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A fibroblast-associated signature predicts prognosis and immunotherapy in esophageal squamous cell cancer
A fibroblast-associated signature predicts prognosis and immunotherapy in esophageal squamous cell cancer
BackgroundCurrent paradigms of anti-tumor therapies are not qualified to evacuate the malignancy ascribing to cancer strom...
Environmental stress and nanoplastics’ effects on Ciona robusta: regulation of immune/stress-related genes and induction of innate memory in pharynx and gut
Environmental stress and nanoplastics’ effects on Ciona robusta: regulation of immune/stress-related genes and induction of innate memory in pharynx and gut
In addition to circulating haemocytes, the immune system of the solitary ascidian Ciona robusta relies on two organs, the ...
Cuproptosis-related gene identification and immune infiltration analysis in systemic lupus erythematosus
Cuproptosis-related gene identification and immune infiltration analysis in systemic lupus erythematosus
BackgroundSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of tolerance to self-antigen, ...
Combined immunodeficiency caused by pathogenic variants in the ZAP70 C-terminal SH2 domain
Combined immunodeficiency caused by pathogenic variants in the ZAP70 C-terminal SH2 domain
IntroductionZAP-70, a protein tyrosine kinase recruited to the T cell receptor (TCR), initiates a TCR signaling cascade up...
Failure to decrease HbA1c levels following TB treatment is associated with elevated Th1/Th17 CD4+ responses
Failure to decrease HbA1c levels following TB treatment is associated with elevated Th1/Th17 CD4+ responses
IntroductionThe rising global burden of metabolic disease impacts the control of endemic tuberculosis (TB) in many regions...
T cell receptor and B cell receptor exhibit unique signatures in tumor and adjacent non-tumor tissues of hepatocellular carcinoma
T cell receptor and B cell receptor exhibit unique signatures in tumor and adjacent non-tumor tissues of hepatocellular carcinoma
BackgroundThe tumor microenvironment in hepatocellular carcinoma (HCC) is complicated. Tumor-infiltrating T and B cells pl...
Targeting immune checkpoints on tumor-associated macrophages in tumor immunotherapy
Targeting immune checkpoints on tumor-associated macrophages in tumor immunotherapy
Unprecedented breakthroughs have been made in cancer immunotherapy in recent years. Particularly immune checkpoint inhibit...
HLA allele and haplotype frequencies of registered stem cell donors in Chile
HLA allele and haplotype frequencies of registered stem cell donors in Chile
Patients in need of hematopoietic stem cell transplantation often rely on unrelated stem cell donors matched in certain hu...
Genetic polymorphisms of bone marrow stromal cell antigen-1 (BST-1/CD157): implications for immune/inflammatory dysfunction in neuropsychiatric disorders
Genetic polymorphisms of bone marrow stromal cell antigen-1 (BST-1/CD157): implications for immune/inflammatory dysfunction in neuropsychiatric disorders
Bone marrow stromal cell antigen-1 (BST-1/CD157) is an immune/inflammatory regulator that functions as both nicotinamide a...
Continuation of anti-PD-1 therapy plus physician-choice treatment beyond first progression is not associated with clinical benefit in patients with advanced non-small cell lung cancer
Continuation of anti-PD-1 therapy plus physician-choice treatment beyond first progression is not associated with clinical benefit in patients with advanced non-small cell lung cancer
ObjectiveFew data are available on the optimal treatment options after disease progression from first-line treatment of im...
Differential recognition of influenza A virus H1N1 neuraminidase by DNA vaccine-induced antibodies in pigs and ferrets
Differential recognition of influenza A virus H1N1 neuraminidase by DNA vaccine-induced antibodies in pigs and ferrets
Neuraminidase (NA) accounts for approximately 10-20% of the total glycoproteins on the surface of influenza viruses. It cl...
Group 1 and group 2 hemagglutinin stalk antibody response according to age
Group 1 and group 2 hemagglutinin stalk antibody response according to age
ObjectiveAntibodies elicited by seasonal influenza vaccines mainly target the head of hemagglutinin (HA). However, antibod...
Neuro-PASC is characterized by enhanced CD4+ and diminished CD8+ T cell responses to SARS-CoV-2 Nucleocapsid protein
Neuro-PASC is characterized by enhanced CD4+ and diminished CD8+ T cell responses to SARS-CoV-2 Nucleocapsid protein
IntroductionMany people with long COVID symptoms suffer from debilitating neurologic post-acute sequelae of SARS-CoV-2 inf...
Incidence and risk factors of acute kidney injury in cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis
Incidence and risk factors of acute kidney injury in cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis
BackgroundThe incidence and risk factors of acute kidney injury (AKI) in patients with malignancies receiving immune check...
Machine learning analysis of humoral and cellular responses to SARS-CoV-2 infection in young adults
Machine learning analysis of humoral and cellular responses to SARS-CoV-2 infection in young adults
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces B and T cell responses, contributing to virus neu...
Construction of a fecal immune-related protein-based biomarker panel for colorectal cancer diagnosis: a multicenter study
Construction of a fecal immune-related protein-based biomarker panel for colorectal cancer diagnosis: a multicenter study
PurposeTo explore fecal immune-related proteins that can be used for colorectal cancer (CRC) diagnosis.Patients and method...
Blocking autofluorescence in brain tissues affected by ischemic stroke, hemorrhagic stroke, or traumatic brain injury
Blocking autofluorescence in brain tissues affected by ischemic stroke, hemorrhagic stroke, or traumatic brain injury
Autofluorescence is frequently observed in animal tissues, interfering with an experimental analysis and leading to inaccu...
Prognostic immunogenic characteristics of iron pendant disease modifiers in colon cancer
Prognostic immunogenic characteristics of iron pendant disease modifiers in colon cancer
BackgroundWe explored the prognostic and immunogenic characteristics of iron pendant disease regulators in colon cancer to...
Self-assembled albumin nanoparticles induce pyroptosis for photodynamic/photothermal/immuno synergistic therapies in triple-negative breast cancer
Self-assembled albumin nanoparticles induce pyroptosis for photodynamic/photothermal/immuno synergistic therapies in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is characterized by a high degree of malignancy, early metastasis, limited treatment,...
Anti-staphylococcus aureus adaptive immunity is impaired in end-stage renal disease patients on hemodialysis: one-year longitudinal study
Anti-staphylococcus aureus adaptive immunity is impaired in end-stage renal disease patients on hemodialysis: one-year longitudinal study
IntroductionPatients with end-stage renal disease (ESRD) display defects in adaptive and innate immunity, increasing susce...
HDAC inhibitors enhance the anti-tumor effect of immunotherapies in hepatocellular carcinoma
HDAC inhibitors enhance the anti-tumor effect of immunotherapies in hepatocellular carcinoma
Hepatocellular carcinoma (HCC), the most common liver malignancy with a poor prognosis and increasing incidence, remains a...
Facilitating systems-level analyses of all-cause and Covid-mediated sepsis through SeptiSearch, a manually-curated compendium of dysregulated gene sets
Facilitating systems-level analyses of all-cause and Covid-mediated sepsis through SeptiSearch, a manually-curated compendium of dysregulated gene sets
BackgroundSepsis is a dysfunctional host response to infection. The syndrome leads to millions of deaths annually (19.7% o...
Immune response plays a role in Mycoplasma pneumoniae pneumonia
Immune response plays a role in Mycoplasma pneumoniae pneumonia
IntroductionMycoplasma pneumoniae (MP) is a major pathogen of community-acquired pneumonia in children. However, the speci...
Tfl deletion induces extraordinary Cxcl13 secretion and cachexia in VavP-Bcl2 transgenic mice
Tfl deletion induces extraordinary Cxcl13 secretion and cachexia in VavP-Bcl2 transgenic mice
Statement of significance: Loss of TFL, found in several types of lymphoma, induces excessive CXCL13 secretion through RNA...
Systematic analysis between inflammation-related index and sex hormones in American adults: cross-sectional research based NHANES 2013-2016
Systematic analysis between inflammation-related index and sex hormones in American adults: cross-sectional research based NHANES 2013-2016
BackgroundA series of novel inflammation-related indexes has been confirmed to be efficient indicators of human immune and...
Tocilizumab versus anakinra in COVID-19: results from propensity score matching
Tocilizumab versus anakinra in COVID-19: results from propensity score matching
BackgroundTocilizumab and anakinra are anti-interleukin drugs to treat severe coronavirus disease 2019 (COVID-19) refracto...
The macrophage infectivity potentiator of Trypanosoma cruzi induces innate IFN-γ and TNF-α production by human neonatal and adult blood cells through TLR2/1 and TLR4
The macrophage infectivity potentiator of Trypanosoma cruzi induces innate IFN-γ and TNF-α production by human neonatal and adult blood cells through TLR2/1 and TLR4
We previously identified the recombinant (r) macrophage (M) infectivity (I) potentiator (P) of the protozoan parasite Tryp...
The CD40 agonist HERA-CD40L results in enhanced activation of antigen presenting cells, promoting an anti-tumor effect alone and in combination with radiotherapy
The CD40 agonist HERA-CD40L results in enhanced activation of antigen presenting cells, promoting an anti-tumor effect alone and in combination with radiotherapy
IntroductionThe ability to modulate and enhance the anti-tumor immune responses is critical in developing novel therapies ...
Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-β-activated kinase 1 deubiquitination
Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-β-activated kinase 1 deubiquitination
Background and aimsIn the course of clinical practice, hepatic ischemia/reperfusion (I/R) injury is a prevalent pathophysi...
Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation
Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation
IntroductionStaphylococcus epidermidis is a commensal bacterium ubiquitously present on human skin. This species is consid...
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