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Do people living with HIV have accelerated lung function decline, despite adequate treatment?
Do people living with HIV have accelerated lung function decline, despite adequate treatment?
Accelerated lung function decline is relatively common from the late 20s and indicates chronic lung disease in many commun...
Do the 'missing millions of COPD patients want to be found?
Do the 'missing millions of COPD patients want to be found?
Finding the ‘missing millions’ of patients with COPD has become a mantra of health policy. In the UK, 1.4 million people h...
ATP binding cassette member A3 (ABCA3): coming of age
ATP binding cassette member A3 (ABCA3): coming of age
Pathogenic variants in the ATP binding cassette member A3 (ABCA3) gene were first described in newborn infants with lethal...
Faster lung function decline in people living with HIV despite adequate treatment: a longitudinal matched cohort study
Faster lung function decline in people living with HIV despite adequate treatment: a longitudinal matched cohort study
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Diagnosis and treatment outcomes from prebronchodilator spirometry performed alongside lung cancer screening in a Lung Health Check programme
Diagnosis and treatment outcomes from prebronchodilator spirometry performed alongside lung cancer screening in a Lung Health Check programme
WHAT IS ALREADY KNOWN ON THIS TOPICBetween 10% and 20% of people attending for low-dose CT screening for lung cancer have ...
The relationship between interstitial lung abnormalities, mortality, and multimorbidity: a cohort study
The relationship between interstitial lung abnormalities, mortality, and multimorbidity: a cohort study
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Effects of enhanced recovery after surgery plus pulmonary rehabilitation on complications after video-assisted lung cancer surgery: a multicentre randomised controlled trial
Effects of enhanced recovery after surgery plus pulmonary rehabilitation on complications after video-assisted lung cancer surgery: a multicentre randomised controlled trial
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MUC5B, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study
MUC5B, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study
IntroductionInterstitial lung disease (ILD) is a group of chronic respiratory disorders characterised by inflammation and ...
COPD in Africa: risk factors, hospitalisation, readmission and associated outcomes--a systematic review and meta-analysis
COPD in Africa: risk factors, hospitalisation, readmission and associated outcomes--a systematic review and meta-analysis
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ABCA3-related interstitial lung disease beyond infancy
ABCA3-related interstitial lung disease beyond infancy
WHAT IS ALREADY KNOWN ON THIS TOPICABCA3 deficiency is the most frequent genetic cause of childhood interstitial lung dise...
Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis
Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis
IntroductionAcute respiratory distress syndrome (ARDS) and sepsis are the biggest cause of mortality in critically ill pat...
C reactive protein utilisation, a biomarker for early COVID-19 treatment, improves lenzilumab efficacy: results from the randomised phase 3 'LIVE-AIR trial
C reactive protein utilisation, a biomarker for early COVID-19 treatment, improves lenzilumab efficacy: results from the randomised phase 3 'LIVE-AIR trial
WHAT IS ALREADY KNOWN ON THIS TOPICGranulocyte macrophage colony-stimulating factor (GM-CSF) is an upstream mediator of th...
Invasive pulmonary infection caused by Trichoderma longibrachiatum
Invasive pulmonary infection caused by Trichoderma longibrachiatum
A 38-year-old woman presented with a 1-month history of progressive cough and phlegm. She was an office worker. She denied...
Tracheal stenosis after endobronchial ultrasound-guided transbronchial needle aspiration
Tracheal stenosis after endobronchial ultrasound-guided transbronchial needle aspiration
A 78-year-old man was referred to our hospital to study a pulmonary nodule in the left lower lobe, suspicious for malignan...
Should we retain smaller growing nodules in lung cancer screening programmes for surveillance?
Should we retain smaller growing nodules in lung cancer screening programmes for surveillance?
The UK National Screening Committee recently approved a national programme for lung cancer screening (LCS) by low-dose CT ...
Minimal important difference in childhood interstitial lung diseases
Minimal important difference in childhood interstitial lung diseases
IntroductionChildhood interstitial lung diseases (chILD) are a heterogeneous group of diffuse and mostly chronic respirato...
When is a lung abscess not a lung abscess? Recurrent pneumonia and empyema associated with intrapulmonary cystic teratoma
When is a lung abscess not a lung abscess? Recurrent pneumonia and empyema associated with intrapulmonary cystic teratoma
A 23-year-old woman presented with gradual-onset left chest and back pain. She had at medical history of asthma. She was a...
ICS/formoterol maintenance and reliever therapy: how far beyond asthma?
ICS/formoterol maintenance and reliever therapy: how far beyond asthma?
In moderate and severe asthma, the use of inhaled corticosteroid (ICS)/formoterol maintenance and reliever therapy (MART) ...
Novel genetic variants associated with inhaled corticosteroid treatment response in older adults with asthma
Novel genetic variants associated with inhaled corticosteroid treatment response in older adults with asthma
AbstractIntroduction Older adults have the greatest burden of asthma and poorest outcomes. The pharmacogenetics of inhaled...
Using a smartphone application maintains physical activity following pulmonary rehabilitation in patients with COPD: a randomised controlled trial
Using a smartphone application maintains physical activity following pulmonary rehabilitation in patients with COPD: a randomised controlled trial
IntroductionPulmonary rehabilitation (PR) is defined as a multidisciplinary and comprehensive intervention based on a thor...
Short-term exposure to ambient air pollution and individual emergency department visits for COVID-19: a case-crossover study in Canada
Short-term exposure to ambient air pollution and individual emergency department visits for COVID-19: a case-crossover study in Canada
Key messagesWhat is the key question?IntroductionOver the past decades, a large number of studies have shown that acute an...
Budesonide/formoterol maintenance and reliever therapy versus fluticasone/salmeterol fixed-dose treatment in patients with COPD
Budesonide/formoterol maintenance and reliever therapy versus fluticasone/salmeterol fixed-dose treatment in patients with COPD
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Elucidating minimal important difference in childhood interstitial lung diseases
Elucidating minimal important difference in childhood interstitial lung diseases
Rare paediatric lung diseases have been a challenge over years for paediatric pulmonologists.There has been growing attent...
Impact of time-to-treatment on survival for advanced non-small cell lung cancer patients in the Netherlands: a nationwide observational cohort study
Impact of time-to-treatment on survival for advanced non-small cell lung cancer patients in the Netherlands: a nationwide observational cohort study
Key messagesWhat is already known on this topicHow this study might affect research, practice or policyIntroductionNon-sma...
Optimising breathlessness triggered services for older people with advanced diseases: a multicentre economic study (OPTBreathe)
Optimising breathlessness triggered services for older people with advanced diseases: a multicentre economic study (OPTBreathe)
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSWe propose the most cost-effective models of breathlessness service...
Bronchopulmonary dysplasia and expiratory airflow at 8 years in children born extremely preterm in the post-surfactant era
Bronchopulmonary dysplasia and expiratory airflow at 8 years in children born extremely preterm in the post-surfactant era
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Placental mesenchymal stem cells boost M2 alveolar over M1 bone marrow macrophages via IL-1{beta} in Klebsiella-mediated acute respiratory distress syndrome
Placental mesenchymal stem cells boost M2 alveolar over M1 bone marrow macrophages via IL-1{beta} in Klebsiella-mediated acute respiratory distress syndrome
IntroductionAcute respiratory distress syndrome (ARDS) is still a lethal complication of severe bacterial pneumonia, with ...
Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease
Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease
IntroductionEosinophils are proinflammatory granulocytes associated with symptom severity and exacerbation frequency in as...
Cost-effectiveness of home non-invasive ventilation in patients with persistent hypercapnia after an acute exacerbation of COPD in the UK
Cost-effectiveness of home non-invasive ventilation in patients with persistent hypercapnia after an acute exacerbation of COPD in the UK
IntroductionChronic obstructive pulmonary disease (COPD) remains a common cause of hospital admission, with patients with ...
Ultra-low-dose CT versus chest X-ray for patients suspected of pulmonary disease at the emergency department: a multicentre randomised clinical trial
Ultra-low-dose CT versus chest X-ray for patients suspected of pulmonary disease at the emergency department: a multicentre randomised clinical trial
IntroductionWhile chest X-ray (CXR) is a standard diagnostic procedure in patients suspected of non-traumatic pulmonary di...
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