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Phase 1 study of GSK3368715, a type I PRMT inhibitor, in patients with advanced solid tumors
Phase 1 study of GSK3368715, a type I PRMT inhibitor, in patients with advanced solid tumors
GSK3368715, a first-in-class, reversible inhibitor of type I protein methyltransferases (PRMTs) demonstrated anticancer ac...
Six-year experience of Australia’s first dedicated cancer of unknown primary clinic
Six-year experience of Australia’s first dedicated cancer of unknown primary clinic
Diagnosis and management of cancers of unknown primary (CUP) remain challenging. This study examines the referral patterns...
Post-diagnostic health behaviour scores and risk of prostate cancer progression and mortality
Post-diagnostic health behaviour scores and risk of prostate cancer progression and mortality
Individual behaviours are associated with prostate cancer (PC) progression. Behavioural scores, comprised of multiple risk...
Whole-exome and targeted gene sequencing of large-cell lung carcinoma reveals recurrent mutations in the PI3K pathway
Whole-exome and targeted gene sequencing of large-cell lung carcinoma reveals recurrent mutations in the PI3K pathway
Large cell lung carcinoma (LCLC) is an exceptionally aggressive disease with a poor prognosis. At present, little is known...
Sleep and cancer recurrence and survival in patients with resected Stage III colon cancer: findings from CALGB/SWOG 80702 (Alliance)
Sleep and cancer recurrence and survival in patients with resected Stage III colon cancer: findings from CALGB/SWOG 80702 (Alliance)
We sought to assess the influences of sleep duration, sleep adequacy, and daytime sleepiness on survival outcomes among St...
Neighbourhood social deprivation and risk of prostate cancer
Neighbourhood social deprivation and risk of prostate cancer
Striking geographic variations in prostate cancer incidence suggest an aetiological role for spatially-distributed factors...
Maternal and childhood medical history and the risk of childhood brain tumours: a case–control study in Ontario, Canada
Maternal and childhood medical history and the risk of childhood brain tumours: a case–control study in Ontario, Canada
Studies to date have yielded inconclusive results as to whether maternal medical history during pregnancy, and a childR...
NDRG1 facilitates self-renewal of liver cancer stem cells by preventing EpCAM ubiquitination
NDRG1 facilitates self-renewal of liver cancer stem cells by preventing EpCAM ubiquitination
Portal vein tumour thrombus (PVTT) is the main pathway of HCC intrahepatic metastasis and is responsible for the poor prog...
Side effects of low-dose tamoxifen: results from a six-armed randomised controlled trial in healthy women
Side effects of low-dose tamoxifen: results from a six-armed randomised controlled trial in healthy women
Adherence to adjuvant tamoxifen therapy is suboptimal, and acceptance of tamoxifen for primary prevention is poor. Publish...
TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer
TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer
Targeting protein for Xenopus kinesin-like protein 2 (TPX2) overexpression in human tumours is associated with increased m...
A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer
A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer
This was a first-in-human Phase 1/2 open-label dose-escalation study of the novel checkpoint kinase 1 (Chk1) inhibitor SRA...
Integrated circulating tumour DNA and cytokine analysis for therapy monitoring of ALK-rearranged lung adenocarcinoma
Integrated circulating tumour DNA and cytokine analysis for therapy monitoring of ALK-rearranged lung adenocarcinoma
Detection of circulating tumour DNA (ctDNA) in biological fluids is a minimally invasive alternative to tissue biopsy for ...
Clinical biomarker-based biological aging and risk of cancer in the UK Biobank
Clinical biomarker-based biological aging and risk of cancer in the UK Biobank
Despite a clear link between aging and cancer, there has been inconclusive evidence on how biological age (BA) may be asso...
In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer
In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer
Epigenomic dysregulation has been linked to solid tumour malignancies, including ovarian cancers. Profiling of re-programm...