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SAMHD1 dysfunction induces IL-34 expression via NF-κB p65 in neuronal SH-SY5Y cells
SAMHD1 dysfunction induces IL-34 expression via NF-κB p65 in neuronal SH-SY5Y cells
SAMHD1 (Sterile alpha motif domain and histidine/aspartic acid domain-containing protein1) is a dGTP-stimulated deoxynucle...
Shared genetic architecture between hypothyroidism and rheumatoid arthritis: A large-scale cross-trait analysis
Shared genetic architecture between hypothyroidism and rheumatoid arthritis: A large-scale cross-trait analysis
The condition of hypothyroidism is characterized by generalized hypometabolism caused by a decrease in thyroid hormone sec...
Efficacy of GalNAc C3 siRNAs in factor H-deficient mice with C3 glomerulopathy
Efficacy of GalNAc C3 siRNAs in factor H-deficient mice with C3 glomerulopathy
Complement C3 glomerulopathy (C3G) is a rare and complex renal disorder characterized by predominant C3 deposition within ...
Empagliflozin attenuates inflammation levels in autoimmune myocarditis through the STAT3 pathway and macrophage phenotype transformation
Empagliflozin attenuates inflammation levels in autoimmune myocarditis through the STAT3 pathway and macrophage phenotype transformation
AbbreviationsEAMexperimental autoimmune myocarditisSGLT-2sodium/glucose cotransporter 2STAT3signal transducer and activato...
The role of transforming growth factor beta in myopia development
The role of transforming growth factor beta in myopia development
The development of myopia has been shown to be influenced by environmental factors, but maintaining intraocular homeostasi...
Anti-inflammation of LZTFL1 knockdown in OVA-induced asthmatic mice: Through ERK/GATA3 signaling pathway
Anti-inflammation of LZTFL1 knockdown in OVA-induced asthmatic mice: Through ERK/GATA3 signaling pathway
Asthma is a common chronic respiratory disease triggered by exposure to allergens and viruses (Francisco et al., 2020). It...
ANXA3 interference inactivates ERK/ELK1 pathway to mitigate inflammation and apoptosis in sepsis-associated acute lung injury
ANXA3 interference inactivates ERK/ELK1 pathway to mitigate inflammation and apoptosis in sepsis-associated acute lung injury
Sepsis is commonly acknowledged as a lethal clinical syndrome initiated by a complicated systemic host response to infecti...
IFITM3 mediates inflammation induced myocardial injury through JAK2/STAT3 signaling pathway
IFITM3 mediates inflammation induced myocardial injury through JAK2/STAT3 signaling pathway
Dilated cardiomyopathy (DCM) represents the most common cause of heart failure in younger patients and often evolves from ...
α-mangostin derivatives ameliorated mouse DSS-induced chronic colitis via regulating Th17/Treg balance
α-mangostin derivatives ameliorated mouse DSS-induced chronic colitis via regulating Th17/Treg balance
Inflammatory bowel disease (IBD) is a chronic condition that involves chronic inflammation in the digestive tract (Silverb...
SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation
SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation
Liver ischemia and reperfusion (IR) injury is a major concern during liver partial resection and liver transplantation, wh...
Influence of pre-B cell receptor deficiency on the immunoglobulin repertoires in peripheral blood B cells before and after immunization
Influence of pre-B cell receptor deficiency on the immunoglobulin repertoires in peripheral blood B cells before and after immunization
During B cell development, the rearrangement of the immunoglobulin heavy chain (HC) gene precedes that of the light chain ...
Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes
Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes
Transforming growth factor-β (TGF-β) is a pleiotropic cytokine essential for multiple biological processes, including the ...
Immunoregulatory function of SP-A
Immunoregulatory function of SP-A
The lungs, as organs in direct contact with the outside world, are often exposed to airborne pathogenic microorganisms. Th...
Investigation of T cell-related hub genes in diabetic nephropathy by bioinformatics analysis and experiment validation
Investigation of T cell-related hub genes in diabetic nephropathy by bioinformatics analysis and experiment validation
Diabetic nephropathy(DN) remains a significant risk factor for cardiovascular and all-cause mortality, and end-stage renal...
A novel Mycobacterium Tuberculosis antigen, MTB48 enhances inflammatory response in LPS-induced RAW264.7 macrophage immune cells
A novel Mycobacterium Tuberculosis antigen, MTB48 enhances inflammatory response in LPS-induced RAW264.7 macrophage immune cells
Tuberculosis (TB) is an infectious illness that spreads from person to person by tiny droplets in the air. Coughing, sneez...
Cytoprotective effects of C1s enzyme in macrophages in atherosclerosis mediated through the LRP5 and Wnt/β-catenin pathway
Cytoprotective effects of C1s enzyme in macrophages in atherosclerosis mediated through the LRP5 and Wnt/β-catenin pathway
C1s enzyme (active C1s) is a subunit of the complement C1 complex that cleaves low-density lipoprotein receptor-related pr...
HDAC6-MYCN-CXCL3 axis mediates allergic inflammation and is necessary for allergic inflammation-promoted cellular interactions
HDAC6-MYCN-CXCL3 axis mediates allergic inflammation and is necessary for allergic inflammation-promoted cellular interactions
Increased activity of histone deacetylase 6 (HDAC6) is closely associated with epithelial barrier defects seen in allergic...
Lipoproteins are key immunostimulatory components of Bacillus species for dendritic cell maturation and activation
Lipoproteins are key immunostimulatory components of Bacillus species for dendritic cell maturation and activation
Dendritic cells (DCs) constantly sample the external environment to sense and respond to invasive pathogens (Cohn and Dela...
Single-cell transcriptional profiling reveals aberrant gene expression patterns and cell states in autoimmune diseases
Single-cell transcriptional profiling reveals aberrant gene expression patterns and cell states in autoimmune diseases
Autoimmune diseases (ADs) have a multifactorial etiology: genetics, environment, hormones, and immunology all play a role ...
The SpyCatcher-SpyTag interaction mediates tunable anti-tumor cytotoxicity of NK cells
The SpyCatcher-SpyTag interaction mediates tunable anti-tumor cytotoxicity of NK cells
Chimeric antigen receptor (CAR)-based therapy is a novel form of immunotherapy that uses genetically modified T or NK cell...
B7-H3 promotes angiogenesis in rheumatoid arthritis
B7-H3 promotes angiogenesis in rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease in which symmetrical polyarthritis is the main clinical manifestation (...
Regulation of the STAT3 pathway by lupus susceptibility gene Pbx1 in T cells
Regulation of the STAT3 pathway by lupus susceptibility gene Pbx1 in T cells
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a genetic predisposition that results from the com...
Mosquito allergy: Immunological aspects and clinical management
Mosquito allergy: Immunological aspects and clinical management
Volume 164, December 2023, Pages 153-158Author links open overlay panel, , , AbstractMosquito allergy has been conceived a...