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GnRH therapy improves cognition
Discover the world’s best science and medicine | Nature.com
Predicting permeable macrocycles
Predicting permeable macrocycles
Discover the world’s best science and medicine | Nature.com
Developing antibody-based PROTACs
Developing antibody-based PROTACs
Discover the world’s best science and medicine | Nature.com
Accelerating therapeutic discoveries for heart failure: a new public–private partnership
The Accelerating Medicines Partnership in Heart Failure is designed to deliver tools and knowledge that enable the develop...
Emerging principles of cytokine pharmacology and therapeutics
Emerging principles of cytokine pharmacology and therapeutics
Cytokines are secreted signalling proteins that play essential roles in the initiation, maintenance and resolution of immu...
mRNA pioneers refocus on therapeutics
mRNA pioneers refocus on therapeutics
Flush with COVID-19 vaccine success, pharma and biotech companies are moving forward with mRNAs engineered to make therape...
A new path to targeted protein degradation?
A new path to targeted protein degradation?
Pearl Huang, incoming CEO of Dunad Therapeutics, is betting that covalent drugs can push the boundaries of the small-molec...
PKN3: a target in cancer metastasis
PKN3: a target in cancer metastasis
Discover the world’s best science and medicine | Nature.com
Fusion protein clears amyloid-β
Discover the world’s best science and medicine | Nature.com
A PROTAC for ALL
A PROTAC for ALL
Discover the world’s best science and medicine | Nature.com
Advances in covalent drug discovery
Advances in covalent drug discovery
Covalent drugs have been used to treat diseases for more than a century, but tools that facilitate the rational design of ...
Advances in the identification and validation of autism biomarkers
A decade on from the launch of the pioneering autism biomarker discovery initiative EU-AIMS, here we highlight advances in...
Derivatization with fatty acids in peptide and protein drug discovery
Derivatization with fatty acids in peptide and protein drug discovery
Peptides and proteins are widely used to treat a range of medical conditions; however, they often have to be injected and ...
The expanding role for small molecules in immuno-oncology
The expanding role for small molecules in immuno-oncology
The advent of immune checkpoint inhibition (ICI) using antibodies against PD1 and its ligand PDL1 has prompted substantial...
Macrophages as tools and targets in cancer therapy
Macrophages as tools and targets in cancer therapy
Tumour-associated macrophages are an essential component of the tumour microenvironment and have a role in the orchestrati...
Modulating biomolecular condensates: a novel approach to drug discovery
Modulating biomolecular condensates: a novel approach to drug discovery
In the past decade, membraneless assemblies known as biomolecular condensates have been reported to play key roles in many...
First de novo deuterated drug poised for approval
First de novo deuterated drug poised for approval
Bristol Myers Squibb’s first-in-class TYK2 inhibitor and blockbuster contender deucravacitinib showcases the role for heav...
INCATE: a partnership to boost the antibiotic pipeline
INCATE, the INCubator for Antibacterial Therapies in Europe, aims to boost the antibiotic pipeline by accelerating the tra...
Pharmaceutical innovation sourcing
Pharmaceutical innovation sourcing
Discover the world’s best science and medicine | Nature.com