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Pre-RA autoantibodies recognize arthritogenic gut bacterium
Pre-RA autoantibodies recognize arthritogenic gut bacterium
A gut bacterium found in people at risk of rheumatoid arthritis (RA) or with early RA is recognized by circulating autoant...
Targeting the DNA damage response attenuates SLE-associated B cell characteristics
Targeting the DNA damage response attenuates SLE-associated B cell characteristics
Inhibition of the DNA damage response kinase ATR prevents B cells from IFNα-mediated acquisition of a systemic lupus ...
Reversal of inflammatory priming prevents arthritic flares
Reversal of inflammatory priming prevents arthritic flares
Inhibition of epigenetic processes in synovial fibroblasts can reverse inflammatory priming and prevent flares in experime...
Understanding synovial cell diversity in post-traumatic OA
Understanding synovial cell diversity in post-traumatic OA
Research related to the role of the synovium and its cell constituents during the pathogenies of osteoarthritis (OA) has t...
Can molecular dynamics facilitate the design of protein–protein-interaction inhibitors?
The design of effective inhibitors of protein–protein interactions is challenging. In a new study, thermal fluctuati...
Glycobiology of rheumatic diseases
Glycobiology of rheumatic diseases
Glycosylation has a profound influence on protein activity and cell biology through a variety of mechanisms, such as prote...
Cutaneous bacteria promote autoimmunity in mice
New research demonstrates that unrestrained cutaneous growth of Staphylococcus aureus causes autoimmunity characteristic o...
Mapping the immune landscape of MDA5+ dermatomyositis
Using a combination of various single-cell and immune profiling approaches, researchers have characterized the unique adap...
Immune cell dysregulation as a mediator of fibrosis in systemic sclerosis
Immune cell dysregulation as a mediator of fibrosis in systemic sclerosis
Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by dysregulation of the immune system an...
Hydroxychloroquine dose: balancing toxicity and SLE flare risk
Contemporary guidelines for the management of systemic lupus erythematosus (SLE) recommend prescribing hydroxychloroquine ...
Single-cell-based platform maps response to candidate DMOADs
A new study demonstrates that a single-cell mass cytometry approach can provide a precise snapshot of how candidate drugs ...
Aberrant regulation of autophagy linked to OA
Aberrant regulation of autophagy linked to OA
Disruption of a newly identified axis involved in the regulation of autophagy in chondrocytes is implicated in osteoarthri...
CXCL5 effective in mouse model of SLE
In a mouse model of lupus, treatment with CXCL5 reduces disease activity and promotes survival.
In-joint photocatalytic hydrogen production prevents RA in mice
In-joint photocatalytic hydrogen production prevents RA in mice
Newly developed nanorods that enable photocatalytic intra-articular release of hydrogen prevent the development of collage...
Age-related mechanisms in the context of rheumatic disease
Age-related mechanisms in the context of rheumatic disease
Ageing is characterized by a progressive loss of cellular function that leads to a decline in tissue homeostasis, increase...
Target neutrophils to treat thrombotic APS?
New research suggests therapies targeting neutrophil activation pathways could protect against arterial and venous thrombo...
CAR T cells induce drug-free SLE remission
CAR T cells induce drug-free SLE remission
Results from a study of CAR T cell therapy in five patients with treatment-refractory systemic lupus erythematosus demonst...
ETS1 implicated in polarization of tissue-destructive fibroblasts
ETS1 implicated in polarization of tissue-destructive fibroblasts
New research suggests that the transcription factor ETS1 expressed in fibroblasts regulates the tissue-destructive propert...
Precision medicine: the precision gap in rheumatic disease
Precision medicine: the precision gap in rheumatic disease
For many oncological conditions, the application of timely and patient-tailored targeted therapies, or precision medicine,...
Immune-checkpoint inhibitor use in patients with cancer and pre-existing autoimmune diseases
Immune-checkpoint inhibitor use in patients with cancer and pre-existing autoimmune diseases
Immune-checkpoint inhibitors (ICIs) have dramatically changed the management of advanced cancers. Designed to enhance the ...
Keeping immunostimulatory self-RNA under the rADAR
Keeping immunostimulatory self-RNA under the rADAR
Structural modification of RNA by adenosine-to-inosine editing renders self-RNA invisible to RNA sensors of the innate imm...
Publisher Correction: The impact of COVID-19 on rare and complex connective tissue diseases: the experience of ERN ReCONNET
Rheumatology Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, ItalyRosaria Talarico, Sara Cannizzo, Andrea Gaglioti, ...
A comprehensive guide for managing the reproductive health of patients with vasculitis
Vasculitides and their therapies affect all areas of the reproductive life cycle. The ACR, EULAR and the Drugs and Lactati...
Thy-1 promotes skin fibrosis in SSc
A new study has identified an association of Thy-1 expression with skin fibrosis in systemic sclerosis, and has shown that...
New guide calls for interdisciplinary approach to TMJ arthritis symptoms
New guide calls for interdisciplinary approach to TMJ arthritis symptoms
Members of the Temporomandibular Joint Juvenile Arthritis Working group (TMJaw) provide a set of interdisciplinary recomme...
Lin28a blunts cartilage loss in a mouse model of OA
Lin28a blunts cartilage loss in a mouse model of OA
New research in a mouse model of osteoarthritis shows that the RNA-binding protein Lin28a is expressed in chondrocytes and...
The role of mitochondria in rheumatic diseases
The role of mitochondria in rheumatic diseases
The mitochondrion is an intracellular organelle thought to originate from endosymbiosis between an ancestral eukaryotic ce...
Optimizing methotrexate withdrawal during COVID vaccination
Results from two parallel trials suggest that withholding methotrexate only after the second dose of a COVID vaccine is sa...
Small wonder: nanoparticles feed hydroxychloroquine to activated neutrophils
Small wonder: nanoparticles feed hydroxychloroquine to activated neutrophils
Although neutrophils are vital components of the innate immune system, they can also contribute to the inflammation and au...