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Mitophagy as a link between ECM stiffness and chondrocyte senescence
Ageing and excessive mechanical strain on the articular cartilage have both been associated with the development of knee o...
Platelets in Kawasaki disease: mediators of vascular inflammation
Platelets in Kawasaki disease: mediators of vascular inflammation
Kawasaki disease, a systemic vasculitis that affects young children and can result in coronary artery aneurysms, is the le...
Advances in viscosupplementation and tribosupplementation for early-stage osteoarthritis therapy
Advances in viscosupplementation and tribosupplementation for early-stage osteoarthritis therapy
Joint kinematic instability, arising from congenital or acquired musculoskeletal pathoanatomy or from imbalances in anabol...
BiTEing refractory RA
BiTEing refractory RA
The bispecific T cell engager (BiTE) blinatumomab showed promising clinical efficacy in a pilot study of six patients with...
The peculiar features, diversity and impact of citrulline-reactive autoantibodies
The peculiar features, diversity and impact of citrulline-reactive autoantibodies
Since entering the stage 25 years ago as a highly specific serological biomarker for rheumatoid arthritis, anti-citrullina...
Wearable device for RA management?
A wearable smart device that uses reconfigurable electronics and conductive polymer-based microneedles was able to monitor...
COVID-19 linked to rise in anti-MDA5 autoimmunity
Researchers have introduced the term ‘MDA5-autoimmunity and interstitial pneumonitis contemporaneous with the COVID-...
PDGFR signalling implicated in anti-resorptive effects of sclerostin blockade
New research provides a potential explanation for why long-term sclerostin neutralization leads to continued bone mass gai...
Osteoporosis and fracture risk are multifactorial in patients with inflammatory rheumatic diseases
Osteoporosis and fracture risk are multifactorial in patients with inflammatory rheumatic diseases
Patients with inflammatory rheumatic and musculoskeletal diseases (iRMDs) such as rheumatoid arthritis, connective tissue ...
Clarity for the language of race, ethnicity and genetic ancestry in rheumatology
As the pace of genetic discovery has accelerated, so too has the need for clinicians and researchers to acknowledge and un...
Publisher Correction: IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting
Authors and AffiliationsDivision of Allergy, Immunology & Rheumatology, Department of Paediatrics, University of Calif...
Two sides of management recommendations for psoriatic arthritis
Guidelines for the management of psoriatic arthritis (PsA) need to undergo revision to take on board new evidence, particu...
Clinical phenotypes, molecular endotypes and theratypes in OA therapeutic development
Clinical phenotypes, molecular endotypes and theratypes in OA therapeutic development
Understanding the molecular endotypes that influence clinical phenotypes is a critical step for the stratification of pati...
Recent advancements in cartilage tissue engineering innovation and translation
Recent advancements in cartilage tissue engineering innovation and translation
Articular cartilage was expected to be one of the first successfully engineered tissues, but today, cartilage repair produ...
Can transcriptomics guide the management of SLE-associated APS?
The management of antiphospholipid syndrome is hindered by heterogeneous clinical presentations. Whole-blood transcriptomi...
Bone-modifying drugs slow OA progression
Drugs used to treat osteoporosis could slow the progression of osteoarthritis, according to the findings of a study in mice.
Adropin inhibits fibrosis in SSc
The peptide hormone adropin, which is downregulated in dermal fibroblasts in patients with systemic sclerosis (SSc), inhib...
Rethinking antiphospholipid syndrome to guide future management and research
Antiphospholipid syndrome (APS) consists of thrombotic, non-thrombotic and obstetric clinical manifestations developing in...
Granzyme serine proteases in inflammation and rheumatic diseases
Granzyme serine proteases in inflammation and rheumatic diseases
Granzymes (granule-secreted enzymes) are a family of serine proteases that have been viewed as redundant cytotoxic enzymes...
Relapsing polychondritis: clinical updates and new differential diagnoses
Relapsing polychondritis: clinical updates and new differential diagnoses
Relapsing polychondritis is a rare inflammatory disease characterized by recurrent inflammation of cartilaginous structure...
Treat-to-target or treat-to-dissolve strategy to improve gout treatment
Medication adherence in gout is low, and discontinuation of urate-lowering therapy puts patients at risk of flares and car...
Advancing precision rheumatology through tissue and blood profiling
Advancing precision rheumatology through tissue and blood profiling
Multidimensional and single-cell profiling of peripheral blood and inflamed tissues is a powerful and high-resolution tool...
Joint-specific memory, resident memory T cells and the rolling window of opportunity in arthritis
Joint-specific memory, resident memory T cells and the rolling window of opportunity in arthritis
In rheumatoid arthritis, juvenile idiopathic arthritis and other forms of inflammatory arthritis, the immune system target...
Molecular biomarker approaches to prevention of post-traumatic osteoarthritis
Molecular biomarker approaches to prevention of post-traumatic osteoarthritis
Up to 50% of individuals develop post-traumatic osteoarthritis (PTOA) within 10 years following knee-joint injuries such a...
Benralizumab noninferior to mepolizumab for EGPA
In a head-to-head phase III trial of two drugs that target IL-5 or its receptor, benralizumab was noninferior to mepolizum...
Author Correction: Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells
Author notesThese authors contributed equally: Christian Jorgensen, Danièle Noël.Authors and AffiliationsIRMB, University ...
Author Correction: Proposals for the rheumatological use of JAK inhibitors
Authors and AffiliationsUniversity della Campania, Department of Precision Medicine, Naples, ItalyFrancesco CicciaUniversi...
Time for a new approach to drug development for rare systemic autoinflammatory diseases
Despite the transformative potential of treatments for systemic autoinflammatory diseases, these conditions remain underfu...
Low-frequency and rare genetic variants associated with rheumatoid arthritis risk
Low-frequency and rare genetic variants associated with rheumatoid arthritis risk
Rheumatoid arthritis (RA) has an estimated heritability of nearly 50%, which is particularly high in seropositive RA. HLA ...