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Pre-diagnosis tea and coffee consumption and survival after a diagnosis of ovarian cancer: results from the Ovarian Cancer Association Consortium
Tea and coffee are the most frequently consumed beverages in the world. Green tea in particular contains compounds with po...
Presence of Fusobacterium nucleatum in relation to patient survival and an acidic environment in oesophagogastric junction and gastric cancers
Presence of Fusobacterium nucleatum in relation to patient survival and an acidic environment in oesophagogastric junction and gastric cancers
Fusobacterium nucleatum inhabits the oral cavity and affects the progression of gastrointestinal cancer. Our prior finding...
An 18-gene signature of recurrence-associated endothelial cells predicts tumor progression and castration resistance in prostate cancer
An 18-gene signature of recurrence-associated endothelial cells predicts tumor progression and castration resistance in prostate cancer
The prognostic and therapeutic implications of endothelial cells (ECs) heterogeneity in prostate cancer (PCa) are poorly u...
Introduction and impact of routine whole genome sequencing in the diagnosis and management of sarcoma
Introduction and impact of routine whole genome sequencing in the diagnosis and management of sarcoma
Sarcomas are diverse neoplasms with highly variable histological appearances in which diagnosis is often challenging and m...
The AKT inhibitor AZD5363 elicits synthetic lethality in ARID1A-deficient gastric cancer cells via induction of pyroptosis
The AKT inhibitor AZD5363 elicits synthetic lethality in ARID1A-deficient gastric cancer cells via induction of pyroptosis
Gastric cancer (GC) is a deadly disease with poor overall survival and limited therapeutic options. Genetic alterations su...
Cell-cell contact-dependent secretion of large-extracellular vesicles from EFNBhigh cancer cells accelerates peritoneal dissemination
Cell-cell contact-dependent secretion of large-extracellular vesicles from EFNBhigh cancer cells accelerates peritoneal dissemination
Large non-apoptotic vesicles released from the plasma membrane protrusions are classified as large-EVs (LEVs). However, th...
Identifying early symptoms associated with a diagnosis of childhood, adolescent and young adult cancers: a population-based nested case-control study
Identifying early symptoms associated with a diagnosis of childhood, adolescent and young adult cancers: a population-based nested case-control study
Childhood, teenage and young adult (CTYA, 0–24 years) cancers are rare and diverse, making timely diagnosis challeng...
Editorial Expression of Concern: Extracellular, cell-permeable survivin inhibits apoptosis while promoting proliferative and metastatic potential
Authors and AffiliationsDivision of Biochemistry and Microbiology, Department of Basic Sciences, Center for Health Dispari...
Correction: DKC1 enhances angiogenesis by promoting HIF-1α transcription and facilitates metastasis in colorectal cancer
Correction: DKC1 enhances angiogenesis by promoting HIF-1α transcription and facilitates metastasis in colorectal cancer
Author notesThese authors contributed equally: Pingfu Hou, Peicong Shi, Tao Jiang.Authors and AffiliationsCancer Institute...
Reply to Dr. Rafael Rosell: Shedding some light on the unresolved issue of YAP1 Ser397 phosphorylation in cancer
This work was supported by the grant PI19/01231 funded by AEI and the European Union. A.R-V contract was funded by the pro...
Cancer risk in individuals with polydactyly: a Swedish population-based cohort study
Polydactyly is a feature of several cancer predisposition syndromes (CPS), however, cancer risk in individuals with polyda...
Correction to: Intravenous and subcutaneous formulations of trastuzumab, and trastuzumab biosimilars: implications for clinical practice
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Correction: Death receptors 4/5 mediate tumour sensitivity to natural killer cell-mediated cytotoxicity in mismatch repair deficient colorectal cancer
Author notesThese authors contributed equally: Lin Yang, Jiahong Yi, Wenzhuo He.Authors and AffiliationsDepartment of Radi...
Dramatic improvements in outcome following pancreatoduodenectomy for pancreatic and periampullary cancers
Dramatic improvements in outcome following pancreatoduodenectomy for pancreatic and periampullary cancers
Pancreatoduodenectomy is the only cure for cancers of the pancreas and the periampullary region but has considerable opera...
The Physical Activity and Cancer Control (PACC) framework: update on the evidence, guidelines, and future research priorities
The Physical Activity and Cancer Control (PACC) framework: update on the evidence, guidelines, and future research priorities
We proposed the Physical Activity and Cancer Control (PACC) framework in 2007 to help organise, focus, and stimulate resea...
Prognostic significance of PET/CT and its association with immuno-genomic profiling in oesophageal squamous cell carcinoma treated with immunotherapy plus chemoradiotherapy: results from a phase II study
Prognostic significance of PET/CT and its association with immuno-genomic profiling in oesophageal squamous cell carcinoma treated with immunotherapy plus chemoradiotherapy: results from a phase II study
A phase II trial (EC-CRT-001) demonstrated the promising efficacy of combining toripalimab (an anti-PD-1 antibody) with de...
A population-based study on trajectories of HER2 status during neoadjuvant chemotherapy for early breast cancer and metastatic progression
A population-based study on trajectories of HER2 status during neoadjuvant chemotherapy for early breast cancer and metastatic progression
This study aimed to investigate the distribution and changes of HER2 status in untreated tumours, in residual disease and ...
A non-invasive artificial intelligence model for identifying axillary pathological complete response to neoadjuvant chemotherapy in breast cancer: a secondary analysis to multicenter clinical trial
A non-invasive artificial intelligence model for identifying axillary pathological complete response to neoadjuvant chemotherapy in breast cancer: a secondary analysis to multicenter clinical trial
This study aims to develop a stacking model for accurately predicting axillary lymph node (ALN) response to neoadjuvant ch...
Efficacy of administration sequence: Sacituzumab Govitecan and Trastuzumab Deruxtecan in HER2-low metastatic breast cancer
Efficacy of administration sequence: Sacituzumab Govitecan and Trastuzumab Deruxtecan in HER2-low metastatic breast cancer
Current guidelines recommend that patients with HER2-low metastatic breast cancer (MBC) receive sequentially two antibody&...
Social determinants of health inequalities in early phase clinical trials in Northern England
Social determinants of health inequalities in early phase clinical trials in Northern England
Early phase clinical trials in Oncology represent a subspecialised area where UK patient selection is influenced by access...
Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records
Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records
There is limited evidence on the safety of Hormone Replacement Therapy (HRT) in women with cancer. Therefore, we systemati...
Late stage melanoma is hallmarked by low NLGN4X expression leading to HIF1A accumulation
Late stage melanoma is hallmarked by low NLGN4X expression leading to HIF1A accumulation
Despite ongoing research and recent advances in therapy, metastatic melanoma remains one of the cancers with the worst pro...
QL1209 (pertuzumab biosimilar) versus reference pertuzumab plus trastuzumab and docetaxel in neoadjuvant treatment for HER2-positive, ER/PR-negative, early or locally advanced breast cancer: A multicenter, randomized, double-blinded, parallel-controlled, phase III equivalence trial
QL1209 (pertuzumab biosimilar) versus reference pertuzumab plus trastuzumab and docetaxel in neoadjuvant treatment for HER2-positive, ER/PR-negative, early or locally advanced breast cancer: A multicenter, randomized, double-blinded, parallel-controlled, phase III equivalence trial
This randomized, parallel-controlled, double-blinded, phase III equivalence study evaluated the equivalence of a proposed ...
MT1G induces lipid droplet accumulation through modulation of H3K14 trimethylation accelerating clear cell renal cell carcinoma progression
MT1G induces lipid droplet accumulation through modulation of H3K14 trimethylation accelerating clear cell renal cell carcinoma progression
Lipid droplet formation is a prominent histological feature in clear cell renal cell carcinoma (ccRCC), but the significan...
Treatment outcome according to genetic tumour alterations and clinical characteristics in digestive high-grade neuroendocrine neoplasms
Treatment outcome according to genetic tumour alterations and clinical characteristics in digestive high-grade neuroendocrine neoplasms
Chemotherapy has limited efficacy in advanced digestive high-grade neuroendocrine neoplasms (HG-NEN) and prognosis is dism...
The in vitro dynamics of pseudo-vascular network formation
The in vitro dynamics of pseudo-vascular network formation
Pseudo-vascular network formation in vitro is considered a key characteristic of vasculogenic mimicry. While many cancer c...
Zurletrectinib is a next-generation TRK inhibitor with strong intracranial activity against NTRK fusion-positive tumours with on-target resistance to first-generation agents
Zurletrectinib is a next-generation TRK inhibitor with strong intracranial activity against NTRK fusion-positive tumours with on-target resistance to first-generation agents
While NTRK fusion-positive cancers can be exquisitely sensitive to first-generation TRK inhibitors, resistance inevitably ...
Anti-PEc: Development of a novel monoclonal antibody against prostate cancer
Anti-PEc: Development of a novel monoclonal antibody against prostate cancer
The Ec peptide (PEc) that defines the IGF-1Ec isoform, is associated with prostate cancer progression by inducing prolifer...
Hit it hard: qualitative patient perspectives on the optimisation of immune checkpoint inhibition
Hit it hard: qualitative patient perspectives on the optimisation of immune checkpoint inhibition
Immune checkpoint inhibitors have transformed the treatment landscape of many cancers, including melanoma and renal cell c...
DPYD genetic polymorphisms in non-European patients with severe fluoropyrimidine-related toxicity: a systematic review
DPYD genetic polymorphisms in non-European patients with severe fluoropyrimidine-related toxicity: a systematic review
Pre-treatment DPYD screening is mandated in the UK and EU to reduce the risk of severe and potentially fatal fluoropyrimid...
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