SCI时时刷

search
+
Rituximab potentially improves clinical outcomes of CAR-T therapy for r/r B-ALL via sensitizing leukemia cells to CAR-T-mediated cytotoxicity and reducing CAR-T exhaustion
Rituximab potentially improves clinical outcomes of CAR-T therapy for r/r B-ALL via sensitizing leukemia cells to CAR-T-mediated cytotoxicity and reducing CAR-T exhaustion
Despite chimeric antigen receptor (CAR) T-cell therapy has achieved great advances in recent year, approximately 50% of re...
Chordoma cells possess bone-dissolving activity at the bone invasion front
Chordoma cells possess bone-dissolving activity at the bone invasion front
Chordomas are malignant tumors that destroy bones, compress surrounding nerve tissues and exhibit phenotypes that recapitu...
Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis
Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis
The overall survival rate for metastatic osteosarcoma hovers around 20%. Responses to second-line chemotherapy, targeted t...
Correction to: Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling
Correction to: Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling
Correction to: Cellular OncologyIn the abstract of this article the line ‘Gut microbi...
The emerging role of CARM1 in cancer
The emerging role of CARM1 in cancer
Coactivator-associated arginine methyltransferase 1 (CARM1), pivotal for catalyzing arginine methylation of histone and no...
Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals immune suppression subtypes and establishes a novel signature for determining the prognosis in lung adenocarcinoma
Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals immune suppression subtypes and establishes a novel signature for determining the prognosis in lung adenocarcinoma
Lung adenocarcinoma (LUAD) is the most common histological type of lung cancer with lower survival rates. Recent advanceme...
Establishment, characterization, and biobanking of 36 pancreatic cancer organoids: prediction of metastasis in resectable pancreatic cancer
Establishment, characterization, and biobanking of 36 pancreatic cancer organoids: prediction of metastasis in resectable pancreatic cancer
Early dissemination of primary pancreatic ductal adenocarcinoma (PDAC) is the main cause of dismal prognosis as it highly ...
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling
α2-adrenoceptor agonist dexmedetomidine (DEX) has been reported to promote tumorigenesis. Stem-cell protein Piwil2 is...
Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its rol...
Efficacy of programmed cell death 1 inhibitor maintenance after chimeric antigen receptor T cells in patients with relapsed/refractory B-cell non-Hodgkin-lymphoma
Efficacy of programmed cell death 1 inhibitor maintenance after chimeric antigen receptor T cells in patients with relapsed/refractory B-cell non-Hodgkin-lymphoma
Chimeric antigen receptor (CAR)-T cells obtained long-term durability in about 30% to 40% of relapsed/refractory (r/r) B-c...
Hedgehog ligand and receptor cooperatively regulate EGFR stability and activity in non-small cell lung cancer
Hedgehog ligand and receptor cooperatively regulate EGFR stability and activity in non-small cell lung cancer
The hyperactivation of epidermal growth factor receptor (EGFR) plays a crucial role in non-small cell lung cancer (NSCLC)....
Copy number signatures and CCNE1 amplification reveal the involvement of replication stress in high-grade endometrial tumors oncogenesis
Copy number signatures and CCNE1 amplification reveal the involvement of replication stress in high-grade endometrial tumors oncogenesis
Managing high-grade endometrial cancer in Martinique poses significant challenges. The diversity of copy number alteration...
3D bioprinted tumor model: a prompt and convenient platform for overcoming immunotherapy resistance by recapitulating the tumor microenvironment
3D bioprinted tumor model: a prompt and convenient platform for overcoming immunotherapy resistance by recapitulating the tumor microenvironment
Cancer immunotherapy is receiving worldwide attention for its induction of an anti-tumor response. However, it has had lim...
DNA hypomethylation patterns and their impact on the tumor microenvironment in colorectal cancer
DNA hypomethylation patterns and their impact on the tumor microenvironment in colorectal cancer
Recent research underscores the pivotal role of immune checkpoints as biomarkers in colorectal cancer (CRC) therapy, highl...
The Ribonuclease ZC3H12A is required for self-inflicted DNA breaks after DNA damage in small cell lung cancer cells
The Ribonuclease ZC3H12A is required for self-inflicted DNA breaks after DNA damage in small cell lung cancer cells
Radiotherapy is the first line treatment for small cell lung cancer (SCLC); However, radio-resistance accompanies with the...
Multi-dimensional characterization of apoptosis in the tumor microenvironment and therapeutic relevance in melanoma
Multi-dimensional characterization of apoptosis in the tumor microenvironment and therapeutic relevance in melanoma
Melanoma is widely utilized as a prominent model for the development of immunotherapy, thought an inadequate immune respon...
Mapping the immune terrain in lung adenocarcinoma progression: Tfh-like cells in tertiary lymphoid structures
Mapping the immune terrain in lung adenocarcinoma progression: Tfh-like cells in tertiary lymphoid structures
R.S. Herbst, D. Morgensztern, C. Boshoff, The biology and management of non-small cell lung cancer. Nature 553, 446–454 (2...
Identification of a novel gene signature related to prognosis and metastasis in gastric cancer
Identification of a novel gene signature related to prognosis and metastasis in gastric cancer
Gastric Cancer (GC) presents poor outcome, which is consequence of the high incidence of recurrence and metastasis at earl...
CAFs vs. TECs: when blood feuds fuel cancer progression, dissemination and therapeutic resistance
CAFs vs. TECs: when blood feuds fuel cancer progression, dissemination and therapeutic resistance
Neoplastic progression involves complex interactions between cancer cells and the surrounding stromal milieu, fostering mi...
STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma
STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is an aggressive disease with a poor prognosis, caused by the inactivation of cr...
The predictive significance of chromobox family members in prostate cancer in humans
The predictive significance of chromobox family members in prostate cancer in humans
The Chromobox (CBX) family proteins are crucial elements of the epigenetic regulatory machinery and play a significant rol...
Nilotinib in combination with sunitinib renders MCL-1 for degradation and activates autophagy that overcomes sunitinib resistance in renal cell carcinoma
Nilotinib in combination with sunitinib renders MCL-1 for degradation and activates autophagy that overcomes sunitinib resistance in renal cell carcinoma
Sunitinib is a recommended drug for metastatic renal cell carcinoma (RCC). However, the therapeutic potential of sunitinib...
The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
Tumor-associated macrophages (TAMs) are associated with unfavorable patient prognosis in many cancer types. However, TAMs ...
PIN1 promotes the metastasis of cholangiocarcinoma cells by RACK1-mediated phosphorylation of ANXA2
PIN1 promotes the metastasis of cholangiocarcinoma cells by RACK1-mediated phosphorylation of ANXA2
Cholangiocarcinoma (CCA), a primary hepatobiliary malignancy, is characterized by a poor prognosis and a lack of effective...
GDF15 induces chemoresistance to oxaliplatin by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis in colorectal cancer
GDF15 induces chemoresistance to oxaliplatin by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis in colorectal cancer
Growth differentiating Factor 15 (GDF15) is linked to several cancers, but its effect on chemoresistance in colorectal can...
O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency
O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency
Glucose not only provides energy for tumor cells, but also provides various biomolecules that are essential for their surv...
Targeting MEK/COX-2 axis improve immunotherapy efficacy in dMMR colorectal cancer with PIK3CA overexpression
Targeting MEK/COX-2 axis improve immunotherapy efficacy in dMMR colorectal cancer with PIK3CA overexpression
PIK3CA mutation or overexpression is associated with immunotherapy resistance in multiple cancer types, but is also parado...
OTUB1 accelerates hepatocellular carcinoma by stabilizing RACK1 via its non-canonical ubiquitination
OTUB1 accelerates hepatocellular carcinoma by stabilizing RACK1 via its non-canonical ubiquitination
Dysregulated ubiquitination modification occupies a pivotal role in hepatocellular carcinoma (HCC) tumorigenesis and progr...
Repaglinide restrains HCC development and progression by targeting FOXO3/lumican/p53 axis
Repaglinide restrains HCC development and progression by targeting FOXO3/lumican/p53 axis
The recent focus on the roles of N-linked glycoproteins in carcinogenesis across various malignancies has prompted our exp...
A novel risk score system based on immune subtypes for identifying optimal mRNA vaccination population in hepatocellular carcinoma
A novel risk score system based on immune subtypes for identifying optimal mRNA vaccination population in hepatocellular carcinoma
Although mRNA vaccines have shown certain clinical benefits in multiple malignancies, their therapeutic efficacies against...
阅读更多
format_indent_increase