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miR-3940-5p reduces amyloid β production via selectively targeting PSEN1
miR-3940-5p reduces amyloid β production via selectively targeting PSEN1
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid beta (Aβ...
Impact of olfactory function on the trajectory of cognition, motor function, and quality of life in Parkinson’s disease
Impact of olfactory function on the trajectory of cognition, motor function, and quality of life in Parkinson’s disease
BackgroundOlfactory dysfunction in Parkinson’s disease (PD) is associated with more severe phenotypes, but trajectories of...
Dual-task turn velocity – a novel digital biomarker for mild cognitive impairment and dementia
Dual-task turn velocity – a novel digital biomarker for mild cognitive impairment and dementia
BackgroundDisorders associated with cognitive impairment impose a significant burden on both families and society. Previou...
Modeling sporadic Alzheimer’s disease in mice by combining Apolipoprotein E4 risk gene with environmental risk factors
Modeling sporadic Alzheimer’s disease in mice by combining Apolipoprotein E4 risk gene with environmental risk factors
IntroductionDeveloping effective treatment for Alzheimer’s disease (AD) remains a challenge. This can be partially attribu...
Sensorineural hearing loss and cognitive impairment: three hypotheses
Sensorineural hearing loss and cognitive impairment: three hypotheses
Sensorineural hearing loss (SNHL) is a category of hearing loss that often leads to difficulty in understanding speech and...
Comparative analysis of multimodal biomarkers for amyloid-beta positivity detection in Alzheimer's disease cohorts
Comparative analysis of multimodal biomarkers for amyloid-beta positivity detection in Alzheimer's disease cohorts
IntroductionEfforts to develop cost-effective approaches for detecting amyloid pathology in Alzheimer's disease (AD) h...
Association of immune cell traits with Parkinson’s disease: a Mendelian randomization study
Association of immune cell traits with Parkinson’s disease: a Mendelian randomization study
BackgroundImmunity and neuroinflammation play crucial roles in the pathogenesis of Parkinson’s disease (PD). Nonetheless, ...
Mentha rotundifolia (L.) Huds. and Salvia officinalis L. hydrosols mitigate aging related comorbidities in rats
Mentha rotundifolia (L.) Huds. and Salvia officinalis L. hydrosols mitigate aging related comorbidities in rats
IntroductionAging is often linked to oxidative stress, where the body experiences increased damage from free radicals. Pla...
Association between serum estradiol levels and cognitive function in older women: a cross-sectional analysis
Association between serum estradiol levels and cognitive function in older women: a cross-sectional analysis
IntroductionEstradiol is a sex steroid hormone, which has been implicated in the pathogenesis of Alzheimer’s disease and c...
Human stem cell transplantation models of Alzheimer’s disease
Human stem cell transplantation models of Alzheimer’s disease
Alzheimer’s disease (AD) is the most frequent form of dementia. It is characterized by pronounced neuronal degeneration wi...
tRNS boosts visual perceptual learning in participants with bilateral macular degeneration
tRNS boosts visual perceptual learning in participants with bilateral macular degeneration
Perceptual learning (PL) has shown promise in enhancing residual visual functions in patients with age-related macular deg...
Effect of the ROCK inhibitor fasudil on the brain proteomic profile in the tau transgenic mouse model of Alzheimer's disease
Effect of the ROCK inhibitor fasudil on the brain proteomic profile in the tau transgenic mouse model of Alzheimer's disease
IntroductionThe goal of this study is to explore the pharmacological potential of the amyloid-reducing vasodilator fasudil...
Enriched oxygen improves age-related cognitive impairment through enhancing autophagy
Enriched oxygen improves age-related cognitive impairment through enhancing autophagy
Age-related cognitive impairment represents a significant health concern, with the understanding of its underlying mechani...
Preliminary study on early diagnosis of Alzheimer’s disease in APP/PS1 transgenic mice using multimodal magnetic resonance imaging
Preliminary study on early diagnosis of Alzheimer’s disease in APP/PS1 transgenic mice using multimodal magnetic resonance imaging
Alzheimer’s disease (AD) has an insidious onset and lacks clear early diagnostic markers, and by the time overt dementia s...
Investigating the shared genetic architecture between frailty and insomnia
Investigating the shared genetic architecture between frailty and insomnia
BackgroundThe epidemiological association between frailty and insomnia is well established, yet the presence of a common g...
Diffusion kurtosis imaging of brain white matter alteration in patients with coronary artery disease based on the TBSS method
Diffusion kurtosis imaging of brain white matter alteration in patients with coronary artery disease based on the TBSS method
ObjectThe aim of our study was to examine the alterations in microstructure in patients with coronary artery disease (CAD)...
High-frequency multimodal training with a focus on Tai Chi in people with Parkinson’s disease: a pilot study
High-frequency multimodal training with a focus on Tai Chi in people with Parkinson’s disease: a pilot study
Background and objectivesCognitive decline is an important and common complication in patients with Parkinson’s disease (P...
IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice
IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice
IntroductionCerebrovascular pathologies contribute to cognitive decline during aging, leading to vascular cognitive impair...
Emerging T cell immunoregulatory mechanisms in multiple sclerosis and Alzheimer’s disease
Emerging T cell immunoregulatory mechanisms in multiple sclerosis and Alzheimer’s disease
Multiple sclerosis (MS) and Alzheimer’s disease (AD) are neuroinflammatory and neurodegenerative diseases with considerabl...
Corrigendum: Comparison of cerebrospinal fluid space between probable normal pressure hydrocephalus and Alzheimer's disease
Corrigendum: Comparison of cerebrospinal fluid space between probable normal pressure hydrocephalus and Alzheimer's disease
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