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Lamivudine modulates the expression of neurological impairment-related genes and LINE-1 retrotransposons in brain tissues of a Down syndrome mouse model
Lamivudine modulates the expression of neurological impairment-related genes and LINE-1 retrotransposons in brain tissues of a Down syndrome mouse model
Elevated activity of retrotransposons is increasingly recognized to be implicated in a wide range of neurodegenerative and...
The influence of eight cognitive training regimes upon cognitive screening tool performance in post-stroke survivors: a network meta-analysis
The influence of eight cognitive training regimes upon cognitive screening tool performance in post-stroke survivors: a network meta-analysis
BackgroundTraditional meta-analysis offers only direct comparative evidence. The optimal cognitive training for poststroke...
Emerging perspectives on precision therapy for Parkinson’s disease: multidimensional evidence leading to a new breakthrough in personalized medicine
Emerging perspectives on precision therapy for Parkinson’s disease: multidimensional evidence leading to a new breakthrough in personalized medicine
PD is a prevalent and progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Genes pla...
Corrigendum: Glutamatergic and GABAergic neurons in the preoptic area of the hypothalamus play key roles in menopausal hot flashes
Corrigendum: Glutamatergic and GABAergic neurons in the preoptic area of the hypothalamus play key roles in menopausal hot flashes
In the published article, there was an error in Figure 3 as published. The wrong slide of microscopy was provided for OV...
Occlusion dysfunction and Alzheimer’s disease: Mendelian randomization study
Occlusion dysfunction and Alzheimer’s disease: Mendelian randomization study
AimOcclusion dysfunction (OD) is increasingly linked to Alzheimer’s disease (AD). This study aimed to elucidate the causal...
Exploring research hotspots and emerging trends in neuroimaging of vascular cognitive impairment: a bibliometric and visualized analysis
Exploring research hotspots and emerging trends in neuroimaging of vascular cognitive impairment: a bibliometric and visualized analysis
BackgroundVascular cognitive impairment (VCI) manifests in memory impairment, mental slowness, executive dysfunction, beha...
Toward the development of a sporadic model of Alzheimer's disease: comparing pathologies between humanized APP and the familial J20 mouse models
Toward the development of a sporadic model of Alzheimer's disease: comparing pathologies between humanized APP and the familial J20 mouse models
BackgroundFinding successful therapies for individuals with Alzheimer's disease (AD) remains an ongoing challenge. On...
Potential increased propofol sensitivity in cognitively impaired elderly: a controlled, double-blind study
Potential increased propofol sensitivity in cognitively impaired elderly: a controlled, double-blind study
BackgroundCognitive impairment in the elderly may lead to potential increased sensitivity to anesthetic agents targeting r...
Associations of endogenous estrogens, plasma Alzheimer’s disease biomarkers, and APOE4 carrier status on regional brain volumes in postmenopausal women
Associations of endogenous estrogens, plasma Alzheimer’s disease biomarkers, and APOE4 carrier status on regional brain volumes in postmenopausal women
BackgroundWomen carrying the APOE4 allele are at greater risk of developing Alzheimer’s disease (AD) from ages 65–75 years...
Editorial: Neuroinflammation and cognitive impairment
Editorial: Neuroinflammation and cognitive impairment
The relationship between neuroinflammation and cognitive impairment represents a crucial area of contemporary neuroscien...
Quantifying neuroinflammation within deep gray matter in small vessel disease using diffusion tensor based free-water imaging: a longitudinal study
Quantifying neuroinflammation within deep gray matter in small vessel disease using diffusion tensor based free-water imaging: a longitudinal study
PurposeEmploying free water (FW) imaging, a cutting-edge diffusion MRI technique, we assessed neuroinflammation within dee...
Resilience to AD pathology in Top Cognitive Performers
Resilience to AD pathology in Top Cognitive Performers
Successful cognitive aging is often thought to result from resistance to the accumulation of pathology, resilience to the ...
The impact of education and occupation on cognitive impairment: a cross-sectional study in China
The impact of education and occupation on cognitive impairment: a cross-sectional study in China
Background and objectivesEducation, occupation, and cognitive activity are key indicators of cognitive reserve and are tho...
The role of Immune cells in Alzheimer's disease: a bidirectional Mendelian randomization study
The role of Immune cells in Alzheimer's disease: a bidirectional Mendelian randomization study
BackgroundAlzheimer's disease (AD) is a leading cause of dementia, characterized by the accumulation of amyloid-beta ...
Bibliometric analysis of neuroinflammation and Alzheimer’s disease
Bibliometric analysis of neuroinflammation and Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is the predominant cause of dementia on a global scale, significantly impacting the hea...
Genetic link between KIF1A mutations and amyotrophic lateral sclerosis: evidence from whole-exome sequencing
Genetic link between KIF1A mutations and amyotrophic lateral sclerosis: evidence from whole-exome sequencing
ObjectivesGenetics have been shown to have a substantial impact on amyotrophic lateral sclerosis (ALS). The ALS process in...
Association of modified dementia risk score with cerebrospinal fluid biomarkers and cognition in adults without dementia
Association of modified dementia risk score with cerebrospinal fluid biomarkers and cognition in adults without dementia
IntroductionThis study aimed to investigate the cognitive profile and prospective cognitive changes in non-demented adults...
Identification of deregulated lncRNAs in Alzheimer’s disease: an integrated gene co-expression network analysis of hippocampus and fusiform gyrus RNA-seq datasets
Identification of deregulated lncRNAs in Alzheimer’s disease: an integrated gene co-expression network analysis of hippocampus and fusiform gyrus RNA-seq datasets
IntroductionThe deregulation of lncRNAs expression has been associated with neuronal damage in Alzheimer’s disease (AD), b...
The relationship between hypoxia and Alzheimer’s disease: an updated review
The relationship between hypoxia and Alzheimer’s disease: an updated review
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases, and the most prevalent form of dementia. Th...
The correlation between rapid eye movement sleep behavior disorder and the progress of Parkinson’s disease: a systematic review and meta-analysis
The correlation between rapid eye movement sleep behavior disorder and the progress of Parkinson’s disease: a systematic review and meta-analysis
BackgroundThis meta-analysis was conducted to evaluate potential differences in symptoms between PD patients with or witho...
Dynamic functional network connectivity in patients with a mismatch between white matter hyperintensity and cognitive function
Dynamic functional network connectivity in patients with a mismatch between white matter hyperintensity and cognitive function
ObjectiveWhite matter hyperintensity (WMH) in patients with cerebral small vessel disease (CSVD) is strongly associated wi...
Detection of freezing of gait in Parkinson's disease from foot-pressure sensing insoles using a temporal convolutional neural network
Detection of freezing of gait in Parkinson's disease from foot-pressure sensing insoles using a temporal convolutional neural network
BackgroundsFreezing of gait (FoG) is a common and debilitating symptom of Parkinson's disease (PD) that can lead to f...
Relations between tactile sensitivity of the finger, arm, and cheek skin over the lifespan showing decline only on the finger
Relations between tactile sensitivity of the finger, arm, and cheek skin over the lifespan showing decline only on the finger
Touch sensitivity generally declines with age, contributing to loss of manual dexterity and tactile function. We investiga...
Positive association of ethylene oxide levels with young stroke: a population-based study
Positive association of ethylene oxide levels with young stroke: a population-based study
BackgroundEthylene oxide (EtO), a highly reactive organic compound with extensive industrial applications, poses significa...
Anatomical-related factors and outcome of percutaneous short-term spinal cord stimulation electrode shift in patients with disorders of consciousness: a retrospective study
Anatomical-related factors and outcome of percutaneous short-term spinal cord stimulation electrode shift in patients with disorders of consciousness: a retrospective study
BackgroundDisorders of consciousness (DoC) represent a spectrum of neurological conditions that pose significant treatment...
Microglia depletion leads to increased susceptibility to ocular hypertension-dependent glaucoma
Microglia depletion leads to increased susceptibility to ocular hypertension-dependent glaucoma
In recent years, microglia have been highlighted for playing integral roles in neurodegenerative diseases, like glaucoma. ...
Age-related reduction in anxiety and neural encoding of negative emotional memory
Age-related reduction in anxiety and neural encoding of negative emotional memory
IntroductionOlder adults experience less anxiety. We examined how memory of negative emotional images varied with age and ...
Transcriptomic analysis reveals novel hub genes associated with astrocyte autophagy in intracerebral hemorrhage
Transcriptomic analysis reveals novel hub genes associated with astrocyte autophagy in intracerebral hemorrhage
IntroductionNeuroinflammation serves as a critical local defense mechanism against secondary brain injury following intrac...
Online awareness is associated with superior performance on assessments of functional cognition
Online awareness is associated with superior performance on assessments of functional cognition
BackgroundIntact awareness facilitates an individual’s adoption of strategies to support community living skills. However,...
Exploring the association of physical activity on cognitive function in older adults from observational and genetic insights: a combined NHANES and Mendelian randomization study
Exploring the association of physical activity on cognitive function in older adults from observational and genetic insights: a combined NHANES and Mendelian randomization study
BackgroundCognitive function (CF) deterioration is a pressing concern in geriatric research. This study aimed to explore t...
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