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Regulatory mechanisms of steroid hormone receptors on gene transcription through chromatin interaction and enhancer reprogramming
Regulatory mechanisms of steroid hormone receptors on gene transcription through chromatin interaction and enhancer reprogramming
Regulation of steroid hormone receptors (SHRs) on transcriptional reprogramming is crucial for breast cancer progression. ...
Cell death in glioblastoma and the central nervous system
Cell death in glioblastoma and the central nervous system
Glioblastoma is the commonest and deadliest primary brain tumor. Glioblastoma is characterized by significant intra- and i...
SUMOylation regulates the aggressiveness of breast cancer-associated fibroblasts
SUMOylation regulates the aggressiveness of breast cancer-associated fibroblasts
Cancer-associated fibroblasts (CAFs) are the most abundant stromal cellular component in the tumor microenvironment (TME)....
Non-glycanated ΔDCN isoform in muscle invasive bladder cancer mediates cancer stemness and gemcitabine resistance
Non-glycanated ΔDCN isoform in muscle invasive bladder cancer mediates cancer stemness and gemcitabine resistance
The small leucine-rich proteoglycan decorin (DCN) is recognized for its diverse roles in tissue homeostasis and malignant ...
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma
Ubiquitination is one of the important modification of proteins which can be reversed by deubiquitinating enzymes (DUBs). ...
BCAT1 contributes to the development of TKI-resistant CML
BCAT1 contributes to the development of TKI-resistant CML
Although most of chronic myeloid leukemia (CML) patients can be effectively treated by the tyrosine kinase inhibitors (TKI...
The long non-coding RNA NEAT1 contributes to aberrant STAT3 signaling in pancreatic cancer and is regulated by a metalloprotease-disintegrin ADAM8/miR-181a-5p axis
The long non-coding RNA NEAT1 contributes to aberrant STAT3 signaling in pancreatic cancer and is regulated by a metalloprotease-disintegrin ADAM8/miR-181a-5p axis
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and several studies demonstrate that STAT3 has c...
Integrating bulk and single-cell transcriptomics to elucidate the role and potential mechanisms of autophagy in aging tissue
Integrating bulk and single-cell transcriptomics to elucidate the role and potential mechanisms of autophagy in aging tissue
Autophagy is frequently observed in tissues during the aging process, yet the tissues most strongly correlated with autoph...
ALKBH4 functions as a hypoxia-responsive tumor suppressor and inhibits metastasis and tumorigenesis
ALKBH4 functions as a hypoxia-responsive tumor suppressor and inhibits metastasis and tumorigenesis
The human AlkB homolog (ALKBH) dioxygenase superfamily plays a crucial role in gene regulation and is implicated in cancer...
Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy
Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy
Glioblastomas (GBMs) are highly treatment-resistant and aggressive brain tumors. 2OHOA, which is currently running a phase...
Mitochondria in tumor immune surveillance and tumor therapies targeting mitochondria
Mitochondria in tumor immune surveillance and tumor therapies targeting mitochondria
Mitochondria play a central role in cellular energy production and metabolic regulation, and their function has been ident...
Tumour cell-released autophagosomes promote lung metastasis by upregulating PD-L1 expression in pulmonary vascular endothelial cells in breast cancer
Tumour cell-released autophagosomes promote lung metastasis by upregulating PD-L1 expression in pulmonary vascular endothelial cells in breast cancer
Establishing an immunosuppressive premetastatic niche (PMN) in distant organs is crucial for breast cancer metastasis. Vas...
Inhibition of EREG/ErbB/ERK by Astragaloside IV reversed taxol-resistance of non-small cell lung cancer through attenuation of stemness via TGFβ and Hedgehog signal pathway
Inhibition of EREG/ErbB/ERK by Astragaloside IV reversed taxol-resistance of non-small cell lung cancer through attenuation of stemness via TGFβ and Hedgehog signal pathway
Taxol is the first-line chemo-drug for advanced non-small cell lung cancer (NSCLC), but it frequently causes acquired resi...
Unveiling therapeutic avenues targeting xCT in head and neck cancer
Unveiling therapeutic avenues targeting xCT in head and neck cancer
Head and neck cancer (HNC) remains a major global health burden, prompting the need for innovative therapeutic strategies....
Unraveling Th subsets: insights into their role in immune checkpoint inhibitor therapy
Unraveling Th subsets: insights into their role in immune checkpoint inhibitor therapy
T helper (Th) cell subsets play pivotal roles in regulating immune responses within the tumor microenvironment, influencin...
Clinical value of 18F-FDG PET/CT in patients with newly diagnosed acute leukemia
Clinical value of 18F-FDG PET/CT in patients with newly diagnosed acute leukemia
To explore the correlation between semi-quantitative parameters of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomo...
Exosomes: from basic research to clinical diagnostic and therapeutic applications in cancer
Exosomes: from basic research to clinical diagnostic and therapeutic applications in cancer
Cancer continues to pose a global threat despite potent anticancer drugs, often accompanied by undesired side effects. To ...
Circadian system disorder induced by aberrantly activated EFNB2-EPHB2 axis leads to facilitated liver metastasis in gastric cancer
Circadian system disorder induced by aberrantly activated EFNB2-EPHB2 axis leads to facilitated liver metastasis in gastric cancer
Liver is one of the most preferred destinations for distant metastasis of gastric cancer (GC) and liver metastasis usually...
Low-dose SAHA enhances CD8+ T cell-mediated antitumor immunity by boosting MHC I expression in non-small cell lung cancer
Low-dose SAHA enhances CD8+ T cell-mediated antitumor immunity by boosting MHC I expression in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is a highly aggressive type of lung cancer with poor responses to traditional therapies...
A review on the functional characteristics of the c-Myeloproliferative Leukaemia (c-MPL) gene and its isoforms
A review on the functional characteristics of the c-Myeloproliferative Leukaemia (c-MPL) gene and its isoforms
The c-MPL-TPO axis regulates hematopoiesis by activating various signalling cascades, including JAK/STAT, MAPK/ERK, and PI...
BHLHE41, a transcriptional repressor involved in physiological processes and tumor development
BHLHE41, a transcriptional repressor involved in physiological processes and tumor development
BHLHE41 is a nuclear transcriptional repressor that belongs to the basic helix-loop-helix protein superfamily. BHLHE41 exp...
Targeting tumor associated macrophages (TAMs) reprograms tumor immune microenvironment to promote solid tumor immunotherapy
Targeting tumor associated macrophages (TAMs) reprograms tumor immune microenvironment to promote solid tumor immunotherapy
A.V.R. Kornepati, R.K. Vadlamudi, T.J. Curiel, Programmed death ligand 1 signals in cancer cells. Nat. Rev. Cancer. 22, 17...
TRIM28 promotes tumor growth and metastasis in breast cancer by targeting the BRD7 protein for ubiquitination and degradation
TRIM28 promotes tumor growth and metastasis in breast cancer by targeting the BRD7 protein for ubiquitination and degradation
Bromodomain-containing protein 7 (BRD7) is downregulated and functions as a tumor suppressor in many types of cancers incl...
Telomere transcripts act as tumor suppressor and are associated with favorable prognosis in colorectal cancer with low proliferating cell nuclear antigen expression
Telomere transcripts act as tumor suppressor and are associated with favorable prognosis in colorectal cancer with low proliferating cell nuclear antigen expression
Telomeric repeat-containing RNAs (TERRA) and telomerase RNA component (TERC) regulate telomerase activity (TA) and thereby...
PSMD2 overexpression as a biomarker for resistance and prognosis in renal cell carcinoma treated with immune checkpoint and tyrosine kinase inhibitors
PSMD2 overexpression as a biomarker for resistance and prognosis in renal cell carcinoma treated with immune checkpoint and tyrosine kinase inhibitors
Integrated immune checkpoint inhibitors (ICIs) plus tyrosine kinase inhibitors (TKIs) are now the recommended first-line t...
Correction to: EMP2 induces cytostasis and apoptosis via the TGFβ/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma
Correction to: EMP2 induces cytostasis and apoptosis via the TGFβ/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma
Department of Medical Research, Chi-Mei Medical Center, Tainan, TaiwanChien-Feng Li & Ti-Chun ChanNational Cancer Rese...
Next-generation BCMA-targeted chimeric antigen receptor CARTemis-1: the impact of manufacturing procedure on CAR T-cell features
Next-generation BCMA-targeted chimeric antigen receptor CARTemis-1: the impact of manufacturing procedure on CAR T-cell features
CAR therapy targeting BCMA is under investigation as treatment for multiple myeloma. However, given the lack of plateau in...
Optimizing the spatial immune landscape of CD103+CD8+ tissue-resident memory T cells in non-small cell lung cancer by neoadjuvant chemotherapy
Optimizing the spatial immune landscape of CD103+CD8+ tissue-resident memory T cells in non-small cell lung cancer by neoadjuvant chemotherapy
Neoadjuvant chemotherapy (NAC) combined with immunotherapy is increasingly used in non-small cell lung cancer (NSCLC). Tis...
Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells
Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells
Docetaxel resistance is a significant obstacle in the treatment of prostate cancer (PCa), resulting in unfavorable patient...
Characterization and proteomic analysis of plasma-derived small extracellular vesicles in locally advanced rectal cancer patients
Characterization and proteomic analysis of plasma-derived small extracellular vesicles in locally advanced rectal cancer patients
Neoadjuvant chemoradiotherapy (nCRT) stands as a pivotal therapeutic approach for locally advanced rectal cancer (LARC), y...
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