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Re-thinking the perception of long-term opioid use in RMDs
Emerging data suggest that the frequency of long-term opioid use is high among individuals with rheumatic and musculoskele...
Placebo effects in osteoarthritis: implications for treatment and drug development
Placebo effects in osteoarthritis: implications for treatment and drug development
Osteoarthritis (OA) is the most common form of arthritis worldwide, affecting ~500 million people, yet there are no effect...
Properties of a new anti-IL-17 antibody
A monoclonal antibody targeting a peptide that replicates the proinflammatory properties of IL-17 has shown potent activit...
Repolarizing macrophages using antagomirs
Repolarizing macrophages using antagomirs
New findings suggest that liposome-mediated delivery of a specific microRNA inhibitor can restore anti-inflammatory macrop...
HIF-1 inhibition mitigates skin damage in CLE
HIF-1 inhibition mitigates skin damage in CLE
HIF-1 can regulate the cytotoxic activity of skin-infiltrating T cells in cutaneous lupus erythematosus and is a potential...
Mechanisms and rationale for uricase use in patients with gout
Mechanisms and rationale for uricase use in patients with gout
Xanthine oxidase inhibitors such as allopurinol and febuxostat have been the mainstay urate-lowering therapy (ULT) for tre...
Imaging in inflammatory arthritis: progress towards precision medicine
Imaging in inflammatory arthritis: progress towards precision medicine
Imaging techniques such as ultrasonography and MRI have gained ground in the diagnosis and management of inflammatory arth...
CD38hiCD8+ T cells characterize ICI-mediated arthritis
Although inflammatory arthritis induced by immune-checkpoint inhibitors clinically resembles that of rheumatoid arthritis ...
PRESTO estimates PsA risk for patients with psoriasis
A new tool, PRESTO, enables estimation of the 1-year and 5-year risks of the development of psoriatic arthritis in patient...
Metal–polyDNA nanoparticles reset the osteoporotic microenvironment
Nanoparticles consisting of long DNA molecules in association with Ca2+ and PPi4− ions can modulate the pathological...
Innate immune memory in inflammatory arthritis
Innate immune memory in inflammatory arthritis
The concept of immunological memory was demonstrated in antiquity when protection against re-exposure to pathogens was obs...
SGLT2 inhibitors protect podocytes in lupus nephritis
New research provides insights into the mechanisms underlying the renal protective effects of sodium glucose cotransporter...
Inflammation across tissues: can shared cell biology help design smarter trials?
Inflammation across tissues: can shared cell biology help design smarter trials?
Immune-mediated inflammatory diseases (IMIDs) are responsible for substantial global disease burden and associated health-...
Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells
Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells
The incidence of rheumatic diseases such as rheumatoid arthritis and osteoarthritis and injuries to articular cartilage th...
Is classifying SSc-ILD drugs as either immunosuppressive or anti-fibrotic misleading?
We read with great interest the comprehensive Review article by Pope et al. on the treatment of systemic ...
Reply to: Is classifying SSc-ILD drugs as either immunosuppressive or anti-fibrotic misleading?
Competing interests J.E.P. declares that she has research grants from AbbVie, Ba...
Fibroblast multiplicity in RA: a synovial state of affairs
Fibroblast multiplicity in RA: a synovial state of affairs
Rheumatoid arthritis synovium contains phenotypically and functionally heterogeneous fibroblast-like synoviocytes. Cutting...
TNF and TNF receptors as therapeutic targets for rheumatic diseases and beyond
TNF and TNF receptors as therapeutic targets for rheumatic diseases and beyond
The cytokine TNF signals via two distinct receptors, TNF receptor 1 (TNFR1) and TNFR2, and is a central mediator of variou...
Remote monitoring in rheumatology: seeing the right patient at the right time
Remote monitoring in rheumatology: seeing the right patient at the right time
The rise in the use of digital health-care technologies such as electronic patient-reported outcome measures enables a tra...
Non-depleting anti-CD19 B cell inhibition
Non-depleting anti-CD19 B cell inhibition
An antibody that targets CD19 on B cells has shown greater inhibitory efficacy than that of anti-CD20 B cell depletion the...
Aminoacyl-tRNA synthetases function as alarmins in RA
New research indicates that extracellular aminoacyl-tRNA synthetases contribute to the pathogenesis of rheumatoid arthriti...
Urchin-like nanoparticles for miRNA therapy of OA
Urchin-like nanoparticles for miRNA therapy of OA
Researchers have developed ‘urchin-like’ ceria nanoparticles with inherent antioxidant properties that efficie...
Platelets promote cardiovascular complications in Kawasaki disease
Platelet activity and the formation of monocyte–platelet aggregates contribute to the production of IL-1β and t...
Oral JAK inhibitor baricitinib effective in JIA
In a phase III trial, the oral Janus kinase inhibitor baricitinib was safe and effective in patients with juvenile idiopat...
Interosseous tendon inflammation associated with arthritis risk
New findings suggest that interosseous tendon inflammation is already present in individuals with clinically suspect arthr...
Biologics in rheumatoid arthritis: a lifetime treatment or possibility of drug holidays?
Drug-free remission is a treatment goal in rheumatoid arthritis that can be achieved by tapering and discontinuation of bi...
Insights into juvenile myositis via engineered muscle
The pathogenesis of juvenile dermatomyositis (JDM) is complex and various evidence implicate a role for type I interferons...
IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration
IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration
IL-17 signalling regulates both protective and harmful immune responses; therefore, its complete inhibition can have adver...
Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis
Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis
Sleep has a homeostatic role in the regulation of the immune system and serves to constrain activation of inflammatory sig...
Towards a novel clinical outcome assessment for systemic lupus erythematosus: first outcomes of an international taskforce
Towards a novel clinical outcome assessment for systemic lupus erythematosus: first outcomes of an international taskforce
Systemic lupus erythematosus (SLE) is a disease of high unmet therapeutic need. The challenge of accurately measuring clin...
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