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Cross-Cultural Adaptation and Clinical Validation of TIME Criteria to Detect Potentially Inappropriate Medication Use in Older Adults: Methodological Report from the TIME International Study Group
Cross-Cultural Adaptation and Clinical Validation of TIME Criteria to Detect Potentially Inappropriate Medication Use in Older Adults: Methodological Report from the TIME International Study Group
Various explicit screening tools, developed mostly in central Europe and the USA, assist clinicians in optimizing medicati...
Patient-Reported Outcomes in Geriatric Oncology—Balancing Quality of Life and Therapeutic Effectiveness Using Primary Breast Cancer as a Model
Patient-Reported Outcomes in Geriatric Oncology—Balancing Quality of Life and Therapeutic Effectiveness Using Primary Breast Cancer as a Model
Breast cancer remains the most prevalent cancer worldwide, necessitating advancements in its management. Surgery remains t...
Considerations for Anesthesia in Older Adults with Cannabis Use
Considerations for Anesthesia in Older Adults with Cannabis Use
Over the past decade, legislative changes occurred in the USA and the western world that were followed by a substantial in...
Anticholinergic Exposure, Drug Dose and Postoperative Delirium: Comparison of Dose-Related and Non-Dose-Related Anticholinergic Burden Scores in a Retrospective Cohort Study of Older Orthopaedic and Trauma Surgery Patients
Anticholinergic Exposure, Drug Dose and Postoperative Delirium: Comparison of Dose-Related and Non-Dose-Related Anticholinergic Burden Scores in a Retrospective Cohort Study of Older Orthopaedic and Trauma Surgery Patients
Postoperative delirium (POD) is a common complication in older adult patients after surgery. A patient’s preoperativ...
Exploring Sex, Gender, and Gender-Related Sociocultural Factors in Clinical Decision-Making for Older Adults Using a Prescribing Cascade Vignette: A Transnational Qualitative Study
Exploring Sex, Gender, and Gender-Related Sociocultural Factors in Clinical Decision-Making for Older Adults Using a Prescribing Cascade Vignette: A Transnational Qualitative Study
Despite growing awareness of sex differences in inappropriate prescribing among older adults, including the initiation of ...
Assessing Frailty-Specific Treatment Effect in Cardiovascular Disease: A Systematic Review
Assessing Frailty-Specific Treatment Effect in Cardiovascular Disease: A Systematic Review
Clinicians are increasingly considering using frailty assessments to individualize treatment for older patients. It remain...
Development of a Frailty Screening Tool Using Electronic Community Pharmacy Records
Development of a Frailty Screening Tool Using Electronic Community Pharmacy Records
Frailty is associated with increased susceptibility to medication-related harm, highlighting the importance of medication ...
Pharmacological Treatment of Obesity in Older Adults
Pharmacological Treatment of Obesity in Older Adults
Obesity is a complex health issue with growing prevalence worldwide. It is also becoming more prevalent in the population ...
Pilocarpine in the Treatment of Presbyopia: Progress, Issues, and Future Prospects
Pilocarpine in the Treatment of Presbyopia: Progress, Issues, and Future Prospects
Presbyopia is a common age-related visual impairment. With the aging of the population, the incidence of presbyopia is inc...
Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults
Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults
Approximately one in three older adults (aged 65 years and over) experience pain, negatively impacting their quality of li...
Assessing Long-Term Adverse Outcomes in Older Kidney Transplant Recipients: A Propensity Score-Matched Comparison of Early Steroid Withdrawal Versus Continuous Steroid Immunosuppression Using a Large Real-World Database
Assessing Long-Term Adverse Outcomes in Older Kidney Transplant Recipients: A Propensity Score-Matched Comparison of Early Steroid Withdrawal Versus Continuous Steroid Immunosuppression Using a Large Real-World Database
Steroids are widely used in maintenance immunosuppression treatment in kidney transplant recipients. Older individuals und...
Prevalence of Adverse Drug Reactions in Hospital Among Older Patients with and Without Dementia
Prevalence of Adverse Drug Reactions in Hospital Among Older Patients with and Without Dementia
Older inpatients with dementia are at an increased risk of an adverse drug reaction (ADR) during hospitalization. To quant...
Co-Designing a Consult Patient Decision Aid for Continuation Versus Deprescribing Cholinesterase Inhibitors in People Living with Dementia
Co-Designing a Consult Patient Decision Aid for Continuation Versus Deprescribing Cholinesterase Inhibitors in People Living with Dementia
As dementia progresses, people living with dementia may take high-risk, unnecessary, or ineffective medicines. Cholinester...
Fall Outcomes in Older Adults Following Benzodiazepine/Z-Drug Discontinuation: A Retrospective Cohort Study in an Academic Health System
Fall Outcomes in Older Adults Following Benzodiazepine/Z-Drug Discontinuation: A Retrospective Cohort Study in an Academic Health System
Benzodiazepines and z-drugs increase the fall risk in older adults. There is a lack of real-world data examining the assoc...
Oral Corticosteroids for Skin Disease in the Older Population: Minimizing Potential Adverse Effects
Oral Corticosteroids for Skin Disease in the Older Population: Minimizing Potential Adverse Effects
Corticosteroids play a crucial role as anti-inflammatory and immunomodulatory agents in dermatology and other medical spec...
Trends in Drug Duplications in Swedish Older Adults: A Nationwide Register Study from 2006 to 2021
Trends in Drug Duplications in Swedish Older Adults: A Nationwide Register Study from 2006 to 2021
Drug duplication (DD), the use of two identical drugs simultaneously, is a medication error increasing the risk of adverse...
Prospective Monitoring of New Drugs in Older Adults with and without Frailty: Near-Real-Time Assessment of Effectiveness and Safety of Oral Anticoagulants in Medicare Data
Prospective Monitoring of New Drugs in Older Adults with and without Frailty: Near-Real-Time Assessment of Effectiveness and Safety of Oral Anticoagulants in Medicare Data
Prospective sequential analyses after a new drug approval allow proactive surveillance of new drugs. In the current study,...
Correction: Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options
Correction: Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options
Illustration of intravesical drug delivery via a transurethral catheter in female mice. Combined instillation of paramagne...
Decreased Kidney Function Explains Higher Vancomycin Exposure in Older Adults
Decreased Kidney Function Explains Higher Vancomycin Exposure in Older Adults
Older adults face a higher risk of vancomycin-related toxicity given their (patho)-physiological changes, making early man...
Direct Oral Anticoagulants in Older and Frail Patients with Atrial Fibrillation: A Decade of Experience
Direct Oral Anticoagulants in Older and Frail Patients with Atrial Fibrillation: A Decade of Experience
Both the prevalence of atrial fibrillation (AF) and its subsequent use of direct oral anticoagulants (DOACs) are rapidly i...
Treating Hypercholesterolemia in Older Adults for Primary Prevention of Cardiovascular Events
Treating Hypercholesterolemia in Older Adults for Primary Prevention of Cardiovascular Events
As the population ages, the demographic of adults aged 75 years and older in the U.S. is projected to grow to 45 ...
Efficacy and safety of insomnia treatment with lemborexant in older adults: analyses from three clinical trials
Efficacy and safety of insomnia treatment with lemborexant in older adults: analyses from three clinical trials
Insomnia is more common as people age. Several common hypnotics used to treat insomnia often do not adequately alleviate s...
The Relationship Between Antipsychotics, Cognitive Enhancers, and Major Adverse Cardiovascular/Cerebrovascular Events (MACCE) in Older Adults with Behavioral and Psychological Symptoms of Dementia
The Relationship Between Antipsychotics, Cognitive Enhancers, and Major Adverse Cardiovascular/Cerebrovascular Events (MACCE) in Older Adults with Behavioral and Psychological Symptoms of Dementia
Antipsychotics and cognitive enhancers are often used to treat psychosis and behavioral disturbances in individuals with d...
Real-World Drug Survival of Biologics and Targeted Synthetic Disease-Modifying Anti-rheumatic Drugs Among Patients with Psoriatic Arthritis
Real-World Drug Survival of Biologics and Targeted Synthetic Disease-Modifying Anti-rheumatic Drugs Among Patients with Psoriatic Arthritis
While the variety of biologics (b) and targeted synthetic (ts) disease-modifying anti-rheumatic drugs (DMARDs) available f...
Low-Dose Glucocorticoids in Older Patients with Rheumatoid Arthritis: What Does the Evidence Say?
Low-Dose Glucocorticoids in Older Patients with Rheumatoid Arthritis: What Does the Evidence Say?
The short-term use of glucocorticoids (GCs) in combination with methotrexate was recommended for the initial treatment of ...
Managing Gout in Patients with Metabolic Syndrome
Managing Gout in Patients with Metabolic Syndrome
Gout is characterized by monosodium urate (MSU) crystal deposition secondary to hyperuricemia. Gout is associated with met...
Prescribing Appropriate Medicines to Older Adults: A Finnish Experience with the Web-Based Meds75+ Database
Prescribing Appropriate Medicines to Older Adults: A Finnish Experience with the Web-Based Meds75+ Database
The Finnish web-based Meds75+ database supports rational, safe and appropriate prescribing to older adults in primary care...
Pre-clinical Models for Geriatric Pharmacotherapy
Pre-clinical Models for Geriatric Pharmacotherapy
With ageing of the population worldwide and discovery of new medications for prevention and management of age-related cond...
The Association of Gabapentin Initiation with Cognitive and Behavioral Changes in Older Adults with Cognitive Impairment: A Retrospective Cohort Study
The Association of Gabapentin Initiation with Cognitive and Behavioral Changes in Older Adults with Cognitive Impairment: A Retrospective Cohort Study
Although gabapentin has been increasingly prescribed to older adults, the relation between gabapentin initiation and longe...
Use of Muscle Relaxants After Surgery in Traditional Medicare Part D Enrollees
Use of Muscle Relaxants After Surgery in Traditional Medicare Part D Enrollees
Surgeons have come under increased scrutiny for postoperative pain management, particularly for opioid prescribing. To dec...
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