SCI时时刷

search
+
Reteplase versus alteplase for acute ischaemic stroke within 4.5 hours (RAISE): rationale and design of a multicentre, prospective, randomised, open-label, blinded-endpoint, controlled phase 3 non-inferiority trial
Reteplase versus alteplase for acute ischaemic stroke within 4.5 hours (RAISE): rationale and design of a multicentre, prospective, randomised, open-label, blinded-endpoint, controlled phase 3 non-inferiority trial
WHAT IS ALREADY KNOWN ON THIS TOPICReperfusion therapy is an evidence-based intervention intended to reduce the global bur...
Safety and efficacy of glibenclamide on cerebral oedema following aneurysmal subarachnoid haemorrhage: a randomised, double-blind, placebo-controlled clinical trial
Safety and efficacy of glibenclamide on cerebral oedema following aneurysmal subarachnoid haemorrhage: a randomised, double-blind, placebo-controlled clinical trial
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSEfficacy and safety of high-dose oral glibenclamide following aneur...
Discontinuation of antiplatelet therapy after stent-assisted coil embolisation of cerebral aneurysm: a nationwide cohort study
Discontinuation of antiplatelet therapy after stent-assisted coil embolisation of cerebral aneurysm: a nationwide cohort study
WHAT IS ALREADY KNOWN ON THIS TOPICAfter the insertion of an endovascular stent, antiplatelet therapy (APT) is a fundament...
Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial
Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial
IntroductionThrombolysis with alteplase is limited by its short half-life and low recanalisation rate of large vessel occl...
Trendelenburg position for acute anterior circulation ischaemic stroke with large artery atherosclerosis aetiology (HOPES 3): rationale and design
Trendelenburg position for acute anterior circulation ischaemic stroke with large artery atherosclerosis aetiology (HOPES 3): rationale and design
Introduction and rationaleThe effect of head position (lying flat vs sitting up) as a non-pharmacological therapy for stro...
CSA declaration of next-generation reperfusion therapy for ischaemic stroke
CSA declaration of next-generation reperfusion therapy for ischaemic stroke
Cerebrovascular disease is a significant health concern that threatens people’s health and life. About 80% of its burden c...
When treating acute ischaemic stroke of LVO type, time window prevails over tissue window
When treating acute ischaemic stroke of LVO type, time window prevails over tissue window
Time is brain. How fast an occluded cerebral artery can be reopened is directly related to how many brain cells can be sav...
Thrombolysis for ischaemic stroke despite direct oral anticoagulation
Thrombolysis for ischaemic stroke despite direct oral anticoagulation
Intravenous thrombolysis is not recommended in anticoagulated patients receiving direct oral anticoagulants (DOACs) and a ...
Anti-stroke biologics: from recombinant proteins to stem cells and organoids
Anti-stroke biologics: from recombinant proteins to stem cells and organoids
IntroductionStroke, a cerebrovascular disease, is the second most common cause of death and the leading cause of disabilit...
Association between Lifes Essential 8 and Cerebral Small Vessel Disease
Association between Lifes Essential 8 and Cerebral Small Vessel Disease
WHAT IS ALREADY KNOWN ON THIS TOPICSome individual lifestyle factors were associated with cerebral small vessel disease (C...
Real-world evaluation of Brainomix e-Stroke software
Real-world evaluation of Brainomix e-Stroke software
IntroductionMechanical thrombectomy has become the standard of care for patients with acute ischaemic stroke due to a prox...
Real-world analysis of two ischaemic stroke and TIA systolic blood pressure goals on 12-month mortality and recurrent vascular events
Real-world analysis of two ischaemic stroke and TIA systolic blood pressure goals on 12-month mortality and recurrent vascular events
IntroductionIn recent years, a more intensive blood pressure (BP) target of <130/80 mm Hg over a less intensive goal of...
Low-intensity focused ultrasound stimulation promotes stroke recovery via astrocytic HMGB1 and CAMK2N1 in mice
Low-intensity focused ultrasound stimulation promotes stroke recovery via astrocytic HMGB1 and CAMK2N1 in mice
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionStroke is the secon...
Efficacy and safety of dual antiplatelet therapy in the elderly for stroke prevention: a subgroup analysis of the CHANCE-2 trial
Efficacy and safety of dual antiplatelet therapy in the elderly for stroke prevention: a subgroup analysis of the CHANCE-2 trial
WHAT IS ALREADY KNOWN ON THIS TOPICThere is limited scientific evidence regarding the optimal antiplatelet therapy regimen...
Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage
Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage
IntroductionCortical superficial siderosis (cSS) and cerebral microbleed (CMB) are both haemorrhagic imaging biomarkers of...
Mass effect, aneurysms and flow diverters: Is the pipeline embolization device the Lone Virtuoso? Commentary on 'Pipeline embolization device for intracranial aneurysms presenting with mass effect: a large Chinese cohort by Zhao et al
Mass effect, aneurysms and flow diverters: Is the pipeline embolization device the Lone Virtuoso? Commentary on 'Pipeline embolization device for intracranial aneurysms presenting with mass effect: a large Chinese cohort by Zhao et al
In the treatment of symptomatic intracranial aneurysms, the study by Zhao et al stands as a notable addition to the growin...
Cerebral small vessel disease modifies outcomes after minimally invasive surgery for intracerebral haemorrhage
Cerebral small vessel disease modifies outcomes after minimally invasive surgery for intracerebral haemorrhage
IntroductionThe pathophysiology of spontaneous intracerebral haemorrhage (ICH) reflects injury to small cerebral blood ves...
Advanced rehabilitation in ischaemic stroke research
Advanced rehabilitation in ischaemic stroke research
For most of the last century, doctors advised less activities and movements after stroke attack. In the 1950s, Twitchell b...
White matter disease derived from vascular and demyelinating origins
White matter disease derived from vascular and demyelinating origins
IntroductionThe white matter of the central nervous system (CNS) is primarily constituted of myelinated axons (tracts) and...
Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical
Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical
IntroductionTo date, stroke remains the second-leading cause of death and the leading cause of disability in much of the w...
Tenecteplase versus alteplase for acute ischaemic stroke: a meta-analysis of phase III randomised trials
Tenecteplase versus alteplase for acute ischaemic stroke: a meta-analysis of phase III randomised trials
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionStroke is the secon...
One-year direct and indirect costs of ischaemic stroke in China
One-year direct and indirect costs of ischaemic stroke in China
IntroductionStroke is one of the leading causes of mortality and disability worldwide,1 and the burden of stroke in China ...
Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke
Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke
IntroductionIschaemic stroke injury disrupts neuronal mitochondrial homeostasis, leading to oxidative stress and subsequen...
Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese
Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSThe association strengths of current PRSs with risks of stroke and ...
Haemorrhage after thrombectomy with adjuvant thrombolysis in unknown onset stroke depends on high early lesion water uptake
Haemorrhage after thrombectomy with adjuvant thrombolysis in unknown onset stroke depends on high early lesion water uptake
MethodsPatientsThe local high-volume university hospital stroke registry was screened consecutively to select all patients...
Longitudinal associations of cardiovascular health and vascular events with incident dementia
Longitudinal associations of cardiovascular health and vascular events with incident dementia
WHAT IS ALREADY KNOWN ON THIS TOPICCardiovascular health is considered as one of the critical factors in the pathogenesis ...
Residual inflammatory risk predicts long-term outcomes following stenting for symptomatic intracranial atherosclerotic stenosis
Residual inflammatory risk predicts long-term outcomes following stenting for symptomatic intracranial atherosclerotic stenosis
IntroductionIn patients with cerebrovascular diseases, elevated high-sensitivity C-reactive protein (hs-CRP) and low-densi...
Surgical timing and long-term outcomes in patients with severe haemorrhagic spinal cord cavernous malformations
Surgical timing and long-term outcomes in patients with severe haemorrhagic spinal cord cavernous malformations
WHAT IS ALREADY KNOWN ON THIS TOPICSpinal cord cavernous malformations (SCCMs) are rare low-flow vascular malformations wh...
Stroke depression: a concept with clinical applicability
Stroke depression: a concept with clinical applicability
Epidemiology of strokeStroke is the second-leading cause of death in the world, accounting for 11.8% of all deaths. It is ...
Neglected Mendelian causes of stroke in adult Chinese patients who had an ischaemic stroke or transient ischaemic attack
Neglected Mendelian causes of stroke in adult Chinese patients who had an ischaemic stroke or transient ischaemic attack
MethodsStudy population and classification of Mendelian causes of strokeThe CNSR-III is a nationwide prospective registry ...
阅读更多
format_indent_increase