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Immunoinformatic design of a multivalent vaccine against Brucella abortus and its evaluation in a murine model using a DNA prime-protein boost strategy
1 IntroductionThe genus Brucella comprises small, non-motile, and non-sporulating Gram-negative coccobacilli. These facult...
PTX3 is expressed in terminal lymphatics and shapes their organization and function
1 IntroductionThe main function of the lymphatic system consists in controlling the balance of body fluids, returning extr...
Characterization of class-switched B cells in chickens
1 IntroductionVaccination is an essential measure to protect commercial poultry flocks against a multitude of pathogens. T...
Efficacy and safety of atezolizumab–bevacizumab vs pembrolizumab-lenvatinib in unresectable hepatocellular carcinoma: a retrospective, cohort study
IntroductionHepatocellular carcinoma (HCC) is a significant global health concern characterized by a rising incidence and ...
Association of inflammatory blood markers and pathological complete response in HER2-positive breast cancer: a retrospective single-center cohort study
1 IntroductionHuman epidermal growth factor receptor 2 (HER2)-positive breast cancer is characterized by the overexpressio...
Non-coding RNAs in bladder cancer, a bridge between gut microbiota and host?
1 IntroductionBladder cancer is one of the most prevalent tumors in urological surgery, exhibiting a high incidence global...
Chitooligosaccharides improves intestinal mucosal immunity and intestinal microbiota in blue foxes
1 IntroductionThe blue fox (Alopex lagopus) is a mammal of the Arctic fox genus Canidae of the carnivoran order, with a ci...
A bibliometric analysis of immunotherapy for atherosclerosis: trends and hotspots prediction
IntroductionAtherosclerosis is the major underlying cause of atherosclerotic cardiovascular disease (ASCVD) (1, 2). The po...
Case report: Satralizumab therapy for bilateral refractory optic neuritis following the first dose of bivalent human papilloma virus vaccine
IntroductionHuman papilloma virus (HPV) vaccines including a bivalent vaccine (HPV2), a quadrivalent HPV (HPV4), and a nin...
Differential regulation of tissue-resident and blood-derived macrophages in models of autoimmune and traumatic peripheral nerve injury
IntroductionAutoimmune polyneuropathies (AP) and traumatic peripheral nerve injury (TPNI) represent two distinct yet inter...
Machine learning-informed liquid-liquid phase separation for personalized breast cancer treatment assessment
IntroductionBreast cancer (BC) is a heterogeneous disease and is the most common cancer in women. Breast cancer morbidity ...
Molecular cloning, expression analysis, and functional characterization of an interleukin-15 like gene in common carp (Cyprinus carpio L.)
1 IntroductionInterleukin-15 (IL-15) is a pleiotropic cytokine influencing both innate and adaptive immunity. It is a memb...
Extensive influence of microsporidian infection on sucrose solution consumption, antioxidant enzyme activity, cell structure, and lifespan of Asian honeybees
1 IntroductionVairimorpha (Nosema) ceranae is a fungal parasite that causes nosemosis, a chronic disease that is frequentl...
Unspecified asthma, childhood-onset, and adult-onset asthma have different causal genes: a Mendelian randomization analysis
1 IntroductionAsthma is a chronic disease of the airways that impacts an estimated 300 million people worldwide (1, 2). Re...
Stimulation of microneedles alleviates pathology of Parkinson’s disease in mice by regulating the CD4+/CD8+ cells from the periphery to the brain
1 IntroductionParkinson’s disease (PD) is the second most common neurodegenerative disease, which is characterized by the ...
Biological characteristics and immune responses of NK Cells in commonly used experimental mouse models
1 IntroductionAn integral part of the immune system, natural killer (NK) cells are vital for both antiviral and anti-tumor...
Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway
IntroductionNeuropathic pain is characterized by spontaneous pain, abnormal pain sensations, sensory abnormalities, and hy...
Cocktail vaccine for the management of Hyalomma anatolicum and Rhipicephalus microplus
1 IntroductionTicks are obligate blood-feeding ectoparasites of vertebrate hosts and act as vectors for various viral, bac...
Disruption of the C5a/C5aR1 axis confers protection against hookworm infection in lung
1 IntroductionHookworms are soil-transmitted, blood-feeding parasites that infect around 500-700 million individuals world...
Alpha-1-antitrypsin as novel substrate for S. aureus’ Spl proteases – implications for virulence
1 IntroductionStaphylococcus aureus is a Gram-positive bacterium known as both asymptomatic colonizer of about 30% of the ...
Scientific issues with rodent models of neuromyelitis optic spectrum disorders
1 IntroductionNeuromyelitis optica spectrum disorders (NMOSDs) are autoimmune central nervous system (CNS) disorders chara...
Long term survival and outcomes in patients with paraneoplastic neurologic syndromes
Graphical Abstract. IntroductionParaneoplastic syndromes are infrequent clinical manifestations characterized as divers...
Telitacicept in combination with B-cell depletion therapy in MuSK antibody-positive myasthenia gravis: a case report and literature review
1 IntroductionMyasthenia gravis (MG) is an autoantibody-mediated autoimmune neuromuscular junction (NMJ) disorder that imp...
Modulation of local immunity by the vaginal microbiome is associated with triggering spontaneous preterm birth
1 IntroductionPreterm birth (PTB), defined as birth before 37 completed weeks of gestation, is the leading cause of death ...
Case report: Pediatric patient with severe clinical course of CTLA-4 insufficiency treated with HSCT
1 IntroductionInborn errors of immunity (IEI) include a large, phenotypically and genotypically heterogeneous group of rar...
Healthy lifestyle choices: new insights into vitiligo management
IntroductionVitiligo is an autoimmune skin disease associated with features such as chronic loss of melanocyte function an...
Research progress of spike protein mutation of SARS-CoV-2 mutant strain and antibody development
1 IntroductionFollowing SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) and MERS (Middle East Respiratory Syndrom...
Upregulation of CRISP3 and its clinical values in adult sepsis: a comprehensive analysis based on microarrays and a two-retrospective-cohort study
IntroductionConceptually, sepsis is now a life-threatening organ dysfunction caused by the dysregulation of the body’s res...
In silico analysis for the development of multi-epitope vaccines against Mycobacterium tuberculosis
1 IntroductionTuberculosis (TB), a highly contagious disease, is one of the most prominent causes of death worldwide and w...
FBXW8 suppresses PDCoV proliferation via the NPD52-dependent autophagic degradation of a viral nucleocapsid protein
1 IntroductionPorcine deltacoronavirus (PDCoV) is an enveloped, positive-sense RNA virus that causes severe disease in swi...
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