SCI时时刷

search
+
New insights into roles of IL-7R gene as a diagnostic biomarker for post-stroke depression
1 IntroductionPost-stroke depression (PSD) is a mental disorder characterized by emotional disturbances after a stroke, af...
Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprograming of the tumour microenvironment
Highlights● What is already known on this topic: miRNA expression is critical in driving macrophage polarisation by simult...
Cutoffs on severity metrics for minimal manifestations or better status in patients with generalized myasthenia gravis
1 IntroductionIn the treatment of generalized myasthenia gravis (gMG), high-dose chronic oral steroid therapy has reduced ...
Editorial: Regulatory T cells in immune-mediated diseases
During the 1970s and 1980s, research in murine models suggested the existence of CD8 + I-J + T cells as suppressor cells. ...
Association between somatic microsatellite instability, hypermutation status, and specific T cell subsets in colorectal cancer tumors
IntroductionColorectal cancer (CRC) is a heterogeneous disease with different underlying mechanisms leading to different m...
The innate defenders: a review of natural killer cell immunotherapies in cancer
1 IntroductionCancer, a well-documented disease, has likely afflicted humans throughout history. The oldest records of thi...
Anlotinib combined with tislelizumab in the treatment of primary small cell neuroendocrine carcinoma of the prostate: a case report and literature review
Primary small cell neuroendocrine carcinoma of the prostate is extremely rare, highly aggressive, and has a very poor prog...
The role of APOE gene polymorphisms in lung adenocarcinoma susceptibility and lipid profile
1 IntroductionThe apolipoprotein E (APOE) gene, located on chromosome 19q13.32, encodes the 34 KDa glycoprotein known as A...
Enhancing cell-mediated immunity through dendritic cell activation: the role of Tri-GalNAc-modified PLGA-PEG nanoparticles encapsulating SR717
Graphical Abstract. M. Tuberculosis fusion proteins (TP) and the STING agonist SR717 are co-encapsulated within Triante...
The role of PPAR in fungal keratitis
1 IntroductionThe treatment of fungal infections is an important part of global public health. Fungi is the most important...
Endostatin as a biomarker of systemic sclerosis: insights from a systematic review and meta-analysis
IntroductionVascular dysfunction and ineffective angiogenesis play a critical pathophysiological role in systemic sclerosi...
Efficacy and safety of chimeric antigen receptor T cells targeting BCMA and GPRC5D in relapsed or refractory multiple myeloma
IntroductionMultiple myeloma (MM) is a malignant plasma cell neoplasm, constituting approximately 10% of all hematological...
Identification and experimental validation of diagnostic and prognostic genes CX3CR1, PID1 and PTGDS in sepsis and ARDS using bulk and single-cell transcriptomic analysis and machine learning
1 IntroductionSepsis is characterized as an abnormal host response to infection that can result in multiorgan failure, aci...
Immunogenicity of the CoronaVac vaccine in children: a real-world study
1 IntroductionDespite the competence of the adaptive immune response against SARS-CoV-2, residual memory after natural inf...
Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis
1 IntroductionMultiple sclerosis (MS) is a chronic autoimmune-mediated disease with a complex etiology. It involves a dysr...
SQLE-mediated squalene metabolism promotes tumor immune evasion in pancreatic cancer
IntroductionPancreatic ductal adenocarcinoma (PDAC) is often not responsive to immunotherapy due in part to an immunologic...
The attenuated Pseudorabies virus vaccine Bartha K61 induces a weak cellular immunity: implications for the development of PRV-vectored vaccines
IntroductionPseudorabies virus (PRV) is the causative agent of Aujeszky’s disease in swine, causing respiratory disease, a...
Elevated levels of exogenous prolactin promote inflammation at the maternal-fetal interface via the JAK2/STAT5B signaling axis
IntroductionPregnant women are immunologically unique because their immune system is influenced by signals originating fro...
From multi-omics to predictive biomarker: AI in tumor microenvironment
1 IntroductionThe tumor is characterized by the uncontrolled growth of abnormal cells, invasion of adjacent parts of the b...
Efficacy and safety of immune checkpoint inhibitors for EGFR mutated non-small cell lung cancer: a network meta-analysis
1 IntroductionLung cancer is the most prevalent type of cancer and the primary cause of cancer-related mortality globally ...
A case of massive hemoptysis caused by immunoglobulin G4-related respiratory disease in adults: case report and review of literature
1 IntroductionImmunoglobulinG4-related disease (IgG4-RD) is a recently recognized immune-mediated chronic fibro-inflammato...
Unveiling sialoglycans’ immune mastery in pregnancy and their intersection with tumor biology
Sialylation is a typical final step of glycosylation, which is a prevalent post-translational modification of proteins. Si...
Evaluation of link between COVID-19 adjacent spike in hydroxychloroquine use and increased reports of pemphigus: a disproportionality analysis of the FDA Adverse Event Reporting System
Highlights● Question: Can an association between hydroxychloroquine use and the development of pemphigus, previously repor...
Subgroup specific transcriptional regulation of salmonid non-classical MHC class I L lineage genes following viral challenges and interferon stimulations
1 IntroductionNon-classical MHC class I genes encode for a heterogeneous group of molecules that in mammals have been show...
MiR-25802: a potential target for treating Alzheimer’s disease by regulating neuroinflammation
Alzheimer's disease (AD) holds global significance as a neurodegenerative disorder with a complex etiology still p...
Recent advances in the role of mesenchymal stem cells as modulators in autoinflammatory diseases
1 IntroductionMesenchymal stem cells (MSCs), which are multipotent progenitor stromal cells, possess the remarkable potent...
An effectively protective VLP vaccine candidate for both genotypes of feline calicivirus
1 IntroductionCats is one of the closest companion animals to humans, whose health has garnered increasing public attentio...
Immunological memory in a teleost fish: common carp IgM+ B cells differentiate into memory and plasma cells
1 IntroductionOver 500 million years ago, ancient cold-blooded fishes emerged along with adaptive immunity (1). Together w...
Editorial: How RSV outsmarts the host
RSV generally causes mild disease, but in some individuals, particularly infants under one year old, it can lead to severe...
Spatially-resolved analyses of muscle invasive bladder cancer microenvironment unveil a distinct fibroblast cluster associated with prognosis
IntroductionMuscle-invasive bladder cancer (MIBC) is a malignancy of the urinary system, which is characterized by a high ...
阅读更多
format_indent_increase