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Geometric deep learning methods and applications in 3D structure-based drug design
Geometric deep learning methods and applications in 3D structure-based drug design
Geometric deep learning, which is one of 15 important research directions of artificial intelligence (AI),(p1) can learn h...
Design of greener drugs: aligning parameters in pharmaceutical R&D and drivers for environmental impact
Design of greener drugs: aligning parameters in pharmaceutical R&D and drivers for environmental impact
Rodrigo Vidaurre is a hydrogeologist and senior fellow at the Ecologic Institute, a nonprofit institute for environmental ...
Targeting furin, a cellular proprotein convertase, for COVID-19 prevention and therapeutics
Targeting furin, a cellular proprotein convertase, for COVID-19 prevention and therapeutics
In March 2020, the World Health Organization (WHO) declared a global pandemic of the novel coronavirus-related pneumonia, ...
An exploration of alternative therapeutic targets for aortic disease in Marfan syndrome
An exploration of alternative therapeutic targets for aortic disease in Marfan syndrome
Marfan syndrome (MFS, OMIM #154700) is an autosomal dominant connective tissue disorder, with an estimated prevalence of a...
All-in-one nanotheranostic platform based on tumor microenvironment: new strategies in multimodal imaging and therapeutic protocol
All-in-one nanotheranostic platform based on tumor microenvironment: new strategies in multimodal imaging and therapeutic protocol
The progression of tumorigenesis, metastasis, and immune escape are closely related to the tumor microenvironment (TME) to...
The importance of a go-to-market strategy in the commercialisation of cellular immunotherapies
The importance of a go-to-market strategy in the commercialisation of cellular immunotherapies
Cellular immunotherapy (CIT) has both demonstrated outstanding levels of efficacy in cancer and presented unique commercia...
Harnessing the role of microneedles as sensors: current status and future perspectives
Harnessing the role of microneedles as sensors: current status and future perspectives
The discovery of microneedles (MNs) has provided a new opportunity in healthcare diagnostics as a technology that enables ...
Enzyme-responsive liposomes for controlled drug release
Enzyme-responsive liposomes for controlled drug release
Liposomes were discovered by Alec D. Bangham in 1965.(p1) Liposomal vesicles are generally formulated with biocompatible l...
The role of RIPK1 in chronic obstructive pulmonary disease
The role of RIPK1 in chronic obstructive pulmonary disease
The lungs are vital organs that are composed of diverse cell types and that are continuously exposed to harmful inhalants ...
Premix technologies for drug delivery: manufacturing, applications, and opportunities in regulatory filing
Premix technologies for drug delivery: manufacturing, applications, and opportunities in regulatory filing
The ever-evolving field of drug delivery is always in need of novel and cost-effective strategies for the delivery of comp...
Text summarization with ChatGPT for drug labeling documents
Text summarization with ChatGPT for drug labeling documents
KeywordsChatGPTtext summarizationdocument summarizationnatural language processing (NLP)artificial intelligence (AI)large ...
Vaginal drug delivery system: A promising route of drug administration for local and systemic diseases
Vaginal drug delivery system: A promising route of drug administration for local and systemic diseases
Modern scientific interventions focus on women’s health as a milestone in improving the world’s health index. Women’s heal...
Making good decisions in early drug discovery
Making good decisions in early drug discovery
Drug discovery is a discipline characterized by much uncertainty, choice and potential. Human biology is still only margin...
The IDMP Ontology – A Catalyst to Unleash the Potential of AI and Accelerate Data-Driven Decisions with Industry-Wide Standards
The IDMP Ontology – A Catalyst to Unleash the Potential of AI and Accelerate Data-Driven Decisions with Industry-Wide Standards
Over the past decade, the pharmaceutical industry has witnessed a significant shift towards data-centric digital transform...
Impact of the diseased lung microenvironment on the in vivo fate of inhaled particles
Impact of the diseased lung microenvironment on the in vivo fate of inhaled particles
Respiratory diseases have become an important public health problem worldwide as a result of the increasingly serious leve...
Artificial intelligence in drug discovery: A mirage or an oasis?
Artificial intelligence in drug discovery: A mirage or an oasis?
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Growing value of data standardization: Allotrope Foundation Connect Workshop Proceedings
Growing value of data standardization: Allotrope Foundation Connect Workshop Proceedings
The ability to correlate data with contextual information across systems impacts our ability to make sound data-driven dec...
How health technology assessment can help to address challenges in drug repurposing: a conceptual framework
How health technology assessment can help to address challenges in drug repurposing: a conceptual framework
Drug repurposing faces various challenges that can impede its success. We developed a framework outlining key challenges i...
How successful are AI-discovered drugs in clinical trials? A first analysis and emerging lessons
How successful are AI-discovered drugs in clinical trials? A first analysis and emerging lessons
AI techniques are making inroads into the field of drug discovery. As a result, a growing number of drugs and vaccines hav...
A retrospective regulatory analysis of FDA recalls carried out by pharmaceutical companies from 2012 to 2023
A retrospective regulatory analysis of FDA recalls carried out by pharmaceutical companies from 2012 to 2023
To introduce products in the US market, pharmaceutical companies must first obtain FDA clearance. Manufacturers might reca...
Development and therapeutic implications of small molecular inhibitors that target calcium-related channels in tumor treatment
Development and therapeutic implications of small molecular inhibitors that target calcium-related channels in tumor treatment
Intracellular calcium, functioning as a second messenger, plays a pivotal role in regulating fundamental cellular function...
The present state and challenges of active learning in drug discovery
The present state and challenges of active learning in drug discovery
The primary objective of drug discovery is to pinpoint specific target molecules possessing desirable characteristics, suc...
A new era of antibody discovery: an in-depth review of AI-driven approaches
A new era of antibody discovery: an in-depth review of AI-driven approaches
Antibodies(p1),(p2),(p3),(p4),(p5),(p6) are Y-shaped proteins produced by plasma B cells, essential for immune defense.(p7...
TPP-based conjugates: potential targeting ligands
TPP-based conjugates: potential targeting ligands
As one of the most significant organelles in eukaryotic cells, mitochondria have a distinctive role and structure in lipid...
From GPUs to AI and quantum: three waves of acceleration in bioinformatics
From GPUs to AI and quantum: three waves of acceleration in bioinformatics
BertilSchmidt is tenured full professor of high-performance computing at Johannes Gutenberg University Mainz and an adjunc...
Unleashing the power of generative AI in drug discovery
Unleashing the power of generative AI in drug discovery
AntonioLavecchia Professor of Medicinal Chemistry and Head of the Drug Discovery Laboratory at the Department of Pharmacy,...
Thyroid receptor β: A promising target for developing novel anti-androgenetic alopecia drugs
Thyroid receptor β: A promising target for developing novel anti-androgenetic alopecia drugs
Androgenetic alopecia (AGA), also known as seborrheic alopecia or male pattern baldness, is the most prevalent form of alo...
AXL receptor as an emerging molecular target in colorectal cancer
AXL receptor as an emerging molecular target in colorectal cancer
The AXL receptor has been demonstrated to be overexpressed in several types of human solid and hematological malignancies,...
Recent advances in the development of DprE1 inhibitors using AI/CADD approaches
Recent advances in the development of DprE1 inhibitors using AI/CADD approaches
Tuberculosis (TB) remains one of the most lethal diseases worldwide,(p1) with >10 million new cases and ∼1.5 million de...
Targeting EED as a key PRC2 complex mediator toward novel epigenetic therapeutics
Targeting EED as a key PRC2 complex mediator toward novel epigenetic therapeutics
Polycomb repressive complex 2 (PRC2) is a major multiprotein transcriptional-repressive complex that mediates the monometh...