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Pathogenic antibodies target stromal antigens in RA
Pathogenic antibodies target stromal antigens in RA
New findings identify HSP60 and other synovial stromal-derived autoantigens as targets for pathogenic autoantibodies, exac...
Integrin-mediated ILC2 adhesion protects against lupus nephritis
Integrin-mediated ILC2 adhesion protects against lupus nephritis
Type 2 innate lymphoid cells protect against kidney inflammation in lupus nephritis, and enhancing their adhesion via inte...
Update on the pathophysiology and treatment of primary Sjögren syndrome
Update on the pathophysiology and treatment of primary Sjögren syndrome
Sjögren syndrome or Sjögren disease is a chronic form of autoimmune epithelitis characterized by lymphocytic inf...
Itaconate targets fibroblast-like synoviocytes in RA
Treatment with the endogenous metabolite itaconate induced phenotypic and metabolic changes in fibroblast-like synoviocyte...
The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies
The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies
The pathogenesis of gout involves a series of steps beginning with hyperuricaemia, followed by the deposition of ...
Integrin signalling in joint development, homeostasis and osteoarthritis
Integrin signalling in joint development, homeostasis and osteoarthritis
Integrins are key regulators of cell–matrix interactions during joint development and joint tissue homeosta...
How muscle influences bone health
FNIP1- and TFEB-dependent secretion of IGF2 by dystrophic muscles contributes to muscle–bone crosstalk.
Mitophagy as a link between ECM stiffness and chondrocyte senescence
Ageing and excessive mechanical strain on the articular cartilage have both been associated with the development of knee o...
Platelets in Kawasaki disease: mediators of vascular inflammation
Platelets in Kawasaki disease: mediators of vascular inflammation
Kawasaki disease, a systemic vasculitis that affects young children and can result in coronary artery aneurysms, is the le...
Advances in viscosupplementation and tribosupplementation for early-stage osteoarthritis therapy
Advances in viscosupplementation and tribosupplementation for early-stage osteoarthritis therapy
Joint kinematic instability, arising from congenital or acquired musculoskeletal pathoanatomy or from imbalances in anabol...
BiTEing refractory RA
BiTEing refractory RA
The bispecific T cell engager (BiTE) blinatumomab showed promising clinical efficacy in a pilot study of six patients with...
The peculiar features, diversity and impact of citrulline-reactive autoantibodies
The peculiar features, diversity and impact of citrulline-reactive autoantibodies
Since entering the stage 25 years ago as a highly specific serological biomarker for rheumatoid arthritis, anti-citrullina...
Wearable device for RA management?
A wearable smart device that uses reconfigurable electronics and conductive polymer-based microneedles was able to monitor...
COVID-19 linked to rise in anti-MDA5 autoimmunity
Researchers have introduced the term ‘MDA5-autoimmunity and interstitial pneumonitis contemporaneous with the COVID-...
PDGFR signalling implicated in anti-resorptive effects of sclerostin blockade
New research provides a potential explanation for why long-term sclerostin neutralization leads to continued bone mass gai...
Osteoporosis and fracture risk are multifactorial in patients with inflammatory rheumatic diseases
Osteoporosis and fracture risk are multifactorial in patients with inflammatory rheumatic diseases
Patients with inflammatory rheumatic and musculoskeletal diseases (iRMDs) such as rheumatoid arthritis, connective tissue ...
Clarity for the language of race, ethnicity and genetic ancestry in rheumatology
As the pace of genetic discovery has accelerated, so too has the need for clinicians and researchers to acknowledge and un...
Publisher Correction: IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting
Authors and AffiliationsDivision of Allergy, Immunology & Rheumatology, Department of Paediatrics, University of Calif...
Two sides of management recommendations for psoriatic arthritis
Guidelines for the management of psoriatic arthritis (PsA) need to undergo revision to take on board new evidence, particu...
Clinical phenotypes, molecular endotypes and theratypes in OA therapeutic development
Clinical phenotypes, molecular endotypes and theratypes in OA therapeutic development
Understanding the molecular endotypes that influence clinical phenotypes is a critical step for the stratification of pati...
Recent advancements in cartilage tissue engineering innovation and translation
Recent advancements in cartilage tissue engineering innovation and translation
Articular cartilage was expected to be one of the first successfully engineered tissues, but today, cartilage repair produ...
Can transcriptomics guide the management of SLE-associated APS?
The management of antiphospholipid syndrome is hindered by heterogeneous clinical presentations. Whole-blood transcriptomi...
Bone-modifying drugs slow OA progression
Drugs used to treat osteoporosis could slow the progression of osteoarthritis, according to the findings of a study in mice.
Adropin inhibits fibrosis in SSc
The peptide hormone adropin, which is downregulated in dermal fibroblasts in patients with systemic sclerosis (SSc), inhib...
Rethinking antiphospholipid syndrome to guide future management and research
Antiphospholipid syndrome (APS) consists of thrombotic, non-thrombotic and obstetric clinical manifestations developing in...
Granzyme serine proteases in inflammation and rheumatic diseases
Granzyme serine proteases in inflammation and rheumatic diseases
Granzymes (granule-secreted enzymes) are a family of serine proteases that have been viewed as redundant cytotoxic enzymes...
Relapsing polychondritis: clinical updates and new differential diagnoses
Relapsing polychondritis: clinical updates and new differential diagnoses
Relapsing polychondritis is a rare inflammatory disease characterized by recurrent inflammation of cartilaginous structure...
Treat-to-target or treat-to-dissolve strategy to improve gout treatment
Medication adherence in gout is low, and discontinuation of urate-lowering therapy puts patients at risk of flares and car...
Advancing precision rheumatology through tissue and blood profiling
Advancing precision rheumatology through tissue and blood profiling
Multidimensional and single-cell profiling of peripheral blood and inflamed tissues is a powerful and high-resolution tool...
Joint-specific memory, resident memory T cells and the rolling window of opportunity in arthritis
Joint-specific memory, resident memory T cells and the rolling window of opportunity in arthritis
In rheumatoid arthritis, juvenile idiopathic arthritis and other forms of inflammatory arthritis, the immune system target...
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