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Corrigendum: Protecting the vulnerable: addressing the COVID-19 care needs of people with compromised immunity
In the published article, there was an error in the Funding statement. The published Funding statement stated that “The au...
Circ_BBS9 as an early diagnostic biomarker for lung adenocarcinoma: direct interaction with IFIT3 in the modulation of tumor immune microenvironment
Circ_BBS9 as an early diagnostic biomarker for lung adenocarcinoma: direct interaction with IFIT3 in the modulation of tumor immune microenvironment
BackgroundIntroduction: Circular RNAs (circRNAs) have been identified as significant contributors to the development and a...
The profile and prognostic significance of bone marrow T-cell differentiation subsets in adult AML at diagnosis
The profile and prognostic significance of bone marrow T-cell differentiation subsets in adult AML at diagnosis
BackgroundT lymphocytes in tumor microenvironment play a pivotal role in the anti-tumor immunity, and the memory of T cell...
Defining correlates of protection for mammalian livestock vaccines against high-priority viral diseases
Defining correlates of protection for mammalian livestock vaccines against high-priority viral diseases
Enhancing livestock biosecurity is critical to safeguard the livelihoods of farmers, global and local economies, and food ...
Advances and clinical challenges of mesenchymal stem cell therapy
Advances and clinical challenges of mesenchymal stem cell therapy
In recent years, cell therapy has provided desirable properties for promising new drugs. Mesenchymal stem cells are promis...
Elucidating T cell dynamics and molecular mechanisms in syngeneic and allogeneic islet transplantation through single-cell RNA sequencing
Elucidating T cell dynamics and molecular mechanisms in syngeneic and allogeneic islet transplantation through single-cell RNA sequencing
Islet transplantation is a promising therapy for diabetes treatment. However, the molecular underpinnings governing the im...
iPSC-derived NK cells expressing high-affinity IgG Fc receptor fusion CD64/16A to mediate flexible, multi-tumor antigen targeting for lymphoma
iPSC-derived NK cells expressing high-affinity IgG Fc receptor fusion CD64/16A to mediate flexible, multi-tumor antigen targeting for lymphoma
IntroductionNK cells can mediate tumor cell killing by natural cytotoxicity and by antibody-dependent cell-mediated cytoto...
Dietary supplementation with Macleaya cordata extract alleviates intestinal injury in broiler chickens challenged with lipopolysaccharide by regulating gut microbiota and plasma metabolites
Dietary supplementation with Macleaya cordata extract alleviates intestinal injury in broiler chickens challenged with lipopolysaccharide by regulating gut microbiota and plasma metabolites
IntroductionThe prevention and mitigation of intestinal immune challenge is crucial for poultry production. This study inv...
Editorial: Immune dysfunction in acute pancreatitis: from bench to bedside research
Acute pancreatitis is an common inflammatory gastrointestinal disease requiring acute admission to hospital (1). Most pati...
The role of innate immune cells in the colorectal cancer tumor microenvironment and advances in anti-tumor therapy research
The role of innate immune cells in the colorectal cancer tumor microenvironment and advances in anti-tumor therapy research
Innate immune cells in the colorectal cancer microenvironment mainly include macrophages, neutrophils, natural killer cell...
A potent, broadly neutralizing human monoclonal antibody that efficiently protects hACE2-transgenic mice from infection with the Wuhan, BA.5, and XBB.1.5 SARS-CoV-2 variants
A potent, broadly neutralizing human monoclonal antibody that efficiently protects hACE2-transgenic mice from infection with the Wuhan, BA.5, and XBB.1.5 SARS-CoV-2 variants
The COVID-19 pandemic has uncovered the high genetic variability of the SARS-CoV-2 virus and its ability to evade the immu...
Femoral nailing associated with bone marrow emboli in pigs induced a specific increase in blood IL-6 and broad inflammatory responses in the heart and lungs
Femoral nailing associated with bone marrow emboli in pigs induced a specific increase in blood IL-6 and broad inflammatory responses in the heart and lungs
IntroductionBone marrow embolization may complicate orthopedic surgery, potentially causing fat embolism syndrome. The inf...
E-selectin in vascular pathophysiology
E-selectin in vascular pathophysiology
Selectins are a group of Ca2+-dependent, transmembrane type I glycoproteins which attract cell adhesion and migration. E-s...
PSGL-1, ADAM8, and selectins as potential biomarkers in the diagnostic process of systemic lupus erythematosus and systemic sclerosis: an observational study
PSGL-1, ADAM8, and selectins as potential biomarkers in the diagnostic process of systemic lupus erythematosus and systemic sclerosis: an observational study
BackgroundEarly diagnosis and treatment of Systemic lupus erythematosus (SLE) and Systemic sclerosis (SSc) present signifi...
β-glucan: a potent adjuvant in immunotherapy for digestive tract tumors
β-glucan: a potent adjuvant in immunotherapy for digestive tract tumors
The immunotherapy for gastrointestinal tumors, as a significant research direction in the field of oncology treatment in r...
Mismatch repair-proficient tumor footprints in the sands of immune desert: mechanistic constraints and precision platforms
Mismatch repair-proficient tumor footprints in the sands of immune desert: mechanistic constraints and precision platforms
Mismatch repair proficient (MMRp) tumors of colorectal origin are one of the prevalent yet unpredictable clinical challeng...
Expression of a stress-inducible heme oxygenase-1 in NK cells is maintained in the process of human aging
Expression of a stress-inducible heme oxygenase-1 in NK cells is maintained in the process of human aging
IntroductionHeme oxygenase-1 (HO-1) is a stress-inducible heat shock protein (HSP32) that exerts cytoprotective effects ag...
Monocyte/macrophage-mediated venous thrombus resolution
Monocyte/macrophage-mediated venous thrombus resolution
Venous thromboembolism (VTE) poses a notable risk of morbidity and mortality. The natural resolution of the venous thrombu...
Multiple unfolded protein response pathways cooperate to link cytosolic dsDNA release to stimulator of interferon gene activation
Multiple unfolded protein response pathways cooperate to link cytosolic dsDNA release to stimulator of interferon gene activation
The double-stranded DNA (dsDNA) sensor STING has been increasingly implicated in responses to “sterile” endogenous threats...
The macrophage polarization in Entamoeba histolytica infection modulation by the C fragment of the intermediate subunit of Gal/GalNAc-inhibitable lectin
The macrophage polarization in Entamoeba histolytica infection modulation by the C fragment of the intermediate subunit of Gal/GalNAc-inhibitable lectin
The protozoan parasite Entamoeba histolytica is the causative agent of amebiasis, with clinical outcomes ranging from asym...
Spatial and phenotypic heterogeneity of resident and monocyte-derived macrophages during inflammatory exacerbations leading to pulmonary fibrosis
Spatial and phenotypic heterogeneity of resident and monocyte-derived macrophages during inflammatory exacerbations leading to pulmonary fibrosis
IntroductionGenetic mutations in critical nodes of pulmonary epithelial function are linked to the pathogenesis of pulmona...
Frequent detection of IFN-gamma -producing memory effector and effector T cells in patients with progressive multifocal leukoencephalopathy
Frequent detection of IFN-gamma -producing memory effector and effector T cells in patients with progressive multifocal leukoencephalopathy
IntroductionProgressive Multifocal Leukoencephalopathy (PML) is a rare and deadly demyelinating disease caused by JC virus...
Long-term use of rituximab increases T cell count in MS patients
Long-term use of rituximab increases T cell count in MS patients
Rituximab has been used to treat MS patients in Iceland for over a decade. However, long-term effect of rituximab on leuko...
Efficacy and safety evaluation of cross-reactive Fibroblast activation protein scFv-based CAR-T cells
Efficacy and safety evaluation of cross-reactive Fibroblast activation protein scFv-based CAR-T cells
IntroductionFibroblast activation protein (FAP) overexpression on cancer-associated fibroblasts (CAFs) is associated with ...
Antibiotic-induced severe cutaneous adverse reactions: a single-center retrospective study over ten years
Antibiotic-induced severe cutaneous adverse reactions: a single-center retrospective study over ten years
ObjectiveSevere cutaneous adverse reactions (SCARs) are rare but life-threatening, with antibiotics being the main cause. ...
Efficacy and safety of stem cell mobilization with etoposide +cytarabine plus G-CSF in poor mobilizers with relapsed or refractory lymphoma
Efficacy and safety of stem cell mobilization with etoposide +cytarabine plus G-CSF in poor mobilizers with relapsed or refractory lymphoma
BackgroundAutologous stem cell transplantation (ASCT) is a potentially curative strategy for relapse or refractory(r/r) ag...
Haptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei
Haptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei
Haptoglobin is a plasma protein of mammals that plays a crucial role in vascular homeostasis by binding free haemoglobin r...
Mathematical models of TCR initial triggering
Mathematical models of TCR initial triggering
T cell receptors (TCRs) play crucial roles in regulating T cell response by rapidly and accurately recognizing foreign and...
Evidence of innate training in bovine γδ T cells following subcutaneous BCG administration
Evidence of innate training in bovine γδ T cells following subcutaneous BCG administration
The Bacillus Calmette Guerin (BCG) vaccine has been shown to induce non-specific protection against diseases other than tu...
The causal role of circulating inflammatory markers in osteoporosis: a bidirectional Mendelian randomized study
The causal role of circulating inflammatory markers in osteoporosis: a bidirectional Mendelian randomized study
BackgroundOsteoporosis (OP) associated with aging exerts substantial clinical and fiscal strains on societal structures. A...
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