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Fasting in combination with the cocktail Sorafenib:Metformin blunts cellular plasticity and promotes liver cancer cell death via poly-metabolic exhaustion
Fasting in combination with the cocktail Sorafenib:Metformin blunts cellular plasticity and promotes liver cancer cell death via poly-metabolic exhaustion
Dual-Interventions targeting glucose and oxidative metabolism are receiving increasing attention in cancer therapy. Sorafe...
Suppressing SENP1 inhibits esophageal squamous carcinoma cell growth via SIRT6 SUMOylation
Suppressing SENP1 inhibits esophageal squamous carcinoma cell growth via SIRT6 SUMOylation
Esophageal squamous cell carcinoma (ESCC) is a prevalent tumor in the gastrointestinal tract, but our understanding of the...
Comprehensive multiomics analysis of the signatures of gastric mucosal bacteria and plasma metabolites across different stomach microhabitats in the development of gastric cancer
Comprehensive multiomics analysis of the signatures of gastric mucosal bacteria and plasma metabolites across different stomach microhabitats in the development of gastric cancer
As an important component of the microenvironment, the gastric microbiota and its metabolites are associated with tumour o...
A dual-targeting approach with anti-IL10R CAR-T cells engineered to release anti-CD33 bispecific antibody in enhancing killing effect on acute myeloid leukemia cells
A dual-targeting approach with anti-IL10R CAR-T cells engineered to release anti-CD33 bispecific antibody in enhancing killing effect on acute myeloid leukemia cells
Immunotherapies, including chimeric antigen receptor (CAR) T cells and bispecific antibodies (BsAbs), encounter several ch...
Acidity and hypoxia of tumor microenvironment, a positive interplay in extracellular vesicle release by tumor cells
Acidity and hypoxia of tumor microenvironment, a positive interplay in extracellular vesicle release by tumor cells
The complex and continuously evolving features of the tumor microenvironment, varying between tumor histotypes, are charac...
IRE1α inhibitor enhances paclitaxel sensitivity of triple-negative breast cancer cells
IRE1α inhibitor enhances paclitaxel sensitivity of triple-negative breast cancer cells
Breast cancer is the most commonly diagnosed cancer in women, and triple-negative breast cancer (TNBC) accounts for approx...
Deciphering the molecular landscape: evolutionary progression from gynecomastia to aggressive male breast cancer
Deciphering the molecular landscape: evolutionary progression from gynecomastia to aggressive male breast cancer
Gynecomastia denotes the benign proliferation of glandular breast tissue and stands as a recognized risk factor for male b...
The PPP2R1A cancer hotspot mutant p.R183W increases clofarabine resistance in uterine serous carcinoma cells by a gain-of-function mechanism
The PPP2R1A cancer hotspot mutant p.R183W increases clofarabine resistance in uterine serous carcinoma cells by a gain-of-function mechanism
Uterine serous carcinoma (USC) is generally associated with poor prognosis due to a high recurrence rate and frequent trea...
Antitumor activity of afatinib in EGFR T790M-negative human oral cancer therapeutically targets mTOR/Mcl-1 signaling axis
Antitumor activity of afatinib in EGFR T790M-negative human oral cancer therapeutically targets mTOR/Mcl-1 signaling axis
This study investigates the role and effectiveness of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibito...
ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity
ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity
Tumor heterogeneity complicates patient treatment and can be due to transitioning of cancer cells across phenotypic cell s...
HVEM in acute lymphocytic leukemia facilitates tumour immune escape by inhibiting CD8+ T cell function
HVEM in acute lymphocytic leukemia facilitates tumour immune escape by inhibiting CD8+ T cell function
Leukaemia remains a major contributor to global mortality, representing a significant health risk for a substantial number...
OrganoIDNet: a deep learning tool for identification of therapeutic effects in PDAC organoid-PBMC co-cultures from time-resolved imaging data
OrganoIDNet: a deep learning tool for identification of therapeutic effects in PDAC organoid-PBMC co-cultures from time-resolved imaging data
Pancreatic Ductal Adenocarcinoma (PDAC) remains a challenging disease due to its complex biology and aggressive behavior w...
A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine
A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine
Cancer is a highly heterogeneous disease, and thus treatment responses vary greatly between patients. To improve therapy e...
Targeted gene delivery systems for T-cell engineering
Targeted gene delivery systems for T-cell engineering
T lymphocytes are indispensable for the host systems of defense against pathogens, tumors, and environmental threats. The ...
SPG21, a potential oncogene targeted by miR-128-3p, amplifies HBx-induced carcinogenesis and chemoresistance via activation of TRPM7-mediated JNK pathway in hepatocellular carcinoma
SPG21, a potential oncogene targeted by miR-128-3p, amplifies HBx-induced carcinogenesis and chemoresistance via activation of TRPM7-mediated JNK pathway in hepatocellular carcinoma
Chronic hepatitis B virus (HBV) infection is the primary risk factor for the malignant progression of hepatocellular carci...
Deciphering fatty acid biosynthesis-driven molecular subtypes in pancreatic ductal adenocarcinoma with prognostic insights
Deciphering fatty acid biosynthesis-driven molecular subtypes in pancreatic ductal adenocarcinoma with prognostic insights
Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge due to its high heterogeneity and aggressiveness. Re...
Research advances in the molecular classification of gastric cancer
Research advances in the molecular classification of gastric cancer
Gastric cancer (GC) is a malignant tumor with one of the lowest five-year survival rates. Traditional first-line treatment...
LILRB2 promotes immune escape in breast cancer cells via enhanced HLA-A degradation
LILRB2 promotes immune escape in breast cancer cells via enhanced HLA-A degradation
Increased expression of leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is associated with immune eva...
Targeting Dectin-1 and or VISTA enhances anti-tumor immunity in melanoma but not colorectal cancer model
Targeting Dectin-1 and or VISTA enhances anti-tumor immunity in melanoma but not colorectal cancer model
Acquired resistance to immune checkpoint blockers (ICBs) is a major barrier in cancer treatment, emphasizing the need for ...
Rituximab potentially improves clinical outcomes of CAR-T therapy for r/r B-ALL via sensitizing leukemia cells to CAR-T-mediated cytotoxicity and reducing CAR-T exhaustion
Rituximab potentially improves clinical outcomes of CAR-T therapy for r/r B-ALL via sensitizing leukemia cells to CAR-T-mediated cytotoxicity and reducing CAR-T exhaustion
Despite chimeric antigen receptor (CAR) T-cell therapy has achieved great advances in recent year, approximately 50% of re...
Chordoma cells possess bone-dissolving activity at the bone invasion front
Chordoma cells possess bone-dissolving activity at the bone invasion front
Chordomas are malignant tumors that destroy bones, compress surrounding nerve tissues and exhibit phenotypes that recapitu...
Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis
Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis
The overall survival rate for metastatic osteosarcoma hovers around 20%. Responses to second-line chemotherapy, targeted t...
Correction to: Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling
Correction to: Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling
Correction to: Cellular OncologyIn the abstract of this article the line ‘Gut microbi...
The emerging role of CARM1 in cancer
The emerging role of CARM1 in cancer
Coactivator-associated arginine methyltransferase 1 (CARM1), pivotal for catalyzing arginine methylation of histone and no...
Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals immune suppression subtypes and establishes a novel signature for determining the prognosis in lung adenocarcinoma
Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals immune suppression subtypes and establishes a novel signature for determining the prognosis in lung adenocarcinoma
Lung adenocarcinoma (LUAD) is the most common histological type of lung cancer with lower survival rates. Recent advanceme...
Establishment, characterization, and biobanking of 36 pancreatic cancer organoids: prediction of metastasis in resectable pancreatic cancer
Establishment, characterization, and biobanking of 36 pancreatic cancer organoids: prediction of metastasis in resectable pancreatic cancer
Early dissemination of primary pancreatic ductal adenocarcinoma (PDAC) is the main cause of dismal prognosis as it highly ...
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling
α2-adrenoceptor agonist dexmedetomidine (DEX) has been reported to promote tumorigenesis. Stem-cell protein Piwil2 is...
Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its rol...
Efficacy of programmed cell death 1 inhibitor maintenance after chimeric antigen receptor T cells in patients with relapsed/refractory B-cell non-Hodgkin-lymphoma
Efficacy of programmed cell death 1 inhibitor maintenance after chimeric antigen receptor T cells in patients with relapsed/refractory B-cell non-Hodgkin-lymphoma
Chimeric antigen receptor (CAR)-T cells obtained long-term durability in about 30% to 40% of relapsed/refractory (r/r) B-c...
Hedgehog ligand and receptor cooperatively regulate EGFR stability and activity in non-small cell lung cancer
Hedgehog ligand and receptor cooperatively regulate EGFR stability and activity in non-small cell lung cancer
The hyperactivation of epidermal growth factor receptor (EGFR) plays a crucial role in non-small cell lung cancer (NSCLC)....
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