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Developing an AI-based prediction model for anaphylactic shock from injection drugs using Japanese real-world data and chemical structure-based analysis
Developing an AI-based prediction model for anaphylactic shock from injection drugs using Japanese real-world data and chemical structure-based analysis
This study aims to develop an AI-based prediction model for injection drugs that cause anaphylactic shock using Japanese R...
New amide and diterpene alkaloids with anticholinesterase activity from Delphinium cyphoplectrum roots
New amide and diterpene alkaloids with anticholinesterase activity from Delphinium cyphoplectrum roots
The cholinergic hypothesis posits a robust correlation between the onset of Alzheimer’s disease and a pronounced def...
Educational interventions in pharmacovigilance to improve the knowledge, attitude and the report of adverse drug reactions in healthcare professionals: Systematic Review and Meta-analysis
Educational interventions in pharmacovigilance to improve the knowledge, attitude and the report of adverse drug reactions in healthcare professionals: Systematic Review and Meta-analysis
Underreporting of adverse drug reactions (ADRs) limits and delays the detection of signs. The aim of this systematic revie...
Freeze-drying of bupivacaine lipospheres: preparation, characterization, and evaluation of anti-microbial properties
Freeze-drying of bupivacaine lipospheres: preparation, characterization, and evaluation of anti-microbial properties
To prepare freeze-dried bupivacaine lipospheres intended for topical application in burn injuries. The aim was improving t...
Dexmedetomidine alleviates Hypoxia/reoxygenation-induced mitochondrial dysfunction in cardiomyocytes via activation of Sirt3/Prdx3 pathway
Dexmedetomidine alleviates Hypoxia/reoxygenation-induced mitochondrial dysfunction in cardiomyocytes via activation of Sirt3/Prdx3 pathway
Myocardial ischemia/reperfusion injury (MIRI) seriously threatens the health of people. The mitochondrial dysfunction in c...
Activity of zinc oxide and zinc borate nanoparticles against resistant bacteria in an experimental lung cancer model
Activity of zinc oxide and zinc borate nanoparticles against resistant bacteria in an experimental lung cancer model
Recent research indicates a prevalence of typical lung infections, such as pneumonia, in lung cancer patients. Klebsiella ...
Antimicrobial activity and mechanism of anti-MRSA of phloroglucinol derivatives
Antimicrobial activity and mechanism of anti-MRSA of phloroglucinol derivatives
In previous studies, authors have completed the total synthesis of several phloroglucinol natural products and synthesized...
A critical overview of challenging roles of medicinal plants in improvement of wound healing technology
A critical overview of challenging roles of medicinal plants in improvement of wound healing technology
Chronic diseases often hinder the natural healing process, making wound infections a prevalent clinical concern. In severe...
Oral regimen for high dose methotrexate urine alkalinization: a systematic review and meta-analysis
Oral regimen for high dose methotrexate urine alkalinization: a systematic review and meta-analysis
Urine alkalinization prevents nephrotoxicity in patients receiving high-dose methotrexate (HDMTX). While the standard appr...
Co-delivery of artemisinin and metformin via PEGylated niosomal nanoparticles: potential anti-cancer effect in treatment of lung cancer cells
Co-delivery of artemisinin and metformin via PEGylated niosomal nanoparticles: potential anti-cancer effect in treatment of lung cancer cells
Despite the advances in treatment, lung cancer is a global concern and necessitates the development of new treatments. Big...
Development of brimonidine niosomes laden contact lenses for extended release and promising delivery system in glaucoma treatment
Development of brimonidine niosomes laden contact lenses for extended release and promising delivery system in glaucoma treatment
Increased intraocular pressure is a common symptom of glaucoma. In severe circumstances, it may result in loss of eyesight...
Imiquimod as a new treatment in refractory idiopathic granulomatous mastitis: report of two cases
Imiquimod as a new treatment in refractory idiopathic granulomatous mastitis: report of two cases
Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory lesion of the breast that mimics breast cancer or i...
The association between anti-diabetic agents and osteoporosis, sarcopenia, and osteosarcopenia among Iranian older adults; Bushehr Elderly Health (BEH) program
The association between anti-diabetic agents and osteoporosis, sarcopenia, and osteosarcopenia among Iranian older adults; Bushehr Elderly Health (BEH) program
Various risk factors are mentioned for osteoporosis, sarcopenia, and osteosarcopenia. Our aim is to assess the impacts of ...
Artificial viruses: A nanotechnology based approach
Artificial viruses: A nanotechnology based approach
The main objective of this work was to review and summarise the detailed literature available on viral nanoparticle and th...
Polymeric nanoparticles delivery circumvents bacterial resistance to ciprofloxacin
Polymeric nanoparticles delivery circumvents bacterial resistance to ciprofloxacin
The efficient inhibition of bacteria and their by-products from infected root canals is hampered by the limitations of tra...
Effectiveness of epigallocatechin gallate nanoparticles on the in-vivo treatment of Alzheimer’s disease in a rat/mouse model: a systematic review
Effectiveness of epigallocatechin gallate nanoparticles on the in-vivo treatment of Alzheimer’s disease in a rat/mouse model: a systematic review
Alzheimer’s disease (AD) is a neurological disease that causes memory loss over time. Current therapies are limited ...
Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation
Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation
In this study, a combination of nanotechnology, organic synthesis and radiochemistry were utilized in order to design an e...
Fruit vinegar as a promising source of natural anti-inflammatory agents: an up-to-date review
Fruit vinegar as a promising source of natural anti-inflammatory agents: an up-to-date review
Fruit vinegar is one of the most famous fruit byproducts worldwide with several unique properties. There are two types of ...
Electrochemical evaluation of nivolumab used in cancer treatment with differential pulse voltammetry: A novel approach with single-use pencil graphite electrode
Electrochemical evaluation of nivolumab used in cancer treatment with differential pulse voltammetry: A novel approach with single-use pencil graphite electrode
Nivolumab is used in a treatment called immunotherapy, which helps the immune system cells to attack cancer cells. The ele...
Ropivacaine suppresses the progression of renal cell carcinoma through regulating the lncRNA RMRP/EZH2/CCDC65 axis
Ropivacaine suppresses the progression of renal cell carcinoma through regulating the lncRNA RMRP/EZH2/CCDC65 axis
Renal cell carcinoma (RCC) is a common malignancy. Local anesthetics were displayed powerful effects against various cance...
Atypical extrapyramidal manifestation of a typical antipsychotic with serotonergic antidepressant
Atypical extrapyramidal manifestation of a typical antipsychotic with serotonergic antidepressant
Typical antipsychotics are known to produce extrapyramidal side effects such as drug induced parkinsonism, acute dystonia,...
Adrenergic receptors blockade alleviates dexamethasone-induced neurotoxicity in adult male Wistar rats: Distinct effects on β-arrestin2 expression and molecular markers of neural injury
Adrenergic receptors blockade alleviates dexamethasone-induced neurotoxicity in adult male Wistar rats: Distinct effects on β-arrestin2 expression and molecular markers of neural injury
Dexamethasone-induced neurotoxicity has been previously reported. However, the molecular mechanisms are still not complete...
Towards greater impact in health technology assessment: System dynamic approach for new and emerging technologies in Iran
Towards greater impact in health technology assessment: System dynamic approach for new and emerging technologies in Iran
As classical health technology assessment models fail to predict the complexities of related impacts, the application of m...
Immediate hypersensitivity reaction to levetiracetam: a case report study
Immediate hypersensitivity reaction to levetiracetam: a case report study
Anticonvulsant drugs are one of the most common causes of delayed hypersensitivity reactions, such as drug reacti...
Chidamide inhibits cell glycolysis in acute myeloid leukemia by decreasing N6-methyladenosine-related GNAS-AS1
Chidamide inhibits cell glycolysis in acute myeloid leukemia by decreasing N6-methyladenosine-related GNAS-AS1
Acute myeloid leukemia (AML) is a hematopoietic malignancy. Chidamide has shown anti-cancer effect in different malignanci...
Utilization patterns of cardiovascular medications in patients with diabetes mellitus; a retrospective cross-sectional study, 2013-17
Utilization patterns of cardiovascular medications in patients with diabetes mellitus; a retrospective cross-sectional study, 2013-17
Diabetes Mellitus (DM) is a prominent health care issue worldwide. One of the most prevalent comorbidities of DM is cardio...
Prophylactic norepinephrine combined with 6% hydroxyethyl starch (130/0.4) co-load infusion for preventing postspinal anesthesia hypotension during cesarean section: a randomized, controlled, dose-finding trial
Prophylactic norepinephrine combined with 6% hydroxyethyl starch (130/0.4) co-load infusion for preventing postspinal anesthesia hypotension during cesarean section: a randomized, controlled, dose-finding trial
Colloid and/or co-load may be more effective than crystalloid for preventing postspinal anesthesia hypotension. We tested ...
Vactosertib potently improves anti-tumor properties of 5-FU for colon cancer
Vactosertib potently improves anti-tumor properties of 5-FU for colon cancer
Several studies have shown that the TGF-β signaling pathway plays a critical role in colorectal cancer (CRC) pathogen...
Identifying natural products for gastric cancer treatment through pharmacophore creation, 3D QSAR, virtual screening, and molecular dynamics studies
Identifying natural products for gastric cancer treatment through pharmacophore creation, 3D QSAR, virtual screening, and molecular dynamics studies
Gastric cancer (GC) is known as the fourth leading cause of cancer-related death and the fifth major cancer in the world, ...
Firstly electrochemical investigetions and determination of anticoagulant drug edoxaban at single-use pencil graphite electrode: an eco-friendly and cost effective voltammetric method
Firstly electrochemical investigetions and determination of anticoagulant drug edoxaban at single-use pencil graphite electrode: an eco-friendly and cost effective voltammetric method
The anticoagulant drug edoxaban has a blood thinning mechanism of action. In this study, a pencil graphite electrode was e...
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