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P2X7 receptor: a potential target for treating comorbid anxiety and depression
P2X7 receptor: a potential target for treating comorbid anxiety and depression
In clinical practice, depression and anxiety frequently coexist, and they are both comorbid with somatic diseases. The P2X...
Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes
Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes
Intestinal low-grade inflammation induced by a high-fat diet has been found to detonate chronic systemic inflammation, whi...
Machine learning-aided search for ligands of P2Y6 and other P2Y receptors
Machine learning-aided search for ligands of P2Y6 and other P2Y receptors
The P2Y6 receptor, activated by uridine diphosphate (UDP), is a target for antagonists in inflammatory, neurodegenerative,...
Cutaneous melanoma and purinergic modulation by phenolic compounds
Cutaneous melanoma and purinergic modulation by phenolic compounds
Cutaneous melanoma is a complex pathology that still has only treatments that lack efficiency and offer many adverse effec...
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine
Berberine (BBR) is a Chinese herb with antioxidant and anti-inflammatory properties. In a previous study, we found that BB...
Electroacupuncture regulates the P2X7R-NLRP3 inflammatory cascade to relieve decreased sensation on ocular surface of type 2 diabetic rats with dry eye
Electroacupuncture regulates the P2X7R-NLRP3 inflammatory cascade to relieve decreased sensation on ocular surface of type 2 diabetic rats with dry eye
Dry eye (DE) is a prevalent ocular surface disease in patients with type 2 diabetes (T2DM). However, current medications a...
The functional role of P2 purinergic receptors in the progression of gastric cancer
The functional role of P2 purinergic receptors in the progression of gastric cancer
Studies have confirmed that P2 purinergic receptors (P2X receptors and P2Y receptors) expressed in gastric cancer (GC) cel...
Implications of COVID-19 in Parkinson’s disease: the purinergic system in a therapeutic-target perspective to diminish neurodegeneration
Implications of COVID-19 in Parkinson’s disease: the purinergic system in a therapeutic-target perspective to diminish neurodegeneration
The pathophysiology of Parkinson’s disease (PD) is marked by degeneration of dopaminergic neurons in the substantia ...
Purinergic pathways and their clinical use in the treatment of acute myeloid leukemia
Purinergic pathways and their clinical use in the treatment of acute myeloid leukemia
Despite the use of various therapies such as hematopoietic stem cell transplantation and chimeric antigen receptor T cell ...
Novel synthesized ionizable lipid for LNP-mediated P2X7siRNA to inhibit migration and induce apoptosis of breast cancer cells
Novel synthesized ionizable lipid for LNP-mediated P2X7siRNA to inhibit migration and induce apoptosis of breast cancer cells
The development of ionizable lipid (IL) was necessary to enable the effective formulation of small interfering RNA (siRNA)...
P2X7 receptors: a bibliometric review from 2002 to 2023
P2X7 receptors: a bibliometric review from 2002 to 2023
For many years, there has been ongoing research on the P2X7 receptor (P2X7R). A comprehensive, systematic, and objective e...
Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells
Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells
The A3 adenosine receptor (AR) is an important inflammatory and immunological target. However, the underlying mechanisms a...
Regulation of nerve-evoked contractions of the murine vas deferens
Regulation of nerve-evoked contractions of the murine vas deferens
Stimulation of sympathetic nerves in the vas deferens yields biphasic contractions consisting of a rapid transient compone...
The impact of purine nucleosides on neuroplasticity in the adult brain
The impact of purine nucleosides on neuroplasticity in the adult brain
Neuroplasticity refers to the nervous system’s ability to adapt and reorganize its cell structures and neuronal netw...
Targeting adenosine A2A receptors for early intervention of retinopathy of prematurity
Targeting adenosine A2A receptors for early intervention of retinopathy of prematurity
Retinopathy of prematurity (ROP) continues to pose a significant threat to the vision of numerous children worldwide, prim...
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain
Acupuncture is a traditional medicinal practice in China that has been increasingly recognized in other countries in recen...
Molecular insights into P2X signalling cascades in acute kidney injury
Molecular insights into P2X signalling cascades in acute kidney injury
Acute kidney injury (AKI) is a critical health issue with high mortality and morbidity rates in hospitalized indi...
Limited contribution of the of P2X4 receptor to LPS-induced microglial reaction in mice
Limited contribution of the of P2X4 receptor to LPS-induced microglial reaction in mice
Sepsis is life-threatening condition that can trigger long-term neurological sequelae, including cognitive impairment in s...
Cell cycle regulation by ADP and IGF-1 in cultured late developing glia progenitors of the avian retina
Cell cycle regulation by ADP and IGF-1 in cultured late developing glia progenitors of the avian retina
In the avian retina, ADP induces the proliferation of late developing glia progenitors. Here, we show that in serum-contai...
P2 purinergic receptors regulate the progression of colorectal cancer
P2 purinergic receptors regulate the progression of colorectal cancer
More and more studies have revealed that P2 purinergic receptors play a key role in the progression of colorectal cancer (...
Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors
Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors
P2X7 receptors (P2X7Rs) are membrane-bound ATP-gated ion channels that are composed of three subunits. Different subunit s...
Purinergic signaling in the battlefield of viral infections
Purinergic signaling in the battlefield of viral infections
Purinergic signaling has been associated with immune defenses against pathogens such as bacteria, protozoa, fungi, and vir...
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis
Leishmania braziliensis is a pathogenic protozoan parasite that causes American Tegumentary Leishmaniasis (ATL), an import...
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing
Inflammatory pain, sustained by a complex network of inflammatory mediators, is a severe and persistent illness affecting ...
Modafinil exerts anti-inflammatory and anti-fibrotic effects by upregulating adenosine A2A and A2B receptors
Modafinil exerts anti-inflammatory and anti-fibrotic effects by upregulating adenosine A2A and A2B receptors
Adenosine receptor (AR) suppresses inflammation and fibrosis by activating cyclic adenosine monophosphate (cAMP) signaling...
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1)
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1)
Trypanosoma cruzi is the pathogen of Chagas disease, a neglected tropical disease that affects more than 6 million people ...
Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme
Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme
Bladder cancer (BC) is the most common cancer of the urinary tract. Bozepinib (BZP), a purine-derived molecule, is a poten...
P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway
P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway
This study was designed to investigate the potential of extracellular adenosine 5′-triphosphate (ATP) via the P2R...
Purinergic system in cancer stem cells
Purinergic system in cancer stem cells
Accumulating evidence supports the idea that cancer stem cells (CSCs) are those with the capacity to initiate tumors, gene...
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation
Diabetic neuropathic pain (DNP) is a common and destructive complication of diabetes mellitus. The discovery of effective ...
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