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The potential effectiveness of tolvaptan in critically ill patients including cardiac and noncardiac populations: a retrospective observational study
The potential effectiveness of tolvaptan in critically ill patients including cardiac and noncardiac populations: a retrospective observational study
We investigated the potential diuretic effectiveness of the selective arginine vasopressin 2 receptor antagonist tolvaptan...
Alpha-lipoic acid, as an effective agent against toxic elements: a review
Alpha-lipoic acid, as an effective agent against toxic elements: a review
This review aims to evaluate the efficacy of alpha-lipoic acid (ALA) in combating toxic elements, such as aluminum, arseni...
Radiation-induced nanogel engineering based on pectin for pH-responsive rutin delivery for cancer treatment
Radiation-induced nanogel engineering based on pectin for pH-responsive rutin delivery for cancer treatment
This research investigates the formulation of a nanogel complex using pectin and poly(acrylic acid) (PAAc) to encapsulate ...
Legal and scientific deficiencies of drug advertisements on German television
Legal and scientific deficiencies of drug advertisements on German television
Drug advertising primarily serves to publicize the product and increase sales. The legal requirements in the Therapeutic P...
Review on recent advancements in understanding acetylsalicylic acid-induced gastrointestinal injury: mechanisms, medication, and dosage refinement
Review on recent advancements in understanding acetylsalicylic acid-induced gastrointestinal injury: mechanisms, medication, and dosage refinement
Acetylsalicylic acid (ASA) is a clinical drug with multiple effects, including prevention of cardiovascular adverse events...
Oxindole derivatives alleviate paracetamol-induced nephrotoxicity and hepatotoxicity: biochemical, histological, and computational expressions
Oxindole derivatives alleviate paracetamol-induced nephrotoxicity and hepatotoxicity: biochemical, histological, and computational expressions
Oxindole is a nature-derived heteroaromatic nucleus with a history of preclinical uses in various conditions. In this stud...
Long-term effects of sub-chronic exposure to L-NAME on reproductive system of male rats
Long-term effects of sub-chronic exposure to L-NAME on reproductive system of male rats
Nω-nitro-l-arginine methyl ester (L-NAME) has been utilized as a nitric oxide synthase antagonist for many years in b...
Identification of potential mechanisms of Schisandrin B in the treatment of idiopathic pulmonary fibrosis by integrating network pharmacology and experimental validation
Identification of potential mechanisms of Schisandrin B in the treatment of idiopathic pulmonary fibrosis by integrating network pharmacology and experimental validation
Idiopathic pulmonary fibrosis (IPF) is a worsening fibrotic condition characterized by a short survival rate and limited t...
A double-edged sword effect of silver nanoparticles on angiogenesis in 4T1 breast cancer-bearing mice
A double-edged sword effect of silver nanoparticles on angiogenesis in 4T1 breast cancer-bearing mice
Silver nanoparticles (AgNPs) are increasingly known to have anticancer effects, but few studies have examined their advers...
Evaluation of pathways involved in the protective effect of trans sodium crocetinate against contrast-induced nephropathy in rats
Evaluation of pathways involved in the protective effect of trans sodium crocetinate against contrast-induced nephropathy in rats
Contrast-induced nephropathy (CIN) is the most important side effect following contrast media application. The purpose of ...
Sennoside A represses the malignant phenotype and tumor immune microenvironment of non-small cell lung cancer cells by inhibiting the TRAF6/NF-κB pathway
Sennoside A represses the malignant phenotype and tumor immune microenvironment of non-small cell lung cancer cells by inhibiting the TRAF6/NF-κB pathway
Non-small cell lung cancer (NSCLC) is a prominent cause of cancer death worldwide. Sennoside A (SA) is the primary anthraq...
Ameliorative impacts of carvacrol on DNA integrity, oxidative stress, and sperm quality in asthenozoospermic infertile individuals during cryopreservation
Ameliorative impacts of carvacrol on DNA integrity, oxidative stress, and sperm quality in asthenozoospermic infertile individuals during cryopreservation
Nowadays, the cryopreservation process can produce reactive oxygen species (ROS), which cause damage to the motility, cell...
Unleashing the potential of Genistein and its derivatives as effective therapeutic agents for breast cancer treatment
Unleashing the potential of Genistein and its derivatives as effective therapeutic agents for breast cancer treatment
Breast cancer remains one of the leading causes of cancer-related deaths among women worldwide. Genistein (Gen), a phytoes...
Bioinformatics combined with network pharmacology and experimental validation to identify key biomarkers of hepatocellular carcinoma and corresponding compounds in Radix Astragali and Pueraria Mirifica
Bioinformatics combined with network pharmacology and experimental validation to identify key biomarkers of hepatocellular carcinoma and corresponding compounds in Radix Astragali and Pueraria Mirifica
The occurrence and death rates of primary hepatocellular carcinoma (HCC) are increasing, and there remains a shortage of e...
Biofabricated zinc oxide nanoparticles mitigate acrylamide-induced immune toxicity and modulate immune-related genes and microRNA in rats
Biofabricated zinc oxide nanoparticles mitigate acrylamide-induced immune toxicity and modulate immune-related genes and microRNA in rats
This study evaluated the potential efficacy of eco-friendly biofabricated zinc oxide nanoparticles (GS-ZnONP) (10&nbsp...
The decline in the clinical relevance of pilocarpine and physostigmine monitored in pharmacology textbooks from 1878 to 2023: nine take-home messages for future (pharmacology) textbook authors
The decline in the clinical relevance of pilocarpine and physostigmine monitored in pharmacology textbooks from 1878 to 2023: nine take-home messages for future (pharmacology) textbook authors
In a recent study, using hydrogen cyanide as paradigm, we have shown that pharmacological knowledge evolves non-linearly (...
Chlorogenic acid improves urogenital dysfunction induced by exposure to ambient particulate matter
Chlorogenic acid improves urogenital dysfunction induced by exposure to ambient particulate matter
Oxidative stress is a well-known underlying mechanism for several diseases in response to environmental pollution. Althoug...
Substantial non-compliance of online pharmacy catalogues with guidelines
Substantial non-compliance of online pharmacy catalogues with guidelines
Online pharmacies are popular worldwide. In Germany, there were 150 active online pharmacies in 2022. As the competition i...
Antioxidant and anticancer activities of hesperetin and its novel formulations in KB cells
Antioxidant and anticancer activities of hesperetin and its novel formulations in KB cells
This study aimed to formulate the hesperetin nanostructured lipid carriers (NLCs) containing oro-mucosal gel for its activ...
Potential therapeutic impacts of vitamin D on hypothyroid-induced heart and kidney fibrosis and oxidative status in male rat
Potential therapeutic impacts of vitamin D on hypothyroid-induced heart and kidney fibrosis and oxidative status in male rat
There are several interactions between thyroid hormones (THs) and kidney and heart function. Consequently, THs deficit res...
Harnessing the power of miRNAs for precision diagnosis and treatment of male infertility
Harnessing the power of miRNAs for precision diagnosis and treatment of male infertility
Infertility is a multifactorial reproductive system disorder, and most infertility cases occur in men. S...
Effects of quercetin-immobilized albumin cerium oxide nanoparticles on glutamate toxicity: in vitro study
Effects of quercetin-immobilized albumin cerium oxide nanoparticles on glutamate toxicity: in vitro study
One aspect of glutamate (Glut) toxicity may be the opening of the blood-brain barrier to albumin (Al), which in itself can...
Dabigatran attenuates methotrexate-induced hepatotoxicity by regulating coagulation, endothelial dysfunction, and the NF-kB/IL-1β/MCP-1 and TLR4/NLRP3 signaling pathways
Dabigatran attenuates methotrexate-induced hepatotoxicity by regulating coagulation, endothelial dysfunction, and the NF-kB/IL-1β/MCP-1 and TLR4/NLRP3 signaling pathways
This study examines Dabigatran’s (Dab) capacity to mitigate methotrexate (MTX)-induced coagulation disorders and end...
Next-generation cancer nanotherapeutics: Pluronic® F127 based mixed micelles for enhanced drug delivery
Next-generation cancer nanotherapeutics: Pluronic® F127 based mixed micelles for enhanced drug delivery
Cancer, projected to become the second leading cause of mortality globally, underscores the critical need for precise drug...
Paeoniflorin-mediated downregulation of VEGFA: unveiling the therapeutic mechanism of buyang huanwu decoction in diabetic retinopathy
Paeoniflorin-mediated downregulation of VEGFA: unveiling the therapeutic mechanism of buyang huanwu decoction in diabetic retinopathy
Diabetic retinopathy (DR) is a leading cause of blindness globally. Buyang Huanwu decoction (BHD) is a traditional Chinese...
ETS1 promotes cisplatin resistance of NSCLC cells by promoting GRP78 transcription
ETS1 promotes cisplatin resistance of NSCLC cells by promoting GRP78 transcription
Non-small cell lung cancer (NSCLC) is a common malignant tumor characterized by rapid growth and invasive power. Glucose r...
Decursin protects against DSS-induced experimental colitis in mice by inhibiting the cGAS-STING signaling pathway
Decursin protects against DSS-induced experimental colitis in mice by inhibiting the cGAS-STING signaling pathway
While studies have shown that Angelica gigas Nakai (A. gigas) can alleviate ulcerative colitis in mice, the therapeutic ro...
Curcumin ameliorates heatstroke-induced lung injury by activating the PI3K/AKT pathway
Curcumin ameliorates heatstroke-induced lung injury by activating the PI3K/AKT pathway
Heatstroke (HS) poses a significant threat to public health. Curcumin, a polyphenolic compound, has been reported to posse...
In vitro, in vivo and in silico anticancer activity and toxicity of Usnic acid extracted from the mycobiont culture of Usnea baileyi
In vitro, in vivo and in silico anticancer activity and toxicity of Usnic acid extracted from the mycobiont culture of Usnea baileyi
Lichen has widespread uses in indigenous medicinal traditions, and it has been used to treat various conditions. Among the...
Bridging gap in treatment of polycystic ovarian syndrome through drug repurposing: what we achieved and where we are?
Bridging gap in treatment of polycystic ovarian syndrome through drug repurposing: what we achieved and where we are?
Polycystic ovarian syndrome (PCOS) is one of the chief causes of infertility in women of reproductive age. Several drugs b...
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