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Association between trajectories of adherence to endocrine therapy and risk of treated breast cancer recurrence among US nonmetastatic breast cancer survivors
Association between trajectories of adherence to endocrine therapy and risk of treated breast cancer recurrence among US nonmetastatic breast cancer survivors
Endocrine therapy is the mainstay treatment for breast cancer (BC) to reduce BC recurrence risk. During the first year of ...
FGFR4-driven plasticity in breast cancer progression and resistance to therapy
FGFR4-driven plasticity in breast cancer progression and resistance to therapy
Breast cancer (BCa) is a complex and heterogeneous disease, with different intrinsic molecular subtypes that have distinct...
Blockade of TGF-β and PD-L1 by bintrafusp alfa promotes survival in preclinical ovarian cancer models by promoting T effector and NK cell responses
Blockade of TGF-β and PD-L1 by bintrafusp alfa promotes survival in preclinical ovarian cancer models by promoting T effector and NK cell responses
Failure of immunotherapy in high-grade serous ovarian cancer (HGSC) may be due to high levels of transforming growth facto...
Radiation Reveal: Moving from research engagement to involvement
Radiation Reveal: Moving from research engagement to involvement
Here, we report on the process of a highly impactful and successful creative, collaborative, and multi-partner public enga...
Predictable changes in the accuracy of human papillomavirus tests after vaccination: review with implications for performance monitoring in cervical screening
Predictable changes in the accuracy of human papillomavirus tests after vaccination: review with implications for performance monitoring in cervical screening
Vaccination against human papillomavirus (HPV) is changing the performance of cytology as a cervical screening test, but i...
Single-cell sequencing reveals VEGFR as a potential target for CAR-T cell therapy in chordoma
Single-cell sequencing reveals VEGFR as a potential target for CAR-T cell therapy in chordoma
Chordomas are rare osseous neoplasms with a dismal prognosis when they recur. Here we identified cell surface proteins tha...
Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance
Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance
Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the...
SPP1 represents a therapeutic target that promotes the progression of oesophageal squamous cell carcinoma by driving M2 macrophage infiltration
SPP1 represents a therapeutic target that promotes the progression of oesophageal squamous cell carcinoma by driving M2 macrophage infiltration
Tumour-associated macrophages (TAMs) are an important component of the tumour microenvironment (TME). However, the crossta...
Pathway-based signatures predict patient outcome, chemotherapy benefit and synthetic lethal dependencies in invasive lobular breast cancer
Pathway-based signatures predict patient outcome, chemotherapy benefit and synthetic lethal dependencies in invasive lobular breast cancer
Invasive Lobular Carcinoma (ILC) is a morphologically distinct breast cancer subtype that represents up to 15% of all brea...
Neratinib could be effective as monotherapy or in combination with trastuzumab in HER2-low breast cancer cells and organoid models
Neratinib could be effective as monotherapy or in combination with trastuzumab in HER2-low breast cancer cells and organoid models
Previous studies have suggested that patients with HER2-low breast cancers do not benefit from trastuzumab treatment altho...
Trajectory patterns and cumulative burden of CEA during follow-up with non-small cell lung cancer outcomes: A retrospective longitudinal cohort study
Trajectory patterns and cumulative burden of CEA during follow-up with non-small cell lung cancer outcomes: A retrospective longitudinal cohort study
Previous studies of non-small cell lung cancer (NSCLC) focused on CEA measured at a single time point, ignoring serial CEA...
Cancer-associated fibroblasts expressing fibroblast activation protein and podoplanin in non-small cell lung cancer predict poor clinical outcome
Cancer-associated fibroblasts expressing fibroblast activation protein and podoplanin in non-small cell lung cancer predict poor clinical outcome
Cancer-associated fibroblasts (CAFs) are a dominant cell type in the stroma of non-small cell lung cancer (NSCLC). Fibrobl...
The prognostic value of MEK pathway–associated estrogen receptor signaling activity for female cancers
The prognostic value of MEK pathway–associated estrogen receptor signaling activity for female cancers
Other than for breast cancer, endocrine therapy has not been highly effective for gynecologic cancers. Endocrine therapy r...
DRP1 inhibition-mediated mitochondrial elongation abolishes cancer stemness, enhances glutaminolysis, and drives ferroptosis in oral squamous cell carcinoma
DRP1 inhibition-mediated mitochondrial elongation abolishes cancer stemness, enhances glutaminolysis, and drives ferroptosis in oral squamous cell carcinoma
Mitochondrial dynamics play a fundamental role in determining stem cell fate. However, the underlying mechanisms of mitoch...
Correction: Inhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
GCN5 mediates DNA-PKcs crotonylation for DNA double-strand break repair and determining cancer radiosensitivity
GCN5 mediates DNA-PKcs crotonylation for DNA double-strand break repair and determining cancer radiosensitivity
DNA double-strand break (DSB) induction and repair are important events for determining cell survival and the outcome of c...
Efficacy and safety of tepotinib in Asian patients with advanced NSCLC with MET exon 14 skipping enrolled in VISION
Efficacy and safety of tepotinib in Asian patients with advanced NSCLC with MET exon 14 skipping enrolled in VISION
Tepotinib, a MET inhibitor approved for the treatment of MET exon 14 (METex14) skipping NSCLC, demonstrated durable clinic...
Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk
Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk
Menopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with a lower risk of ...
Identification of MYCN non-amplified neuroblastoma subgroups points towards molecular signatures for precision prognosis and therapy stratification
Identification of MYCN non-amplified neuroblastoma subgroups points towards molecular signatures for precision prognosis and therapy stratification
Despite the extensive study of MYCN-amplified neuroblastomas, there is a significant unmet clinical need in MYCN non-ampli...
Fibroblast activation protein-targeted near-infrared photoimmunotherapy depletes immunosuppressive cancer-associated fibroblasts and remodels local tumor immunity
Fibroblast activation protein-targeted near-infrared photoimmunotherapy depletes immunosuppressive cancer-associated fibroblasts and remodels local tumor immunity
Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) play a critical role in tumor immunosuppression. ...
Oesophageal cancer awareness and anticipated time to help-seeking: results from a population-based survey
Oesophageal cancer awareness and anticipated time to help-seeking: results from a population-based survey
Modifying public awareness of oesophageal cancer symptoms might help to decrease late-stage diagnosis and, in turn, improv...
Extending the dosing intervals of nivolumab: model-based simulations in unselected cancer patients
Extending the dosing intervals of nivolumab: model-based simulations in unselected cancer patients
Reducing nivolumab dose intensity could increase patients’ life quality and decrease the financial burden while main...
Incidental pathogenic germline alterations detected through liquid biopsy in patients with solid tumors: prevalence, clinical utility and implications
Incidental pathogenic germline alterations detected through liquid biopsy in patients with solid tumors: prevalence, clinical utility and implications
Liquid biopsy, a minimally invasive approach for detecting tumor biomarkers in blood, has emerged as a leading-edge techni...
Identification of unique rectal cancer-specific subtypes
Identification of unique rectal cancer-specific subtypes
Existing colorectal cancer subtyping methods were generated without much consideration of potential differences in express...
Methylation analysis of DCC gene in saliva samples is an efficient method for non-invasive detection of superficial hypopharyngeal cancer
Methylation analysis of DCC gene in saliva samples is an efficient method for non-invasive detection of superficial hypopharyngeal cancer
Advances in upper gastrointestinal endoscopic technology have enabled early detection and treatment of hypopharyngeal canc...
Radiation therapy with phenotypic medicine: towards N-of-1 personalization
Radiation therapy with phenotypic medicine: towards N-of-1 personalization
In current clinical practice, radiotherapy (RT) is prescribed as a pre-determined total dose divided over daily doses (fra...
Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma
Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma
More than half of mesothelioma tumours show alterations in the tumour suppressor gene BAP1. BAP1-deficient mesothelioma is...
Persistence of peripheral CD8 + CD28− T cells indicates a favourable outcome and tumour immunity in first-line HER2-positive metastatic breast cancer
Persistence of peripheral CD8 + CD28− T cells indicates a favourable outcome and tumour immunity in first-line HER2-positive metastatic breast cancer
The contradictory role of CD8 + CD28− T cells in tumour immunity has been reported, while their biologic...
Association of immune-related adverse events with durvalumab efficacy after chemoradiotherapy in patients with unresectable Stage III non-small cell lung cancer
Association of immune-related adverse events with durvalumab efficacy after chemoradiotherapy in patients with unresectable Stage III non-small cell lung cancer
Immune-related adverse events (irAEs) have been found to predict PD-L1 inhibitor efficacy in metastatic NSCLC. However, th...
Retraction Note: Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy
These authors contributed equally: Q. Tan, A. M. Joshua.Department of Medical Biophysics, University Health Network, Unive...
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