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Unmasking delays: bridging the gap in timely lung cancer diagnosis for UK primary care
Unmasking delays: bridging the gap in timely lung cancer diagnosis for UK primary care
There is little room for debate regarding the fact that primary care in the UK is currently confronting one of its most su...
Lung function as independent predictor of cardiovascular disease risk: implications for practice and policy
Lung function as independent predictor of cardiovascular disease risk: implications for practice and policy
The intimately connected physiology of the cardiovascular and pulmonary systems gives rise to numerous shared risk factors...
Integrated stop smoking interventions are essential to maximise the health benefits from lung cancer screening
Integrated stop smoking interventions are essential to maximise the health benefits from lung cancer screening
In the current issue of Thorax, Williams et al offer timely and much needed evidence regarding the optimal form of smoking...
Identifying a hyperinflammatory subphenotype of ARDS associated with worse outcomes: may ferritin help?
Identifying a hyperinflammatory subphenotype of ARDS associated with worse outcomes: may ferritin help?
Attributable mortality of acute respiratory distress syndrome (ARDS) is considerable.1 2 Yet, no survival benefit has been...
Cause-specific mortality in COPD subpopulations: a cohort study of 339 647 people in England
Cause-specific mortality in COPD subpopulations: a cohort study of 339 647 people in England
WHAT IS ALREADY KNOWN ON THIS TOPICPeople with chronic obstructive pulmonary disease (COPD) have a higher risk of mortalit...
Lower airway microbiota in COPD and healthy controls
Lower airway microbiota in COPD and healthy controls
AbstractBackground The lower airway microbiota in patients with chronic obstructive pulmonary disease (COPD) are likely al...
Cluster randomised controlled trial of specialist-led integrated COPD care (INTEGR COPD)
Cluster randomised controlled trial of specialist-led integrated COPD care (INTEGR COPD)
IntroductionChronic obstructive pulmonary disease (COPD) is estimated by the British Lung Foundation to be the fifth-leadi...
Guideline concordance for timely chest imaging after new presentations of dyspnoea or haemoptysis in primary care: a retrospective cohort study
Guideline concordance for timely chest imaging after new presentations of dyspnoea or haemoptysis in primary care: a retrospective cohort study
IntroductionInternational and regional variation in cancer outcomes indicates the need for improvement in lung cancer diag...
Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS)
Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS)
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Predictive value of lung function measures for cardiovascular risk: a large prospective cohort study
Predictive value of lung function measures for cardiovascular risk: a large prospective cohort study
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Retrospective analysis of referrals for hypoxic challenge testing in children born preterm
Retrospective analysis of referrals for hypoxic challenge testing in children born preterm
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Immediate smoking cessation support during lung cancer screening: long-term outcomes from two randomised controlled trials
Immediate smoking cessation support during lung cancer screening: long-term outcomes from two randomised controlled trials
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Combination pharmacological therapy targeting multiple mechanisms of sleep apnoea: a randomised controlled cross-over trial
Combination pharmacological therapy targeting multiple mechanisms of sleep apnoea: a randomised controlled cross-over trial
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Dry cough with abnormal airway connection
Dry cough with abnormal airway connection
A 69-year-old man of Indian origin presented to the chest clinic with an excessive dry cough for 3 months. He did not repo...
Phenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK Biobank
Phenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK Biobank
IntroductionTelomere length reflects the cumulative burden of exposures, endogenous factors, and age. We investigated phen...
Effects of non-invasive ventilation on sleep in chronic hypercapnic respiratory failure
Effects of non-invasive ventilation on sleep in chronic hypercapnic respiratory failure
IntroductionHypercapnic respiratory failure is a severe complication of several underlying neuromuscular and cardiopulmona...
Innocent bystanders: effects of the COVID-19 pandemic on non-COVID-19 critical illness outcomes
Innocent bystanders: effects of the COVID-19 pandemic on non-COVID-19 critical illness outcomes
The COVID-19 pandemic massively impacted healthcare directly and indirectly causing staggering collateral damage on innoce...
Symptom-related screening programme for early detection of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: the SYSPPE study
Symptom-related screening programme for early detection of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: the SYSPPE study
IntroductionPulmonary hypertension (PH) is a serious disease with several possible aetiologies and associations with respi...
Diffuse hyperdense micronodular airspace opacities in pulmonary alveolar microlithiasis
Diffuse hyperdense micronodular airspace opacities in pulmonary alveolar microlithiasis
A 44-year-old woman with a childhood history of pulmonary tuberculosis presented with mild exertional dyspnoea and abnorma...
Understanding the aetiology of lung function impairment: the crucial role of age of onset
Understanding the aetiology of lung function impairment: the crucial role of age of onset
During the last two decades, a paradigm shift in the aetiology of impaired lung function has been unfolding. Here, chronic...
Inflammatory ARDS subphenotypes are generalisable across the age spectrum
Inflammatory ARDS subphenotypes are generalisable across the age spectrum
Adult patients with acute respiratory distress syndrome (ARDS) are nowadays considered to be a heterogeneous population. P...
E-cigarette use in young adults and adolescents: not so safe?
E-cigarette use in young adults and adolescents: not so safe?
For several decades, it has been well known that smoking causes irreversible obstructive lung damage in adults1 and is ass...
Non-COVID-19 intensive care admissions during the pandemic: a multinational registry-based study
Non-COVID-19 intensive care admissions during the pandemic: a multinational registry-based study
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Influence of age on clinical characteristics, pharmacological management and exacerbations in children with asthma
Influence of age on clinical characteristics, pharmacological management and exacerbations in children with asthma
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Causal role of lipid metabolism in pulmonary alveolar proteinosis: an observational and mendelian randomisation study
Causal role of lipid metabolism in pulmonary alveolar proteinosis: an observational and mendelian randomisation study
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Identification of molecular subphenotypes in two cohorts of paediatric ARDS
Identification of molecular subphenotypes in two cohorts of paediatric ARDS
WHAT IS ALREADY KNOWN ON THIS TOPICWe explored PubMed without age or date limitations using terms related to acute respira...
Spirometric patterns in young and middle-aged adults: a 20-year European study
Spirometric patterns in young and middle-aged adults: a 20-year European study
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Tobacco use: a smoking gun for IPF?
Tobacco use: a smoking gun for IPF?
IPF is increasing in incidence globally.1 Epidemiological studies have identified a number of risk factors for the develop...
Association of indicators of extensive disease and rifampin-resistant tuberculosis treatment outcomes: an individual participant data meta-analysis
Association of indicators of extensive disease and rifampin-resistant tuberculosis treatment outcomes: an individual participant data meta-analysis
Search strategy and study selectionUsing a previously described database of RR/MDR-TB patients,14 we conducted an individu...
Prospective study of e-cigarette use and respiratory symptoms in adolescents and young adults
Prospective study of e-cigarette use and respiratory symptoms in adolescents and young adults
WHAT IS ALREADY KNOWN ON THIS TOPICE-cigarette use has been associated with increased respiratory symptoms like wheeze, br...