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The type I interferon antiviral response in the choroid plexus and the cognitive risk in COVID-19
The type I interferon antiviral response in the choroid plexus and the cognitive risk in COVID-19
The type I interferon (IFN) response is the body’s typical immune defense against viruses. Previous studies linked h...
A patient-centric modeling framework captures recovery from SARS-CoV-2 infection
A patient-centric modeling framework captures recovery from SARS-CoV-2 infection
The biology driving individual patient responses to severe acute respiratory syndrome coronavirus 2 infection remains ill ...
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens
Antigen receptor loci are organized into variable (V), diversity (D) and joining (J) gene segments that rearrange to gener...
Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis
Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis
2-Arachidonoylglycerol (2-AG) is the most abundant endogenous cannabinoid. Inhibition of 2-AG metabolism by inactivation o...
Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress
Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). Anxiety and depression...
Associations of IL-17 and IL-17 receptor polymorphisms with Behçet’s disease in Denizli Province of Turkey
Associations of IL-17 and IL-17 receptor polymorphisms with Behçet’s disease in Denizli Province of Turkey
Although the etiopathogenesis of Behçet’s disease is not known, studies conducted in different populations show...
Melatonin: a potential therapeutic approach for the management of primary Sjögren’s syndrome
Melatonin: a potential therapeutic approach for the management of primary Sjögren’s syndrome
Primary Sjögren’s syndrome (pSS) is an autoimmune disease that primarily affects the exocrine glands and is mai...
Shorter Cilia Length and Aberrant Ciliated Marker DNAI1 in Allergic Rhinitis
Shorter Cilia Length and Aberrant Ciliated Marker DNAI1 in Allergic Rhinitis
Investigating whether the impaired ciliary length and aberrant ciliary ultrastructure marker, DNAI1, are important in pati...
The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge
The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge
Mechanism of ferroptosis in chronic liver disease, aiming to outline the blueprint of ferroptosis as an effective option f...
Screening for diagnostic targets in tuberculosis and study on its pathogenic mechanism based on mRNA sequencing technology and miRNA-mRNA-pathway regulatory network
Screening for diagnostic targets in tuberculosis and study on its pathogenic mechanism based on mRNA sequencing technology and miRNA-mRNA-pathway regulatory network
PurposeTuberculosis is common infectious diseases, characterized by infectivity, concealment and chronicity, and the early...
Immune responses in mildly versus critically ill COVID-19 patients
Immune responses in mildly versus critically ill COVID-19 patients
The current coronavirus pandemic (COVID-19), caused by SARS-CoV-2, has had devastating effects on the global health and ec...
Overlapping anti-NMDAR encephalitis and multiple sclerosis: A case report and literature review
Overlapping anti-NMDAR encephalitis and multiple sclerosis: A case report and literature review
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune-mediated disease characterized by complicated neu...
γδ T cells and their clinical application in colon cancer
γδ T cells and their clinical application in colon cancer
In recent years, research has focused on colorectal cancer to implement modern treatment approaches to improve patient sur...
Sex-disaggregated outcomes of adverse events after COVID-19 vaccination: A Dutch cohort study and review of the literature
Sex-disaggregated outcomes of adverse events after COVID-19 vaccination: A Dutch cohort study and review of the literature
BackgroundAlbeit the need for sex-disaggregated results of adverse events after immunization (AEFIs) is gaining attention ...
Association between human leukocyte antigen and immunosuppressive treatment outcomes in Chinese patients with aplastic anemia
Association between human leukocyte antigen and immunosuppressive treatment outcomes in Chinese patients with aplastic anemia
BackgroundActivated cytotoxic T cells (CTLs) recognize the auto-antigens presented on hematopoietic stem/progenitor cells ...
Changes of natural killer cells’ phenotype in patients with chronic hepatitis B in intermittent interferon therapy
Changes of natural killer cells’ phenotype in patients with chronic hepatitis B in intermittent interferon therapy
BackgroundTo investigate the changes of natural killer (NK) cell phenotype in the interferon alpha (IFN-α) treatment of ch...
Evaluating the effects of vitamin D Level on airway obstruction in two asthma endotypes in humans and in two mouse models with different intake of vitamin D during early-life
Evaluating the effects of vitamin D Level on airway obstruction in two asthma endotypes in humans and in two mouse models with different intake of vitamin D during early-life
IntroductionAsthma is primarily divided into two categories: type 2 (T2-high) and non-type 2 (T2-low). A relationship betw...
Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation
Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation
Interferons (IFNs), IFN-stimulated genes (ISGs), and inflammatory cytokines mediate innate immune responses, and are essen...
Single-cell mass cytometry on peripheral cells in Myasthenia Gravis identifies dysregulation of innate immune cells
Single-cell mass cytometry on peripheral cells in Myasthenia Gravis identifies dysregulation of innate immune cells
Myasthenia Gravis (MG) is a neurological autoimmune disease characterized by disabling muscle weaknesses due to anti-acety...
Retinal structural and microvascular changes in myelin oligodendrocyte glycoprotein antibody disease and neuromyelitis optica spectrum disorder: An OCT/OCTA study
Retinal structural and microvascular changes in myelin oligodendrocyte glycoprotein antibody disease and neuromyelitis optica spectrum disorder: An OCT/OCTA study
PurposeTo compare the optical coherence tomography (OCT)/OCT angiography (OCTA) measures in patients with neuromyelitis op...
Application of quantitative proteomics to discover biomarkers for tick resistance in cattle
Application of quantitative proteomics to discover biomarkers for tick resistance in cattle
IntroductionBreeding for tick resistance is a sustainable alternative to control cattle ticks due to widespread resistance...
Immune regulation based on sex differences in ischemic stroke pathology
Immune regulation based on sex differences in ischemic stroke pathology
Ischemic stroke is one of the world’s leading causes of death and disability. It has been established that gender differen...
Association between genetically predicted leukocyte telomere length and non-scarring alopecia: A two-sample Mendelian randomization study
Association between genetically predicted leukocyte telomere length and non-scarring alopecia: A two-sample Mendelian randomization study
BackgroundThe most commonly acknowledged non-scarring alopecia are androgenetic alopecia (AGA) and alopecia areata (AA). P...
CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome
CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome
IntroductionAtypical hemolytic uremic syndrome (aHUS) is a rare disease that manifests with microangiopathic hemolytic ane...
Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival
Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival
Ischemia-reperfusion injury (IRI) amplifies T cell alloimmune responses after transplantation with thrombin playing a key ...
Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces neutralizing salivary IgA
Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces neutralizing salivary IgA
Intramuscularly administered vaccines stimulate robust serum neutralizing antibodies, yet they are often less competent in...
A rare case of IgG4-related disease masquerading as periurethral malignancy and review of the literature
A rare case of IgG4-related disease masquerading as periurethral malignancy and review of the literature
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disease that typically manifests as ma...
Melanocortin therapies to resolve fibroblast-mediated diseases
Melanocortin therapies to resolve fibroblast-mediated diseases
Stromal cells have emerged as central drivers in multiple and diverse diseases, and consequently, as potential new cellula...
Evaluation of immunotherapy efficacy in gynecologic cancer
Evaluation of immunotherapy efficacy in gynecologic cancer
Various immunotherapies have demonstrated remarkable success over the past few decades, and have been approved for the tre...
High-fiber diet ameliorates gut microbiota, serum metabolism and emotional mood in type 2 diabetes patients
High-fiber diet ameliorates gut microbiota, serum metabolism and emotional mood in type 2 diabetes patients
Previous studies have demonstrated that patients with type 2 diabetes mellitus (T2DM) often had the problems of fecal micr...
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