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Regulatory T lymphocytes as a therapy for ischemic stroke
Regulatory T lymphocytes as a therapy for ischemic stroke
Unrestrained excessive inflammatory responses exacerbate ischemic brain injury and impede post-stroke brain recovery. CD4+...
The immunopathology of B lymphocytes during stroke-induced injury and repair
The immunopathology of B lymphocytes during stroke-induced injury and repair
B cells, also known as B lymphocytes or lymphoid lineage cells, are a historically understudied cell population with regar...
Highly multiplexed spatial profiling with CODEX: bioinformatic analysis and application in human disease
Highly multiplexed spatial profiling with CODEX: bioinformatic analysis and application in human disease
Multiplexed imaging, which enables spatial localization of proteins and RNA to cells within tissues, complements existing ...
Single-cell RNA-seq methods to interrogate virus-host interactions
Single-cell RNA-seq methods to interrogate virus-host interactions
The twenty-first century has seen the emergence of many epidemic and pandemic viruses, with the most recent being the SARS...
Human T lymphocytes at tumor sites
Human T lymphocytes at tumor sites
CD4+ and CD8+ T lymphocytes mediate most of the adaptive immune response against tumors. Naïve T lymphocytes specific...
Sex differences in the inflammatory response to stroke
Sex differences in the inflammatory response to stroke
Ischemic stroke is a leading cause of morbidity and mortality and disproportionally affects women, in part due to their hi...
Systemic innate myeloid responses to acute ischaemic and haemorrhagic stroke
Systemic innate myeloid responses to acute ischaemic and haemorrhagic stroke
Acute ischaemic and haemorrhagic stroke account for significant disability and morbidity burdens worldwide. The myeloid ar...
Heterogeneity of tissue-resident immunity across organs and in health and disease
Heterogeneity of tissue-resident immunity across organs and in health and disease
The conception of how the immune system is operational has been significantly better understo...
Tissue-resident immunity in the lung: a first-line defense at the environmental interface
Tissue-resident immunity in the lung: a first-line defense at the environmental interface
The lung is a vital organ that incessantly faces external environmental challenges. Its homeostasis and unimpeded vital fu...
Beyond direct killing—novel cellular immunotherapeutic strategies to reshape the tumor microenvironment
Beyond direct killing—novel cellular immunotherapeutic strategies to reshape the tumor microenvironment
The clinical use of cellular immunotherapies is gaining momentum and the number of approved indications is steadily increa...
Neuroimmune interactions in health and disease
Neuroimmune interactions in health and disease
On our bookshelf is a monograph with a series of reviews from the 1950s edited by Marian Kies...
Tumor microenvironment antigens
Tumor microenvironment antigens
The identification and characterization of tumor antigens are central objectives in developing anti-cancer immunotherapy. ...
Role of alarmins in poststroke inflammation and neuronal repair
Role of alarmins in poststroke inflammation and neuronal repair
Severe loss of cerebral blood flow causes hypoxia and glucose deprivation in the brain tissue, resulting in necrotic cell ...
Targeting tumour-reprogrammed myeloid cells: the new battleground in cancer immunotherapy
Targeting tumour-reprogrammed myeloid cells: the new battleground in cancer immunotherapy
Tumour microenvironment is a complex ecosystem in which myeloid cells are the most abundant immune elements. This cell com...
Metabolic regulation and function of T helper cells in neuroinflammation
Metabolic regulation and function of T helper cells in neuroinflammation
Neuroinflammatory conditions such as multiple sclerosis (MS) are initiated by pathogenic immune cells invading the central...
Local anesthetics and immunotherapy: a novel combination to fight cancer
Local anesthetics and immunotherapy: a novel combination to fight cancer
Intratumoral injection of oncolytic agents such as modified herpes simplex virus T-VEC or local administration of non-vira...
Revisiting transplant immunology through the lens of single-cell technologies
Revisiting transplant immunology through the lens of single-cell technologies
Solid organ transplantation (SOT) is the standard of care for end-stage organ disease. The most frequent complication of S...
Immunization of preterm infants: current evidence and future strategies to individualized approaches
Immunization of preterm infants: current evidence and future strategies to individualized approaches
Preterm infants are at particularly high risk for infectious diseases. As this vulnerability extends beyond the neonatal p...
Neuropathogenesis of HIV-1: insights from across the spectrum of acute through long-term treated infection
Neuropathogenesis of HIV-1: insights from across the spectrum of acute through long-term treated infection
This review outlines the neuropathogenesis of HIV, from initial HIV entry into the central nervous system (CNS) to chronic...
Correction to: MAIT cells in liver inflammation and fibrosis
Correction to: MAIT cells in liver inflammation and fibrosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which ...
Unveiling the gut-brain axis: structural and functional analogies between the gut and the choroid plexus vascular and immune barriers
Unveiling the gut-brain axis: structural and functional analogies between the gut and the choroid plexus vascular and immune barriers
The vasculature plays an essential role in the development and maintenance of blood-tissue interface homeostasis. Knowledg...
Tolerance and autoimmunity in the liver
Tolerance and autoimmunity in the liver
Carambia A, Freund B, Schwinge D, Bruns OT, Salmen SC, Ittrich H, Reimer R, Heine M, Huber S, Waurisch C, Eychmüller A, Wr...
Gut instincts in neuroimmunity from the eighteenth to twenty-first centuries
Gut instincts in neuroimmunity from the eighteenth to twenty-first centuries
In the past two decades, work on the microbiota-gut-brain axis has led to a renewed appreciation for the interconnectednes...
Inflammatory Responses After Ischemic Stroke
Inflammatory Responses After Ischemic Stroke
Ischemic stroke generates an immune response that contributes to neuronal loss as well as tissue repair. This is a complex...
Basic principles of neuroimmunology
Basic principles of neuroimmunology
The brain is an immune-privileged organ such that immune cell infiltration is highly regulated and better tolerating the i...
The immunology of Parkinson’s disease
The immunology of Parkinson’s disease
Parkinson’s disease (PD) is the second most common neurodegenerative disorder which affects 6.1 million people world...
How genetic risk contributes to autoimmune liver disease
How genetic risk contributes to autoimmune liver disease
Genome-wide association studies (GWAS) for autoimmune hepatitis (AIH) and GWAS/genome-wide meta-analyses (GWMA) for primar...
Immuno-pathogenesis of neuromyelitis optica and emerging therapies
Immuno-pathogenesis of neuromyelitis optica and emerging therapies
Neuromyelitis optica (NMO) is an inflammatory disease that resembles MS in the relapsing clinical course of optic neuritis...