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A cross-sectional study of explainable machine learning in Alzheimer’s disease: diagnostic classification using MR radiomic features
A cross-sectional study of explainable machine learning in Alzheimer’s disease: diagnostic classification using MR radiomic features
IntroductionAlzheimer’s disease (AD) even nowadays remains a complex neurodegenerative disease and its diagnosis relies ma...
Gut microbiota and intestinal barrier function in subjects with cognitive impairments: a cross-sectional study
Gut microbiota and intestinal barrier function in subjects with cognitive impairments: a cross-sectional study
BackgroundGut-brain axis might play an important role in cognitive impairments by various diseases including Alzheimer’s d...
Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field
Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field
Insulin-like growth factor-1 (IGF-1) is an active polypeptide protein that closely resembles the structural sequence of in...
Latin American women in dementia research: outstanding contributions, barriers, and opportunities from Argentinian, Chilean, and Colombian colleagues
Latin American women in dementia research: outstanding contributions, barriers, and opportunities from Argentinian, Chilean, and Colombian colleagues
Women’s contributions to science have been consistently underrepresented throughout history. Despite many efforts and some...
Comparison of the effects of remimazolam and dexmedetomidine on early postoperative cognitive function in elderly patients with gastric cancer
Comparison of the effects of remimazolam and dexmedetomidine on early postoperative cognitive function in elderly patients with gastric cancer
PurposeTo compare the effects of remimazolam and dexmedetomidine on early postoperative cognitive dysfunction (POCD) in ag...
c-Abl tyrosine kinase down-regulation as target for memory improvement in Alzheimer’s disease
c-Abl tyrosine kinase down-regulation as target for memory improvement in Alzheimer’s disease
BackgroundGrowing evidence suggests that the non-receptor tyrosine kinase, c-Abl, plays a significant role in the pathogen...
Decoding the genetic relationship between Alzheimer’s disease and type 2 diabetes: potential risk variants and future direction for North Africa
Decoding the genetic relationship between Alzheimer’s disease and type 2 diabetes: potential risk variants and future direction for North Africa
IntroductionAlzheimer’s disease (AD) and Type 2 diabetes (T2D) are both age-associated diseases. Identification of shared ...
Gait performance and prefrontal cortex activation during single and dual task walking in older adults with different cognitive levels
Gait performance and prefrontal cortex activation during single and dual task walking in older adults with different cognitive levels
BackgroundGrowing evidence shows the cognitive function influences the motor performance. The prefrontal cortex (PFC) as a...
The correlation between changes in gray matter microstructure and cerebral blood flow in Alzheimer’s disease
The correlation between changes in gray matter microstructure and cerebral blood flow in Alzheimer’s disease
ObjectiveTo investigate the relationship between changes in cerebral blood flow (CBF) and gray matter (GM) microstructure ...
Classification of Parkinson's disease stages with a two-stage deep neural network
Classification of Parkinson's disease stages with a two-stage deep neural network
IntroductionParkinson's disease is one of the most prevalent neurodegenerative diseases. In the most advanced stages, ...
Neuronal ApoE4 in Alzheimer’s disease and potential therapeutic targets
Neuronal ApoE4 in Alzheimer’s disease and potential therapeutic targets
The most prevalent genetic risk factor for Alzheimer’s disease (AD) is Apolipoprotein E (ApoE), a gene located on chromoso...
The efficacy of memory load on speech-based detection of Alzheimer’s disease
The efficacy of memory load on speech-based detection of Alzheimer’s disease
IntroductionThe study aims to test whether an increase in memory load could improve the efficacy in detection of Alzheimer...
Uncovering neuroinflammation-related modules and potential repurposing drugs for Alzheimer's disease through multi-omics data integrative analysis
Uncovering neuroinflammation-related modules and potential repurposing drugs for Alzheimer's disease through multi-omics data integrative analysis
BackgroundNeuroinflammation is one of the key factors leading to neuron death and synapse dysfunction in Alzheimer's d...
CREB5 hypermethylation involved in the ganglioside GM1 therapy of Parkinson’s disease
CREB5 hypermethylation involved in the ganglioside GM1 therapy of Parkinson’s disease
IntroductionThe treatment with monosialotetrahexosylganglioside (GM1) improves the symptoms of Parkinson’s disease (PD). T...
Network meta-analysis of comparative efficacy of animal-assisted therapy vs. pet-robot therapy in the management of dementia
Network meta-analysis of comparative efficacy of animal-assisted therapy vs. pet-robot therapy in the management of dementia
ObjectiveThis network meta-analysis aimed to compare and rank the efficacy of animal-assisted therapy (AAT) and pet-roboti...
Targeting the autophagy-lysosomal pathway in Huntington disease: a pharmacological perspective
Targeting the autophagy-lysosomal pathway in Huntington disease: a pharmacological perspective
The autophagy-lysosomal pathway (ALP) is the major biological pathway responsible for clearing intracellular protein aggre...
Association between migraine and Alzheimer’s disease: a nationwide cohort study
Association between migraine and Alzheimer’s disease: a nationwide cohort study
Background and objectiveMigraine is a common chronic neurological disease characterized by pulsating headaches, photophobi...
Association of cataract extraction and the risk of dementia—A systematic review and meta-analysis
Association of cataract extraction and the risk of dementia—A systematic review and meta-analysis
ObjectivesThis research aims to investigate if cataract extraction lowers the risk of all-cause dementia.MethodsOriginal l...
Multistable perception elicits compensatory alpha activity in older adults
Multistable perception elicits compensatory alpha activity in older adults
Multistable stimuli lead to the perception of two or more alternative perceptual experiences that spontaneously reverse fr...
The ANeED study – ambroxol in new and early dementia with Lewy bodies (DLB): protocol for a phase IIa multicentre, randomised, double-blinded and placebo-controlled trial
The ANeED study – ambroxol in new and early dementia with Lewy bodies (DLB): protocol for a phase IIa multicentre, randomised, double-blinded and placebo-controlled trial
BackgroundCurrently, there are no disease-modifying pharmacological treatment options for dementia with Lewy bodies (DLB)....
Subjective cognitive decline in patients with Parkinson’s disease: an updated review
Subjective cognitive decline in patients with Parkinson’s disease: an updated review
Cognitive impairment in patients with Parkinson’s disease (PD) worsens the prognosis of PD and increases caregivers’ burde...
Genetic analysis of dystonia-related genes in Parkinson's disease
Genetic analysis of dystonia-related genes in Parkinson's disease
ObjectiveParkinson's disease (PD) and dystonia are two closely related movement disorders with overlaps in clinical ph...
Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases
Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases
Neurodegenerative diseases have reached alarming numbers in the past decade. Unfortunately, clinical trials testing potent...
Relationship between cognitive dysfunction and the promoter methylation of PER1 and CRY1 in patients with cerebral small vessel disease
Relationship between cognitive dysfunction and the promoter methylation of PER1 and CRY1 in patients with cerebral small vessel disease
Background and purposeThe prevalence of cerebral small vessel disease (CSVD) is increasing due to the accelerating global ...
Education differentiates cognitive performance and resting state fMRI connectivity in healthy aging
Education differentiates cognitive performance and resting state fMRI connectivity in healthy aging
ObjectivesIn healthy aging, the way people cope differently with cognitive and neural decline is influenced by exposure to...
Discrete Ricci curvatures capture age-related changes in human brain functional connectivity networks
Discrete Ricci curvatures capture age-related changes in human brain functional connectivity networks
IntroductionGeometry-inspired notions of discrete Ricci curvature have been successfully used as markers of disrupted brai...
Serum chloride as a respiratory failure marker in amyotrophic lateral sclerosis
Serum chloride as a respiratory failure marker in amyotrophic lateral sclerosis
Respiratory failure is the most common cause of death in patients with amyotrophic lateral sclerosis (ALS) and occurs with...
Investigation of brain iron levels in Chinese patients with Alzheimer’s disease
Investigation of brain iron levels in Chinese patients with Alzheimer’s disease
IntroductionWe aimed (i) to explore the diagnostic value of deep gray matter magnetic susceptibility in Alzheimer’s diseas...
Age- and time-of-day dependence of glymphatic function in the human brain measured via two diffusion MRI methods
Age- and time-of-day dependence of glymphatic function in the human brain measured via two diffusion MRI methods
Advanced age, accompanied by impaired glymphatic function, is a key risk factor for many neurodegenerative diseases. To st...
Access to, use of, and experiences with social alarms in home-living people with dementia: results from the LIVE@Home.Path trial
Access to, use of, and experiences with social alarms in home-living people with dementia: results from the LIVE@Home.Path trial
BackgroundSocial alarms are considered an appropriate technology to ensure the safety and independence of older adults, bu...
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