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The flagellar germ‐line hypothesis: How flagellate and ciliate gametes significantly shaped the evolution of organismal complexity
The flagellar germ‐line hypothesis: How flagellate and ciliate gametes significantly shaped the evolution of organismal complexity
Abstract This essay presents a hypothesis which contends that the development of organismic complexity in the eukaryotes d...
Airborne particles and cardiovascular morbidity in severe inherited hypercholesterolemia: Vulnerable endothelium under multiple attacks
Airborne particles and cardiovascular morbidity in severe inherited hypercholesterolemia: Vulnerable endothelium under multiple attacks
Abstract Despite recent advances in the research related to air pollution and associated adverse cardiovascular events, th...
Aberrant post‐translational modifications in endosomal trafficking are potential therapeutic targets to avert therapy resistance in solid cancers
Aberrant post‐translational modifications in endosomal trafficking are potential therapeutic targets to avert therapy resistance in solid cancers
Abstract Drugs targeting a single TK/RTK in the treatment of solid cancers has not had the same success seen in blood canc...
BioEssays 1/2022
BioEssays 1/2022
Volume 44, Issue 1 2270002 PDF ShareShare Ple...
Rho GTPases: Non‐canonical regulation by cysteine oxidation
Rho GTPases: Non‐canonical regulation by cysteine oxidation
Abstract Rho GTPases are critically important and are centrally positioned regulators of the actomyosin cytoskeleton. By i...
Functional interplay within the epitranscriptome: Reality or fiction?
Functional interplay within the epitranscriptome: Reality or fiction?
Abstract RNA modifications have recently emerged as an important regulatory layer of gene expression. The most prevalent a...
The editor at scientific conferences
The editor at scientific conferences
Have you ever been to a scientific conference and wondered about seeing the names and affiliations of editors among the li...
Better communication between experts is needed to solve the environmental origins of birth defects
Better communication between experts is needed to solve the environmental origins of birth defects
Abstract More than 6% of babies are born with a structural or functional defect, and many of these need special care and t...
Minichromosome maintenance proteins in eukaryotic chromosome segregation
Minichromosome maintenance proteins in eukaryotic chromosome segregation
Abstract Minichromosome maintenance (Mcm) proteins are well-known for their functions in DNA replication. However, their r...
Highway to hell‐thy meiotic divisions: Chromosome passenger complex functions driven by microtubules
Highway to hell‐thy meiotic divisions: Chromosome passenger complex functions driven by microtubules
Abstract The chromosome passenger complex (CPC) localizes to chromosomes and microtubules, sometimes simultaneously. The C...
Cell population‐based framework of genetic epidemiology in the single‐cell omics era
Cell population‐based framework of genetic epidemiology in the single‐cell omics era
Abstract Genetic epidemiology is a rapidly advancing field due to the recent availability of large amounts of omics data. ...
Assay technologies facilitating drug discovery for ADP‐ribosyl writers, readers and erasers
Assay technologies facilitating drug discovery for ADP‐ribosyl writers, readers and erasers
Abstract ADP-ribosylation is a post-translational modification catalyzed by writer enzymes – ADP-ribosyltransferase...
The SARS‐CoV‐2 origin dilemma: Zoonotic transfer or laboratory leak?
The SARS‐CoV‐2 origin dilemma: Zoonotic transfer or laboratory leak?
Abstract The COVID-19 pandemic is responsible for millions of deaths worldwide yet its origin remains unclear. Two potenti...
Tick bite induced α‐gal syndrome highlights anticancer effect of allergy
Tick bite induced α‐gal syndrome highlights anticancer effect of allergy
Abstract Tick bite induced α-gal syndrome (AGS) following consumption of mammalian meat is a recently described intr...
A word of heartfelt thanks to our reviewers
A word of heartfelt thanks to our reviewers
PDF ShareShare Please review our Terms and Conditions of Use...
In grateful recognition of our Editorial Board
In grateful recognition of our Editorial Board
At the end of the year we would like once again to express our deep thanks to the members of our Editorial Board listed be...
BioEssays 12/2021
BioEssays 12/2021
The Hedgehog pathway is a signaling pathway with important roles during embryonic development and adult homeostatic mainte...
Evolutionary physiology at 30+: Has the promise been fulfilled?
Evolutionary physiology at 30+: Has the promise been fulfilled?
Abstract Three decades ago, interactions between evolutionary biology and physiology gave rise to evolutionary physiology....
Degeneracy in the nervous system: from neuronal excitability to neural coding
Degeneracy in the nervous system: from neuronal excitability to neural coding
Abstract Degeneracy is ubiquitous across biological systems where structurally different elements can yield a similar outc...
Aspartate‐phobia of thermophiles as a reaction to deleterious chemical transformations
Aspartate‐phobia of thermophiles as a reaction to deleterious chemical transformations
Abstract Prokaryotes growing at high temperatures have a high proportion of charged residues in their proteins to stabiliz...
Skin aging: Dermal adipocytes metabolically reprogram dermal fibroblasts
Skin aging: Dermal adipocytes metabolically reprogram dermal fibroblasts
Abstract Emerging data connects the aging process in dermal fibroblasts with metabolic reprogramming, provided by enhanced...
Keeping intracellular DNA untangled: A new role for condensin?
Keeping intracellular DNA untangled: A new role for condensin?
Abstract The DNA-passage activity of topoisomerase II accidentally produces DNA knots and interlinks within and between ch...
An emerging role of transcription in chromosome segregation: Ongoing centromeric transcription maintains centromeric cohesion
An emerging role of transcription in chromosome segregation: Ongoing centromeric transcription maintains centromeric cohesion
Abstract Non-coding centromeres, which dictate kinetochore formation for proper chromosome segregation, are extremely dive...
What are we doing, people? We have to challenge vested interests much more vigorously
What are we doing, people? We have to challenge vested interests much more vigorously
My inbox is overflowing (again!) with invitations to submit to predatory journals, or attend bogus scientific events. The ...
Bridging the explanatory gaps: What can we learn from a biological agency perspective?
Bridging the explanatory gaps: What can we learn from a biological agency perspective?
Abstract We begin this article by delineating the explanatory gaps left by prevailing gene-focused approaches in our under...
Lewontin did not commit Lewontin's fallacy, his critics do: Why racial taxonomy is not useful for the scientific study of human variation
Lewontin did not commit Lewontin's fallacy, his critics do: Why racial taxonomy is not useful for the scientific study of human variation
Abstract In 1972, R.C. Lewontin concluded that it follows from the fact that the large majority of human genetic variation...
Protein modifications in Hedgehog signaling
Protein modifications in Hedgehog signaling
Abstract The complexity of the Hedgehog (Hh) signaling cascade has increased over the course of evolution; however, it doe...
Fatty acids may influence insulin dynamics through modulation of albumin‐Zn2+ interactions
Fatty acids may influence insulin dynamics through modulation of albumin‐Zn2+ interactions
Abstract Insulin is stored within the pancreas in an inactive Zn2+-bound hexameric form prior to release. Similarly, clini...
From celiac disease to coccidia infection and vice‐versa: The polyQ peptide CXCR3‐interaction axis
From celiac disease to coccidia infection and vice‐versa: The polyQ peptide CXCR3‐interaction axis
Abstract Zonulin is a physiological modulator of intercellular tight junctions, which upregulation is involved in several ...
Processed pseudogenes: A substrate for evolutionary innovation
Processed pseudogenes: A substrate for evolutionary innovation
Abstract Processed pseudogenes may serve as a genetic reservoir for evolutionary innovation. Here, we argue that through t...
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