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Pre-clinical Models for Geriatric Pharmacotherapy
Pre-clinical Models for Geriatric Pharmacotherapy
With ageing of the population worldwide and discovery of new medications for prevention and management of age-related cond...
The Association of Gabapentin Initiation with Cognitive and Behavioral Changes in Older Adults with Cognitive Impairment: A Retrospective Cohort Study
The Association of Gabapentin Initiation with Cognitive and Behavioral Changes in Older Adults with Cognitive Impairment: A Retrospective Cohort Study
Although gabapentin has been increasingly prescribed to older adults, the relation between gabapentin initiation and longe...
Use of Muscle Relaxants After Surgery in Traditional Medicare Part D Enrollees
Use of Muscle Relaxants After Surgery in Traditional Medicare Part D Enrollees
Surgeons have come under increased scrutiny for postoperative pain management, particularly for opioid prescribing. To dec...
Development of a Predictive Model for Potentially Inappropriate Medications in Older Patients with Cardiovascular Disease
Development of a Predictive Model for Potentially Inappropriate Medications in Older Patients with Cardiovascular Disease
Older patients with cardiovascular disease (CVD) are highly susceptible to adverse drug reactions due to age-related physi...
Prevention of Chronic Kidney Disease and Its Complications in Older Adults
Prevention of Chronic Kidney Disease and Its Complications in Older Adults
In an era marked by a global demographic shift towards an aging society, there is a heightened prevalence of chronic kidne...
Prevalence and Factors Associated with De-escalation of Anti-TNFs in Older Adults with Rheumatoid Arthritis: A Medicare Claims-Based Observational Study
Prevalence and Factors Associated with De-escalation of Anti-TNFs in Older Adults with Rheumatoid Arthritis: A Medicare Claims-Based Observational Study
The aim was to evaluate prevalence and factors associated with anti-tumor necrosis factor (anti-TNF) de-escalation in olde...
Exploring Antipsychotic Use for Delirium Management in Adults in Hospital, Sub-Acute Rehabilitation and Aged Care Settings: A Systematic Literature Review
Exploring Antipsychotic Use for Delirium Management in Adults in Hospital, Sub-Acute Rehabilitation and Aged Care Settings: A Systematic Literature Review
International guidelines discourage antipsychotic use for delirium; however, concerns persist about their continued use in...
Validation of MyFORTA: An Automated Tool to Improve Medications in Older People Based on the FORTA List
Validation of MyFORTA: An Automated Tool to Improve Medications in Older People Based on the FORTA List
Listing tools have been developed to improve medications in older patients, including the Fit fOR The Aged (FORTA) list, a...
Relationship Between Frailty and Diabetic Pharmacologic Therapy in Older Adults with Type 2 Diabetes: A Cross-Sectional Study
Relationship Between Frailty and Diabetic Pharmacologic Therapy in Older Adults with Type 2 Diabetes: A Cross-Sectional Study
Older adults with diabetes mellitus require drug treatment considering their frailty, cognitive function, and hypoglycemia...
Associations Between Midlife Anticholinergic Medication Use and Subsequent Cognitive Decline: A British Birth Cohort Study
Associations Between Midlife Anticholinergic Medication Use and Subsequent Cognitive Decline: A British Birth Cohort Study
Anticholinergic medication use is associated with cognitive decline and incident dementia. Our study, a prospective birth&...
Toxicity in Older Patients with Cancer Receiving Immunotherapy: An Observational Study
Toxicity in Older Patients with Cancer Receiving Immunotherapy: An Observational Study
Checkpoint inhibition has emerged as an effective treatment strategy for a variety of cancers, including in older adults. ...
Measuring Quality of Life in Deprescribing Trials: A Scoping Review
Measuring Quality of Life in Deprescribing Trials: A Scoping Review
Quality of life (QoL) is an important outcome to capture in clinical trials evaluating deprescribing interventions. We aim...
Respiratory Syncytial Virus Infection in Older Adults: An Update
Respiratory Syncytial Virus Infection in Older Adults: An Update
Respiratory syncytial virus (RSV) infection represents one of the most common infections during childhood, with significan...
Rosacea in Older Adults and Pharmacologic Treatments
Rosacea in Older Adults and Pharmacologic Treatments
Rosacea is a chronic inflammatory skin condition that is often more severe in older patients. The main clinical features a...
Association of Tumor Necrosis Factor-α Inhibitors with Incident Dementia: Analysis Based on Population-Based Cohort Studies
Association of Tumor Necrosis Factor-α Inhibitors with Incident Dementia: Analysis Based on Population-Based Cohort Studies
Preliminary evidence suggests a possible preventive effect of tumor necrosis factor-α inhibitors (TNFi) on incident d...
Lipid-Lowering Medications are Associated with Reduced Sarcopenia-Related Quality of Life in Older Adults with Hyperlipidemia
Lipid-Lowering Medications are Associated with Reduced Sarcopenia-Related Quality of Life in Older Adults with Hyperlipidemia
Statins medications negatively affect age-associated loss of muscle mass and strength, termed sarcopenia, and neuromuscula...
Patterns of Comorbidities and Prescribing and Dispensing of Non-steroidal Anti-inflammatory Drugs (NSAIDs) Among Patients with Osteoarthritis in the USA: Real-World Study
Patterns of Comorbidities and Prescribing and Dispensing of Non-steroidal Anti-inflammatory Drugs (NSAIDs) Among Patients with Osteoarthritis in the USA: Real-World Study
Osteoarthritis (OA) is a major cause of chronic pain. Non-steroidal anti-inflammatory drugs (NSAIDs) are analgesics common...
Older Canadians’ Perceptions of the Safety, Effectiveness and Accessibility of Cannabis for Medicinal Purposes: A Cross-Sectional Analysis
Older Canadians’ Perceptions of the Safety, Effectiveness and Accessibility of Cannabis for Medicinal Purposes: A Cross-Sectional Analysis
Cannabis use is increasing among older adults, with use primarily for medicinal purposes. Much of the evidence on percepti...
Cumulative Anticholinergic Burden and its Predictors among Older Adults with Alzheimer’s Disease Initiating Cholinesterase Inhibitors
Cumulative Anticholinergic Burden and its Predictors among Older Adults with Alzheimer’s Disease Initiating Cholinesterase Inhibitors
Cumulative anticholinergic burden refers to the cumulative effect of multiple medications with anticholinergic properties....
Management of Scleritis in Older Adults
Management of Scleritis in Older Adults
Scleritis, an inflammatory disease of the eye affecting scleral tissue, presents unique challenges in the older adult popu...
Safety and Efficacy of Cenobamate for the Treatment of Focal Seizures in Older Patients: Post Hoc Analysis of a Phase III, Multicenter, Open-Label Study
Safety and Efficacy of Cenobamate for the Treatment of Focal Seizures in Older Patients: Post Hoc Analysis of a Phase III, Multicenter, Open-Label Study
Cenobamate is an antiseizure medication (ASM) approved in the US and Europe for the treatment of uncontrolled focal seizur...
Real-World Experience of Immune-Checkpoint Inhibitors in Older Patients with Advanced Cutaneous Squamous Cell Carcinoma
Real-World Experience of Immune-Checkpoint Inhibitors in Older Patients with Advanced Cutaneous Squamous Cell Carcinoma
Older patients are often underrepresented in clinical trials owing to exclusionary comorbidities, which are more common wi...
Post-Stroke Depression in Older Adults: An Overview
Post-Stroke Depression in Older Adults: An Overview
Detailed data on post-stroke depression (PSD) in older adults are limited in spite of the high vulnerability of this popul...
The Difficulties of Managing Pain in People Living with Frailty: The Potential for Digital Phenotyping
The Difficulties of Managing Pain in People Living with Frailty: The Potential for Digital Phenotyping
Pain and frailty are closely linked. Chronic pain is a risk factor for frailty, and frailty is a risk factor for pain. Peo...
Impact of Immunosenescence in Older Kidney Transplant Recipients: Associated Clinical Outcomes and Possible Risk Stratification for Immunosuppression Reduction
Impact of Immunosenescence in Older Kidney Transplant Recipients: Associated Clinical Outcomes and Possible Risk Stratification for Immunosuppression Reduction
The number of older individuals receiving a kidney transplant as replacement therapy has significantly increased in the pa...
Proton Pump Inhibitor Use and the Risk of Cardiovascular Complications and Death in Older Adults with Diabetes: A Population-Based Cohort Study
Proton Pump Inhibitor Use and the Risk of Cardiovascular Complications and Death in Older Adults with Diabetes: A Population-Based Cohort Study
The unfavorable effect of proton pump inhibitors (PPIs) on cardiovascular (CV) outcomes and mortality was reported in the ...
Helicobacter pylori Eradication Treatment in Older Patients
Helicobacter pylori Eradication Treatment in Older Patients
Helicobacter pylori is the main etiopathogenetic factor of chronic gastritis, peptic ulcer disease and gastric cancer. The...
Development and Pilot Testing of an Algorithm-Based Approach to Anticholinergic Deprescribing in Older Patients
Development and Pilot Testing of an Algorithm-Based Approach to Anticholinergic Deprescribing in Older Patients
Adverse anticholinergic drug reactions are common, yet evidence on how to reduce exposure to anticholinergic activity and ...
The Current Landscape of Pharmacotherapies for Sarcopenia
The Current Landscape of Pharmacotherapies for Sarcopenia
Sarcopenia is a skeletal muscle disorder characterized by progressive and generalized decline in muscle mass and function....
Are Lists of Potentially Inappropriate Medications Associated with Hospital Readmissions? A Systematic Review
Are Lists of Potentially Inappropriate Medications Associated with Hospital Readmissions? A Systematic Review
Suboptimal prescribing, including the prescription of potentially inappropriate medications (PIM), is frequent in patients...
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