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In silico method and bioactivity evaluation to discover novel antimicrobial agents targeting FtsZ protein: Machine learning, virtual screening and antibacterial mechanism study
In silico method and bioactivity evaluation to discover novel antimicrobial agents targeting FtsZ protein: Machine learning, virtual screening and antibacterial mechanism study
This research paper utilizes a fused-in-silico approach alongside bioactivity evaluation to identify active FtsZ inhibitor...
Characteristics and trends in adverse drug reactions in Ghana—evidence of spontaneous reports, 2005—2021
Characteristics and trends in adverse drug reactions in Ghana—evidence of spontaneous reports, 2005—2021
Adverse drug reaction (ADR) monitoring is crucial in ensuring patient and pharmaceutical safety. However, there is a lack ...
History of toxicology at the Technical University of Munich (TUM)
History of toxicology at the Technical University of Munich (TUM)
Toxicology at the TUM is mainly associated with the Faculty of Medicine at the Klinikum rechts der Isar (MRI). The Departm...
Deferiprone promoted remyelination and functional recovery through enhancement of oligodendrogenesis in experimental demyelination animal model
Deferiprone promoted remyelination and functional recovery through enhancement of oligodendrogenesis in experimental demyelination animal model
Remyelination refers to myelin regeneration, which reestablishes metabolic supports to axons. However, remyelination often...
Patterns, outcomes, and preventability of clinically manifest drug-drug interactions in older outpatients: a subgroup analysis from a 6-year-long observational study in North India
Patterns, outcomes, and preventability of clinically manifest drug-drug interactions in older outpatients: a subgroup analysis from a 6-year-long observational study in North India
Older adults are vulnerable to adverse drug reactions (ADRs) and drug-drug interactions (DDIs). Evidence on clinically man...
Gestationally administered RAS modulators reprogram endotoxic cardiovascular and inflammatory profiles in adult male offspring of preeclamptic rats
Gestationally administered RAS modulators reprogram endotoxic cardiovascular and inflammatory profiles in adult male offspring of preeclamptic rats
Previous studies showed that preeclampsia (PE) amplifies cardiovascular dysfunction induced by endotoxemia in adult male, ...
Ginsenoside Rb1 reduced ischemic stroke-induced apoptosis through endoplasmic reticulum stress-associated IRE1/TRAF2/JNK pathway
Ginsenoside Rb1 reduced ischemic stroke-induced apoptosis through endoplasmic reticulum stress-associated IRE1/TRAF2/JNK pathway
The neuroprotective function of ginsenoside Rb1 (GRb1) in cerebral ischemia–reperfusion (I/R) was lately emphasized....
Revealing the active ingredients and mechanisms of Xiatianwu against hepatocellular carcinoma: a study based on network pharmacology and bioinformatics
Revealing the active ingredients and mechanisms of Xiatianwu against hepatocellular carcinoma: a study based on network pharmacology and bioinformatics
Xiatianwu is a traditional Chinese medicine. This study investigates the function of Xiatianwu in treating HCC through dat...
Molecular mechanism of geniposide against ANIT-induced intrahepatic cholestasis by integrative analysis of transcriptomics and metabolomics
Molecular mechanism of geniposide against ANIT-induced intrahepatic cholestasis by integrative analysis of transcriptomics and metabolomics
Geniposide (GE), a bioactive compound extracted from the fruit of Gardenia jasminoides Ellis, has attracted significant at...
Paeonol alleviates ox-LDL-induced endothelial cell injury by targeting the heme oxygenase-1/phosphoinositide 3-kinase/protein kinase B pathway
Paeonol alleviates ox-LDL-induced endothelial cell injury by targeting the heme oxygenase-1/phosphoinositide 3-kinase/protein kinase B pathway
Atherosclerosis is a leading cause of vascular disease worldwide. Paeonol has been reported to have therapeutical potentia...
Oswald Schmiedeberg (1838–1921)
Oswald Schmiedeberg (1838–1921)
Oswald Schmiedeberg was born in one of the former Baltic provinces of Russia. He studied medicine in Dorpat (Tartu) and jo...
Ameliorative effect of nodakenin in combating TNBS-induced ulcerative colitis by suppressing NFƙB-mediated NLRP3 inflammasome pathway
Ameliorative effect of nodakenin in combating TNBS-induced ulcerative colitis by suppressing NFƙB-mediated NLRP3 inflammasome pathway
Ulcerative colitis (UC) is an enduring and complex inflammatory bowel disease that is clinically prevalent, progressive, a...
Antiepileptic profile of Parawixin-11, purified from Parawixia bistriata spider venom (Araneae, Araneidae), in Wistar rats
Antiepileptic profile of Parawixin-11, purified from Parawixia bistriata spider venom (Araneae, Araneidae), in Wistar rats
The pharmacological treatment of epilepsy is often complex due to the lack of efficacy in many patients and profound side ...
DDD-costs have a strong influence on antibacterial drug prescription in Germany: a differentiated correlation analysis from 1985 to 2022
DDD-costs have a strong influence on antibacterial drug prescription in Germany: a differentiated correlation analysis from 1985 to 2022
Antibacterial drugs are vital in modern medicine, and understanding the factors influencing their prescriptions is essenti...
Dexmedetomidine on the interplay of IL-6 and STAT3 pathways in adrenal gland damage-induced scalding burns in rats
Dexmedetomidine on the interplay of IL-6 and STAT3 pathways in adrenal gland damage-induced scalding burns in rats
Scalding burns are a common form of thermal injury that often leads to systemic complications. Pro-inflammatory cytokines ...
Renoprotective effects of apocynin and/or umbelliferone against acrylamide-induced acute kidney injury in rats: role of the NLRP3 inflammasome and Nrf-2/HO-1 signaling pathways
Renoprotective effects of apocynin and/or umbelliferone against acrylamide-induced acute kidney injury in rats: role of the NLRP3 inflammasome and Nrf-2/HO-1 signaling pathways
Acrylamide (ACR) is a toxic, probably carcinogenic compound commonly found in fried foods and used in the production of ma...
Natural products and long noncoding RNA signatures in gallbladder cancer: a review focuses on pathogenesis, diagnosis, and drug resistance
Natural products and long noncoding RNA signatures in gallbladder cancer: a review focuses on pathogenesis, diagnosis, and drug resistance
Gallbladder cancer (GBC) is an aggressive and lethal malignancy with a poor prognosis. Long noncoding RNAs (lncRNAs) and n...
Effect of anti-diabetic agent on interstitial lung disease in patients with diabetes mellitus
Effect of anti-diabetic agent on interstitial lung disease in patients with diabetes mellitus
The objective was to assess the protective role of anti-diabetic agent (ADA) in predicting interstitial lung disease (ILD)...
Sotrovimab in the treatment of coronavirus disease-2019 (COVID-19): a systematic review and meta-analysis of randomized clinical trials
Sotrovimab in the treatment of coronavirus disease-2019 (COVID-19): a systematic review and meta-analysis of randomized clinical trials
This study was carried out to verify the evidence regarding the effectiveness and safety of sotrovimab in patients with CO...
Perioperative complications of middle cerebral artery occlusion in rats alleviated by human umbilical cord mesenchymal stem cells
Perioperative complications of middle cerebral artery occlusion in rats alleviated by human umbilical cord mesenchymal stem cells
For acute ischemic stroke treatment, the limitations of treatment methods and the high incidence of perioperative complica...
The quassinoids bruceines A–M: pharmacology, mechanism of action, synthetic advance, and pharmacokinetics—a review
The quassinoids bruceines A–M: pharmacology, mechanism of action, synthetic advance, and pharmacokinetics—a review
Bruceines A–L are among the quassinoid representatives found in the medicinal plant Brucea javanica (L.). An overvie...
Epicatechin as a promising agent against arsenic-induced neurobehavioral toxicity in NMRI mice: behavioral and biochemical alterations
Epicatechin as a promising agent against arsenic-induced neurobehavioral toxicity in NMRI mice: behavioral and biochemical alterations
Epicatechin (Epi) is one of the most abundant flavonoids present in different fruits and tea leaves. Emerging research ill...
A critical appraisal on the involvement of plant-based extracts as neuroprotective agents (2012–2022): an effort to ease out decision-making process for researchers
A critical appraisal on the involvement of plant-based extracts as neuroprotective agents (2012–2022): an effort to ease out decision-making process for researchers
The purpose of this review study is to provide a condensed compilation of 164 medicinal plants that have been investigated...
Celecoxib inhibits NLRP1 inflammasome pathway in MDA-MB-231 Cells
Celecoxib inhibits NLRP1 inflammasome pathway in MDA-MB-231 Cells
NLRP1 is predominantly overexpressed in breast cancer tissue, and the evaluated activation of NLRP1 inflammasome is associ...
Paclitaxel in colon cancer management: from conventional chemotherapy to advanced nanocarrier delivery systems
Paclitaxel in colon cancer management: from conventional chemotherapy to advanced nanocarrier delivery systems
Paclitaxel, a potent chemotherapeutic agent derived from the bark of the Pacific yew tree, has demonstrated significant ef...
Promising the potential of β-caryophyllene on mercury chloride–induced alteration in cerebellum and spinal cord of young Wistar albino rats
Promising the potential of β-caryophyllene on mercury chloride–induced alteration in cerebellum and spinal cord of young Wistar albino rats
Mercury chloride (ME) is a chemical pollutant commonly found in the environment, which can contribute to undesirable healt...
The power of trans-sodium crocetinate: exploring its renoprotective effects in a rat model of colistin-induced nephrotoxicity
The power of trans-sodium crocetinate: exploring its renoprotective effects in a rat model of colistin-induced nephrotoxicity
Colistin, a multidrug-resistant gram-negative bacterial infection medication, has been associated with renal impairment an...
The effects of empagliflozin on ventricular arrhythmias in heart failure patients with an implantable cardioverter-defibrillator: a double-blind randomized controlled trial
The effects of empagliflozin on ventricular arrhythmias in heart failure patients with an implantable cardioverter-defibrillator: a double-blind randomized controlled trial
Sodium-glucose transporter 2 (SGLT2) inhibitors such as empagliflozin are one of the main treatments for type 2 diabetes m...
MicroRNA-143 overexpression enhances the chemosensitivity of A172 glioblastoma cells to carmustine
MicroRNA-143 overexpression enhances the chemosensitivity of A172 glioblastoma cells to carmustine
As an aggressive malignancy, glioblastoma multiforme (GBM) is the most common type of brain tumor. The existing treatments...
Methane-rich saline ameliorates depressive-like behaviors during chronic unpredictable mild stress (CUMS)
Methane-rich saline ameliorates depressive-like behaviors during chronic unpredictable mild stress (CUMS)
Depression, considered the most prevalent neuropsychiatric disorder, is multifactorial and complex. Oxidative stress and i...
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