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Diversity of NF-κB signalling and inflammatory heterogeneity in Rheumatic Autoimmune Disease
Available online 3 September 2022, 101649Highlights•NF-κB-related genetic variants have been identified in most Systemic A...
Cellular and molecular diversity in rheumatic autoimmune diseases
Available online 6 August 2022, 101648AbstractWith the increasing armamentarium of high-throughput tools available at mana...
Recent developments in C3-targeted complement therapeutics
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Targeting the tissue-complosome for curbing inflammatory disease
Available online 26 July 2022, 101644Highlights•Tissue-resident cells and infiltrating immune cells shape local inflammato...
Complement C3 activation in the ICU: Disease and therapy as Bonnie and Clyde
Available online 16 July 2022, 101640AbstractPatients in the intensive care unit (ICU) often straddle the divide between l...
The gut-enthesis axis and the pathogenesis of Spondyloarthritis
Available online 15 July 2022, 101607Highlights•Enthesitis is central in the initiation and perpetuation of the disease an...
Complement activation in cancer: Effects on tumor-associated myeloid cells and immunosuppression
Cancer-related inflammation plays a central role in the establishment of tumor-promoting mechanisms. Tumor-associated myel...
Complement C3-targeted therapy in C3 glomerulopathy, a prototype of complement-mediated kidney diseases
Available online 8 July 2022, 101634AbstractC3 glomerulopathy (C3G) is a rare and complex kidney disease that primarily af...
Emerging opportunities for C3 inhibition in the eye
Available online 2 July 2022, 101633AbstractThe eye presents a unique opportunity for complement component 3 (C3) therapeu...
Pathophysiology of neurodegenerative diseases: An interplay among axonal transport failure, oxidative stress, and inflammation?
Available online 30 June 2022, 101628AbstractNeurodegenerative diseases (NDs) are heterogeneous neurological disorders cha...
Discovering C3 targeting therapies for paroxysmal nocturnal hemoglobinuria: Achievements and pitfalls
Available online 25 June 2022, 101618Highlights•C3-mediated extravascular hemolysis limits the hematological benefit of an...
Reparative inflammation in multiple sclerosis
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Age-related changes in multiple sclerosis and experimental autoimmune encephalomyelitis
Available online 22 June 2022, 101631AbstractA better understanding of the pathological mechanisms that drive neurodegener...
Immune response after central nervous system injury
Traumatic injuries of the central nervous system (CNS) affect millions of people worldwide, and they can lead to severely ...
Complement component C3: A structural perspective and potential therapeutic implications
Available online 25 June 2022, 101627AbstractAs the most abundant component of the complement system, C3 and its proteolyt...
Non-coding RNA-based regulation of inflammation
PTENphosphatase and tensin homologPI3Kphosphoinositide 3-kinasemTORmammalian target of rapamycinPAMPspathogen-associated m...
Introduction to the special issue: Neutrophils in the tumor microenvironment
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C3-targeted host-modulation approaches to oral inflammatory conditions
Available online 9 June 2022, 101608AbstractPeriodontitis is an inflammatory disease caused by biofilm accumulation and dy...
Specialized pro-resolving mediators as modulators of immune responses
Available online 2 June 2022, 101605AbstractSpecialized pro-resolving mediators (SPMs) are endogenous small molecules prod...
Translational advances of melanocortin drugs: Integrating biology, chemistry and genetics
Available online 25 March 2022, 101603Highlights•Melanocortin (MC) drugs act by binding to five different melanocortin rec...
Microbiota-targeted therapies in inflammation resolution
Available online 15 March 2022, 101599Highlights•The gut microbiota regulates the susceptibility to intestinal and extra i...
Formyl peptide receptor 2 and heart disease
Available online 8 March 2022, 101602AbstractFormyl peptide receptor type 2 (FPR2) regulates the initiation and resolution...
APOE mediated neuroinflammation and neurodegeneration in Alzheimer’s disease
Available online 26 February 2022, 101594Highlights•APOE4 isoform is the strongest genetic risk factor for Alzheimer’s dis...
Resolving inflammatory links between myocardial infarction and vascular dementia
Available online 25 February 2022, 101600AbstractMyocardial infarction is associated with increased risk for vascular deme...
Connecting the dots: Neutrophils at the interface of tissue regeneration and cancer
Available online 24 February 2022, 101598AbstractKnowledge about neutrophil biology has exponentially grown over the past ...
Pro-resolving therapies as potential adjunct treatment for infectious diseases: Evidence from studies with annexin A1 and angiotensin-(1-7)
Available online 23 February 2022, 101601Highlights•Resolution of inflammation is an active process mediated by molecules ...
Corrigendum to “Nanoalum adjuvanted vaccines: Small details make a big difference” [Semin. Immunol. 56 (2021) 101544]
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