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Branched-chain amino acids prevent obesity by inhibiting the cell cycle in an NADPH-FTO-m6A coordinated manner
Branched-chain amino acids prevent obesity by inhibiting the cell cycle in an NADPH-FTO-m6A coordinated manner
Obesity, featured by increased adipose tissue mass, is linked with a strong predisposition toward many metabolic diseases ...
Synthetic lethality in human bladder cancer cells by curcumin via concurrent Aurora A inhibition and autophagy induction
Synthetic lethality in human bladder cancer cells by curcumin via concurrent Aurora A inhibition and autophagy induction
Oncoprotein Aurora A kinase is a member of the Aurora kinase family, which regulates the centrosomal and microtubule activ...
POTENTIAL MECHANISMS OF ACTION OF RESVERATROL IN PREVENTION AND THERAPY FOR MENTAL DISORDERS
POTENTIAL MECHANISMS OF ACTION OF RESVERATROL IN PREVENTION AND THERAPY FOR MENTAL DISORDERS
Food quality has been recognized as a potential factor capable of affecting mood stability, cognition, modulation of brain...
The Interaction Between Apigenin and PKM2 Restrains Progression of Colorectal Cancer
The Interaction Between Apigenin and PKM2 Restrains Progression of Colorectal Cancer
Colorectal cancers are the second most common cause of mortality in the USA, Western Europe and also Hungary. After the re...
Genistein enhances NAD+ biosynthesis by upregulating nicotinamide phosphoribosyltransferase in adipocytes
Genistein enhances NAD+ biosynthesis by upregulating nicotinamide phosphoribosyltransferase in adipocytes
Obesity is a major global health challenge because of its association with systemic metabolic dysfunctions in different or...
Novel mechanism for zinc inducing hepatic lipolysis via the HDAC3-mediated deacetylation of β-catenin at lysine 311
Novel mechanism for zinc inducing hepatic lipolysis via the HDAC3-mediated deacetylation of β-catenin at lysine 311
The micronutrient zinc (Zn) is required by all living organisms and is engaged in multiple biological functions, such as a...
Managing ferroptosis-related diseases with indirect dietary modulators of ferroptosis
Managing ferroptosis-related diseases with indirect dietary modulators of ferroptosis
Iron is an essential micronutrient for humans. Given its redox-active nature, dysregulation of iron metabolism can produce...
Dietary docosahexaenoic acid plays an opposed role in ferroptotic and non-ferroptotic acute kidney injury
Dietary docosahexaenoic acid plays an opposed role in ferroptotic and non-ferroptotic acute kidney injury
The physiological function of the kidney depends on homeostasis of lipid metabolism [1], [2], [3], [4], [5]. Acute kidney ...
Selenium modulates AR/IGF-1R/EGFR and TROP2 signaling pathways and improves anticancer efficacy in murine mammary carcinoma 4T1
Triple-negative breast cancer (TNBC), a specific type of breast cancer, is a lack of expression of three particular recept...
Quercetin ameliorates nonalcoholic fatty liver disease (NAFLD) via the promotion of AMPK-mediated hepatic mitophagy
Nonalcoholic fatty liver disease (NAFLD) carries the highest burden of morbidity among all liver diseases worldwide, with ...
EGCG alleviates obesity-exacerbated lung cancer progression by STAT1/SLC7A11 pathway and gut microbiota
One of the newly recognized types of cell death is ferroptosis which is related to the accumulation of iron and lipid-reac...
Nedd4-1 regulates human sodium-dependent vitamin C transporter-2 functional expression in neuronal and epithelial cells
Vitamin C (ascorbic acid; AA) is a naturally occurring micronutrient in some foods and is also available as a common dieta...
Fructose aggravates copper-deficiency-induced non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) has reached epidemic proportions and emerged as a global public health issue, wi...
The early impact of diets enriched with saturated and unsaturated fatty acids on intestinal inflammation and tight junctions
In 1993, Hotamisligil et al. [1] showed that adipocytes could perform functions beyond only stock energy, by proportioning...
Gene network based analysis identifies a coexpression module involved in regulating plasma lipids with high-fat diet response
Plasma lipids are controlled by both genetic and environmental variables, particularly physical activity and diet. The mai...
Dynamic chromatin accessibility during nutritional iron overload reveals a BMP6-independent induction of cell cycle genes
Iron is critical to many physiological processes such as oxygen transport, various enzymatic reactions, the electron trans...