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Genetic risk scores may compound rather than solve the issue of prostate cancer overdiagnosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Comprehensive small RNA-sequencing of primary myeloma cells identifies miR-105-5p as a predictor of patient survival
Comprehensive small RNA-sequencing of primary myeloma cells identifies miR-105-5p as a predictor of patient survival
Small RNAs (sRNAs), a heterogenous group of non-coding RNAs, are emerging as promising molecules for cancer patient risk s...
The importance of long-term follow up of participants in clinical trials
The importance of long-term follow up of participants in clinical trials
Doll R, Peto R, Boreham J, Sutherland I. Mortality in relation to smoking: 50 years’ observations on male British doctors....
Body shape phenotypes of multiple anthropometric traits and cancer risk: a multi-national cohort study
Body shape phenotypes of multiple anthropometric traits and cancer risk: a multi-national cohort study
Classical anthropometric traits may fail to fully represent the relationship of weight, adiposity, and height with cancer ...
Correction: Integrative analysis of multi-omics data for liquid biopsy
Authors and AffiliationsShanghai Skin Disease Hospital, School of Medicine, Tongji University, 200443, Shanghai, ChinaGeng...
Additional consensus recommendations for conducting complex innovative trials of oncology agents: a post-pandemic perspective
In our 2020 consensus paper, we devised ten recommendations for conducting Complex Innovative Design (CID) trials to evalu...
Lynch syndrome, molecular mechanisms and variant classification
Lynch syndrome, molecular mechanisms and variant classification
Patients with the heritable cancer disease, Lynch syndrome, carry germline variants in the MLH1, MSH2, MSH6 and PMS2 genes...
Clinical significance and functional role of adhesion G-protein-coupled receptors in human pancreatic ductal adenocarcinoma
Clinical significance and functional role of adhesion G-protein-coupled receptors in human pancreatic ductal adenocarcinoma
The adhesion G-protein-coupled receptors (GPCRs) play crucial roles in tumour pathogenesis, however, their clinical signif...
Evolving roles of CD38 metabolism in solid tumour microenvironment
Evolving roles of CD38 metabolism in solid tumour microenvironment
Given that plenty of clinical findings and reviews have already explained in detail on the progression of CD38 in multiple...
Association between angiotensin-converting enzyme inhibitors and the risk of lung cancer: a systematic review and meta-analysis
Association between angiotensin-converting enzyme inhibitors and the risk of lung cancer: a systematic review and meta-analysis
The association between the use of angiotensin-converting enzyme inhibitors (ACEIs) and lung cancer risk remains controver...
Downregulation of CBX7 induced by EZH2 upregulates FGFR3 expression to reduce sensitivity to cisplatin in bladder cancer
Downregulation of CBX7 induced by EZH2 upregulates FGFR3 expression to reduce sensitivity to cisplatin in bladder cancer
Cisplatin-based cytotoxic chemotherapy is considered to be the first-line therapy for advanced bladder cancer (BC), but re...
Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes
Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes
Survival rates for ovarian cancer remain poor, and monitoring and prediction of therapeutic response may benefit from addi...
UK Biobank: a globally important resource for cancer research
UK Biobank: a globally important resource for cancer research
UK Biobank is a large-scale prospective study with deep phenotyping and genomic data. Its open-access policy allows resear...
Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils
Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils
Immunotherapy of gastrointestinal cancers is challenging; however, several lines of evidence suggest that adoptive transfe...
The impact of the first 2 years of the COVID-19 pandemic on breast cancer diagnoses: a population-based study in England
Cancer services were seriously disrupted during the COVID-19 pandemic. Using publicly available data for England, we show ...
Integrative analysis of multi-omics data for liquid biopsy
Integrative analysis of multi-omics data for liquid biopsy
The innovation of liquid biopsy holds great potential to revolutionise cancer management through early diagnosis and timel...
Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension
Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension
Vascular endothelial growth factor inhibitors (VEGFIs) are effective anticancer agents which often induce hypertension. VE...
50 years on and still very much alive: ‘Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics’
50 years on and still very much alive: ‘Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics’
Cell death is part of the lifecycle of every multicellular organism. Nineteenth-century pathologists already recognised th...
Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer
Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer
Naturally occurring germline gene deletions (KO) represent a unique setting to interrogate gene functions. Complete deleti...
Progress and priorities in reducing the time to cancer diagnosis
Key developments in early diagnosis research and policy since the publication of the highly cited BJC review “Is inc...
How the histological structure of some lung cancers shaped almost 70 years of radiobiology
How the histological structure of some lung cancers shaped almost 70 years of radiobiology
Pivotal research led by Louis Harold Gray in the 1950s suggested that oxygen plays a vital role during radiotherapy. By pr...