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Pulmonary fibrosis may begin in infancy: from childhood to adult interstitial lung disease
Pulmonary fibrosis may begin in infancy: from childhood to adult interstitial lung disease
IntroductionChildhood interstitial lung disease (chILD) comprises a diverse group of rare respiratory disorders affecting ...
Multiple lung cyst formation caused by metastatic bladder cancer
Multiple lung cyst formation caused by metastatic bladder cancer
A 90-year-old man visited our hospital with a chief problem of haemoptysis lasting for a month. He had a medical history o...
Imaging in early tuberculosis
Imaging in early tuberculosis
Tuberculosis (TB) is a pressing global human health problem that resulted in over 10 million cases and 1.3 million deaths ...
Air pollution and respiratory health in patients with COPD: should we focus on indoor or outdoor sources?
Air pollution and respiratory health in patients with COPD: should we focus on indoor or outdoor sources?
WHAT IS ALREADY KNOWN ON THIS TOPICAir pollution is known to worsen respiratory health in patients with chronic obstructiv...
CD206+ macrophages are relevant non-invasive imaging biomarkers and therapeutic targets in experimental lung fibrosis
CD206+ macrophages are relevant non-invasive imaging biomarkers and therapeutic targets in experimental lung fibrosis
WHAT IS ALREADY KNOWN ON THIS TOPICPrediction of disease progression and therapy efficacy remain a clinical issues in prog...
Variability in forced expiratory volume in 1 s in children with symptomatically well-controlled asthma
Variability in forced expiratory volume in 1 s in children with symptomatically well-controlled asthma
IntroductionAsthma is a common chronic condition in childhood and is characterised by chronic airway inflammation which le...
Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts
Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts
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A structural and metabolic framework for classifying pre-clinical tuberculosis infection phenotypes using 18F-FDG PET-CT: a prospective cohort analysis following M. tuberculosis exposure
A structural and metabolic framework for classifying pre-clinical tuberculosis infection phenotypes using 18F-FDG PET-CT: a prospective cohort analysis following M. tuberculosis exposure
IntroductionTuberculosis infection (TBI) is defined by T-cell immunoreactivity to Mycobacterium tuberculosis (Mtb) antigen...
Platelet aggregates in lung capillaries in severely decompensated pulmonary hypertension
Platelet aggregates in lung capillaries in severely decompensated pulmonary hypertension
IntroductionThrombocytopenia is reported to occur in about 20% of patients with pulmonary hypertension (PH).1 The severity...
Added complexity to genotype-phenotype relationships in primary ciliary dyskinesia: TAS2R38 as a gene modifier
Added complexity to genotype-phenotype relationships in primary ciliary dyskinesia: TAS2R38 as a gene modifier
Primary ciliary dyskinesia (PCD), an inherited motile ciliopathy, is characterised by recurrent upper and lower respirator...
Collagen neoepitopes in sarcoidosis: what do they tell us?
Collagen neoepitopes in sarcoidosis: what do they tell us?
Fibrosis is scarring due to the replacement of tissue architecture by extracellular matrix (ECM), which consists largely o...
Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia
Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia
IntroductionIn spite of decades-long efforts, therapeutics capable of ameliorating disease pathophysiology and improving p...
Perivascular epithelioid cell neoplasm of lung
Perivascular epithelioid cell neoplasm of lung
A 73-year-old woman was found to have a pulmonary mass on a CT scan of the chest 10 years ago, but did not receive any tre...
Impact of TAS2R38 polymorphisms on nasal nitric oxide and Pseudomonas infections in primary ciliary dyskinesia: relation to genotype
Impact of TAS2R38 polymorphisms on nasal nitric oxide and Pseudomonas infections in primary ciliary dyskinesia: relation to genotype
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Unusual cause of trepopnea
Unusual cause of trepopnea
A 19-year-old female presented with a 6-month history of progressive shortness of breath. She reported a new onset of palp...
Inequalities in care and the burden of wheeze and asthma in young children from diverse socioeconomic and ethnic backgrounds
Inequalities in care and the burden of wheeze and asthma in young children from diverse socioeconomic and ethnic backgrounds
Worldwide inequalities in care significantly impact respiratory health outcomes.1 2 Despite this, there are few studies ex...
Non-cigarette tobacco products, aryl-hydrocarbon receptor repressor gene methylation and smoking-related health outcomes
Non-cigarette tobacco products, aryl-hydrocarbon receptor repressor gene methylation and smoking-related health outcomes
Study populationThe National Heart, Lung and Blood Institute (NHLBI) Pooled Cohorts Study12 harmonised data from four pros...
Refractory granulomatous Pneumocystis jirovecii pneumonia masquerading as malignancy
Refractory granulomatous Pneumocystis jirovecii pneumonia masquerading as malignancy
An elderly female, lifelong non-smoker, with rheumatoid arthritis treated with methotrexate and prednisone for 10 years wa...
Association between socioeconomic deprivation, ethnicity and health outcomes in preschool children with recurrent wheeze in England: a retrospective cohort study
Association between socioeconomic deprivation, ethnicity and health outcomes in preschool children with recurrent wheeze in England: a retrospective cohort study
IntroductionWheezing illnesses in young children are extremely common, with up to half experiencing an episode by the age ...
Chronic berylliosis disease: uncommon pulmonary granulomas beyond sarcoidosis
Chronic berylliosis disease: uncommon pulmonary granulomas beyond sarcoidosis
A 47-year-old male presented with chronic cough, which has worsened over the last 5–6 months. Dyspnoea, fever and signific...
Editorial of utility of the Global Lung Function Initiative (GLI) for ILD
Editorial of utility of the Global Lung Function Initiative (GLI) for ILD
Interstitial lung disease (ILD) is a heterogeneous parenchymal disorder.1 2 Patients with ILD often present with non-speci...
Predicting the risk of pulmonary deterioration in sarcoidosis
Predicting the risk of pulmonary deterioration in sarcoidosis
In sarcoidosis, any organ may be affected, and the majority of cases have pulmonary involvement. The disease course in pul...
Consensus palliative care referral criteria for people with chronic obstructive pulmonary disease
Consensus palliative care referral criteria for people with chronic obstructive pulmonary disease
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Implications of the 2022 lung function update and GLI global reference equations among patients with interstitial lung disease
Implications of the 2022 lung function update and GLI global reference equations among patients with interstitial lung disease
WHAT IS ALREADY KNOWN ON THIS TOPICLung function indices are important in the prognostication of patients with interstitia...
Glucagon-like peptide-1 receptor agonists may benefit cardiopulmonary outcomes in patients with COPD
Glucagon-like peptide-1 receptor agonists may benefit cardiopulmonary outcomes in patients with COPD
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Software using artificial intelligence for nodule and cancer detection in CT lung cancer screening: systematic review of test accuracy studies
Software using artificial intelligence for nodule and cancer detection in CT lung cancer screening: systematic review of test accuracy studies
WHAT IS ALREADY KNOWN ON THIS TOPICArtificial intelligence (AI)-based software is increasingly used to assist the detectio...
Pulmonary sarcoidosis: differences in lung function change over time
Pulmonary sarcoidosis: differences in lung function change over time
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Harm from tobacco: a common thread
Harm from tobacco: a common thread
Industry uses market segmentation of products to attract and retain consumers from a variety of groups based on demographi...
Sleep-disordered breathing in children and adults with intellectual disability: mind the gap!
Sleep-disordered breathing in children and adults with intellectual disability: mind the gap!
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Association of positive airway pressure termination with mortality and non-fatal cardiovascular events in patients with obstructive sleep apnoea
Association of positive airway pressure termination with mortality and non-fatal cardiovascular events in patients with obstructive sleep apnoea
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