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Epigenetic clock as the new hand of time for lung cancer in never smokers
Epigenetic clock as the new hand of time for lung cancer in never smokers
Estimates of lung cancer among persons who never smoked are 10%–20% in the USA, translating into 20–40 000 cases annually....
Quantifying sustained health system benefits of primary care-based integrated disease management for COPD: a 6-year interrupted time series study
Quantifying sustained health system benefits of primary care-based integrated disease management for COPD: a 6-year interrupted time series study
WHAT IS ALREADY KNOWN ON THIS TOPICGlobally, the care of patients with chronic obstructive pulmonary disease (COPD) is cha...
Adaptive multi-interventional trial platform to improve patient care for fibrotic interstitial lung diseases
Adaptive multi-interventional trial platform to improve patient care for fibrotic interstitial lung diseases
REMAP trials are characterised by five key features as described in table 2. These key features provide multiple advantage...
QRISK3 underestimates the risk of cardiovascular events in patients with COPD
QRISK3 underestimates the risk of cardiovascular events in patients with COPD
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSWe show that a widely used CVD risk scoring tool, QRISK, substantia...
Human mesenchymal stromal cells inhibit Mycobacterium avium replication in clinically relevant models of lung infection
Human mesenchymal stromal cells inhibit Mycobacterium avium replication in clinically relevant models of lung infection
Introduction Mycobacterium avium complex (MAC) is an emerging, multidrug-resistant pathogen driving a global rise in pulmo...
Lifetime lung function trajectories: insights into risk factors, consequences and implications
Lifetime lung function trajectories: insights into risk factors, consequences and implications
Maintaining optimal lung function throughout life is important not only for respiratory health but also for overall health...
Lung allocation: a vexed, complex multifaceted challenge
Lung allocation: a vexed, complex multifaceted challenge
We read with interest the paper from Roussel et al.1 In this study, the authors examine the outcomes for lung transplant r...
Reinforcing the benefits of childrens physical activity on lung health
Reinforcing the benefits of childrens physical activity on lung health
Lung development starts already in utero whereas lung function development can be conceived to begin shortly after birth, ...
Respiratory rescue is the new frontier
Respiratory rescue is the new frontier
The cost of delivering healthcare is increasing in many countries, while at the same time, populations are ageing and fert...
Undertreating cardiovascular disease in people with chronic obstructive pulmonary disease (COPD)
Undertreating cardiovascular disease in people with chronic obstructive pulmonary disease (COPD)
Chronic obstructive pulmonary disease (COPD) is the third-leading cause of death globally following ischaemic heart diseas...
Improvements of the shape and strength of the diaphragm after endoscopic lung volume reduction
Improvements of the shape and strength of the diaphragm after endoscopic lung volume reduction
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Integrated disease management: good news but more work to do
Integrated disease management: good news but more work to do
Despite regularly updated guidelines, new evidence generation and a growing awareness of the prevalence and burden of asth...
MAC attack: MSCs and macrophages join forces against chronic lung infection
MAC attack: MSCs and macrophages join forces against chronic lung infection
Mesenchymal stromal cells (MSCs) possess several characteristics that make them attractive as a potential adjunct therapy ...
Bilateral mediastinal cysts with müllerian differentiation
Bilateral mediastinal cysts with müllerian differentiation
A chest X-ray was ordered in a 40-year-old woman due to an acute cough, showing an enlarged mediastinal silhouette (figure...
Survival outcomes following urgent lung transplantation in France and the USA
Survival outcomes following urgent lung transplantation in France and the USA
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Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China
Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China
AbstractBackground The aetiology of lung cancer among individuals who never smoked remains elusive, despite 15% of lung ca...
Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study
Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study
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Distinct trajectories of lung function from childhood to mid-adulthood
Distinct trajectories of lung function from childhood to mid-adulthood
MethodsCohortThe Dunedin Study investigates health and behaviour in a population-based cohort born in Dunedin in 1972/1973...
Lung function trajectories from school age to adulthood and their relationship with markers of cardiovascular disease risk
Lung function trajectories from school age to adulthood and their relationship with markers of cardiovascular disease risk
IntroductionSpirometry is the most commonly used pulmonary function test for identifying patterns of physiological abnorma...
To progress or not to progress: new insights into the evolution of pleuropulmonary blastomas come from studying lung cysts in adolescents and adults with DICER1-related tumour predisposition
To progress or not to progress: new insights into the evolution of pleuropulmonary blastomas come from studying lung cysts in adolescents and adults with DICER1-related tumour predisposition
Almost all cases of pleuropulmonary blastoma (PPB), the most common lung malignancy in childhood, are related to biallelic...
Transbronchial cryoablation in peripheral lung parenchyma with a novel thin cryoprobe and initial clinical testing
Transbronchial cryoablation in peripheral lung parenchyma with a novel thin cryoprobe and initial clinical testing
IntroductionSurgical resection remains the recommended treatment for early-stage non-small cell lung cancer (NSCLC) and so...
Unilateral pleural effusion with pulmonary hypertension in sarcoidosis: do not forget the pulmonary veins!
Unilateral pleural effusion with pulmonary hypertension in sarcoidosis: do not forget the pulmonary veins!
A 64-year-old woman presented with exertional dyspnoea and ankle oedema. She had lung biopsy-confirmed sarcoidosis 6 years...
Incidence, prevalence and mortality of idiopathic pulmonary fibrosis in England from 2008 to 2018: a cohort study
Incidence, prevalence and mortality of idiopathic pulmonary fibrosis in England from 2008 to 2018: a cohort study
AbstractBackground Owing to discrepancies in methodologies and how idiopathic pulmonary fibrosis (IPF) is diagnosed it is ...
Environmental pollutants exposure-derived extracellular vesicles: crucial players in respiratory disorders
Environmental pollutants exposure-derived extracellular vesicles: crucial players in respiratory disorders
IntroductionRespiratory disorders encompass a range of acute and chronic disorders caused by disordered phenotypes at the ...
New path for understanding mucociliary clearance
New path for understanding mucociliary clearance
The mucociliary clearance (MC) system is a vital host defence in the lungs and upper airways. Airway mucus traps inhaled b...
Heteroresistance in tuberculosis: are we missing drug-resistant bacteria hiding in plain sight?
Heteroresistance in tuberculosis: are we missing drug-resistant bacteria hiding in plain sight?
Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) remains the dominant cause of death from a bacterial infectio...
Toxic metals and lung health: silent poisons?
Toxic metals and lung health: silent poisons?
Lady Astor: ‘Sir, if you were my husband , I would put arsenic in your tea!’ Churchill: ‘If I were your husband , I woul...
Ablation for lung cancer: hot or cold intervention
Ablation for lung cancer: hot or cold intervention
Over the past two decades, there has been a notable shift in the natural history and epidemiology of lung cancer. Previous...
Epidemiology of idiopathic pulmonary fibrosis: opportunities and hurdles for population-level studies of rare disease
Epidemiology of idiopathic pulmonary fibrosis: opportunities and hurdles for population-level studies of rare disease
Idiopathic pulmonary fibrosis (IPF) is a rare condition for which reliable disease trends over time can be difficult to ob...
Comprehensive analysis of environmental exposure to hazardous trace elements and lung function: a national cross-sectional study
Comprehensive analysis of environmental exposure to hazardous trace elements and lung function: a national cross-sectional study
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