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Serum proteomics analysis of biomarkers for evaluating clinical response to MTX/IGU therapy in early rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by inflammation of joints, and could further invo...
Single-cell atlas reveals a high selection of IgA1- or IgG1-expressing plasma cells in patients with psoriasis
Psoriasis is a common, recurrent, and inflammatory skin disease (Griffiths et al., 2021). It leads to a substantial burden...
NONO regulates multiple cytokine production in sepsis via the ERK1/2 signaling pathway
Sepsis is a systemic inflammatory response syndrome caused by infection, leading to life-threatening organ dysfunction cau...
Long noncoding RNA H19 synergizes with STAT1 to regulate SNX10 in rheumatoid arthritis
Rheumatoid arthritis (RA), an autoimmune disease, contributes to progressive articular destruction and comorbidities in va...
Reserve of Wnt/β-catenin Signaling Alleviates Mycoplasma pneumoniae P1-C-induced Inflammation in airway epithelial cells and lungs of mice
Mycoplasma pneumoniae (M. pneumoniae) is the most common pathogen of respiratory tract infections in both children and adu...
GATA2 promotes oxidative stress to aggravate renal ischemia-reperfusion injury by up-regulating Redd1
Acute kidney injury (AKI) is a common clinical emergency, during which kidney cells are damaged by various causes, and it ...
Knockdown of Brg1 reduced mucus secretion in HDM stimulated airway inflammation
BackgroundThe Brg1 (Brahma-related gene 1) is an important chromatin remodeling factor protein. The Brg1 protein can promo...
The transcription factor E2A can bind to and cleave single-stranded immunoglobulin heavy chain locus DNA
Class switch recombination (CSR) changes the constant region of the immunoglobulin heavy chain (IgH), and somatic hypermut...
Overview of the anti-inflammatory function of the innate immune sensor NLRC3
An efficient host defense mechanism is necessary for human beings to survive in an environment full of microbes. The first...
Acid-sensitive ion channel 1a regulates TNF-α expression in LPS-induced acute lung injury via ERS-CHOP-C/EBPα signaling pathway
Acute lung injury (ALI) is an acute hypoxic respiratory failure caused by various internal and external pulmonary factors ...
Apelin-13 facilitates mitochondria homeostasis via mitophagy to prevent against airway oxidative injury in asthma
Asthma is a common chronic airway inflammatory disease characterized by chronic airway inflammation, resulting in mucus ov...
Multiplexed analysis of gene expression and chromatin accessibility of human umbilical cord blood using scRNA-Seq and scATAC-Seq
Cells from umbilical cord blood (UCB), once considered medical waste, are increasingly recognized as valuable therapeutic ...
Ibrutinib protects against acute lung injury via inhibiting NLRP3/Caspase-1 in septic mice model
Sepsis is a life-threatening syndrome caused by an abnormal host response to infection, often leading to multiple organ dy...
Antibody multispecificity: A necessary evil?
Antibodies represent key effectors of the adaptive immune system. The specificity of antibodies is an established hallmark...
Antibody-Dependent Enhancement (ADE) and the role of complement system in disease pathogenesis
Antibody-dependent enhancement (ADE) has been associated with severe disease outcomes in several viral infections, includi...
Splicing factor SRSF1 controls autoimmune-related molecular pathways in regulatory T cells distinct from FoxP3
Regulatory T cells (Tregs) are vital for maintaining immune self-tolerance, and their impaired function leads to autoimmun...
Endogenous neutralization of TGF-β and IL-6 ameliorates septic arthritis by altering RANKL/OPG interaction in lymphocytes
Septic arthritis is an inflammatory joint disease caused by S. aureus. Hematogenous entry of the bacteria to the synovium ...
Identification of virus-specific B-cell epitopes by convalescent plasma from COVID-19 patients
Identification of immunologic epitopes against SARS-CoV-2 is crucial for the discovery of diagnostic, therapeutic, and pre...
IL-8 exacerbates CCl4-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway
Liver fibrosis is an excessive accumulation of extracellular matrix (ECM) due to chronic liver injury. In recent years, th...
Cholesterol-binding sequence is a key regulatory motif of cellular folding and conformational activation for C-reactive protein
Human, rat, and mouse C-reactive protein (CRP) possess distinct expression patterns, but have similar conformations and co...
TGF-β1 contributes to the hepatic inflammation in animal models with nonalcoholic steatohepatitis by Smad3/TLR2 signaling pathway
Non-alcoholic fatty liver disease (NAFLD) is increasingly affecting human health and the economy worldwide due to various ...
Five commercially-available antibodies react differentially with allelic forms of human HLA-DR beta chain
Allelic variants of HLA-DRB1 have been associated with a variety of autoimmune and infectious diseases. Although the preci...
RIG-I contributes to dsDNA-induced innate immune activation in human brain microvascular endothelial cells
Human brain microvascular epithelial cells (HBMECs) play a pivotal role in maintaining the stability of the blood-brain ba...
rM2e-ΔPly protein immunization induces protection against influenza viruses and its co-infection with Streptococcus pneumoniae in mice
Current seasonal influenza A virus (IAV) vaccines only protect against specific virus and require annual reconstitution to...
The mechanism underlying ICAM-1 and E-selectin-mediated hypertriglyceridemic pancreatitis-associated lung injury
PurposeTo investigate the possible mechanism by which adhesion molecules ICAM-1 and E-selectin mediate hypertriglyceridemi...
The transcription factor KLF14 attenuates LPS-induced acute lung injury by ameliorating apoptosis of alveolar epithelial cells in mice
Lipopolysaccharide (LPS)-induced lung injury (ALI) is characterized by severe lung inflammation with high mortality. Pulmo...