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Circulating tumour DNA and risk of recurrence in patients with asymptomatic versus symptomatic colorectal cancer
Circulating tumour DNA and risk of recurrence in patients with asymptomatic versus symptomatic colorectal cancer
Multiple initiatives aim to develop circulating tumour DNA (ctDNA) tests for early cancer detection in asymptomatic indivi...
The SRC-family serves as a therapeutic target in triple negative breast cancer with acquired resistance to chemotherapy
The SRC-family serves as a therapeutic target in triple negative breast cancer with acquired resistance to chemotherapy
Resistance to chemotherapy, combined with heterogeneity among resistant tumors, represents a significant challenge in the ...
Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma
Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma
Uveal melanoma (UM) is a highly aggressive disease with very few treatment options. We previously demonstrated that mUM is...
Quiescent cancer cells induced by high-density cultivation reveals cholesterol-mediated survival and lung metastatic traits
Quiescent cancer cells induced by high-density cultivation reveals cholesterol-mediated survival and lung metastatic traits
The metastatic cascade, a multifaceted and highly aggressive process, is the primary cause of mortality. The survival of q...
A Myc-SED mechanism?
Sir,In their article entitled Metformin abrogates Fusobacterium nucleatum-induced chemoresistance in colorectal cancer by ...
Whole tumour- and subregion-based radiomics of contrast-enhanced mammography in differentiating HER2 expression status of invasive breast cancers: A double-centre pilot study
Whole tumour- and subregion-based radiomics of contrast-enhanced mammography in differentiating HER2 expression status of invasive breast cancers: A double-centre pilot study
To explore the value of whole tumour- and subregion-based radiomics of contrast-enhanced mammography (CEM) in differentiat...
Height and breast cancer risk in premenopausal Korean women aged under 40 years of age
Height and breast cancer risk in premenopausal Korean women aged under 40 years of age
Taller women are at an increased risk of breast cancer; however, evidence regarding this in younger women is limited. This...
Role of 18F-FDG-PET/CT in the initial staging of very high-risk Ewing Sarcoma in a prospective multicentric Phase II Study: Is there still a place for bone marrow sampling?
Role of 18F-FDG-PET/CT in the initial staging of very high-risk Ewing Sarcoma in a prospective multicentric Phase II Study: Is there still a place for bone marrow sampling?
The Ewing Sarcoma Family of Tumors (ESFT) constitutes a group of rare malignancies, wherein approximately one-third of cas...
Serum bilirubin levels and risk of colorectal cancer in Korean adults: results from the Korean Genome and Epidemiology Study-Health Examinee (KoGES-HEXA) Cohort Study
Serum bilirubin levels and risk of colorectal cancer in Korean adults: results from the Korean Genome and Epidemiology Study-Health Examinee (KoGES-HEXA) Cohort Study
Current evidence on associations between circulating bilirubin and colorectal cancer (CRC) risk is inconsistent. In this p...
The αvβ6 integrin specific virotherapy, Ad5NULL-A20.FCU1, selectively delivers potent “in-tumour” chemotherapy to pancreatic ductal adenocarcinoma
The αvβ6 integrin specific virotherapy, Ad5NULL-A20.FCU1, selectively delivers potent “in-tumour” chemotherapy to pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) represent an unmet clinical need. Approximately 90% of PDACs express high levels o...
Losartan rewires the tumor-immune microenvironment and suppresses IGF-1 to overcome resistance to chemo-immunotherapy in ovarian cancer
Losartan rewires the tumor-immune microenvironment and suppresses IGF-1 to overcome resistance to chemo-immunotherapy in ovarian cancer
Ovarian cancer (OvCa) is the most lethal of the gynecologic malignancies. Immune checkpoint inhibitors, which have revolut...
Waist circumference-years and cancer risk: a prospective study of the association and comparison of predictive performance with waist circumference and body mass index
Waist circumference-years and cancer risk: a prospective study of the association and comparison of predictive performance with waist circumference and body mass index
Associations of waist circumferences (WC) and body mass index (BMI) measured once or over time, with cancer incidence were...
Melanoma-specific mutation hotspots in distal, non-coding, promoter-interacting regions implicate novel candidate driver genes
Melanoma-specific mutation hotspots in distal, non-coding, promoter-interacting regions implicate novel candidate driver genes
To develop targeted treatments, it is crucial to identify the full spectrum of genetic drivers in melanoma, including thos...
The EXO1/Polη/Polι axis as a promising target for miR-3163-mediated attenuation of cancer stem-like cells in non-small cell lung carcinoma
The EXO1/Polη/Polι axis as a promising target for miR-3163-mediated attenuation of cancer stem-like cells in non-small cell lung carcinoma
Cancer stem-like cells (CSLCs) drive tumour progression and chemoresistance. The concerted efforts of EXO1 and TLS polymer...
Loss of EMI1 compromises chromosome stability and is associated with cellular transformation in colonic epithelial cell contexts
Loss of EMI1 compromises chromosome stability and is associated with cellular transformation in colonic epithelial cell contexts
Colorectal cancer (CRC) is still a leading cause of cancer deaths worldwide. Thus, identifying the aberrant genes and prot...
Prognostic role of pre-diagnostic circulating inflammatory biomarkers in breast cancer survival: evidence from the EPIC cohort study
Prognostic role of pre-diagnostic circulating inflammatory biomarkers in breast cancer survival: evidence from the EPIC cohort study
Inflammation influences tumour progression and cancer prognosis, but its role preceding breast cancer (BC) and its prognos...
Association of metabolic obesity phenotypes with risk of overall and site-specific cancers: a systematic review and meta-analysis of cohort studies
Association of metabolic obesity phenotypes with risk of overall and site-specific cancers: a systematic review and meta-analysis of cohort studies
Adiposity is a known risk factor for certain cancers; however, it is not clear whether the risk of cancer differs between ...
GFPT2: A novel biomarker in mesothelioma for diagnosis and prognosis and its molecular mechanism in malignant progression
GFPT2: A novel biomarker in mesothelioma for diagnosis and prognosis and its molecular mechanism in malignant progression
Mesothelioma (MESO) is an insidious malignancy with a complex diagnosis and a poor prognosis. Our study unveils Glutamine-...
Functional activation of the AKT-mTOR signalling axis in a real-world metastatic breast cancer cohort
Functional activation of the AKT-mTOR signalling axis in a real-world metastatic breast cancer cohort
Mutations of the PIK3CA/AKT/mTOR axis are common events in metastatic breast cancers (MBCs). This study was designed to ev...
Nuclear receptor TLX functions to promote cancer stemness and EMT in prostate cancer via its direct transactivation of CD44 and stem cell-regulatory transcription factors
Nuclear receptor TLX functions to promote cancer stemness and EMT in prostate cancer via its direct transactivation of CD44 and stem cell-regulatory transcription factors
Prostate cancer stem cells (PCSCs) play crucial roles in therapy-resistance and metastasis in castration-resistant prostat...
SON is an essential RNA splicing factor promoting ErbB2 and ErbB3 expression in breast cancer
SON is an essential RNA splicing factor promoting ErbB2 and ErbB3 expression in breast cancer
In breast cancer, ErbB receptors play a critical role, and overcoming drug resistance remains a major challenge in the cli...
Tumor-infiltrating immune cell profiles and changes associate with additional trastuzumab in preoperative chemotherapy for patients with HER2-positive gastric cancer
Tumor-infiltrating immune cell profiles and changes associate with additional trastuzumab in preoperative chemotherapy for patients with HER2-positive gastric cancer
HER2(+) gastric cancer (GC) can benefit from trastuzumab. However, the impact of additional trastuzumab in preoperative tr...
Comparison of methods for cancer stem cell detection in prognosis of early stages NSCLC
Comparison of methods for cancer stem cell detection in prognosis of early stages NSCLC
Despite advances in diagnosis and treatment in lung cancer, therapies still fail to improve patient management due to resi...
Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer
Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer
The objective of this study was to develop an innovative treatment strategy utilizing antisense oligonucleotides (ASOs) th...
Validation of the BOADICEA model for epithelial tubo-ovarian cancer risk prediction in UK Biobank
Validation of the BOADICEA model for epithelial tubo-ovarian cancer risk prediction in UK Biobank
The clinical validity of the multifactorial BOADICEA model for epithelial tubo-ovarian cancer (EOC) risk prediction has no...
Testing of rapid evaporative mass spectrometry for histological tissue classification and molecular diagnostics in a multi-site study
Testing of rapid evaporative mass spectrometry for histological tissue classification and molecular diagnostics in a multi-site study
While REIMS technology has successfully been demonstrated for the histological identification of ex-vivo breast tumor tiss...
Fractionated photoimmunotherapy stimulates an anti-tumour immune response: an integrated mathematical and in vitro study
Fractionated photoimmunotherapy stimulates an anti-tumour immune response: an integrated mathematical and in vitro study
Advanced epithelial ovarian cancer (EOC) has high recurrence rates due to disseminated initial disease presentation. Cytot...
Specific features of ß-catenin-mutated hepatocellular carcinomas
Specific features of ß-catenin-mutated hepatocellular carcinomas
CTNNB1, encoding the ß-catenin protein, is a key oncogene contributing to liver carcinogenesis. Hepatocellular carcin...
Live birth and maternity outcome in childhood and adolescent cancer survivors under 18 years at diagnosis: a 40-year population-based cohort study
Live birth and maternity outcome in childhood and adolescent cancer survivors under 18 years at diagnosis: a 40-year population-based cohort study
Survival from childhood and adolescent cancer has increased, but the chance of a livebirth in female survivors under 18 ye...
Andrographolide sensitizes glioma to temozolomide by inhibiting DKK1 expression
Andrographolide sensitizes glioma to temozolomide by inhibiting DKK1 expression
Temozolomide (TMZ) is the first-line chemotherapeutic drug for gliomas treatment. However, the clinical efficacy of TMZ in...
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