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The emergence of SLE-causing UNC93B1 variants in 2024
During the past year, four studies have reported ten mutations in UNC93B1, which encodes the Toll-like receptor (TLR) chap...
Publisher Correction: Recent advances in the diagnosis and management of neuropsychiatric lupus
Authors and AffiliationsDivision of Rheumatology, Department of Medicine, Dalhousie University and Queen Elizabeth II Heal...
The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus
The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus
Emerging evidence indicates that memory B cells are dysfunctional in systemic lupus erythematosus (SLE). They are hyporesp...
The management of adult and paediatric uveitis for rheumatologists
The management of adult and paediatric uveitis for rheumatologists
Uveitis encompasses multiple different conditions that are all characterized by intra-ocular inflammation. Uveitis occurs ...
Management strategies in rheumatoid arthritis
Management strategies in rheumatoid arthritis
Management of rheumatoid arthritis (RA) has evolved from simply the direct translation of drug efficacy results from clini...
Rheumatic diseases and metabolism: where centre and periphery meet
Rheumatic diseases and metabolism: where centre and periphery meet
Over the past few decades, the connection between metabolism and various inflammatory and rheumatic diseases has been an a...
Risk of uveitis in SpA is changing
Findings from an observational study suggest that the frequency of uveitis in patients with spondyloarthritis has declined...
Rheumatology in the digital health era: status quo and quo vadis?
Rheumatology in the digital health era: status quo and quo vadis?
Rheumatology faces a critical shortage of health-care professionals, exacerbated by an ageing patient population and escal...
Novel autoantigen in idiopathic lung disease
The presence of anti-IFI16 autoantibodies in patients with idiopathic interstitial pneumonia is linked to poor prognosis a...
Dupuytren contracture treatments compared
In an open-label clinical trial, collagenase injection was not noninferior to limited fasciectomy for the treatment of Dup...
Mito+ RBCs prompt IFN and IL-1β release by SLE monocytes
In a subset of monocytes in systemic lupus erythematosus, internalization of mitochondria-retaining red blood cells leads ...
Osmo-sensitive anion channels reduce crystal-induced inflammation
New research demonstrates a key role for osmo-sensitive LRRC8 anion channels in crystal-induced inflammation.
Erosive cargo from synovial fibroblasts
Synovial fibroblasts from individuals with OA release small extracellular vesicles with potentially pathogenic miRNA cargo.
Somatic mutations in autoinflammatory and autoimmune disease
Somatic mutations in autoinflammatory and autoimmune disease
Somatic mutations (also known as acquired mutations) are emerging as common, age-related processes that occur in all cells...
Epstein–Barr virus as a potentiator of autoimmune diseases
Epstein–Barr virus as a potentiator of autoimmune diseases
The Epstein–Barr virus (EBV) is epidemiologically associated with development of autoimmune diseases, including syst...
JAK inhibitors improve RA pain
Consistent with findings from clinical trials, in a retrospective cohort study, Janus kinase inhibitors improved pain asso...
Recent advances in the diagnosis and management of neuropsychiatric lupus
Recent advances in the diagnosis and management of neuropsychiatric lupus
Neuropsychiatric manifestations of systemic lupus erythematosus (SLE) are common and frequently associated with a substant...
Downregulation of invariant chain causes autoreactive T cell expansion
Neoself-antigens presented by MHC-II molecules in the absence of invariant chain drive clonal expansion of autoreactive T ...
BiTE therapy for rheumatic diseases
The bispecific T cell engager antibody teclistamab has now been used to successfully treat five patients with treatment-re...
Combination therapy for Behçet uveitis
A study has compared the safety and efficacy of three different immunomodulatory drugs combined with glucocorticoids for t...
Lupus nephritis-related chronic kidney disease
Lupus nephritis-related chronic kidney disease
Lupus nephritis is a common complication of systemic lupus erythematosus (SLE) and a determinant of overall morbi...
The PU.1– IL-9 axis in TH9 cells promotes RA
Findings show a role for the PU.1–IL-9 axis in TH9 cells in the pathogenesis of RA.
Defining axial involvement in juvenile SpA
New classification criteria for axial disease in juvenile spondyloarthritis aim to enhance the identification and study of...
Publisher Correction: Integrin signalling in joint development, homeostasis and osteoarthritis
Authors and AffiliationsCell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes ...
Interferon disrupts immune and tissue homeostasis in SLE via CXCL13
Interferon disrupts immune and tissue homeostasis in SLE via CXCL13
Type I interferon has a crucial role in the immunopathogenesis of systemic lupus erythematosus (SLE). Analysis of CD4+ T c...
JAK inhibitor selectivity: new opportunities, better drugs?
JAK inhibitor selectivity: new opportunities, better drugs?
Cytokines function as communication tools of the immune system, serving critical functions in many biological responses an...
Distinct mucosal endotypes as initiators and drivers of rheumatoid arthritis
Distinct mucosal endotypes as initiators and drivers of rheumatoid arthritis
Rheumatoid arthritis (RA) is a potentially devastating autoimmune disease. The great majority of patients with RA are sero...
The immune health metric as an indicator of health and disease
The immune health metric as an indicator of health and disease
Immune health has been considered impossible to assess through the use of traditional biomarkers. The newly devised immune...
Current understanding and management of cardiovascular involvement in rheumatic immune-mediated inflammatory diseases
Current understanding and management of cardiovascular involvement in rheumatic immune-mediated inflammatory diseases
Immune-mediated inflammatory diseases (IMIDs) are a spectrum of disorders of overlapping immunopathogenesis, with a preval...
Helicobacter pylori-induced citrullination linked to RA exacerbation
Helicobacter pylori-induced citrullination linked to RA exacerbation
New findings reveal a potential mechanism by which Helicobacter pylori exacerbates rheumatoid arthritis
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