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Silymarin administration after cerebral ischemia improves survival of obese mice by increasing cortical BDNF and IGF1 levels
1 Introduction Obesity is a global health problem, representing the sixth cause of death worldwide (Hruby and Hu, 2015)....
Reorganized brain functional network topology in stable and progressive mild cognitive impairment
Introduction Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and ...
Trajectories of cognitive function and frailty in older adults in China: a longitudinal study
1 Introduction China’s population is aging rapidly. By the end of 2022, the number of individuals aged 60 and above had ...
The role of serum α-Klotho levels in preventing hearing impairment among middle-aged and older adults: insights from a nationally representative sample
1 Introduction Klotho is a gene involved in the suppression of multiple aging phenotypes and is known to participate in a...
Identification of altered immune cell types and molecular mechanisms in Alzheimer’s disease progression by single-cell RNA sequencing
Graphical Abstract. The flowchart of this study. AD, Alzheimer’s disease; AUC, area under receiver operating...
The novel estrogen receptor beta agonist EGX358 and APOE genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer’s mouse model
1 Introduction Women comprise nearly two-thirds of individuals in the U.S. living with Alzheimer’s Disease (AD), a major...
Association of dementia with the 28-day mortality of sepsis: an observational and Mendelian randomization study
1 Introduction Globally, dementia ranks as the seventh main contributor to mortality and is a significant factor in disab...
Association between exercise habits in adolescence and old age and the risk of mild cognitive impairment: the Bunkyo health study
Introduction Long-term care (LTC) is becoming increasingly significant in developed countries with the increasing aging o...
Efficacy of acupuncture in ameliorating anxiety in Parkinson's disease: a systematic review and meta-analysis with trial sequential analysis
1 Introduction Parkinson's disease (PD) is a common neurodegenerative disorder, typically characterized by motor symptoms...
The impact of body position on neurofluid dynamics: present insights and advancements in imaging
1 Introduction The human cranium serves as an enclosed space where the structural and functional properties of the brain ...
Specific gut microbiome signatures predict the risk of acute ischemic stroke
1 Introduction Acute ischemic stroke (AIS) is a leading cause of death and long-term disability worldwide, driven by com...
Somatosensory integration in robot-assisted motor restoration post-stroke
1 Introduction Disruption of somatosensorimotor integration (SMI) after a stroke is a key barrier to motor restoration be...
Causal association between Parkinson’s disease and cancer: a bidirectional Mendelian randomization study
1 Introduction Parkinson’s disease (PD) is a prevalent and intricate neurodegenerative condition, impacting approximatel...
Association of serum klotho with cognitive function among individuals with nonalcoholic fatty liver disease
1 Introduction Nonalcoholic fatty liver disease (NAFLD) has a high prevalence worldwide, and there is evidence suggestin...
Network-based statistics reveals an enhanced subnetwork in prefrontal cortex in mild cognitive impairment: a functional near-infrared spectroscopy study
1 Introduction According to surveillance data published in Lancet Public Health in 2020 (Jia et al., 2020), the estimate...
Biomarkers and Alzheimer’s disease: a bibliometric analysis
1 Introduction Alzheimer’s disease (AD) is clinically characterized by progressive cognitive and behavioral impairments....
Editorial: Dance, embodied agency and neuroplasticity in aging
Dance is a multi-modal artistic engagement whose group-delivered protocols have resulted in positive impacts on elderly he...
Mechanisms of ozone-induced neurotoxicity in the development and progression of dementia: a brief review
1 Introduction Dementia encompasses a broad range of neurodegenerative disorders that represent a growing global health c...
MRI radiomics combined with machine learning for diagnosing mild cognitive impairment: a focus on the cerebellar gray and white matter
MRI radiomics combined with machine learning for diagnosing mild cognitive impairment: a focus on the cerebellar gray and white matter
ObjectiveMild Cognitive Impairment (MCI) is a recognized precursor to Alzheimer’s Disease (AD), presenting a significant r...
Disparities in structural brain imaging in older adults from rural communities in Southern Nevada
Disparities in structural brain imaging in older adults from rural communities in Southern Nevada
IntroductionIdentifying the associations between rural-living or neighborhood disadvantage and neurobiology may clarify ru...
Diffusion and functional MRI reveal microstructural and network connectivity impairment in adult-onset neuronal intranuclear inclusion disease
Diffusion and functional MRI reveal microstructural and network connectivity impairment in adult-onset neuronal intranuclear inclusion disease
ObjectivesNeuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder lacking reliable neuroimagin...
Editorial: Model organisms in neuroinflammation and neuropathy: Drosophila melanogaster
neuroinflammation contributes to the pathogenesis of neurological disorders including Alzheimer's disease, Parkins...
Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in older participants
Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in older participants
IntroductionWith age, sensory, cognitive, and motor abilities decline, and the risk for neurodegenerative disorders increa...
Association of frailty and serum neurofilament light chain levels: the mediating role of estimated glomerular filtration rate
Association of frailty and serum neurofilament light chain levels: the mediating role of estimated glomerular filtration rate
BackgroundBoth frailty and elevated serum neurofilament light chain (sNfL) levels are linked to cognitive impairment. Howe...
Genetically stratified Parkinson’s disease with freezing of gait is related to specific pattern of cognitive impairment and non-motor dominant endophenotype
Genetically stratified Parkinson’s disease with freezing of gait is related to specific pattern of cognitive impairment and non-motor dominant endophenotype
BackgroundFreezing of gait (FOG) is an important milestone in the individual disease trajectory of people with Parkinson’s...
Implicit memory reduced selectively for negative words with aging
Implicit memory reduced selectively for negative words with aging
BackgroundDisproportionally better memory for positive versus negative information (mnemonic positivity effect, MPE) in ol...
Grip strength and depressive symptoms in Chinese middle-aged and older adults: the mediating effects of cognitive function
Grip strength and depressive symptoms in Chinese middle-aged and older adults: the mediating effects of cognitive function
ObjectiveThis study investigates the associations and mediating pathways between grip strength, cognitive function, and de...
Changes of brain structure and structural covariance networks in Parkinson’s disease associated cognitive impairment
Changes of brain structure and structural covariance networks in Parkinson’s disease associated cognitive impairment
BackgroundCognitive impairment (CI) is common in Parkinson’s disease (PD). Multiple brain regions and their interactions a...
Iron overload regulates cognitive function in rats with minimal hepatic encephalopathy by inducing an increase in frontal butyrylcholinesterase activity
Iron overload regulates cognitive function in rats with minimal hepatic encephalopathy by inducing an increase in frontal butyrylcholinesterase activity
Background and aimsThis study aimed to investigate the effect of iron overload on acetylcholinesterase activity in the fro...
The role of PI3K signaling pathway in Alzheimer’s disease
The role of PI3K signaling pathway in Alzheimer’s disease
Alzheimer’s disease (AD) is a debilitating progressively neurodegenerative disease. The best-characterized hallmark of AD,...
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