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Repurposing artemisinins as neuroprotective agents: a focus on the PI3k/Akt signalling pathway
Repurposing artemisinins as neuroprotective agents: a focus on the PI3k/Akt signalling pathway
Artemisinin and its derivatives, since their discovery by professor Tu Youyou in the early 1970s, have been the bedrock fo...
Cholinergic dysfunction in COVID-19: frantic search and hoping for the best
Cholinergic dysfunction in COVID-19: frantic search and hoping for the best
A novel coronavirus known as severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a potential cause of acu...
The modulation of sirtuins by natural compounds in the management of cisplatin-induced nephrotoxicity
The modulation of sirtuins by natural compounds in the management of cisplatin-induced nephrotoxicity
Cisplatin is a highly effective antitumor agent. However, its use is limited due to severe adverse effects, particularly n...
Nobiletin is capable of regulating certain anti-cancer pathways in a colon cancer cell line
Nobiletin is capable of regulating certain anti-cancer pathways in a colon cancer cell line
Natural remedies have the potential to improve conventional cancer therapies and enhance patient outcomes. Citrus polymeth...
Levosimendan increases the phosphorylation state of phospholamban in the isolated human atrium
Levosimendan increases the phosphorylation state of phospholamban in the isolated human atrium
Levosimendan (up to 10 µM) given alone failed to increase force of contraction in isolated electrically stim...
Verapamil inhibits Kir2.3 channels by binding to the pore and interfering with PIP2 binding
Verapamil inhibits Kir2.3 channels by binding to the pore and interfering with PIP2 binding
The inwardly rectifying potassium current of the cardiomyocyte (IK1) is the main determinant of the resting potential. Ion...
Demethylation of CADM1 and SOCS1 using capsaicin in cervical cancer cell line
Demethylation of CADM1 and SOCS1 using capsaicin in cervical cancer cell line
Cervical cancer is one of the leading causes of women’s mortality in developing countries. The prevalence of cervica...
The effect of tamsulosin in postoperative urinary retention: a meta-analysis of randomized controlled trials
The effect of tamsulosin in postoperative urinary retention: a meta-analysis of randomized controlled trials
Tamsulosin is a therapeutic drug of alpha-adrenergic antagonists. Previous randomized controlled trials and retrospective ...
The phytochemical profiling, pharmacological activities, and safety of malva sylvestris: a review
The phytochemical profiling, pharmacological activities, and safety of malva sylvestris: a review
Malva sylvestris is a plant commonly found in Europe, Asia, and Africa. The leaves and flowers of this plant have been use...
The trend of ammonia levels in patients with glufosinate ammonium poisoning with respect to neurotoxicity
The trend of ammonia levels in patients with glufosinate ammonium poisoning with respect to neurotoxicity
Since glufosinate irreversibly inhibits glutamine synthetase, leading to intracellular accumulation of ammonia, hyperammon...
Effects of omecamtiv mecarbil and mavacamten in isolated human atrium
Effects of omecamtiv mecarbil and mavacamten in isolated human atrium
Heart failure is a syndrome that can result from impaired heart muscle contractions like in dilative cardiomyopathy but al...
Commiphora myrrh: a phytochemical and pharmacological update
Commiphora myrrh: a phytochemical and pharmacological update
Medicinal plants have a long track record of use in history, and one of them is Commiphora myrrh which is commonly found i...
Inhibition of mitochondrial respiration by general anesthetic drugs
Inhibition of mitochondrial respiration by general anesthetic drugs
General anesthetic drugs have been associated with various unwanted effects including an interference with mitochondrial f...
Bioactive compounds, pharmacological actions and pharmacokinetics of Cupressus sempervirens
Bioactive compounds, pharmacological actions and pharmacokinetics of Cupressus sempervirens
The roles of plants and its products in all forms of life cannot be overemphasized. The medicinal products from plant are ...
Pharmacokinetics of chromium-enriched yeast in rats following oral administration
Pharmacokinetics of chromium-enriched yeast in rats following oral administration
Chromium (Cr) is required for carbohydrate, lipid, and protein metabolisms in humans and animals. Cr insufficiency is asso...
Tanshinone IIA promotes apoptosis by downregulating BCL2 and upregulating TP53 in triple-negative breast cancer
Tanshinone IIA promotes apoptosis by downregulating BCL2 and upregulating TP53 in triple-negative breast cancer
Tanshinone IIA (Tan IIA) was mainly used for cardiovascular disease treatment. Recent studies have demonstrated the role o...