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Synthesis and antimicrobial evaluation of a new hybrid bis-cyanoacrylamide-based-piperazine containing sulphamethoxazole moiety against rheumatoid arthritis-associated pathogens
Synthesis and antimicrobial evaluation of a new hybrid bis-cyanoacrylamide-based-piperazine containing sulphamethoxazole moiety against rheumatoid arthritis-associated pathogens
Piperazine-based compounds have garnered significant attention due to their notable biological and pharmacological activit...
Platelet-rich plasma alleviates skin photoaging by activating autophagy and inhibiting inflammasome formation
Platelet-rich plasma alleviates skin photoaging by activating autophagy and inhibiting inflammasome formation
Platelet-rich plasma (PRP) holds promising prospects for the treatment of skin photoaging. This study aims to unravel the ...
In silico and in vitro evaluation of the potential genotoxic impurities of vildagliptin
In silico and in vitro evaluation of the potential genotoxic impurities of vildagliptin
Establishing the safety of impurities in drug substances or products is crucial. The assessment of genotoxicity for these ...
Recent advances in therapeutic strategies of Erdheim-Chester disease
Recent advances in therapeutic strategies of Erdheim-Chester disease
Erdheim-Chester disease (ECD) is a rare form of non-LCH characterized by excessive accumulation of histiocytes in various ...
Pharmacokinetics and bioequivalence evaluation of two oral formulations of topiramate tablets in healthy Chinese male volunteers under fasting and fed conditions
Pharmacokinetics and bioequivalence evaluation of two oral formulations of topiramate tablets in healthy Chinese male volunteers under fasting and fed conditions
Topiramate is an antiepileptic drug (AED) that is effective in treating various types of epilepsy. This study evaluated th...
Oral supplementation of curcumin-encapsulated chitosan nanoconjugates as an innovative strategy for mitigating nickel-mediated hepatorenal toxicity in rats
Oral supplementation of curcumin-encapsulated chitosan nanoconjugates as an innovative strategy for mitigating nickel-mediated hepatorenal toxicity in rats
Nickel pollution adversely affects human health and causes various disorders, mainly hepatic and renal dysfunction. The pr...
The impact of graphene oxide nanoparticles on the migratory behavior of metastatic human breast cancer cell, MDA-MB-231
The impact of graphene oxide nanoparticles on the migratory behavior of metastatic human breast cancer cell, MDA-MB-231
Breast cancer (BC) with aggressive metastasis is a serious ongoing public health problem among women. Graphene oxide (GO) ...
Icariin mediates autophagy and apoptosis of hepatocellular carcinoma cells induced by the β-catenin signaling pathway through lncRNA LOXL1-AS1
Icariin mediates autophagy and apoptosis of hepatocellular carcinoma cells induced by the β-catenin signaling pathway through lncRNA LOXL1-AS1
To investigate the effect of icariin (ICA) on hepatocellular carcinoma (HCC) and its autophagy/apoptosis mechanism in HCC....
Weekly administration of betulinic acid prevents development of chronic renal failure from acute renal failure in folic acid-induced mouse model of kidney injury
Weekly administration of betulinic acid prevents development of chronic renal failure from acute renal failure in folic acid-induced mouse model of kidney injury
Betulinic acid (BA) has been shown to exhibit various pharmacological activities and it has shown the protective effect on...
Nobiletin reduces 5-FU-induced lung injury with antioxidative, anti-inflammatory and anti-apoptotic activities
Nobiletin reduces 5-FU-induced lung injury with antioxidative, anti-inflammatory and anti-apoptotic activities
Like other chemotherapeutic agents, 5-fluorouracil (5-FU) targets cancerous cells, but it also causes many unwanted side e...
Liraglutide mitigates dexamethasone-induced fatty acid synthase (FASN) and the cluster of differentiation36 (CD36) expression: a potential treatment for glucocorticoid-induced non-alcoholic fatty liver disease (NAFLD)
Liraglutide mitigates dexamethasone-induced fatty acid synthase (FASN) and the cluster of differentiation36 (CD36) expression: a potential treatment for glucocorticoid-induced non-alcoholic fatty liver disease (NAFLD)
The clinical use of dexamethasone (DXM) is associated with the development of non-alcoholic fatty liver disease (NAFLD). H...
Taurine protection attenuates bisphenol-A-induced behavioral, neurochemical, and histopathological alterations in male rats
Taurine protection attenuates bisphenol-A-induced behavioral, neurochemical, and histopathological alterations in male rats
Due to the continuous exposure to bisphenol-A (BPA), the current study was conducted to evaluate taurine’s neuroprot...
Nanoparticle innovations in targeted cancer therapy: advancements in antibody–drug conjugates
Nanoparticle innovations in targeted cancer therapy: advancements in antibody–drug conjugates
Antibody–drug conjugates (ADCs) have emerged as a promising strategy in targeted cancer therapy, enabling the precis...
Natural products and long non-coding RNAs in prostate cancer: insights into etiology and treatment resistance
Natural products and long non-coding RNAs in prostate cancer: insights into etiology and treatment resistance
Globally, the incidence and death rates associated with cancer persist in rising, despite considerable advancements in can...
Innovating alopecia treatment: nanostructured lipid carriers as advanced delivery platforms
Innovating alopecia treatment: nanostructured lipid carriers as advanced delivery platforms
Alopecia, a common dermatological condition, poses significant psychological and social challenges. Despite the availabili...
Ranolazine effectively improves clinical symptoms in patients with slow flow coronary arteries: a randomized, double-blind, placebo-controlled clinical trial
Ranolazine effectively improves clinical symptoms in patients with slow flow coronary arteries: a randomized, double-blind, placebo-controlled clinical trial
The coronary slow flow phenomenon (CSF) causes persistent chest pains that can affect patients’ quality of life. We ...
Neurotensin receptor agonist PD149163 modulates LPS-induced enterocyte apoptosis by downregulating TNFR pathway and executioner caspase 3 in endotoxemic mice: insights from in vivo and in silico study
Neurotensin receptor agonist PD149163 modulates LPS-induced enterocyte apoptosis by downregulating TNFR pathway and executioner caspase 3 in endotoxemic mice: insights from in vivo and in silico study
This study was designed to evaluate the dose-dependent efficacy of neurotensin receptor-1 (NTSR1) agonist PD149163 in the ...
An update on selective estrogen receptor modulator: repurposing and formulations
An update on selective estrogen receptor modulator: repurposing and formulations
The selective estrogen receptor modulator (SERM) raloxifene hydrochloride (RLH) is used extensively in the management and ...
Targeting ferroptosis: the role of non-coding RNAs in hepatocellular carcinoma progression and therapy
Targeting ferroptosis: the role of non-coding RNAs in hepatocellular carcinoma progression and therapy
One of the most common tumors is hepatocellular carcinoma (HCC), and the prognosis for late-stage HCC is still not good. I...
Doxorubicin treatment has a biphasic effect over time on dopamine release and impulsive behavior in Wistar rats
Doxorubicin treatment has a biphasic effect over time on dopamine release and impulsive behavior in Wistar rats
Doxorubicin (Dox) is a chemotherapy agent commonly used to treat multiple types of cancers and is associated with cognitiv...
Morin, as a natural flavonoid, provides promising influences against cardiovascular diseases
Morin, as a natural flavonoid, provides promising influences against cardiovascular diseases
The present investigation evaluated the potential impacts of morin, a natural flavonoid, against cardiovascular disorders....
MiRNAs: main players of cancer drug resistance target ABC transporters
MiRNAs: main players of cancer drug resistance target ABC transporters
Chemotherapy remains the cornerstone of cancer treatment; however, its efficacy is frequently compromised by the developme...
MircoRNAs predict and modulate responses to chemotherapy in leukemic patients
MircoRNAs predict and modulate responses to chemotherapy in leukemic patients
Leukemia covers a broad category of cancer malignancies that specifically affect bone marrow and blood cells. While differ...
Suppressing the progression of bladder cancer using cyclovirobuxine D based on network pharmacology and bioinformatics approaches
Suppressing the progression of bladder cancer using cyclovirobuxine D based on network pharmacology and bioinformatics approaches
Limited treatment options are available for bladder cancer (BCa) resulting in extremely high mortality rates. Cyclovirobux...
Marine-derived bioactive compounds for neuropathic pain: pharmacology and therapeutic potential
Marine-derived bioactive compounds for neuropathic pain: pharmacology and therapeutic potential
Neuropathic pain, a challenging condition often associated with diabetes, trauma, or chemotherapy, impairs patients’...
Sexual dysfunctions associated with antipsychotic drug intake: a retrospective analysis of the FDA adverse events reporting system (FAERS)
Sexual dysfunctions associated with antipsychotic drug intake: a retrospective analysis of the FDA adverse events reporting system (FAERS)
Sexual dysfunctions (SD) are common and debilitating side effects of antipsychotics. The current study analyzes the occurr...
Tocilizumab alleviated lipopolysaccharide-induced acute lung injury by improving PI3K/AKT pathway
Tocilizumab alleviated lipopolysaccharide-induced acute lung injury by improving PI3K/AKT pathway
Acute lung injury (ALI) is a severe inflammatory condition of the respiratory system, associated with high morbidity and m...
Exploring the impact of cuproptosis-related genes on immune infiltration in rheumatoid arthritis
Exploring the impact of cuproptosis-related genes on immune infiltration in rheumatoid arthritis
Immune infiltration plays a significant role in the pathogenesis of rheumatoid arthritis (RA). Cuproptosis, a newly charac...
Modulation of PI3K/AKT signaling and DFT modeling via selected pharmaceutical compounds attenuates carrageenan-induced inflammation and oxidative stress in rats
Modulation of PI3K/AKT signaling and DFT modeling via selected pharmaceutical compounds attenuates carrageenan-induced inflammation and oxidative stress in rats
The main goal of the current study is to estimate the in vivo anti-inflammatory/antioxidant ability of four selected pharm...
Silibinin alleviates acute liver failure by modulating AKT/GSK3β/Nrf2/GPX4 pathway
Silibinin alleviates acute liver failure by modulating AKT/GSK3β/Nrf2/GPX4 pathway
Silibinin (Sil) is a major bioactive component of silymarin, extracted from the fruit and seeds of Silybum marianum. Silib...
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