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Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells
The P2X7 receptor, an ATP-gated ion channel which belongs to the P2X receptor family, plays critical roles in recognizing ...
Mechanosensitive release of ATP in the urinary bladder mucosa
Mechanosensitive release of ATP in the urinary bladder mucosa
The urinary bladder mucosa (urothelium and suburothelium/lamina propria) functions as a barrier between the content of the...
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats
Our previous work had identified that at the acupuncture point (acupoint), acupuncture-induced ATP release was a pivotal e...
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats
An increasing number of traditional Chinese medicine(TCM) have been confirmed to possess analgesic bioactivity. 701 Dieda ...
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex
Increasing evidence indicated that purinergic signalling involved in electroacupuncture (EA)-induced analgesia. Whether pu...
P2Y12 receptor-mediated cyclooxygenase 2 (COX-2) expression enhances tumor cell progression in a mouse model of lymphoma
P2Y12 receptor-mediated cyclooxygenase 2 (COX-2) expression enhances tumor cell progression in a mouse model of lymphoma
The pro-inflammatory enzyme cyclooxygenase 2 (COX-2) has been known to impart metastatic property to cancer cells. However...
Role of adenosine in the pathophysiology and treatment of attention deficit hyperactivity disorder
Role of adenosine in the pathophysiology and treatment of attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder (ADHD) is a complex neurodevelopmental condition characterized by persistent inat...
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7
 P2X7 is an emerging therapeutic target for several disorders and diseases due to its role in inflammatory signal...
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior
Tumor-associated macrophages (TAMs) exhibit antitumor or protumor responses related to inflammatory (or M1) and alternativ...
P2 purinergic receptor expression and function in tumor-related immune cells
P2 purinergic receptor expression and function in tumor-related immune cells
P2 purinergic receptor expression is dysregulated in multiple cancer subtypes and is associated with worse outcomes. Studi...
Purines and purinergic receptors in primary tumors of the central nervous system
Purines and purinergic receptors in primary tumors of the central nervous system
Purine nucleotides and nucleosides play critical roles in various pathological conditions, including tumor cell growth. Ad...
Purinergic signaling in liver disease: calcium signaling and induction of inflammation
Purinergic signaling in liver disease: calcium signaling and induction of inflammation
Purinergic signaling regulates many metabolic functions and is implicated in liver physiology and pathophysiology. Liver f...
Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation
Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation
Acute stress causes depressive-like reactions in the tail suspension (TST) and forced swim tests (FST) of mice. Similarly,...
Moxibustion pre-treatment attenuates seizure severity during status epilepticus and counteracts the proconvulsant function of the purinergic P2X7 receptor
Moxibustion pre-treatment attenuates seizure severity during status epilepticus and counteracts the proconvulsant function of the purinergic P2X7 receptor
Moxibustion, traditional Chinese medicine treatment, involves the warming of specific acupuncture points of the body using...
Schwann cells transplantation improves nerve injury and alleviates neuropathic pain in rats
Schwann cells transplantation improves nerve injury and alleviates neuropathic pain in rats
The mechanism of neuropathic pain induced by nerve injury is complex and there are no effective treatment methods. P2X4 re...
Astrocytic P2X7 receptor in retrosplenial cortex drives electroacupuncture analgesia
Astrocytic P2X7 receptor in retrosplenial cortex drives electroacupuncture analgesia
P2X7 receptor (P2X7R) has been found to contribute to the peripheral mechanism of acupuncture analgesia (AA). However, whe...
Regulation of transcription factor function by purinergic signalling in cardiovascular diseases
Regulation of transcription factor function by purinergic signalling in cardiovascular diseases
Cardiovascular diseases (CVDs), including hypertension, atherosclerosis, myocardial ischemia, and myocardial infarction, c...
Role of the P2X7 receptor in breast cancer progression
Role of the P2X7 receptor in breast cancer progression
Breast cancer is a common malignant tumor, whose incidence is increasing year by year, and it has become the malignant tum...
Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease
Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease
Purinergic receptors regulate the processing of neural information in the hippocampus and cerebral cortex, structures rela...
Assessment of ATP metabolism to adenosine by ecto-nucleotidases carried by tumor-derived small extracellular vesicles
Assessment of ATP metabolism to adenosine by ecto-nucleotidases carried by tumor-derived small extracellular vesicles
Immunosuppression is a hallmark of cancer progression. Tumor-derived small extracellular vesicles (sEV), also known as TEX...
Partners in health and disease: pineal gland and purinergic signalling
Partners in health and disease: pineal gland and purinergic signalling
In mammal’s pineal glands, ATP interacts with the high-affinity P2Y1 and the low-affinity P2X7 receptors. ATP releas...
Rosmarinic acid modulates purinergic signaling and induces apoptosis in melanoma cells
Rosmarinic acid modulates purinergic signaling and induces apoptosis in melanoma cells
Cancer cases have increased worldwide. Cutaneous melanoma (CM), a highly metastatic skin cancer, largely contributes to gl...
Identification of purinergic system components in the venom of Bothrops mattogrossensis and the inhibitory effect of specioside extracted from Tabebuia aurea
Identification of purinergic system components in the venom of Bothrops mattogrossensis and the inhibitory effect of specioside extracted from Tabebuia aurea
Snake bites are a severe problem in the countryside of Brazil and are usually attributed to snakes of the genera Bothrops,...
Ectonucleotidase inhibitors: targeting signaling pathways for therapeutic advancement—an in-depth review
Ectonucleotidase inhibitors: targeting signaling pathways for therapeutic advancement—an in-depth review
Ectonucleotidase inhibitors are a family of pharmacological drugs that, by selectively targeting ectonucleotidases, are es...
ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis
ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis
Medulloblastoma is the most common malignant tumor in the pediatric population. Its classification has incorporated key mo...
Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward a multimodal mechanism of action?
Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward a multimodal mechanism of action?
Neurodegenerative diseases and brain tumours represent important health challenges due to their severe nature and debilita...
P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain
P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain
Although multiple purinergic receptors mediate the analgesic effects of acupuncture, it remains unclear whether there is m...
Microglial purinergic signaling in Alzheimer’s disease
Microglial purinergic signaling in Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disease. The prevalent features of AD pathogen...
Role and recent progress of P2Y12 receptor in cancer development
Role and recent progress of P2Y12 receptor in cancer development
P2Y12 receptor (P2Y12R) is an adenosine-activated G protein-coupled receptor (GPCR) that plays a central role in platelet ...
Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools
Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools
The human equilibrative nucleoside transporter 1 (SLC29A1, hENT1) is a solute carrier that modulates the passive transport...
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