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Lighting up the biological darkness, with structures and chemical probes
Lighting up the biological darkness, with structures and chemical probes
Aled Edwards celebrates 20 years of open science at the Structural Genomics Consortium — and keeps calling for more focus ...
Proximity-inducing drugs get closer
Proximity-inducing drugs get closer
Move over degraders; proximity-inducing drugs that stabilize, phosphorylate and inhibit their targets are coming through.
R&D re-balancing act
R&D re-balancing act
Discover the world’s best science and medicine | Nature.com
Inhibiting cap snatching
Discover the world’s best science and medicine | Nature.com
Expanding HSCs without cytokines
Discover the world’s best science and medicine | Nature.com
The opportunity for greater patient and public involvement and engagement in drug development and regulation
Patients and the wider public are beneficiaries of scientific research that leads to new drugs and medical technologies, b...
Delivering on the promise of protein degraders
Delivering on the promise of protein degraders
Over the past 3 years, the first bivalent protein degraders intentionally designed for targeted protein degradation ...
Application of Bayesian approaches in drug development: starting a virtuous cycle
Application of Bayesian approaches in drug development: starting a virtuous cycle
The pharmaceutical industry and its global regulators have routinely used frequentist statistical methods, such as null hy...
Mini-organs attract big pharma
Mini-organs attract big pharma
Hans Clevers, head of Pharma Research & Early Development at Roche, discusses the role for organoids in drug discovery...
The evolving role of investigative toxicology in the pharmaceutical industry
The evolving role of investigative toxicology in the pharmaceutical industry
For decades, preclinical toxicology was essentially a descriptive discipline in which treatment-related effects were caref...
Targeting galectin-driven regulatory circuits in cancer and fibrosis
Targeting galectin-driven regulatory circuits in cancer and fibrosis
Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a broad range of physiological and...
Solving opioid receptor structures
Discover the world’s best science and medicine | Nature.com
Profiling AAV tropism
Discover the world’s best science and medicine | Nature.com
Strategic recommendations from the STARS project to foster academic drug development
Improved understanding of regulatory requirements by academic researchers can accelerate the translation of new medical in...