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Optimizing Informed Consent in Cancer Clinical Trials
Optimizing Informed Consent in Cancer Clinical Trials
Volume 33, Issue 4, October 2023, Pages 349-357Author links open overlay panel, , The concept of informed consent has evol...
Patient-Reported Outcomes in Clinical Trials: From an Endpoint to an Intervention in Cancer Care
Patient-Reported Outcomes in Clinical Trials: From an Endpoint to an Intervention in Cancer Care
A patient-reported outcome (PRO) tool is “a measurement of any aspect of a patient's health status that comes directly fro...
Selection and Prejudice: Addressing Clinical Trial Disparities With a Review of Current Shortcomings and Future Directions
Selection and Prejudice: Addressing Clinical Trial Disparities With a Review of Current Shortcomings and Future Directions
Randomized clinical trials (RCTs) are often considered the highest level of evidence to guide medical practice. Unlike oth...
Real-World Data: Applications and Relevance to Cancer Clinical Trials
Real-World Data: Applications and Relevance to Cancer Clinical Trials
In medicine, randomized controlled trials (RCTs) are considered the gold standard for evaluating the efficacy and safety o...
Integrating Artificial Intelligence and Machine Learning Into Cancer Clinical Trials
Integrating Artificial Intelligence and Machine Learning Into Cancer Clinical Trials
In just a few years, we have seen artificial intelligence (AI) and machine learning (ML) in healthcare transition from buz...
The Importance of Quality Assurance in Radiation Oncology Clinical Trials
The Importance of Quality Assurance in Radiation Oncology Clinical Trials
Quality has become an important and elemental metric in modern clinical medicine. Senior leadership groups in modern hospi...
Advances and Challenges in Conducting Clinical Trials With Proton Beam Therapy
Advances and Challenges in Conducting Clinical Trials With Proton Beam Therapy
Numerous technological advances over the past several decades in radiation oncology have allowed a stepwise progression to...
Advances and Challenges in Trials of Local Therapy for Patients With Oligometastatic or Oligoprogressive Disease
Advances and Challenges in Trials of Local Therapy for Patients With Oligometastatic or Oligoprogressive Disease
Over the past decade, there has been a paradigm shift in the management of patients with metastatic cancer. This change ha...
Challenges, Complexities, and Considerations in the Design and Interpretation of Late-Phase Oncology Trials
Challenges, Complexities, and Considerations in the Design and Interpretation of Late-Phase Oncology Trials
Late-phase oncology randomized controlled trials (RCT) form the primary basis for approval of new cancer therapies by regu...
Advancing Towards Personalized Prescription of Radiotherapy Dose
Volume 33, Issue 3, July 2023, Pages 219-220Author links open overlay panel, Section snippetsConflict of InterestDr. Citri...
Towards Data Driven RT Prescription: Integrating Genomics into RT Clinical Practice
Radiation Therapy (RT) remains the single most utilized cytotoxic agent for cancer treatment. It has been estimated that a...
Histology Specific Molecular Biomarkers: Ushering in a New Era of Precision Radiation Oncology
Oncologists have historically been limited to utilizing clinical features such as histopathology and staging information t...
Machine Learning & Molecular Radiation Tumor Biomarkers
Radiation therapy is a core component of the treatment of cancer patients, with over 50% of patients receiving radiation t...
The Promise and Future of Radiomics for Personalized Radiotherapy Dosing and Adaptation
Quantitative image analysis, also known as radiomics, channeling its "omics" counter parts from molecular biology (genomic...
Emerging Roles of Circulating Tumor DNA for Increased Precision and Personalization in Radiation Oncology
Volume 33, Issue 3, July 2023, Pages 262-278Author links open overlay panel, , , , , Recent breakthroughs in circulating t...
Radiation Sensitivity: The Rise of Predictive Patient-Derived Cancer Models
For as long as radiation therapy (RT) has been used to treat cancer, physicians have wanted to know what dose is right for...
[18F]FDG-PET-Based Personalized Radiotherapy Dose Prescription
Volume 33, Issue 3, July 2023, Pages 287-297Author links open overlay panel, , , , , , , PET imaging with 2’-deoxy-2’-[18F...
Hypoxia-Targeted Dose Painting in Radiotherapy
Hypoxia (a state of oxygen deprivation with oxygen level ≤2-3%, ≤15.2-22.8 mm Hg) occurs in most solid malignancies,1 albe...
Normal Tissue Toxicity Prediction: Clinical Translation on the Horizon
Improvements in radiotherapy delivery have enabled higher therapeutic doses and improved efficacy, contributing to the gro...
Theranostics and Patient-Specific Dosimetry
The concept of personalized medicine dates to the writings of Hippocrates around 400 BC. In the Corpus Hippocraticum the p...
Radiotherapy Dose in Patients Receiving Immunotherapy
As immuno-oncology (IO) agents have become integrated into the treatment of various cancers, an increasing number of studi...
Lessons and Opportunities for Biomarker-Driven Radiation Personalization in Head and Neck Cancer
Head and neck cancer is notoriously challenging to treat in part because it constitutes an anatomically and biologically d...
Palliative Radiation Oncology: Personalized Approaches to Radiotherapeutic Technologies, Quality of Life, and End-of-life Cancer Care
Volume 33, Issue 2, April 2023, Pages 91-92Author links open overlay panelTracy A. Balboni †, Dirk Rades ‡Show moreReferen...
Pharmacologic Pain Management: What Radiation Oncologists Should Know
Individuals with cancer often experience pain. Pain may be from tumor growth, such as invasion of bone; surgery, radiother...
Prognostication for Patients Receiving Palliative Radiation Therapy
Volume 33, Issue 2, April 2023, Pages 104-113Author links open overlay panel, , Estimation of patient prognosis plays a ce...
Precision Radiation for Brain Metastases With a Focus on Hypofractionated Stereotactic Radiosurgery
Volume 33, Issue 2, April 2023, Pages 114-128Author links open overlay panel, , There are multiple published randomized co...
Brain Metastases: Is There Still a Role for Whole-Brain Radiation Therapy?
Whole-brain radiotherapy (WBRT), which was considered the standard approach for most scenarios of brain metastases (both i...
Radiation Therapy for Painful Bone Metastases: Fractionation, Recalcification, and Symptom Control
Metastases to bone, a common occurrence in patients with advanced cancer, may not only cause pain and reduce quality of li...
Personalization of Radiation Therapy in the Primary Treatment of Malignant Epidural Spinal Cord Compression (MESCC)
Malignant epidural spinal cord compression (MESCC) was first described almost 100 years ago.1 MESCC is most frequently cau...
Stereotactic Body Radiation Therapy for Spinal Metastases: Benefits and Limitations
Volume 33, Issue 2, April 2023, Pages 159-171Author links open overlay panel, , , Progress in biological cancer characteri...
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