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Sodium nitrite orchestrates macrophage mimicry of tongue squamous carcinoma cells to drive lymphatic metastasis
Sodium nitrite orchestrates macrophage mimicry of tongue squamous carcinoma cells to drive lymphatic metastasis
Tongue squamous cell carcinoma (TSCC) is a malignant oral cancer with unclear pathogenesis that shows a tendency for early...
A UK population-based case-control study of blood tests before cancer diagnosis in patients with non-specific abdominal symptoms
A UK population-based case-control study of blood tests before cancer diagnosis in patients with non-specific abdominal symptoms
Abnormal results in commonly used primary care blood tests could be early markers of cancer in patients presenting with no...
Alkaline phosphatase decline and pain response as predictors of overall survival benefit in patients treated with radium-223: a post hoc analysis of the REASSURE study
Alkaline phosphatase decline and pain response as predictors of overall survival benefit in patients treated with radium-223: a post hoc analysis of the REASSURE study
Alkaline phosphatase (ALP) declines and pain responses can occur during radium-223 (223Ra) treatment, but their associatio...
Correction: Cardiotoxicity following thoracic radiotherapy for lung cancer
Schytte T, Hansen O, Stolberg-Rohr T, Brink C. Cardiac toxicity and radiation dose to the heart in definitive treated non-...
Oxaliplatin induces pyroptosis in hepatoma cells and enhances antitumor immunity against hepatocellular carcinoma
Oxaliplatin induces pyroptosis in hepatoma cells and enhances antitumor immunity against hepatocellular carcinoma
Pyroptosis is closely associated with chemotherapeutic drugs and immune response. Here, we investigated whether oxaliplati...
Impact of lymph node metastasis on immune microenvironment and prognosis in colorectal cancer liver metastasis: insights from multiomics profiling
Impact of lymph node metastasis on immune microenvironment and prognosis in colorectal cancer liver metastasis: insights from multiomics profiling
This study aimed to investigate the prognostic impact of lymph node metastasis (LNM) on patients with colorectal cancer li...
Pro-survival roles for p21(Cip1/Waf1) in non-small cell lung cancer
Pro-survival roles for p21(Cip1/Waf1) in non-small cell lung cancer
Quiescence is reversible proliferative arrest. Multiple mechanisms regulate quiescence that are not fully understood. High...
Targeting PTGDS Promotes ferroptosis in peripheral T cell lymphoma through regulating HMOX1-mediated iron metabolism
Targeting PTGDS Promotes ferroptosis in peripheral T cell lymphoma through regulating HMOX1-mediated iron metabolism
Peripheral T cell lymphoma (PTCL) is characterized by high heterogeneity, strong aggressiveness, and extremely poor progno...
Reproductive factors and risk of epithelial ovarian cancer: results from the Asia Cohort Consortium
Reproductive factors and risk of epithelial ovarian cancer: results from the Asia Cohort Consortium
There are scarce data on risk factors for epithelial ovarian cancer (EOC) in Asian populations. Our goal was to advance kn...
Women’s perspectives of molecular breast imaging: a qualitative study
Women’s perspectives of molecular breast imaging: a qualitative study
Mammography has poor sensitivity in dense breast tissue. Retrospective studies suggest that Molecular Breast Imaging (MBI)...
The accuracy of fluorine 18-labelled prostate-specific membrane antigen PET/CT and MRI for diagnosis of prostate cancer in PSA grey zone
The accuracy of fluorine 18-labelled prostate-specific membrane antigen PET/CT and MRI for diagnosis of prostate cancer in PSA grey zone
The diagnostic utility of prostate biopsy is limited for prostate cancer (PCa) in the prostate-specific antigen (PSA) grey...
Identification of diagnostic biomarkers in prostate cancer-related fatigue by construction of predictive models and experimental validation
Identification of diagnostic biomarkers in prostate cancer-related fatigue by construction of predictive models and experimental validation
Cancer-related fatigue (CRF) is a prominent cancer-related complication occurring in Prostate cancer (PCa) patients, profo...
Commentary to: Cancer and treatment specific incidence rates of immune related adverse events induced by immune checkpoint inhibitors: a systematic review
We read with considerable interest the manuscript by Jayathilaka et al. [1] regarding the adverse events associated with C...
Dietary intake of isoflavones and coumestrol and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
Although phytoestrogens modulated pancreatic tumour growth in experimental studies, it remains unclear whether phytoestrog...
The long-lasting impacts of the COVID-19 pandemic on population-based cancer survival: what are the implications for data analysis?
The long-lasting impacts of the COVID-19 pandemic on population-based cancer survival: what are the implications for data analysis?
Monitoring trends of cancer incidence, mortality and survival is vital for the planning and delivery of health services, a...
Advancing radiomics from contrast-enhanced mammography in breast cancer
Zardavas D, Irrthum A, Swanton C, Piccart M. Clinical management of breast cancer heterogeneity. Nat Rev Clin Oncol. 2015;...
Correction: Cancer and treatment specific incidence rates of immune-related adverse events induced by immune checkpoint inhibitors: a systematic review
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Heterogeneity of tertiary lymphoid structures predicts the response to neoadjuvant therapy and immune microenvironment characteristics in triple-negative breast cancer
Heterogeneity of tertiary lymphoid structures predicts the response to neoadjuvant therapy and immune microenvironment characteristics in triple-negative breast cancer
Tertiary lymphoid structures (TLSs) impact cancer outcomes, including in triple-negative breast cancer (TNBC), where their...
Post-diagnosis statin use and survival among head and neck cancer patients: a cohort study in a universal health care system
Little research has been conducted on the relationship between statin use and the survival of head and neck cancer patient...
Long term efficacy of first-line afatinib and the clinical utility of ctDNA monitoring in patients with suspected or confirmed EGFR mutant non-small cell lung cancer who were unsuitable for chemotherapy
Long term efficacy of first-line afatinib and the clinical utility of ctDNA monitoring in patients with suspected or confirmed EGFR mutant non-small cell lung cancer who were unsuitable for chemotherapy
Here we present long-term outcomes of first line afatinib in comorbid patients with suspected or confirmed EGFR mutant NSC...
A histopathology-based artificial intelligence system assisting the screening of genetic alteration in intrahepatic cholangiocarcinoma
A histopathology-based artificial intelligence system assisting the screening of genetic alteration in intrahepatic cholangiocarcinoma
Targeted therapy for intrahepatic cholangiocarcinoma (ICC) shows superior survival outcomes but patients with certain targ...
Editorial Expression of Concern: Clusterin inhibition using OGX-011 synergistically enhances antitumour activity of sorafenib in a human renal cell carcinoma model
Authors and AffiliationsDivision of Urology, Kobe University Graduate School of Medicine, Kobe, JapanY. Kususda, H. Miyake...
ATR inhibition potentiates FOLFIRINOX cytotoxic effect in models of pancreatic ductal adenocarcinoma by remodelling the tumour microenvironment
ATR inhibition potentiates FOLFIRINOX cytotoxic effect in models of pancreatic ductal adenocarcinoma by remodelling the tumour microenvironment
In pancreatic ductal adenocarcinoma (PDAC), the dense stroma rich in cancer-associated fibroblasts (CAFs) and the immunosu...
Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas
Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas
We aimed to validate the prognostic significance of tumor budding (TB) in p16-positive oropharyngeal squamous cell carcino...
Early onset metastatic colorectal cancer patients as a distinctive clinical and molecular phenomenon
Early onset metastatic colorectal cancer patients as a distinctive clinical and molecular phenomenon
Despite a reduction of both incidence and mortality from CRC, recent studies have shown an increase in the incidence of ea...
Normal weight obesity, circulating biomarkers and risk of breast cancer: a prospective cohort study and meta-analysis
Normal weight obesity, circulating biomarkers and risk of breast cancer: a prospective cohort study and meta-analysis
Individuals with normal weight obesity (NWO) often escape the attention of healthcare providers who may assume that a norm...
Effects of tamoxifen on cognitive function in patients with primary breast cancer
Effects of tamoxifen on cognitive function in patients with primary breast cancer
Tamoxifen may adversely affect cognitive function by interfering with estrogen action in the brain. Despite growing eviden...
IL-10RA governor the expression of IDO in the instruction of lymphocyte immunity
IL-10RA governor the expression of IDO in the instruction of lymphocyte immunity
Indoleamine 2,3-dioxygenase (IDO) impairs anti-pathogen and anti-tumour immunity. Mesenchymal stem cells (MSCs) modulate i...
Pregabalin for chronic cough due to lung cancer: randomized, double-blind, placebo-controlled trial
Pregabalin for chronic cough due to lung cancer: randomized, double-blind, placebo-controlled trial
Developing effective therapies for cough in lung cancer is an unmet need Neuromodulators like pregabalin may act centrally...
SKP2 inhibition activates tumor cell-intrinsic immunity by inducing DNA replication stress and genomic instability
SKP2 inhibition activates tumor cell-intrinsic immunity by inducing DNA replication stress and genomic instability
S-phase kinase-associated protein 2 (SKP2) is a typical oncogene aberrantly overexpressing in a variety of cancer types, b...
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