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Fibroblast growth factor 10 delays the progression of osteoarthritis by attenuating synovial fibrosis via inhibition of IL-6/JAK2/STAT3 signaling in vivo and in vitro
Osteoarthritis (OA) is a leading cause of disability in the elderly worldwide, and is associated with pain and functional ...
Immunometabolic changes of β-glucan-trained immunity induction and inhibition on neonatal calf immune innate cells
Neonatal calf mortality from infectious diseases contributes considerably to economic losses for the cattle industry, notw...
Crystal structures of the human IgD Fab reveal insights into CH1 domain diversity
Antibodies of the IgD isotype remain the least well characterized of the mammalian immunoglobulin isotypes. Here we report...
Plasmacytoid dendritic cells: A dendritic cell in disguise
Since their discovery, the identity of plasmacytoid dendritic cells (pDCs) has been at the center of a continuous dispute ...
AXL-Induced Autophagy mitigates experimental autoimmune encephalomyelitis by suppressing microglial inflammation via the PI3K/AKT/mTOR signaling pathway
It is widely believed that the most common pathological changes in multiple sclerosis (MS) are neuroinflammatory demyelina...
Corrigendum to “Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer’s disease”, [Mol. Immunol. 142 (2022) 22–36]
Available online 22 April 2023Author links open overlay panelJohn Bosco Ruganzu 1, Xiaoqian Peng 1, Yingying He, Xiangyuan...
Diagnostic value and underlying mechanism of nasal nitric oxide in eosinophilic chronic rhinosinusitis with nasal polyps
AbbreviationsCRSwNPChronic rhinosinusitis with nasal polypseNOSEndothelial nitric oxide synthaseFeNOFractional exhaled nit...
HSPA5, as a ferroptosis regulator, may serve as a potential therapeutic for head and neck squamous cell carcinoma
As one of the most serious types of cancer known, about 600,000 new cases of head and neck squamous cell carcinoma (HNSCC)...
1,5-AG suppresses pro-inflammatory polarization of macrophages and promotes the survival of B-ALL in vitro by upregulating CXCL14
Cancer metabolic reprogramming is essential for tumor initiation and progression, and the role of tumor metabolites has be...
Analysis of type I hypersensitivity-induced inflammatory response in children of different age groups with acute appendicitis
ObjectiveTo explore the differences in type I hypersensitivity-induced inflammatory response among children of different a...
Sirtuin 6 is a negative regulator of the anti-tumor function of natural killer cells in murine inflammatory colorectal cancer
Colorectal cancer (CRC) is the world’s third most commonly diagnosed and second most fatal cancer (Hossain et al., 2022). ...
House dust mite allergy: The importance of house dust mite allergens for diagnosis and immunotherapy
KeywordsHouse dust miteRecombinant allergenComponent-resolved diagnosisImmunotherapyAbbreviationsAPCsantigen-presenting ce...
CD1a-mediated immunity from a molecular perspective
The most essential function of the immune system relies on its capacity to recognise foreign- and self- molecules to surve...
Protective effects of resolvin D1 in Pseudomonas aeruginosa keratitis
Bacterial keratitis (BK) is an ophthalmic emergency and a major cause of blindness globally. Gram-positive and gram-negati...
Diesel exhaust exposure impairs recovery of lung epithelial and cellular damage in murine model
Air pollution has emerged as the major environmental determinant affecting lung health. WHO estimated 7 million deaths wor...
Human amniotic mesenchymal stem cell-conditioned medium inhibited LPS-induced cell injury and inflammation by modulating CD14/TLR4-mediated signaling pathway in monocytes
It has been 100 years since the amniotic membrane was first used in skin transplantation in 1910 (Parolini et al., 2008). ...
Brain-derived neurotrophic factor promotes airway smooth muscle cell proliferation in asthma through regulation of transient receptor potential channel-mediated autophagy
Asthma is one of the most common chronic diseases, affecting an estimated 334 million people worldwide (Ntontsi et al., 20...
Unveiling the TGF- β1 paradox: Significant implication of TGF- β1 promoter variants and its mRNA and protein expression in atopic dermatitis
Atopic Dermatitis (AD), also known as Atopic eczema (AE), is a heterogeneous inflammatory disorder of the skin with varyin...
Identification of molecular candidates which regulate calcium-dependent CD8+ T-cell cytotoxicity
Key wordsCalciumCTL (cytotoxic T lymphocytes)Real-time killing assayCytotoxic efficiencyDifferential expression analysesTr...
Analysis of Madelung disease based on sc-RNA sequencing: A case report and literature review
Madelung disease (MD) is also referred to as multiple symmetric lipomatosis, Launois–Bensaude syndrome, or benign symmetri...
SMURF1 inhibits the Th17 and Th17.1 polarization and improves the Treg/Th17 imbalance in systemic lupus erythematosus through the ubiquitination of RORγt
Systemic lupus erythematosus (SLE) is regarded as a systemic autoimmune disease (Kiriakidou and Ching, 2020). Patients suf...
Low temperature reduces occludin expression in bronchial epithelial cells: Implications in cold-induced asthma
As one of the most common respiratory diseases, asthma affects over 300 million people worldwide. It is estimated that app...
Aberrant expression of T cell receptors in monocyte/macrophage RAW 264.7 cells: FCγRII/III compensates the need for CD3
Over a decade ago, several reports in the literature demonstrated the expression of T cell receptor (TCR) αβ and γδ in cel...
Highly pathogenic natural monoclonal antibody B4-IgM recognizes a post-translational modification comprised of acetylated N-terminal methionine followed by aspartic or glutamic acid
Natural antibodies (nAbs) are immunoglobulins present in circulation or tissues in the absence of pathological conditions ...
LKB1 isoform expression modulates T cell plasticity downstream of PKCθ and IL-6
Following activation, CD4 T cells undergo metabolic and transcriptional changes as they respond to external cues and diffe...
Bone marrow mesenchymal stem cell-derived exosomes alleviate skin fibrosis in systemic sclerosis by inhibiting the IL-33/ST2 axis via the delivery of microRNA-214
Systemic sclerosis (SSc, also named scleroderma), a rare connective tissue disease, is featured by immune disorder and pro...
Monomeric C-reactive protein evokes TCR Signaling-dependent bystander activation of CD4+ T cells
T cells play a central role in mediating adaptive immune responses (Chang et al., 2014, Jameson and Masopust, 2018, Jarjou...
Environmental estrogen exposures alter molecular signaling in immune cells that promote the development of childhood asthma
The prevalence of asthma, particularly in children in developed countries, has been increasing rapidly over the last 30 ye...
Tumor antigen-unbiased variable epitope library contains mimotopes with antitumor effect in a mouse model of breast cancer
Any cancer immunotherapy modality aims to harness the immune system to eliminate cancer cells. T cells are the primary cel...
Transcriptome profiling reveals transcriptional regulation of VISTA in T cell activation
PurposeV-domain immunoglobulin suppressor of T-cell activation (VISTA) is a novel type of immune checkpoint. This study wa...
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