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Abatacept for myositis
In a phase III clinical trial of abatacept for idiopathic inflammatory myopathy, the primary endpoint was not met but the ...
European expert recommendations for managing systemic sclerosis and its complications
The updated 2023 EULAR recommendations for treatment of systemic sclerosis bring notable changes to recommendations for sk...
Synovial dendritic cell subsets in RA
Synovial dendritic cell profiles and localization patterns provide insights about the roles of dendritic cell subsets in t...
Blocking CDK7 attenuates inflammatory arthritis
In a new study, inhibition of CDK7 disrupted the RNA polymerase II transcription cycle, leading to anti-inflammatory effec...
Insights into IVDD pathogenesis in 2024
Emerging research in intervertebral disc degeneration in 2024 highlights microbial, immune and inflammatory mechanisms tha...
Molecular profiling for advancing precision rheumatology
Molecular profiling for advancing precision rheumatology
Here, we highlight three publications in 2024 that have advanced the field of molecular and immunological profiling, for&a...
Antigen-specific immunotherapies for autoimmune disease
Antigen-specific immunotherapies for autoimmune disease
Antigen-specific therapies have a long history in the treatment of allergy but have not been successful in autoimmunity. H...
Inebilizumab shows promise for IgG4-RD
In a phase III trial, the CD19-targeting antibody inebilizumab was effective for the treatment of IgG4-related disease ove...
Appraising the evolving landscape of protease inhibition in osteoarthritis
The role of proteases in cartilage degradation and the development of osteoarthritis is undeniable. Despite over two decad...
Publisher Correction: Lupus nephritis-related chronic kidney disease
In the version of the article initially published, in Fig. 2b, the label “IIanalumab” was incorrect and has now been amend...
The ‘Treg paradox’ in inflammatory arthritis
The ‘Treg paradox’ in inflammatory arthritis
Classic regulatory T (Treg) cells expressing CD4 and the hallmark transcription factor FOXP3 are integral to the ...
Impaired adipocyte-mediated regulation of fibroblasts in inflammatory arthritis
A study reports that adipocytes can regulate the metabolism of fibroblasts in the healthy synovium via cortisol, but in in...
Wnt-induced IGF1 drives OA
New research suggests that insulin-like growth factor 1 is an important contributor to Wnt-induced joint damage, and that ...
A subset of ITGA5+ synovial fibroblasts alter the inflammatory niche in RA
A subset of ITGA5+ synovial fibroblasts alter the inflammatory niche in RA
The release of TGFβ by a subset of ITGA5+ synovial fibroblasts can promote the differentiation of pathogenic PD-1hiCX...
A lung–joint axis in smokers with RA?
Shared T cell clones identified in the lungs and joints of smokers with early RA.
DADA2 prevalence in China
Analysis of exome sequencing data indicates that the prevalence of DADA2 is higher in China compared with other regions.
Revisiting the heterogeneity of interferon-related autoimmune diseases
Revisiting the heterogeneity of interferon-related autoimmune diseases
The identification of shared molecular mechanisms across systemic inflammatory autoimmune diseases with overlapping clinic...
HLA-B27 and spondyloarthritis: at the crossroads of innate and adaptive immunity
HLA-B27 and spondyloarthritis: at the crossroads of innate and adaptive immunity
HLA-B*27 confers a strong risk of developing spondyloarthritis (SpA), which includes axial SpA with or without peripheral ...
Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus
Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus
Over the past two decades, the number of genetically defined autoinflammatory interferonopathies has steadily increased. A...
An update on autoantibodies in the idiopathic inflammatory myopathies
An update on autoantibodies in the idiopathic inflammatory myopathies
Myositis-specific autoantibodies (MSAs) have become pivotal biomarkers for idiopathic inflammatory myopathies and have rev...
The quest for targetable pain mechanisms in 2024
Studies published in 2024 suggest that although the repurposing of established rheumatology drugs seems to deliver increme...
EULAR and PReS bridge the age gap in Still’s disease
EULAR and PReS bridge the age gap in Still’s disease
EULAR and the Paediatric Rheumatology European Society (PReS) now view systemic juvenile idiopathic arthritis and adult-on...
The emergence of SLE-causing UNC93B1 variants in 2024
During the past year, four studies have reported ten mutations in UNC93B1, which encodes the Toll-like receptor (TLR) chap...
Publisher Correction: Recent advances in the diagnosis and management of neuropsychiatric lupus
Authors and AffiliationsDivision of Rheumatology, Department of Medicine, Dalhousie University and Queen Elizabeth II Heal...
The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus
The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus
Emerging evidence indicates that memory B cells are dysfunctional in systemic lupus erythematosus (SLE). They are hyporesp...
The management of adult and paediatric uveitis for rheumatologists
The management of adult and paediatric uveitis for rheumatologists
Uveitis encompasses multiple different conditions that are all characterized by intra-ocular inflammation. Uveitis occurs ...
Management strategies in rheumatoid arthritis
Management strategies in rheumatoid arthritis
Management of rheumatoid arthritis (RA) has evolved from simply the direct translation of drug efficacy results from clini...
Rheumatic diseases and metabolism: where centre and periphery meet
Rheumatic diseases and metabolism: where centre and periphery meet
Over the past few decades, the connection between metabolism and various inflammatory and rheumatic diseases has been an a...
Risk of uveitis in SpA is changing
Findings from an observational study suggest that the frequency of uveitis in patients with spondyloarthritis has declined...
Rheumatology in the digital health era: status quo and quo vadis?
Rheumatology in the digital health era: status quo and quo vadis?
Rheumatology faces a critical shortage of health-care professionals, exacerbated by an ageing patient population and escal...
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