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Role of angiotensin II in aging
Role of angiotensin II in aging
Aging is an inevitable progressive decline in physiological organ function that increases the chance of disease and death....
The role of ADAM10 in astrocytes: Implications for Alzheimer’s disease
The role of ADAM10 in astrocytes: Implications for Alzheimer’s disease
Much of the early research into AD relies on a neuron-centric view of the brain, however, evidence of multiple altered cel...
Targets and mechanisms of Alpinia oxyphylla Miquel fruits in treating neurodegenerative dementia
Targets and mechanisms of Alpinia oxyphylla Miquel fruits in treating neurodegenerative dementia
The dried and ripe fruits of Alpinia oxyphylla and ripe fruits of Alpinia oxyphylla Miquel (AO) have the effects of tonify...
Proteomics analysis of the p.G849D variant in neurexin 2 alpha may reveal insight into Parkinson’s disease pathobiology
Proteomics analysis of the p.G849D variant in neurexin 2 alpha may reveal insight into Parkinson’s disease pathobiology
Parkinson’s disease (PD), the fastest-growing neurological disorder globally, has a complex etiology. A previous study by ...
Systematic evaluation of urinary formic acid as a new potential biomarker for Alzheimer’s disease
Systematic evaluation of urinary formic acid as a new potential biomarker for Alzheimer’s disease
IntroductionThe accumulation of endogenous formaldehyde is considered a pathogenic factor in Alzheimer’s disease (AD). The...
Exercise improves behavioral dysfunction and inhibits the spontaneous excitatory postsynaptic current of D2-medium spiny neurons
Exercise improves behavioral dysfunction and inhibits the spontaneous excitatory postsynaptic current of D2-medium spiny neurons
The abnormal function of striatal medium spiny neurons (MSNs) leads to the excitation-inhibition imbalance of the basal ga...
A primary rodent triculture model to investigate the role of glia-neuron crosstalk in regulation of neuronal activity
A primary rodent triculture model to investigate the role of glia-neuron crosstalk in regulation of neuronal activity
Neuroinflammation and hyperexcitability have been implicated in the pathogenesis of neurodegenerative disease, and new mod...
Stroke-associated infection in patients with co-morbid diabetes mellitus is associated with in-hospital mortality
Stroke-associated infection in patients with co-morbid diabetes mellitus is associated with in-hospital mortality
Background and objectiveThe association between infection and acute ischemic stroke (AIS) with diabetes mellitus (DM) rema...
Analysis of shared underlying mechanism in neurodegenerative disease
Analysis of shared underlying mechanism in neurodegenerative disease
In this review, the relationship between bioenergetics, mitochondrial dysfunction, and inflammation will be and how they c...
Predicting AT(N) pathologies in Alzheimer’s disease from blood-based proteomic data using neural networks
Predicting AT(N) pathologies in Alzheimer’s disease from blood-based proteomic data using neural networks
Background and objectiveBlood-based biomarkers represent a promising approach to help identify early Alzheimer’s disease (...
Cystatin C predicts cognitive decline in multiple system atrophy: A 1-year prospective cohort study
Cystatin C predicts cognitive decline in multiple system atrophy: A 1-year prospective cohort study
BackgroundAccumulating evidence has suggested that cystatin C is associated with cognitive impairment in patients with neu...
Evidence of Filamin A loss of solubility at the prodromal stage of neuropathologically-defined Alzheimer’s disease
Evidence of Filamin A loss of solubility at the prodromal stage of neuropathologically-defined Alzheimer’s disease
IntroductionAlzheimer’s disease (AD) is a multifactorial disorder diagnosed through the assessment of amyloid-beta (Aβ) an...
Self Assessment Memory Scale (SAMS), a new simple method for evaluating memory function
Self Assessment Memory Scale (SAMS), a new simple method for evaluating memory function
We have developed a new method for easy self-assessment of changes in memory recall impairment, which can be used during t...
Discovery and validation of Ferroptosis-related molecular patterns and immune characteristics in Alzheimer’s disease
Discovery and validation of Ferroptosis-related molecular patterns and immune characteristics in Alzheimer’s disease
BackgroundTo date, the pathogenesis of Alzheimer’s disease is still not fully elucidated. Much evidence suggests that Ferr...