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Branched-chain amino acids prevent obesity by inhibiting the cell cycle in an NADPH-FTO-m6A coordinated manner
Branched-chain amino acids prevent obesity by inhibiting the cell cycle in an NADPH-FTO-m6A coordinated manner
Obesity, featured by increased adipose tissue mass, is linked with a strong predisposition toward many metabolic diseases ...
Genistein upregulates AHR to protect against environmental toxin-induced NASH by inhibiting NLRP3 inflammasome activation and reconstructing antioxidant defense mechanisms
Genistein upregulates AHR to protect against environmental toxin-induced NASH by inhibiting NLRP3 inflammasome activation and reconstructing antioxidant defense mechanisms
Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD) characterized by h...
Synthetic lethality in human bladder cancer cells by curcumin via concurrent Aurora A inhibition and autophagy induction
Synthetic lethality in human bladder cancer cells by curcumin via concurrent Aurora A inhibition and autophagy induction
Oncoprotein Aurora A kinase is a member of the Aurora kinase family, which regulates the centrosomal and microtubule activ...
POTENTIAL MECHANISMS OF ACTION OF RESVERATROL IN PREVENTION AND THERAPY FOR MENTAL DISORDERS
POTENTIAL MECHANISMS OF ACTION OF RESVERATROL IN PREVENTION AND THERAPY FOR MENTAL DISORDERS
Food quality has been recognized as a potential factor capable of affecting mood stability, cognition, modulation of brain...
The chronic consumption of dietary fructose promotes the gut Clostridium species imbalance and bile acid alterations in developing nonalcoholic fatty liver disease
The chronic consumption of dietary fructose promotes the gut Clostridium species imbalance and bile acid alterations in developing nonalcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is defined as the pathological accumulation of macrovesicular lipid droplets in ...
The Interaction Between Apigenin and PKM2 Restrains Progression of Colorectal Cancer
The Interaction Between Apigenin and PKM2 Restrains Progression of Colorectal Cancer
Colorectal cancers are the second most common cause of mortality in the USA, Western Europe and also Hungary. After the re...
Genistein enhances NAD+ biosynthesis by upregulating nicotinamide phosphoribosyltransferase in adipocytes
Genistein enhances NAD+ biosynthesis by upregulating nicotinamide phosphoribosyltransferase in adipocytes
Obesity is a major global health challenge because of its association with systemic metabolic dysfunctions in different or...
Human milk-derived MANF, as an immuno‐nutritional factor, maintains the intestinal epithelial barrier and protects against necrotizing enterocolitis
Human milk-derived MANF, as an immuno‐nutritional factor, maintains the intestinal epithelial barrier and protects against necrotizing enterocolitis
Available online 29 August 2023, 109431Author links open overlay panel, , , , , , , , , , AbstractNecrotizing enterocoliti...
Maternal protein deficiency impairs peroxisome biogenesis and leads to oxidative stress and ferroptosis in liver of fetal growth restriction offspring
Maternal protein deficiency impairs peroxisome biogenesis and leads to oxidative stress and ferroptosis in liver of fetal growth restriction offspring
The Developmental Origins of Health and Disease (DOHaD) states that early life environmental exposures have a profound eff...
Novel mechanism for zinc inducing hepatic lipolysis via the HDAC3-mediated deacetylation of β-catenin at lysine 311
Novel mechanism for zinc inducing hepatic lipolysis via the HDAC3-mediated deacetylation of β-catenin at lysine 311
The micronutrient zinc (Zn) is required by all living organisms and is engaged in multiple biological functions, such as a...
Dietary phenolics and their microbial metabolites are poor inhibitors of trimethylamine oxidation to trimethylamine N-oxide by hepatic flavin monooxygenase 3
Dietary phenolics and their microbial metabolites are poor inhibitors of trimethylamine oxidation to trimethylamine N-oxide by hepatic flavin monooxygenase 3
Cardiovascular disease (CVD) is one of the major causes of death worldwide [1]. A key factor in the development of CVD, ca...
Managing ferroptosis-related diseases with indirect dietary modulators of ferroptosis
Managing ferroptosis-related diseases with indirect dietary modulators of ferroptosis
Iron is an essential micronutrient for humans. Given its redox-active nature, dysregulation of iron metabolism can produce...
Dietary docosahexaenoic acid plays an opposed role in ferroptotic and non-ferroptotic acute kidney injury
Dietary docosahexaenoic acid plays an opposed role in ferroptotic and non-ferroptotic acute kidney injury
The physiological function of the kidney depends on homeostasis of lipid metabolism [1], [2], [3], [4], [5]. Acute kidney ...
Combined resistant dextrin and low-dose Mg oxide administration increases short-chain fatty acid and lactic acid production by gut microbiota
Volume 120, October 2023, 109420Author links open overlay panel, , , , , , , AbstractThe consumption of resistant dextrin ...
Transgenic mice producing the trans 10, cis 12-conjugated linoleic acid present reduced adiposity and increased thermogenesis and fibroblast growth factor 21 (FGF21)
Trans 10, cis 12-conjugated linoleic acid (t10c12-CLA), an isomer of linoleic acid (18:2n-6, LA), occurs naturally in rumi...
Supplementation with EPA and DHA omega-3 fatty acids improves peripheral immune cell mitochondrial dysfunction and inflammation in subjects with obesity
Keywordslow-grade inflammationmitochondrial bioenergetics dysfunctionoxygen consumption rateextracellular acidification ra...
Selenium modulates AR/IGF-1R/EGFR and TROP2 signaling pathways and improves anticancer efficacy in murine mammary carcinoma 4T1
Triple-negative breast cancer (TNBC), a specific type of breast cancer, is a lack of expression of three particular recept...
Thermoneutrality or standard temperature: is there an ideal housing temperature to study the antisteatotic effects of green tea in obese mice?
Nonalcoholic fatty liver disease (NAFLD) or a new definition based on clinical practice, metabolic associated fatty liver ...
Quercetin ameliorates nonalcoholic fatty liver disease (NAFLD) via the promotion of AMPK-mediated hepatic mitophagy
Nonalcoholic fatty liver disease (NAFLD) carries the highest burden of morbidity among all liver diseases worldwide, with ...
EGCG alleviates obesity-exacerbated lung cancer progression by STAT1/SLC7A11 pathway and gut microbiota
One of the newly recognized types of cell death is ferroptosis which is related to the accumulation of iron and lipid-reac...
Nedd4-1 regulates human sodium-dependent vitamin C transporter-2 functional expression in neuronal and epithelial cells
Vitamin C (ascorbic acid; AA) is a naturally occurring micronutrient in some foods and is also available as a common dieta...
Butyrate restores the fat/lean mass ratio balance and energy metabolism and reinforces the tight junction-mediated intestinal epithelial barrier in prediabetic mice independently of its anti-inflammatory and epigenetic actions
Type 2 diabetes mellitus (T2D) is the most frequent form of diabetes, accounting for approximately 90% of the diagnosed ca...
The ketogenic diet promotes triacylglycerol recycling in white adipose tissue and uncoupled fat oxidation in brown adipose tissue, but does not reduce adiposity in rats
Functional adipose tissue (AT) is crucial for the prevention of insulin resistance and Type 2 diabetes [1]. There are gene...
Increasing dietary nutrient levels modulates colon immune adaptation and alleviates inflammation in the epithelial heterogeneous nuclear ribonucleoprotein I (Hnrnp I) knockout mice
Volume 119, September 2023, 109406Author links open overlay panel, , , , , , , , AbstractHeterogeneous nuclear ribonucleop...
γ‐glutamylcysteine alleviates insulin resistance and hepatic steatosis by regulating adenylate cyclase and IGF‐1R/IRS1/PI3K/Akt signaling pathways
T2DM is a metabolic disease, which is characterized by ranging from predominantly IR with relative insulin deficiency to p...
Fructose aggravates copper-deficiency-induced non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) has reached epidemic proportions and emerged as a global public health issue, wi...
The early impact of diets enriched with saturated and unsaturated fatty acids on intestinal inflammation and tight junctions
In 1993, Hotamisligil et al. [1] showed that adipocytes could perform functions beyond only stock energy, by proportioning...
Gene network based analysis identifies a coexpression module involved in regulating plasma lipids with high-fat diet response
Plasma lipids are controlled by both genetic and environmental variables, particularly physical activity and diet. The mai...
Dynamic chromatin accessibility during nutritional iron overload reveals a BMP6-independent induction of cell cycle genes
Iron is critical to many physiological processes such as oxygen transport, various enzymatic reactions, the electron trans...
Through regulation of the SIRT1 pathway plant sterol ester of α-linolenic acid inhibits pyroptosis thereby attenuating the development of NASH in mice
Non-alcoholic fatty liver disease (NAFLD) represents the most common liver disease worldwide and its global prevalence is ...
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