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Ten-year follow-up investigation of stroke risk in systemic lupus erythematosus
Ten-year follow-up investigation of stroke risk in systemic lupus erythematosus
WHAT IS ALREADY KNOWN ON THIS TOPICPatients with systemic lupus erythematosus (SLE) are at higher risk of developing strok...
In patients who had a stroke or TIA, enlarged perivascular spaces in basal ganglia may cause future haemorrhagic strokes
In patients who had a stroke or TIA, enlarged perivascular spaces in basal ganglia may cause future haemorrhagic strokes
IntroductionTo avoid early and long-term complications in patients already with an acute ischaemic stroke (AIS) or transie...
Clinical features, treatment strategies and outcomes of craniocervical junction arteriovenous fistulas: a cohort study of 193 patients
Clinical features, treatment strategies and outcomes of craniocervical junction arteriovenous fistulas: a cohort study of 193 patients
IntroductionThe craniocervical junction (CCJ), known as a craniovertebral junction that usually represents the occipital b...
Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study
Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study
WHAT IS ALREADY KNOWN ON THIS TOPICEarly anticoagulation after ischaemic stroke associated with atrial fibrillation (AF) m...
Prehospital transdermal glyceryl trinitrate for ultra-acute ischaemic stroke: data from the RIGHT-2 randomised sham-controlled ambulance trial
Prehospital transdermal glyceryl trinitrate for ultra-acute ischaemic stroke: data from the RIGHT-2 randomised sham-controlled ambulance trial
WHAT IS ALREADY KNOWN ON THIS TOPICTransdermal glyceryl trinitrate (GTN) was associated with less death and dependency in ...
Intra-arterial tenecteplase during thrombectomy for acute stroke (BRETIS-TNK II): rationale and design
Intra-arterial tenecteplase during thrombectomy for acute stroke (BRETIS-TNK II): rationale and design
Introduction and rationaleAcute ischaemic stroke (AIS) is one of the leading causes of morbidity and mortality worldwide, ...
Pipeline Embolization Device for intracranial aneurysms presenting with mass effect: a large Chinese cohort
Pipeline Embolization Device for intracranial aneurysms presenting with mass effect: a large Chinese cohort
IntroductionUnruptured intracranial aneurysms (UIAs) have the potential to induce symptoms through mass effect, which can ...
Tirofiban combined with Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction (STRATEGY): protocol for a multicentre, randomised controlled trial
Tirofiban combined with Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction (STRATEGY): protocol for a multicentre, randomised controlled trial
WHAT IS ALREADY KNOWN ON THIS TOPICPerforating artery territorial infarction (PAI) caused by branch atheromatous disease (...
Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis (BASIS): protocol of a prospective, multicentre, randomised, controlled trial
Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis (BASIS): protocol of a prospective, multicentre, randomised, controlled trial
WHAT IS ALREADY KNOWN ON THIS TOPICOptimal treatment for patients with symptomatic intracranial artery stenosis (sICAS), e...
Efficacy and safety of Y-2 sublingual tablet for patients with acute ischaemic stroke: protocol of a phase III randomised double-blind placebo-controlled multicentre trial
Efficacy and safety of Y-2 sublingual tablet for patients with acute ischaemic stroke: protocol of a phase III randomised double-blind placebo-controlled multicentre trial
Introduction and rationalAlthough stroke is largely preventable, stroke has remained the second greatest cause of death an...
Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events III (TRACE III): a randomised, phase III, open-label, controlled trial
Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events III (TRACE III): a randomised, phase III, open-label, controlled trial
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionAcute large vessel ...
Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases: executive summary and 2023 update
Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases: executive summary and 2023 update
HighlightsThe clinical management of ischaemic cerebrovascular diseases comprises a total of 287 recommendations, includin...
Comparing a novel Catfish flow restoration device and the Solitaire stent retriever for thrombectomy revascularisation in emergent largevessel occlusion stroke: a prospective randomised controlled study
Comparing a novel Catfish flow restoration device and the Solitaire stent retriever for thrombectomy revascularisation in emergent largevessel occlusion stroke: a prospective randomised controlled study
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYThere are many distinct kinds o...
Photochemically induced thalamus infarction impairs cognition in a mouse model
Photochemically induced thalamus infarction impairs cognition in a mouse model
IntroductionSmall subcortical infarct, commonly known as lacunar infarct, mostly results from ischaemia in the territory o...
Somatic GJA4 mutation in intracranial extra-axial cavernous hemangiomas
Somatic GJA4 mutation in intracranial extra-axial cavernous hemangiomas
IntroductionExtra-axial cavernous hemangiomas (ECHs) are rare intracranial lesions,1 mostly in the cavernous sinus (repres...
Preclinical evaluation of ZL006-05, a new antistroke drug with fast-onset antidepressant and anxiolytic effects
Preclinical evaluation of ZL006-05, a new antistroke drug with fast-onset antidepressant and anxiolytic effects
IntroductionTo date, stroke remained the second-leading cause of death and one of the leading causes of disability in much...
Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages
Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages
IntroductionIntracerebral haemorrhage (ICH) accounts for 12%–20% of all types of stroke with over 2 million individuals wo...
Development of machine learning-based models to predict 10-year risk of cardiovascular disease: a prospective cohort study
Development of machine learning-based models to predict 10-year risk of cardiovascular disease: a prospective cohort study
WHAT IS ALREADY KNOWN ON THIS TOPICSeveral cardiovascular diseases (CVD) prediction models have been developed to deliver ...
Prestroke physical activity is associated with admission haematoma volume and the clinical outcome of intracerebral haemorrhage
Prestroke physical activity is associated with admission haematoma volume and the clinical outcome of intracerebral haemorrhage
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSEngaging in regular, light physical activity prior to experiencing ...
Detailed phenotype of RNF213 p.R4810K variant identified by the Chinese patients with acute ischaemic stroke or transient ischaemic attack
Detailed phenotype of RNF213 p.R4810K variant identified by the Chinese patients with acute ischaemic stroke or transient ischaemic attack
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSThis study first identified the RNF213 p.R4810K variant was associa...
Cerebral haemodynamics in symptomatic intracranial atherosclerotic disease: a narrative review of the assessment methods and clinical implications
Cerebral haemodynamics in symptomatic intracranial atherosclerotic disease: a narrative review of the assessment methods and clinical implications
IntroductionIntracranial atherosclerotic disease (ICAD) is a common cause of ischaemic stroke and transient ischaemic atta...
Loss of life expectancy due to stroke and its subtypes in urban and rural areas in China, 2005-2020
Loss of life expectancy due to stroke and its subtypes in urban and rural areas in China, 2005-2020
Materials and methodsData sourceData for mortality of stroke and its subtypes were obtained from the NMSS in China, which ...
Blood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adults
Blood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adults
IntroductionBlood pressure (BP) is a major risk factor for cerebrovascular disease.1 Asymptomatic brain pathologies found ...
Long-term functional outcomes improved with deep brain stimulation in patients with disorders of consciousness
Long-term functional outcomes improved with deep brain stimulation in patients with disorders of consciousness
IntroductionDisorders of consciousness (DoCs) are neuropsychiatric disturbances in arousal and awareness that are commonly...
Retinal microvascular signs and recurrent vascular events in patients with TIA or minor stroke
Retinal microvascular signs and recurrent vascular events in patients with TIA or minor stroke
IntroductionMicrovascular changes of the retina have been linked to a higher risk of incidental ischaemic stroke as well a...
Characteristics of intracranial plaque in patients with non-cardioembolic stroke and intracranial large vessel occlusion
Characteristics of intracranial plaque in patients with non-cardioembolic stroke and intracranial large vessel occlusion
What is already known on this topicThe characteristics of intracranial plaque proximal to large vessel occlusion (LVO) in ...
Efficacy and safety of early anticoagulation after endovascular treatment in patients with atrial fibrillation
Efficacy and safety of early anticoagulation after endovascular treatment in patients with atrial fibrillation
IntroductionIn acute ischaemic stroke (AIS) with large vessel occlusion (LVO), endovascular treatment (EVT) has become one...
Comparison of carotid endarterectomy and repeated carotid angioplasty and stenting for in-stent restenosis (CERCAS trial): a randomised study
Comparison of carotid endarterectomy and repeated carotid angioplasty and stenting for in-stent restenosis (CERCAS trial): a randomised study
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSBoth carotid endarterectomy and repeat percutaneous transluminal an...
Group 2 innate lymphoid cells resolve neuroinflammation following cerebral ischaemia
Group 2 innate lymphoid cells resolve neuroinflammation following cerebral ischaemia
IntroductionInflammation and immune responses are the main events in the pathological process following strokes.1 2 The ce...
Impaired glymphatic system as evidenced by low diffusivity along perivascular spaces is associated with cerebral small vessel disease: a population-based study
Impaired glymphatic system as evidenced by low diffusivity along perivascular spaces is associated with cerebral small vessel disease: a population-based study
IntroductionCerebral small vessel disease (CSVD) is a whole-brain disorder that mainly damages small brain vessels and is ...
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