitis: report of two cases
Imiquimod as a new treatment in refractory idiopathic granulomatous mastitis: report of two cases
Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory lesion of the breast that mimics breast cancer or i...
The association between anti-diabetic agents and osteoporosis, sarcopenia, and osteosarcopenia among Iranian older adults; Bushehr Elderly Health (BEH) program
The association between anti-diabetic agents and osteoporosis, sarcopenia, and osteosarcopenia among Iranian older adults; Bushehr Elderly Health (BEH) program
Various risk factors are mentioned for osteoporosis, sarcopenia, and osteosarcopenia. Our aim is to assess the impacts of ...
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