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Immunotherapy in non-small-cell lung cancer: new data support its use, but some challenges remain
Immunotherapy in non-small-cell lung cancer: new data support its use, but some challenges remain
Over the last decade, immune checkpoints inhibitors (ICIs) have changed the landscape of treatment for patients with advan...
Chronic neonatal lung disease: time to look beyond the alveolus
Chronic neonatal lung disease: time to look beyond the alveolus
Modern neonatal care has made remarkable progress to improve the outcome of premature infants. However, the syndrome of ch...
Impact of PD1 and PDL1 immunotherapy on non-small cell lung cancer outcomes: a systematic review
Impact of PD1 and PDL1 immunotherapy on non-small cell lung cancer outcomes: a systematic review
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Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant
Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant
IntroductionChronic lung disease (CLD), that is, bronchopulmonary dysplasia (BPD) affects more than 30% of all preterm inf...
Effects of switching from a metered dose inhaler to a dry powder inhaler on climate emissions and asthma control: post-hoc analysis
Effects of switching from a metered dose inhaler to a dry powder inhaler on climate emissions and asthma control: post-hoc analysis
Key messagesWhat is the key question?Under conditions close to routine clinical practice, what are the effects of switchin...
Effect modification of greenness on PM2.5 associated all-cause mortality in a multidrug-resistant tuberculosis cohort
Effect modification of greenness on PM2.5 associated all-cause mortality in a multidrug-resistant tuberculosis cohort
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Performance of QuantiFERON-TB Gold Plus assays in children and adolescents at risk of tuberculosis: a cross-sectional multicentre study
Performance of QuantiFERON-TB Gold Plus assays in children and adolescents at risk of tuberculosis: a cross-sectional multicentre study
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High-dose rifamycins in the treatment of TB: a systematic review and meta-analysis
High-dose rifamycins in the treatment of TB: a systematic review and meta-analysis
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Relative environmental and social disadvantage in patients with idiopathic pulmonary fibrosis
Relative environmental and social disadvantage in patients with idiopathic pulmonary fibrosis
IntroductionIdiopathic pulmonary fibrosis (IPF) is a progressive fibrotic interstitial lung disease (ILD) of complex aetio...
Lung directed antibody gene transfer confers protection against SARS-CoV-2 infection
Lung directed antibody gene transfer confers protection against SARS-CoV-2 infection
Key messagesWhat is the key question?What is the bottom line?Using a mimic of SARS-CoV-2 based on recombinant lentivirus p...
Medical treatments for idiopathic pulmonary fibrosis: a systematic review and network meta-analysis
Medical treatments for idiopathic pulmonary fibrosis: a systematic review and network meta-analysis
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Incidence, treatment and survival of malignant pleural and peritoneal mesothelioma: a population-based study
Incidence, treatment and survival of malignant pleural and peritoneal mesothelioma: a population-based study
IntroductionMalignant mesothelioma (MM) is a highly lethal tumour that primarily arises from the pleura and, to a lesser e...
From bronchiolitis endotyping to asthma risk assessment
From bronchiolitis endotyping to asthma risk assessment
Bronchiolitis is the most common lower respiratory tract infection in young children, and it is associated with significan...
COVID-19 hospital activity and in-hospital mortality during the first and second waves of the pandemic in England: an observational study
COVID-19 hospital activity and in-hospital mortality during the first and second waves of the pandemic in England: an observational study
Key messagesWhat is the key question?In-hospital mortality rates are a key marker for the performance of health services i...
Young woman with multiple lung nodules: a pulmonary oxymoron
Young woman with multiple lung nodules: a pulmonary oxymoron
Dr Hiromu Tanaka (respiratory specialist trainee)A 31-year-old Japanese woman was referred to our outpatient clinic after ...
Nasopharyngeal lipidomic endotypes of infants with bronchiolitis and risk of childhood asthma: a multicentre prospective study
Nasopharyngeal lipidomic endotypes of infants with bronchiolitis and risk of childhood asthma: a multicentre prospective study
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Plasma adiponectin and risk of asthma: observational analysis, genetic Mendelian randomisation and meta-analysis
Plasma adiponectin and risk of asthma: observational analysis, genetic Mendelian randomisation and meta-analysis
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Benefit-harm analysis of azithromycin for the prevention of acute exacerbations of chronic obstructive pulmonary disease
Benefit-harm analysis of azithromycin for the prevention of acute exacerbations of chronic obstructive pulmonary disease
Key messagesWhat is the key question?What is the bottom line?Daily maintenance azithromycin therapy is very likely net-ben...
TB and COPD in low-income settings: a collision of old foes
TB and COPD in low-income settings: a collision of old foes
Tuberculosis (TB) remains a major global public health challenge, with 10 million incident cases estimated in 2019. Histor...
Higher exhaled nitric oxide at 6 weeks of age is associated with less bronchiolitis and wheeze in the first 12 months of age
Higher exhaled nitric oxide at 6 weeks of age is associated with less bronchiolitis and wheeze in the first 12 months of age
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Respiratory symptoms and lung function in patients treated for pulmonary tuberculosis in Malawi: a prospective cohort study
Respiratory symptoms and lung function in patients treated for pulmonary tuberculosis in Malawi: a prospective cohort study
Key messagesWhat is the key question?What is the bottom line?We found that among adults in Malawi who had completed treatm...
High prevalence of multiple serotypes of pneumococci in patients with pneumonia and their associated risk factors
High prevalence of multiple serotypes of pneumococci in patients with pneumonia and their associated risk factors
Key messagesWhat is already known on the topic?More than one serotype of pneumococci can simultaneously colonise the nasop...
Lung cancer screening provides an opportunity for early diagnosis and treatment of interstitial lung disease
Lung cancer screening provides an opportunity for early diagnosis and treatment of interstitial lung disease
IntroductionEarly detection and treatment of lung cancer through low-dose CT (LDCT) screening reduces mortality.1 Intersti...
Building a home ventilation programme: population, equipment, delivery and cost
Building a home ventilation programme: population, equipment, delivery and cost
IntroductionHypercapnic respiratory failure due to alveolar hypoventilation is a common complication of severe neuromuscul...
Pulmonary tuberculosis presenting as massive spontaneous pneumomediastinum and subcutaneous emphysema
Pulmonary tuberculosis presenting as massive spontaneous pneumomediastinum and subcutaneous emphysema
A 56-year-old man, a never smoker, presented to the emergency department with a 3-day history of right-sided chest pain—tr...
Osteoblastic flare phenomenon in a patient treated for disseminated non-tuberculous mycobacterial infection
Osteoblastic flare phenomenon in a patient treated for disseminated non-tuberculous mycobacterial infection
A previously healthy 64-year-old woman presented with a 2-month history of anterior chest pain. Physical examination discl...
In search of the elusive biomarker(s): a proteomics analysis in rheumatoid arthritis-associated interstitial lung disease
In search of the elusive biomarker(s): a proteomics analysis in rheumatoid arthritis-associated interstitial lung disease
The development of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) leads to significant morbidi...