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CHinese Acute Tissue-Based Imaging Selection for Lysis In Stroke Tenecteplase II (CHABLIS-T II): rationale and design
CHinese Acute Tissue-Based Imaging Selection for Lysis In Stroke Tenecteplase II (CHABLIS-T II): rationale and design
Background and purpose Tenecteplase (TNK) has demonstrated non-inferiority to alteplase in patients who had an acute ischa...
Risk stratification of delayed causative aneurysm detection and long-term outcome in angiographically negative spontaneous subarachnoid haemorrhage
Risk stratification of delayed causative aneurysm detection and long-term outcome in angiographically negative spontaneous subarachnoid haemorrhage
Background The risk factors of aetiology and poor outcome in angiographically negative subarachnoid haemorrhage (anSAH) we...
Intelligent cholinergic white matter pathways algorithm based on U-net reflects cognitive impairment in patients with silent cerebrovascular disease
Intelligent cholinergic white matter pathways algorithm based on U-net reflects cognitive impairment in patients with silent cerebrovascular disease
Background and objective The injury of the cholinergic white matter pathway underlies cognition decline in patients with s...
Assessment of Perfusion Volumes by a New Automated Software for Computed Tomography Perfusion
Assessment of Perfusion Volumes by a New Automated Software for Computed Tomography Perfusion
Introduction To compare the perfusion volumes assessed by a new automated CT perfusion (CTP) software iStroke with the cir...
Rationale and design of ProUrokinase in Mild IsChemic strokE (PUMICE): a multicentre, prospective, randomised, open-label, blinded-endpoint controlled trial
Rationale and design of ProUrokinase in Mild IsChemic strokE (PUMICE): a multicentre, prospective, randomised, open-label, blinded-endpoint controlled trial
Background and purpose Recombinant human prourokinase (rhPro-UK) is a new generation of specific plasminogen activator, th...
Design of trials in lacunar stroke and cerebral small vessel disease: review and experience with the LACunar Intervention Trial 2 (LACI-2)
Design of trials in lacunar stroke and cerebral small vessel disease: review and experience with the LACunar Intervention Trial 2 (LACI-2)
Cerebral small vessel disease (cSVD) causes lacunar stroke (25% of ischaemic strokes), haemorrhage, dementia, physical fra...
Chinese Stroke Association guidelines on emergency stroke unit
Chinese Stroke Association guidelines on emergency stroke unit
Organised stroke care has become a keystone in delivering efficient and effective treatment to patients with stroke with i...
TIMP1 protects against blood-brain barrier disruption after subarachnoid haemorrhage by inhibiting ubiquitination of astrocytic {beta}1-integrin
TIMP1 protects against blood-brain barrier disruption after subarachnoid haemorrhage by inhibiting ubiquitination of astrocytic {beta}1-integrin
Background Astrocytes regulate blood-brain barrier (BBB) integrity, whereas subarachnoid haemorrhage (SAH) results in astr...
Rationale and design of Treatment of Acute Ischaemic Stroke with Edaravone Dexborneol II (TASTE-2): a multicentre randomised controlled trial
Rationale and design of Treatment of Acute Ischaemic Stroke with Edaravone Dexborneol II (TASTE-2): a multicentre randomised controlled trial
Background Edaravone dexborneol is believed to be a novel cytoprotective drug, demonstrating a synergistic combination of ...
Isolated anterior cerebral artery occlusion: an atypical form of moyamoya disease
Isolated anterior cerebral artery occlusion: an atypical form of moyamoya disease
Background The relationship between anterior cerebral artery (ACA) occlusion and moyamoya disease (MMD) has rarely been st...
Rationale and design of the GOLDEN BRIDGE II: a cluster-randomised multifaceted intervention trial of an artificial intelligence-based cerebrovascular disease clinical decision support system to improve stroke outcomes and care quality in China
Rationale and design of the GOLDEN BRIDGE II: a cluster-randomised multifaceted intervention trial of an artificial intelligence-based cerebrovascular disease clinical decision support system to improve stroke outcomes and care quality in China
Background Given the swift advancements in artificial intelligence (AI), the utilisation of AI-based clinical decision sup...
Intravenous tenecteplase compared with alteplase for minor ischaemic stroke: a secondary analysis of the AcT randomised clinical trial
Intravenous tenecteplase compared with alteplase for minor ischaemic stroke: a secondary analysis of the AcT randomised clinical trial
Background In ischaemic stroke, minor deficits (National Institutes of Health Stroke Scale (NIHSS) ≤5) at presentation are...
Outcomes associated to the time to treatment with intravenous tenecteplase for acute ischaemic stroke: subgroup analysis of the TRACE-2 randomised controlled clinical trial
Outcomes associated to the time to treatment with intravenous tenecteplase for acute ischaemic stroke: subgroup analysis of the TRACE-2 randomised controlled clinical trial
Background The benefit of intravenous alteplase in acute ischaemic stroke (AIS) is time-dependent. Tenecteplase is non-inf...
Gut Microbiome and Stroke: a Bidirectional Mendelian Randomisation Study in East Asian and European Populations
Gut Microbiome and Stroke: a Bidirectional Mendelian Randomisation Study in East Asian and European Populations
Background and aims Observational studies have implicated the involvement of gut microbiome in stroke development. Convers...
Intracerebral haemorrhage in patients taking different types of oral anticoagulants: a pooled individual patient data analysis from two national stroke registries
Intracerebral haemorrhage in patients taking different types of oral anticoagulants: a pooled individual patient data analysis from two national stroke registries
Background We investigated outcomes in patients with intracerebral haemorrhage (ICH) according to prior anticoagulation tr...
Prediction of futile recanalisation after endovascular treatment in acute ischaemic stroke: development and validation of a hybrid machine learning model
Prediction of futile recanalisation after endovascular treatment in acute ischaemic stroke: development and validation of a hybrid machine learning model
Background Identification of futile recanalisation following endovascular therapy (EVT) in patients with acute ischaemic s...
Recurrent intracerebral haemorrhages as main manifestations in cerebral amyloid angiopathy-related inflammation
Recurrent intracerebral haemorrhages as main manifestations in cerebral amyloid angiopathy-related inflammation
Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a relatively rare and treatable subtype of CAA. We have herei...
Prevalence, risk factors and prognostic value of atrial fibrillation detected after stroke after haemorrhagic versus ischaemic stroke
Prevalence, risk factors and prognostic value of atrial fibrillation detected after stroke after haemorrhagic versus ischaemic stroke
Background and objectives Prior evidence suggests that atrial fibrillation detected after stroke (AFDAS) is distinct from ...
Application of bedside HINTS, ABCD2 score and truncal ataxia to differentiate cerebellar-brainstem stroke from vestibular neuritis in the emergency room
Application of bedside HINTS, ABCD2 score and truncal ataxia to differentiate cerebellar-brainstem stroke from vestibular neuritis in the emergency room
Background and purpose Acute vestibular syndrome (AVS) typically manifests as isolated dizziness or vertigo with no appare...
Reteplase versus alteplase for acute ischaemic stroke within 4.5 hours (RAISE): rationale and design of a multicentre, prospective, randomised, open-label, blinded-endpoint, controlled phase 3 non-inferiority trial
Reteplase versus alteplase for acute ischaemic stroke within 4.5 hours (RAISE): rationale and design of a multicentre, prospective, randomised, open-label, blinded-endpoint, controlled phase 3 non-inferiority trial
WHAT IS ALREADY KNOWN ON THIS TOPICReperfusion therapy is an evidence-based intervention intended to reduce the global bur...
Safety and efficacy of glibenclamide on cerebral oedema following aneurysmal subarachnoid haemorrhage: a randomised, double-blind, placebo-controlled clinical trial
Safety and efficacy of glibenclamide on cerebral oedema following aneurysmal subarachnoid haemorrhage: a randomised, double-blind, placebo-controlled clinical trial
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSEfficacy and safety of high-dose oral glibenclamide following aneur...
Discontinuation of antiplatelet therapy after stent-assisted coil embolisation of cerebral aneurysm: a nationwide cohort study
Discontinuation of antiplatelet therapy after stent-assisted coil embolisation of cerebral aneurysm: a nationwide cohort study
WHAT IS ALREADY KNOWN ON THIS TOPICAfter the insertion of an endovascular stent, antiplatelet therapy (APT) is a fundament...
Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial
Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial
IntroductionThrombolysis with alteplase is limited by its short half-life and low recanalisation rate of large vessel occl...
Trendelenburg position for acute anterior circulation ischaemic stroke with large artery atherosclerosis aetiology (HOPES 3): rationale and design
Trendelenburg position for acute anterior circulation ischaemic stroke with large artery atherosclerosis aetiology (HOPES 3): rationale and design
Introduction and rationaleThe effect of head position (lying flat vs sitting up) as a non-pharmacological therapy for stro...
CSA declaration of next-generation reperfusion therapy for ischaemic stroke
CSA declaration of next-generation reperfusion therapy for ischaemic stroke
Cerebrovascular disease is a significant health concern that threatens people’s health and life. About 80% of its burden c...
When treating acute ischaemic stroke of LVO type, time window prevails over tissue window
When treating acute ischaemic stroke of LVO type, time window prevails over tissue window
Time is brain. How fast an occluded cerebral artery can be reopened is directly related to how many brain cells can be sav...
Thrombolysis for ischaemic stroke despite direct oral anticoagulation
Thrombolysis for ischaemic stroke despite direct oral anticoagulation
Intravenous thrombolysis is not recommended in anticoagulated patients receiving direct oral anticoagulants (DOACs) and a ...
Anti-stroke biologics: from recombinant proteins to stem cells and organoids
Anti-stroke biologics: from recombinant proteins to stem cells and organoids
IntroductionStroke, a cerebrovascular disease, is the second most common cause of death and the leading cause of disabilit...
Association between Lifes Essential 8 and Cerebral Small Vessel Disease
Association between Lifes Essential 8 and Cerebral Small Vessel Disease
WHAT IS ALREADY KNOWN ON THIS TOPICSome individual lifestyle factors were associated with cerebral small vessel disease (C...
Real-world evaluation of Brainomix e-Stroke software
Real-world evaluation of Brainomix e-Stroke software
IntroductionMechanical thrombectomy has become the standard of care for patients with acute ischaemic stroke due to a prox...
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