SCI时时刷

search
+
Germline BRCA1/2 status and chemotherapy response score in high-grade serous ovarian cancer
Germline BRCA1/2 status and chemotherapy response score in high-grade serous ovarian cancer
High-grade serous ovarian cancer (HGSOC) can be treated with platinum-based neoadjuvant chemotherapy (NACT) and delayed pr...
UK guidelines for the management of bone sarcomas
This document is an update of the British Sarcoma Group guidelines (2016) and provides a reference standard for the clinic...
Phenotypical differences of neutrophils patrolling tumour-draining lymph nodes in head and neck cancer
Phenotypical differences of neutrophils patrolling tumour-draining lymph nodes in head and neck cancer
The complexity and heterogeneity of neutrophils are recognized, especially their roles in modulating inflammation and canc...
Integrated proteomics and scRNA-seq analyses of ovarian cancer reveal molecular subtype-associated cell landscapes and immunotherapy targets
Integrated proteomics and scRNA-seq analyses of ovarian cancer reveal molecular subtype-associated cell landscapes and immunotherapy targets
Epithelial ovarian cancer (EOC) represents the most lethal gynaecological malignancy, yet understanding the connections be...
The abscopal effects of sonodynamic therapy in cancer
The abscopal effects of sonodynamic therapy in cancer
The abscopal effect is a phenomenon wherein localised therapy on the primary tumour leads to regression of distal metastat...
Correction: Height and breast cancer risk in premenopausal Korean women aged under 40 years of age
Thi Xuan Mai Tran and Yoosoo Chang contributed equally to this work as co-first authors.These authors jointly supervised t...
Comparing cancer stage at diagnosis between migrants and non-migrants: a meta-analysis
Comparing cancer stage at diagnosis between migrants and non-migrants: a meta-analysis
Migrants face barriers accessing healthcare, risking delays in cancer diagnosis. Diagnostic delays result in later stage d...
VEGF-C propagates ‘onward’ colorectal cancer metastasis from liver to lung
VEGF-C propagates ‘onward’ colorectal cancer metastasis from liver to lung
The formation of lung metastasis as part of the progression of colon cancer is a poorly understood process. Theoretically,...
Real-world evidence for pembrolizumab in non-small cell lung cancer: a nationwide cohort study
Real-world evidence for pembrolizumab in non-small cell lung cancer: a nationwide cohort study
Based on favourable results from clinical trials, immune checkpoint inhibitors (ICI) have become the standard first line (...
Cardiotoxicity following thoracic radiotherapy for lung cancer
Cardiotoxicity following thoracic radiotherapy for lung cancer
Radiotherapy is the standard of care treatment for unresectable NSCLC, combined with concurrent chemotherapy and adjuvant ...
Perioperative safety of risk-reducing mastectomy
Metcalfe K, Huzarski T, Gronwald J, Kotsopoulos J, Kim R, Moller P, et al. Risk-reducing mastectomy and breast cancer mort...
Low-dose arsenic trioxide inhibits pancreatic stellate cell activation via LOXL3 expression to enhance immunotherapy in pancreatic cancer
Low-dose arsenic trioxide inhibits pancreatic stellate cell activation via LOXL3 expression to enhance immunotherapy in pancreatic cancer
Pancreatic cancer (PC) is characterized by abnormally fibrotic mesenchyme, which notably influences on the effectiveness o...
Cancer and treatment specific incidence rates of immune-related adverse events induced by immune checkpoint inhibitors: a systematic review
Cancer and treatment specific incidence rates of immune-related adverse events induced by immune checkpoint inhibitors: a systematic review
Immune-related adverse events (irAE) induced by immune checkpoint inhibitors (ICI) are a treatment-limiting barrier. There...
Temporal dynamics of immune cell patterns in bladder cancer patients receiving Bacillus Calmette-Guérin therapy
Temporal dynamics of immune cell patterns in bladder cancer patients receiving Bacillus Calmette-Guérin therapy
Bacillus Calmette-Guérin (BCG) is capable of enhancing the infiltration of immune cells into the tumour. However the ...
Crucial immunological roles of the invasion front in innate and adaptive immunity in cervical cancer
Crucial immunological roles of the invasion front in innate and adaptive immunity in cervical cancer
The immunostimulatory actions of innate and adaptive immune responses play a crucial role in the cancer-immunity cycle. Al...
The potential clinical utility of Whole Genome Sequencing for patients with cancer: evaluation of a regional implementation of the 100,000 Genomes Project
The potential clinical utility of Whole Genome Sequencing for patients with cancer: evaluation of a regional implementation of the 100,000 Genomes Project
The 100,000 Genomes Project established infrastructure for Whole Genome Sequencing (WGS) in the United Kingdom. A retrospe...
Recurrent somatic mutations of FAT family cadherins induce an aggressive phenotype and poor prognosis in anaplastic large cell lymphoma
Recurrent somatic mutations of FAT family cadherins induce an aggressive phenotype and poor prognosis in anaplastic large cell lymphoma
Anaplastic Large Cell Lymphoma (ALCL) is a rare and aggressive T-cell lymphoma, classified into ALK-positive and ALK-negat...
A proteome-wide association study identifies putative causal proteins for breast cancer risk
A proteome-wide association study identifies putative causal proteins for breast cancer risk
Genome-wide association studies (GWAS) have identified more than 200 breast cancer risk-associated genetic loci, yet the c...
Immune therapeutic strategies for the senescent tumor microenvironment
Immune therapeutic strategies for the senescent tumor microenvironment
Senescent cells can either to promote immunosuppressive tumor microenvironment or facilitate immune surveillance. Despite ...
Deep learning analysis of histopathological images predicts immunotherapy prognosis and reveals tumour microenvironment features in non-small cell lung cancer
Deep learning analysis of histopathological images predicts immunotherapy prognosis and reveals tumour microenvironment features in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer mortality worldwide. Immune checkpoint inhibitor...
Author Correction: CDK9 inhibition constrains multiple oncogenic transcriptional and epigenetic pathways in prostate cancer
These authors contributed equally: Razia Rahman, Muhammed H. Rahaman.These authors jointly supervised this work: Shudong W...
Phase II Study of Irinotecan, Trifluridine/tipiracil (TAS-102) plus Bevacizumab as a Later-line Therapy for Patients with Metastatic Colorectal Cancer (mCRC): a prospective single-center explorative study
Phase II Study of Irinotecan, Trifluridine/tipiracil (TAS-102) plus Bevacizumab as a Later-line Therapy for Patients with Metastatic Colorectal Cancer (mCRC): a prospective single-center explorative study
To explore the efficacy and safety of the combination of irinotecan, trifluridine/tipiracil (TAS-102), and bevacizumab in ...
Correction: Comorbidity in patients with cancer treated at The Christie
Correction: Comorbidity in patients with cancer treated at The Christie
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Spatial analysis by current multiplexed imaging technologies for the molecular characterisation of cancer tissues
Spatial analysis by current multiplexed imaging technologies for the molecular characterisation of cancer tissues
Tumours are composed of tumour cells and the surrounding tumour microenvironment (TME), and the molecular characterisation...
Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma
Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma
There is increased pan-cancer specific interest in repurposing the poly adenosine diphosphate-ribose polymerase-1 (PARP-1)...
Non-B DNA-informed mutation burden as a marker of treatment response and outcome in cancer
Non-B DNA-informed mutation burden as a marker of treatment response and outcome in cancer
Genomic instability is crucial in tumorigenesis, with Tumour Mutation Burden (TMB) being a biomarker to indicate therapeut...
Author Correction: Long-term activation of anti-tumor immunity in pancreatic cancer by a p53-expressing telomerase-specific oncolytic adenovirus
Author Correction: Long-term activation of anti-tumor immunity in pancreatic cancer by a p53-expressing telomerase-specific oncolytic adenovirus
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Identification of a 5-gene signature panel for the prediction of prostate cancer progression
Identification of a 5-gene signature panel for the prediction of prostate cancer progression
Despite nearly 100% 5-year survival for localised prostate cancer, the survival rate for metastatic prostate cancer signif...
Improved ex vivo fluorescence imaging of human head and neck cancer using the peptide tracer TPP-IRDye800 targeting membrane-bound Hsp70 on tumor cells
Improved ex vivo fluorescence imaging of human head and neck cancer using the peptide tracer TPP-IRDye800 targeting membrane-bound Hsp70 on tumor cells
The primary goal of surgery in HNSCC is the complete resection of tumor cells with maximum preservation of normal tissue. ...
Circulating tumour DNA and risk of recurrence in patients with asymptomatic versus symptomatic colorectal cancer
Circulating tumour DNA and risk of recurrence in patients with asymptomatic versus symptomatic colorectal cancer
Multiple initiatives aim to develop circulating tumour DNA (ctDNA) tests for early cancer detection in asymptomatic indivi...
阅读更多
format_indent_increase