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Correction to: Reshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Risk-reducing surgery for individuals with cancer-predisposing germline pathogenic variants and no personal cancer history: a review of current UK guidelines
Risk-reducing surgery for individuals with cancer-predisposing germline pathogenic variants and no personal cancer history: a review of current UK guidelines
Identifying healthy carriers of germline pathogenic variants in high penetrance cancer susceptibility genes offers the pot...
Phase 1 study of GSK3368715, a type I PRMT inhibitor, in patients with advanced solid tumors
Phase 1 study of GSK3368715, a type I PRMT inhibitor, in patients with advanced solid tumors
GSK3368715, a first-in-class, reversible inhibitor of type I protein methyltransferases (PRMTs) demonstrated anticancer ac...
What do women think about having received their breast cancer risk as part of a risk-stratified NHS Breast Screening Programme? A qualitative study
What do women think about having received their breast cancer risk as part of a risk-stratified NHS Breast Screening Programme? A qualitative study
Risk-stratified screening is being considered for national breast screening programmes. It is unclear how women experience...
Six-year experience of Australia’s first dedicated cancer of unknown primary clinic
Six-year experience of Australia’s first dedicated cancer of unknown primary clinic
Diagnosis and management of cancers of unknown primary (CUP) remain challenging. This study examines the referral patterns...
Post-diagnostic health behaviour scores and risk of prostate cancer progression and mortality
Post-diagnostic health behaviour scores and risk of prostate cancer progression and mortality
Individual behaviours are associated with prostate cancer (PC) progression. Behavioural scores, comprised of multiple risk...
Targeting metabolism by B-raf inhibitors and diclofenac restrains the viability of BRAF-mutated thyroid carcinomas with Hif-1α-mediated glycolytic phenotype
Targeting metabolism by B-raf inhibitors and diclofenac restrains the viability of BRAF-mutated thyroid carcinomas with Hif-1α-mediated glycolytic phenotype
B-raf inhibitors (BRAFi) are effective for BRAF-mutated papillary (PTC) and anaplastic (ATC) thyroid carcinomas, although ...
Pembrolizumab alone and pembrolizumab plus chemotherapy in previously treated, extrapulmonary poorly differentiated neuroendocrine carcinomas
Pembrolizumab alone and pembrolizumab plus chemotherapy in previously treated, extrapulmonary poorly differentiated neuroendocrine carcinomas
To date, single-agent immune checkpoint inhibitor (CPI) therapy has proven to be ineffective against biomarker-unselected ...
Phase 1 dose-escalation study evaluating the safety, pharmacokinetics, and clinical activity of OBI-3424 in patients with advanced or metastatic solid tumors
Phase 1 dose-escalation study evaluating the safety, pharmacokinetics, and clinical activity of OBI-3424 in patients with advanced or metastatic solid tumors
Report of a Phase 1 dose-escalation study of OBI-3424 monotherapy in patients with advanced solid tumors (NCT03592264). A ...
Whole-exome and targeted gene sequencing of large-cell lung carcinoma reveals recurrent mutations in the PI3K pathway
Whole-exome and targeted gene sequencing of large-cell lung carcinoma reveals recurrent mutations in the PI3K pathway
Large cell lung carcinoma (LCLC) is an exceptionally aggressive disease with a poor prognosis. At present, little is known...
A randomised phase 2 study of continuous or intermittent dosing schedule of imatinib re-challenge in patients with tyrosine kinase inhibitor-refractory gastrointestinal stromal tumours
A randomised phase 2 study of continuous or intermittent dosing schedule of imatinib re-challenge in patients with tyrosine kinase inhibitor-refractory gastrointestinal stromal tumours
Imatinib re-challenge is one of the available therapeutic options for patients with treatment-refractory gastrointestinal ...
Sleep and cancer recurrence and survival in patients with resected Stage III colon cancer: findings from CALGB/SWOG 80702 (Alliance)
Sleep and cancer recurrence and survival in patients with resected Stage III colon cancer: findings from CALGB/SWOG 80702 (Alliance)
We sought to assess the influences of sleep duration, sleep adequacy, and daytime sleepiness on survival outcomes among St...
Neighbourhood social deprivation and risk of prostate cancer
Neighbourhood social deprivation and risk of prostate cancer
Striking geographic variations in prostate cancer incidence suggest an aetiological role for spatially-distributed factors...
Maternal and childhood medical history and the risk of childhood brain tumours: a case–control study in Ontario, Canada
Maternal and childhood medical history and the risk of childhood brain tumours: a case–control study in Ontario, Canada
Studies to date have yielded inconclusive results as to whether maternal medical history during pregnancy, and a childR...
Cost-effectiveness analysis of molecular testing in minimally invasive samples to detect endometrial cancer in women with postmenopausal bleeding
Cost-effectiveness analysis of molecular testing in minimally invasive samples to detect endometrial cancer in women with postmenopausal bleeding
New approaches are being developed to early detect endometrial cancer using molecular biomarkers. These approaches offer h...
NDRG1 facilitates self-renewal of liver cancer stem cells by preventing EpCAM ubiquitination
NDRG1 facilitates self-renewal of liver cancer stem cells by preventing EpCAM ubiquitination
Portal vein tumour thrombus (PVTT) is the main pathway of HCC intrahepatic metastasis and is responsible for the poor prog...
‘Evaluation of adverse prognostic gene alterations & MRD positivity in BCR::ABL1-like B-lineage acute lymphoblastic leukaemia patients, in a resource-constrained setting
‘Evaluation of adverse prognostic gene alterations & MRD positivity in BCR::ABL1-like B-lineage acute lymphoblastic leukaemia patients, in a resource-constrained setting
Early detection of BCR::ABL1-like ALL could impact treatment management and improve the overall survival/outcome. BCR::ABL...
Inequalities in cancer screening participation between adults with and without severe mental illness: results from a cross-sectional analysis of primary care data on English Screening Programmes
People with severe mental illness (SMI) are 2.5 times more likely to die prematurely from cancer in England. Lower partici...
Side effects of low-dose tamoxifen: results from a six-armed randomised controlled trial in healthy women
Side effects of low-dose tamoxifen: results from a six-armed randomised controlled trial in healthy women
Adherence to adjuvant tamoxifen therapy is suboptimal, and acceptance of tamoxifen for primary prevention is poor. Publish...
Chemoradiotherapy versus triplet chemotherapy as initial therapy for T4b esophageal cancer: survival results from a multicenter randomized Phase 2 trial
Chemoradiotherapy versus triplet chemotherapy as initial therapy for T4b esophageal cancer: survival results from a multicenter randomized Phase 2 trial
We report the long-term results as primary endpoint in a multicentre randomized prospective Phase 2 trial which compared c...
TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer
TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer
Targeting protein for Xenopus kinesin-like protein 2 (TPX2) overexpression in human tumours is associated with increased m...
Deep learning-based pathology signature could reveal lymph node status and act as a novel prognostic marker across multiple cancer types
Deep learning-based pathology signature could reveal lymph node status and act as a novel prognostic marker across multiple cancer types
Identifying lymph node metastasis (LNM) relies mainly on indirect radiology. Current studies omitted the quantified associ...
NK cell activity and methylated HOXA9 ctDNA as prognostic biomarkers in patients with non-small cell lung cancer treated with PD-1/PD-L1 inhibitors
NK cell activity and methylated HOXA9 ctDNA as prognostic biomarkers in patients with non-small cell lung cancer treated with PD-1/PD-L1 inhibitors
PD-1/PD-L1 inhibitors have improved survival for patients with non-small cell lung cancer (NSCLC). We evaluated natural ki...
Precision medicine for prostate cancer—improved outcome prediction for low-intermediate risk disease using a six-gene copy number alteration classifier
Precision medicine for prostate cancer—improved outcome prediction for low-intermediate risk disease using a six-gene copy number alteration classifier
A multiplex 6-gene copy number classifier was used to distinguish between low- or intermediate-risk prostate cancer patien...
A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer
A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer
This was a first-in-human Phase 1/2 open-label dose-escalation study of the novel checkpoint kinase 1 (Chk1) inhibitor SRA...
Integrated circulating tumour DNA and cytokine analysis for therapy monitoring of ALK-rearranged lung adenocarcinoma
Integrated circulating tumour DNA and cytokine analysis for therapy monitoring of ALK-rearranged lung adenocarcinoma
Detection of circulating tumour DNA (ctDNA) in biological fluids is a minimally invasive alternative to tissue biopsy for ...
Anticipating changes in the HER2 status of breast tumours with disease progression—towards better treatment decisions in the new era of HER2-low breast cancers
Anticipating changes in the HER2 status of breast tumours with disease progression—towards better treatment decisions in the new era of HER2-low breast cancers
HER2 expression is often negative or low in primary breast cancers (BCs) but its changes with disease progression remain p...
Clinical biomarker-based biological aging and risk of cancer in the UK Biobank
Clinical biomarker-based biological aging and risk of cancer in the UK Biobank
Despite a clear link between aging and cancer, there has been inconclusive evidence on how biological age (BA) may be asso...
In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer
In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer
Epigenomic dysregulation has been linked to solid tumour malignancies, including ovarian cancers. Profiling of re-programm...
Reshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
Reshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
In recent years, the tumour microenvironment (TME) of solid tumours has attracted more and more attention from researchers...
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