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Investigation of the biochemical and histopathological effects of vitamin C, selenium, and therapeutic ultrasound on muscle damage in rats
Investigation of the biochemical and histopathological effects of vitamin C, selenium, and therapeutic ultrasound on muscle damage in rats
Muscle injury is a common type of soft tissue injury. Increased oxidative damage has been reported after muscle injuries. ...
Correction to: Geraniol activates Nrf-2/HO-1 signaling pathway mediating protection against oxidative stress-induced apoptosis in hepatic ischemia–reperfusion injury
Correction to: Geraniol activates Nrf-2/HO-1 signaling pathway mediating protection against oxidative stress-induced apoptosis in hepatic ischemia–reperfusion injury
Correction to: Naunyn-Schmiedeberg’s Archives of Pharmacology (2020) 393...
Berberine nanostructures attenuate ß-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma
Berberine nanostructures attenuate ß-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma
Lung cancer (LC) is the leading cause of cancer-related deaths globally. It accounts for more than 1.9 million cases each ...
Harnessing three-dimensional (3D) cell culture models for pulmonary infections: State of the art and future directions
Harnessing three-dimensional (3D) cell culture models for pulmonary infections: State of the art and future directions
Pulmonary infections have been a leading etiology of morbidity and mortality worldwide. Upper and lower respiratory tract ...
Long-term 1,2-dimethylhydrazine triggers pathological remodeling of colon mucosa through repression of sestrin2, nuclear factor (erythroid-derived 2)-like 2, and sirtuin4 stimulating mitochondrial stress and metabolic reprogramming
Long-term 1,2-dimethylhydrazine triggers pathological remodeling of colon mucosa through repression of sestrin2, nuclear factor (erythroid-derived 2)-like 2, and sirtuin4 stimulating mitochondrial stress and metabolic reprogramming
1,2-Dimethylhydrazine (DMH) is a plant toxicant that enters the food web through the diet. It is biotransformed into azoxy...
Glycoside combinations of Buyang Huanwu decoction ameliorate atherosclerosis via STAT3, HIF-1, and VEGF
Glycoside combinations of Buyang Huanwu decoction ameliorate atherosclerosis via STAT3, HIF-1, and VEGF
Buyang Huanwu decoction (BYHWD) is a classical traditional prescription. Glycosides are effective extracts of BYHWD, which...
Induction of apoptosis in glioma cells by lycorine via reactive oxygen species generation and regulation of NF-κB pathways
Induction of apoptosis in glioma cells by lycorine via reactive oxygen species generation and regulation of NF-κB pathways
Glioma is an extremely aggressive primary brain tumor, which is highly resistant to chemotherapy, presenting a therapeutic...
Pharmacological evaluation of carvacrol anti-migraine potential
Pharmacological evaluation of carvacrol anti-migraine potential
Migraine is a devitalizing neurovascular disorder that affects millions of people worldwide. This study was directed again...
A pilot study of neuroprotective effect of granulocyte colony-stimulating factor (G-CSF) in patients with carbon monoxide poisoning: a double-blind, randomized, placebo-controlled trial
A pilot study of neuroprotective effect of granulocyte colony-stimulating factor (G-CSF) in patients with carbon monoxide poisoning: a double-blind, randomized, placebo-controlled trial
Although neuroprotective effects of granulocyte colony-stimulating factor (G-CSF) have been shown in rats exposed to carbo...
Modulation of the oxidative damage, inflammation, and apoptosis-related genes by dicinnamoyl-L-tartaric acid in liver cancer
Modulation of the oxidative damage, inflammation, and apoptosis-related genes by dicinnamoyl-L-tartaric acid in liver cancer
Cancer cells can become resistant to existing treatments over time, so it is important to develop new treatments that targ...
Role of phytocompounds as the potential anti-viral agent: an overview
Role of phytocompounds as the potential anti-viral agent: an overview
Viral diseases are the most notorious infective agent(s) causing morbidity and mortality in every nook and corner for ages...
Ursolic acid–loaded chitosan nanoparticles suppress 7,12-dimethylbenz(a)anthracene-induced oral tumor formation through their antilipid peroxidative potential in golden Syrian hamsters
Ursolic acid–loaded chitosan nanoparticles suppress 7,12-dimethylbenz(a)anthracene-induced oral tumor formation through their antilipid peroxidative potential in golden Syrian hamsters
Oral cancer, a disfiguring and life threatening cancer, significantly affects the day-to-day life of not only the patients...
Fasudil promotes polyploidization of megakaryoblasts in an acute megakaryocyte leukemia model
Fasudil promotes polyploidization of megakaryoblasts in an acute megakaryocyte leukemia model
Acute megakaryocytic leukemia (AMKL) is a rare neoplasm caused by abnormal megakaryoblasts. Megakaryoblasts keep dividing ...
Modulatory effect of liraglutide on doxorubicin-induced testicular toxicity and behavioral abnormalities in rats: role of testicular-brain axis
Modulatory effect of liraglutide on doxorubicin-induced testicular toxicity and behavioral abnormalities in rats: role of testicular-brain axis
Doxorubicin (DOX) is a powerful chemotherapeutic agent used in many types of malignancies. However, its use results in tes...
Astaxanthin ameliorates spinal cord edema and astrocyte activation via suppression of HMGB1/TLR4/NF-κB signaling pathway in a rat model of spinal cord injury
Astaxanthin ameliorates spinal cord edema and astrocyte activation via suppression of HMGB1/TLR4/NF-κB signaling pathway in a rat model of spinal cord injury
Spinal cord edema is a quick-onset phenomenon with long-term effects. This complication is associated with inflammatory re...
Diarylheptanoids/sorafenib as a potential anticancer combination against hepatocellular carcinoma: the p53/MMP9 axis of action
Diarylheptanoids/sorafenib as a potential anticancer combination against hepatocellular carcinoma: the p53/MMP9 axis of action
Hepatocellular carcinoma (HCC) is a serious and potentially fatal form of cancer associated with liver damage. New antican...
Exploring the mechanism by which quercetin re-sensitizes breast cancer to paclitaxel: network pharmacology, molecular docking, and experimental verification
Exploring the mechanism by which quercetin re-sensitizes breast cancer to paclitaxel: network pharmacology, molecular docking, and experimental verification
This study is aimed to explore the potential molecular mechanism of quercetin reversing paclitaxel (PTX) resistance in bre...
Involvement of oxidative stress and pro-inflammatory cytokines in copper sulfate-induced depression-like disorders and abnormal neuronal morphology in mice
Involvement of oxidative stress and pro-inflammatory cytokines in copper sulfate-induced depression-like disorders and abnormal neuronal morphology in mice
Epidemiological studies have implicated copper as one of the key environmental risk factors for the pathogenesis of depres...
Pharmacological evidence for glutamatergic pathway involvement in the antidepressant-like effects of 2-phenyl-3-(phenylselanyl)benzofuran in male Swiss mice
Pharmacological evidence for glutamatergic pathway involvement in the antidepressant-like effects of 2-phenyl-3-(phenylselanyl)benzofuran in male Swiss mice
Depression is a multifactorial and heterogeneous disease with several neurobiological mechanisms underlying its pathophysi...
Liquiritin reduces ferroptosis in doxorubicin-induced cardiotoxicity through targeting SLC7A11/GPX4 pathway
Liquiritin reduces ferroptosis in doxorubicin-induced cardiotoxicity through targeting SLC7A11/GPX4 pathway
Solute carrier family 7 member (SLC7A11) and glutathione peroxidase 4 (GPX4) mediated ferroptosis in doxorubicin-induced c...
A new insight into the hepatoprotective effect of sildenafil: The role of H2S
A new insight into the hepatoprotective effect of sildenafil: The role of H2S
High-calorie diet, alcohol, and multiple drug use increase reactive oxygen species (ROS) and cause liver damage. ROS are c...
Analysis of non-volatile metabolites and quantitation of the anti-arthritic alkaloid sinomenine from blood fruit (Haematocarpus validus (Miers) Bakh.f. ex Forman)
Analysis of non-volatile metabolites and quantitation of the anti-arthritic alkaloid sinomenine from blood fruit (Haematocarpus validus (Miers) Bakh.f. ex Forman)
Haematocarpus validus (Miers) Bakh. f. ex Forman, a lesser-known fruit and medicinal plant of high nutraceutical and medic...
Attenuation of sodium arsenite mediated ovarian DNA damage, follicular atresia, and oxidative injury by combined application of vitamin E and C in post pubertal Wistar rats
Attenuation of sodium arsenite mediated ovarian DNA damage, follicular atresia, and oxidative injury by combined application of vitamin E and C in post pubertal Wistar rats
Arsenic being a toxic metalloid ubiquitously persists in environment and causes several health complications including fem...
Urolithin C reveals anti-NAFLD potential via AMPK-ferroptosis axis and modulating gut microbiota
Urolithin C reveals anti-NAFLD potential via AMPK-ferroptosis axis and modulating gut microbiota
The pharmacology of urolithin C (UroC) on non-alcoholic fatty liver disease (NAFLD) is largely undetermined. We sought to ...
Anti-inflammatory activity of novel derivatives of pyrazolo [3,4d] pyridazine against digestive system inflammation
Anti-inflammatory activity of novel derivatives of pyrazolo [3,4d] pyridazine against digestive system inflammation
The digestive system is exposed to severe inflammation as a result of taking some medications that have gastrointestinal s...
Drug consumption in German cities and municipalities during the COVID-19 lockdown: a wastewater analysis
Drug consumption in German cities and municipalities during the COVID-19 lockdown: a wastewater analysis
Analysis of illicit drugs, medicines, and pathogens in wastewater is a powerful tool for epidemiological studies to monito...
LncRNA NEAT1 antagonizes the inhibition of melanoma proliferation, migration, invasion and EMT by Polyphyllin B
LncRNA NEAT1 antagonizes the inhibition of melanoma proliferation, migration, invasion and EMT by Polyphyllin B
Polyphyllin B (PPB) is a compound with anti-tumor effects. Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long-str...
Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement
Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement
The Cucurbitaceae family produces a class of secondary metabolites known as cucurbitacins. The eight cucurbitacin subunits...
Tanshinone-IIA mediated neuroprotection by modulating neuronal pathways
Tanshinone-IIA mediated neuroprotection by modulating neuronal pathways
The progression of neurological diseases is mainly attributed to oxidative stress, apoptosis, inflammation, and trauma, ma...
Network pharmacology and molecular docking to explore the potential mechanism of urolithin A in combined allergic rhinitis and asthma syndrome
Network pharmacology and molecular docking to explore the potential mechanism of urolithin A in combined allergic rhinitis and asthma syndrome
This research used network pharmacology, molecular docking, in vivo studies, and other techniques to investigate the biolo...
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