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Preliminary study using a small plasma extracellular vesicle miRNA panel as a potential biomarker for early diagnosis and prognosis in laryngeal cancer
Plasma extracellular vesicle (EV) miRNAs are important biomarkers for body fluid biopsy. The purpose of this study was to ...
RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis
Evidence suggests that calcium release from the endoplasmic reticulum (ER) can be induced to cause calcium overload, which...
The ceramide synthase (CERS/LASS) family: Functions involved in cancer progression
Ceramide synthases (CERSes) are also known longevity assurance (LASS) genes. CERSes play important roles in the regulation...
VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma
The deubiquitinase ovarian tumor domain-containing 1 (OTUD1) has been considered as a tumor suppressor in many tumors, but...
Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner
Available evidence indicates that dipyridamole enhances the anti-thrombotic effects of aspirin for the prevention of secon...
Atp8a1 deletion increases the proliferative activity of hematopoietic stem cells by impairing PTEN function
The eukaryotic cell plasma membrane contains several asymmetrically distributed phospholipids, which is maintained by the ...
The autocrine glycosylated-GREM1 interacts with TGFB1 to suppress TGFβ/BMP/SMAD-mediated EMT partially by inhibiting MYL9 transactivation in urinary carcinoma
Urothelial carcinoma (UC) is a common disease in developed counties. This study aimed to identify autocrine roles and sign...
Targeting CD43 optimizes cancer immunotherapy through reinvigorating antitumor immune response in colorectal cancer
Colorectal cancer (CRC) is one of the most common malignancies worldwide, with dramatically increasing incidence and morta...
Correction to: Tumour-derived exosomal lncRNA SNHG16 induces telocytes to promote metastasis of hepatocellular carcinoma via the miR-942-3p/MMP9 axis
Cite this articleXu, Y., Luan, G., Li, Z. et al. Correction to: Tumour-derived exosomal lncRNA SNHG16 induces telocytes to...
The negative effect of G1958A polymorphism on MTHFD1 protein stability and HCC growth
Methylenetetrahydrofolate dehydrogenase (MTHFD1), a key enzyme on the folate pathway, has been implicated in the tumor dev...
LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation
Accumulating evidence indicates that long noncoding RNAs (lncRNAs) are abnormal expression in various malignant tumors. Ou...
STIM1-regulated exosomal EBV-LMP1 empowers endothelial cells with an aggressive phenotype by activating the Akt/ERK pathway in nasopharyngeal carcinoma
Stromal interaction molecule 1 (STIM1)-mediated Ca2+ signaling regulates tumor angiogenesis in nasopharyngeal carcinoma (N...
In vivo detection demonstrates circulating tumor cell reduction instead of baseline number has prognostic value in bladder cancer patients receiving neoadjuvant chemotherapy
Previous studies have suggested the potential prognostic value of circulating tumor cells (CTCs) in bladder cancer (BC) pa...
TIMEAS, a promising method for the stratification of testicular germ cell tumor patients with distinct immune microenvironment, clinical outcome and sensitivity to frontline therapies
With the heterogeneous genetic background, prognosis prediction and therapeutic targets for testicular germ cell tumors (T...
The role of pyroptosis in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the main histologic type of liver cancer. It accounts for the majority of all diagnoses ...
Altered iron metabolism as a target for ferroptosis induction in head and neck cancer
Iron is a mineral micronutrient essential for survival and vital functions in many biological processes in living organism...
Tumor-associated macrophage-derived GDNF promotes gastric cancer liver metastasis via a GFRA1-modulated autophagy flux
Liver metastasis, a lethal malignancy of gastric cancer (GC) patients, execrably impairs their prognosis. As yet, however,...
Fatty acid synthase as a new therapeutic target for HER2-positive gastric cancer
Trastuzumab is an HER2-specific agent approved as the gold-standard therapy for advanced HER2-positive (HER2+) gastric can...
E3 ubiquitin ligases in cancer stem cells: key regulators of cancer hallmarks and novel therapeutic opportunities
Human malignancies are composed of heterogeneous subpopulations of cancer cells with phenotypic and functional diversity. ...
In-depth quantitative proteomics analysis revealed C1GALT1 depletion in ECC-1 cells mimics an aggressive endometrial cancer phenotype observed in cancer patients with low C1GALT1 expression
Endometrial cancer (EC) is the most common cancer of the female reproductive organs. Despite the good overall prognosis of...
USP13 promotes breast cancer metastasis through FBXL14-induced Twist1 ubiquitination
Epithelial-to-mesenchymal transition (EMT) is an important cause of high mortality in breast cancer. Twist1 is one of the ...
circRNA_0067717 promotes paclitaxel resistance in nasopharyngeal carcinoma by acting as a scaffold for TRIM41 and p53
Circular RNAs (circRNAs) play important roles in tumour progression. This study aimed to explore the mechanism of hsa_circ...
The application of patient-derived organoid in the research of lung cancer
Lung cancer is the most common cancer and the leading cause of cancer-related death worldwide. However, mechanisms of its ...
Beyond metabolic waste: lysine lactylation and its potential roles in cancer progression and cell fate determination
Lactate is an important metabolite derived from glycolysis under physiological and pathological conditions. The Warburg ef...
Aberrant N-glycosylation in cancer: MGAT5 and β1,6-GlcNAc branched N-glycans as critical regulators of tumor development and progression
Changes in protein glycosylation are widely observed in tumor cells. N-glycan branching through adding β1,6-linked N-...
Circulating tumour cell isolation, analysis and clinical application
Circulating tumour cells (CTCs) are cancer cells that circulate in the bloodstream after being shed from solid tumours. Th...
The role of tumor-platelet interplay and micro tumor thrombi during hematogenous tumor metastasis
In addition to their pivotal roles in coagulation and thrombosis, platelets are crucial in tumor progression, with plenty ...
Correction to: H3K27 acetylation activated long noncoding RNA RP11-162G10.5 promotes breast cancer progression via the YBX1/GLO1 axis
Department of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, 510120, Guangzhou, ...
Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts
Reprogramming of metabolism is strongly associated with the development of cancer. However, the role of metabolic reprogra...
Tumor ratio of unsaturated to saturated sulfatide species is associated with disease-free survival in intrahepatic cholangiocarcinoma
Cholangiocarcinoma (CCA) is a malignancy arising from the bile duct epithelium and has a poor outcome. Sulfatides are lipi...
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