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Well‐differentiated lipomatous neoplasms with p53 alterations: a clinicopathological and molecular study of eight cases with features of atypical pleomorphic lipomatous tumour
Aims Well-differentiated lipomatous neoplasms encompass a broad spectrum of benign and malignant tumours, many of which ar...
Large cell calcifying Sertoli cell tumour: a contemporary multi‐institutional case series highlighting the diagnostic utility of PRKAR1A immunohistochemistry
Aims Large cell calcifying Sertoli cell tumour (LCCSCT) is a rare testicular sex cord-stromal tumour that primarily affect...
Clinical, radiological and pathological features of idiopathic and secondary interstitial pneumonia with pleuroparenchymal fibroelastosis in patients undergoing lung transplantation
Aims Idiopathic pleuroparenchymal fibroelastosis (PPFE) is a rare type of idiopathic interstitial pneumonia, and pathologi...
ALK rearrangements in infantile fibrosarcoma‐like spindle cell tumours of soft tissue and kidney
Aims Recurrent alterations in receptor tyrosine kinase (RTK) and downstream effectors are described in infantile fibrosarc...
A comparative study of AJCC and the modified staging system in pT2/pT3 penile squamous cell carcinoma – a validation on an external data set
Aims The recent changes in the American Joint Commission on Cancer, 8th edition (AJCC-8E) pT2 and pT3 tumour definitions f...
Looking forward for ’Histopathology‘
Volume 80, Issue 2 p. 253-254 Editorial Daniel M Berney, Corresponding Author ...
SWI/SNF complex (SMARCA4, SMARCA2, INI1/SMARCB1) deficient colorectal carcinomas are strongly associated with microsatellite instability: An incidence study in 4508 colorectal carcinomas
Aims Loss of expression of mammalian SWI/SNF (BAF) complex subunits including SMARCA4, SMARCA2 and INI1/SMARCB1 (termed SW...
Artificial intelligence for histological subtype classification of breast cancer: combining multi‐scale feature maps and recurrent attention model
Aims The aim of this study was to apply a two-stage deep model combining multi-scale feature maps and the recurrent attent...
SRY‐box transcription factor 10 is a highly specific biomarker of basal‐like breast cancer
Aims Basal-like breast cancer is an aggressive molecular subtype associated with younger age and early relapse. Most cases...
EBV+ high‐grade B cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a multi‐institutional study
Aims It is unknown whether Epstein–Barr virus (EBV) infection can occur in high-grade B cell lymphoma with MYC and ...
Interobserver agreement in the diagnosis of anal dysplasia: comparison between gastrointestinal and gynaecological pathologists and utility of consensus conferences
Aims Management of anal dysplasia relies upon the accurate diagnosis of anal biopsy specimens. As institutions move toward...
Cribriform architecture outperforms Gleason pattern 4 percentage and tertiary Gleason pattern 5 in predicting the outcome of Grade Group 2 prostate cancer patients
Aims Gleason pattern 4 (GP4) percentage, invasive cribriform and/or intraductal carcinoma (IC/IDC) and the presence of ter...
Hepatocellular Adenoma: What We Know, What We Do Not Know, and Why It Matters
Abstract In the last 2 decades there has been significant progress in research and diagnosis of hepatocellular adenoma (HC...
ALK rearrangements in infantile fibrosarcoma‐like spindle cell tumors of soft tissue and kidney
ABSTRACT Aims Recurrent alterations in receptor tyrosine kinase (RTK) and downstream effectors are described in infantile ...
Centrizonal hepatocyte dropout in allograft liver biopsies: A clinicopathologic study
Abstract Background Centrizonal hepatocyte dropout has been described in diverse liver pathologies, including viral hepati...
JAZF1, YWHAE, and BCOR Gene Translocation in Primary Extrauterine Low‐Grade and High‐Grade Endometrial Stromal Sarcomas
Abstract Aims JAZF1 gene translocation is the most common genetic change in low-grade endometrial stromal sarcoma (LG-ESS)...
A mimic of lung adenocarcinoma: a case report of histological conversion of metastatic thyroid papillary carcinoma
Abstract In a patient with a history of cancer, distinguishing a metastasis of the prior tumour from a new primary tumour ...
The prognostic significance of pleomorphism in gastrointestinal stromal tumours
Aim Gastrointestinal stromal tumours (GISTs) typically show uniform nuclear morphology, with spindle cell, epithelioid or ...
Primary synovial sarcoma of bone: A retrospective analysis of 25 patients
ABSTRACT Aims To evaluate diagnostic accuracy of SSX and SSX-SS18 antibodies in decalcified surgical specimens and outcome...
Diagnostic variability in the histopathological assessment of advanced colorectal adenomas and early colorectal cancer in a screening population
Abstract Aim The aim of this study was to evaluate interobserver variability between individual pathologists and a panel o...
Comparative effectiveness of pathologic techniques to improve lymph node yield from colorectal cancer specimens. A systematic review and network meta‐analysis
Abstract Background A number of randomized controlled trials (RCT) have compared different techniques to improve lymph nod...
Development and validation of a supervised deep learning algorithm for automated whole‐slide programmed death‐ligand 1 tumour proportion score assessment in non‐small cell lung cancer
Aims Immunohistochemical programmed death-ligand 1 (PD-L1) staining to predict responsiveness to immunotherapy in patients...
Sclerosing stromal tumour: a clinicopathological study of 100 cases of a distinctive benign ovarian stromal tumour typically occurring in the young
Aims Since the sclerosing stromal tumour (SST) of the ovary was first described in 1973, few studies have expanded upon it...
The bowel cancer screening programme expert board – an analysis of activity during 2017‐2020
Abstract Aims The inception of the NHS Bowel Cancer Screening Programme (BCSP) in England in 2006 highlighted that the dif...
Evaluating programmed death‐ligand 1 (PD‐L1) in head and neck squamous cell carcinoma: concordance between the 22C3 PharmDx assay and the SP263 assay on whole sections from a multicentre study
Aims The introduction of immunotherapy for patients with head and neck squamous cell carcinoma (HNSCC) raises the need for...
Lessons learnt from MDM2 fluorescence in‐situ hybridisation analysis of 439 mature lipomatous lesions with an emphasis on atypical lipomatous tumour/well‐differentiated liposarcoma lacking cytological atypia
Aims Amplification of the murine double minute-2 (MDM2) gene, which is usually detected with fluorescence in-situ hybridis...
Primary cutaneous adenoid cystic carcinoma: a clinicopathologic, immunohistochemical, and fluorescence in‐situ hybridisation study of 13 cases
Aims This study aimed to investigate the clinical, histological, immunohistochemical and chromosomal features of primary c...
Pulmonary Neuroendocrine Carcinomas in Situ: Do They Exist?
ABSTRACT Introduction Although precursor lesions of pulmonary squamous carcinoma, adenocarcinoma, and carcinoid tumor are ...
Clinical, radiological, and pathological features of idiopathic and secondary interstitial pneumonia cases with pleuroparenchymal fibroelastosis undergoing lung transplantation
Abstract Aims Idiopathic pleuroparenchymal fibroelastosis (PPFE) is a rare type of idiopathic interstitial pneumonia, and ...
Cicatricial organising pneumonia associated with fibrosing interstitial pneumonia – a clinicopathological study
Aims The recent recognition of cicatricial organising pneumonia (ciOP) indicates that the ciOP may resemble or simulate fi...
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