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FDA approves l-amino acid decarboxylase deficiency gene therapy
Discover the world’s best science and medicine | Nature.com
Senescence as a therapeutic target in cancer and age-related diseases
Senescence as a therapeutic target in cancer and age-related diseases
Cellular senescence is a stress response that restrains the growth of aged, damaged or abnormal cells. Thus, senescence ha...
DNA damage response inhibitors in cancer therapy: lessons from the past, current status and future implications
DNA damage response inhibitors in cancer therapy: lessons from the past, current status and future implications
The DNA damage response (DDR) is a network of proteins that coordinate DNA repair and cell-cycle checkpoints to prevent da...
Benchmarking recruitment rates for phase III trials
Benchmarking recruitment rates for phase III trials
Discover the world’s best science and medicine | Nature.com
The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap
The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap
In recent years, a small number of people with rare diseases caused by unique genetic variants have been treated with ther...
FDA approves first anti-TFPI antibody for haemophilia A and B
Discover the world’s best science and medicine | Nature.com
Bivalent molecules unmute silenced genes
Bivalent molecules unmute silenced genes
Discover the world’s best science and medicine | Nature.com
Anti-tau antibody stumbles in phase II Alzheimer trial
Discover the world’s best science and medicine | Nature.com
How GLP-1 went from being a hard-to-handle hormone to a blockbuster success
How GLP-1 went from being a hard-to-handle hormone to a blockbuster success
Lotte Bjerre Knudsen, chief scientific advisor in research and early development at Novo Nordisk, discusses the past and f...
Antimalarial drug hits cardiac fibrosis
Antimalarial drug hits cardiac fibrosis
Discover the world’s best science and medicine | Nature.com
Lundbeck pays US$2.6 billion for Longboard and its lead epilepsy drug
Discover the world’s best science and medicine | Nature.com
JAK inhibition combats adverse skin reaction
JAK inhibition combats adverse skin reaction
Discover the world’s best science and medicine | Nature.com
Glucose-sensitive insulin protects against hypoglycaemia
Glucose-sensitive insulin protects against hypoglycaemia
Discover the world’s best science and medicine | Nature.com
Antibody vanquishes SARS-CoV-2 variants
Antibody vanquishes SARS-CoV-2 variants
Discover the world’s best science and medicine | Nature.com
Targeting the TNF and TNFR superfamilies in autoimmune disease and cancer
Targeting the TNF and TNFR superfamilies in autoimmune disease and cancer
The first anti-tumour necrosis factor (TNF) monoclonal antibody, infliximab (Remicade), celebrated its 25th anniversary of...
Advanced technologies for the development of infectious disease vaccines
Advanced technologies for the development of infectious disease vaccines
Vaccines play a critical role in the prevention of life-threatening infectious disease. However, the development of effect...
FDA approves first claudin-18.2-targeted antibody for gastric cancer
Discover the world’s best science and medicine | Nature.com
TLK2: a target for cancer and viral latency
TLK2: a target for cancer and viral latency
Discover the world’s best science and medicine | Nature.com
Immunogenicity risk assessment and mitigation for engineered antibody and protein therapeutics
Immunogenicity risk assessment and mitigation for engineered antibody and protein therapeutics
Remarkable progress has been made in recent decades in engineering antibodies and other protein therapeutics, including en...
Protein degraders push into novel target space
Protein degraders push into novel target space
Clinic-ready molecular glues and heterobifunctional PROTAC drugs are taking targeted protein degradation into uncharted te...
New eyes on the infectious disease prize
New eyes on the infectious disease prize
Jeanne Marrazzo, the director of the NIAID, discusses post-COVID pandemic preparedness, H5N1 avian flu and the tension bet...
Tumour cells get a dendritic cell makeover
Tumour cells get a dendritic cell makeover
Discover the world’s best science and medicine | Nature.com
Reply to ‘Bayesian approaches in drug development: continuing the virtuous cycle’
We are thankful that Igl and Constant1 are joining the creation of the virtuous cycle for the use of ...
Bayesian approaches in drug development: continuing the virtuous cycle
Ruberg et al. recently published an article with the aim of starting a virtuous cycle in the use of B...
FDA new drug approvals in Q3 2024
Discover the world’s best science and medicine | Nature.com
A viral–lipid hybrid delivery system for genetic therapies
Discover the world’s best science and medicine | Nature.com
mRNA vaccines for infectious diseases — advances, challenges and opportunities
mRNA vaccines for infectious diseases — advances, challenges and opportunities
The concept of mRNA-based vaccines emerged more than three decades ago. Groundbreaking discoveries and technological advan...
FDA approves first monoclonal antibody for COPD
FDA approves first monoclonal antibody for COPD
Discover the world’s best science and medicine | Nature.com
Two decades of new drug approvals in Japan
Two decades of new drug approvals in Japan
Discover the world’s best science and medicine | Nature.com
Targeting fibrin in COVID-19
Discover the world’s best science and medicine | Nature.com
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