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Ferritinophagy induced ferroptosis in the management of cancer
Ferritinophagy induced ferroptosis in the management of cancer
Ferroptosis, a newly form of regulated cell death (RCD), is characterized by iron dyshomeostasis and unrestricted lipid pe...
Ubiquilin-4 induces immune escape in gastric cancer by activating the notch signaling pathway
Ubiquilin-4 induces immune escape in gastric cancer by activating the notch signaling pathway
We aimed to investigate the role of ubiquilin-4 in predicting the immunotherapy response in gastric cancer. Retrospective ...
ATM-Mediated translocation of RanBPM regulates DNA damage response by stabilizing p21 in non-small cell lung cancer cells
ATM-Mediated translocation of RanBPM regulates DNA damage response by stabilizing p21 in non-small cell lung cancer cells
Platinum-based chemotherapy remains a standard-of-care for most patients with advanced non-small cell lung cancer (NSCLC)....
Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization
Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization
For patients with osteosarcoma, disease-related mortality most often results from lung metastasis—a phenomenon share...
Synergistic antitumor efficacy of gemcitabine and cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via Sp1-SAT1-polyamine metabolism pathway
Synergistic antitumor efficacy of gemcitabine and cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via Sp1-SAT1-polyamine metabolism pathway
The combination of cisplatin and gemcitabine-based chemotherapy has been recommended as a preferred regimen for pancreatic...
SAMHD1 expression is a surrogate marker of immune infiltration and determines prognosis after neoadjuvant chemotherapy in early breast cancer
SAMHD1 expression is a surrogate marker of immune infiltration and determines prognosis after neoadjuvant chemotherapy in early breast cancer
The lack of validated surrogate biomarkers is still an unmet clinical need in the management of early breast cancer cases ...
Overexpressed FAM111B degrades GSDMA to promote esophageal cancer tumorigenesis and cisplatin resistance
Overexpressed FAM111B degrades GSDMA to promote esophageal cancer tumorigenesis and cisplatin resistance
Chemotherapeutic agents such as cisplatin are commonly used in patients with clinically unresectable or recurrent esophage...
tRNA-derived fragments: mechanism of gene regulation and clinical application in lung cancer
tRNA-derived fragments: mechanism of gene regulation and clinical application in lung cancer
Lung cancer, being the most widespread and lethal form of cancer globally, has a high incidence and mortality rate primari...
Osteopontin secreted from obese adipocytes enhances angiogenesis and promotes progression of pancreatic ductal adenocarcinoma in obesity
Osteopontin secreted from obese adipocytes enhances angiogenesis and promotes progression of pancreatic ductal adenocarcinoma in obesity
Obesity is a risk factor and poor prognostic factor for pancreatic ductal adenocarcinoma (PDAC), but the underlying mechan...
Vimentin promotes glioma progression and maintains glioma cell resistance to oxidative phosphorylation inhibition
Vimentin promotes glioma progression and maintains glioma cell resistance to oxidative phosphorylation inhibition
Glioma has been demonstrated as one of the most malignant intracranial tumors and currently there is no effective treatmen...
Integrative proteomics and n-glycoproteomics reveal the synergistic anti-tumor effects of aspirin- and gemcitabine-based chemotherapy on pancreatic cancer cells
Integrative proteomics and n-glycoproteomics reveal the synergistic anti-tumor effects of aspirin- and gemcitabine-based chemotherapy on pancreatic cancer cells
Pancreatic cancer is a highly malignant tumor that is well known for its poor prognosis. Based on glycosylation, we perfor...
Targeting PUF60 prevents tumor progression by retarding mRNA decay of oxidative phosphorylation in ovarian cancer
Targeting PUF60 prevents tumor progression by retarding mRNA decay of oxidative phosphorylation in ovarian cancer
Ovarian cancer (OC) is the leading cause of death from gynecological malignancies, and its etiology and pathogenesis are c...
Targeting ONECUT3 blocks glycolytic metabolism and potentiates anti-PD-1 therapy in pancreatic cancer
Targeting ONECUT3 blocks glycolytic metabolism and potentiates anti-PD-1 therapy in pancreatic cancer
Reprogramming glucose metabolism, also known as the Warburg effect (aerobic glycolysis), is a hallmark of cancers. Increas...
Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour
Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour
Retinoblastoma, a childhood cancer, is most frequently caused by bi-allelic inactivation of RB1 gene. However, other oncog...
Lactate score classification of hepatocellular carcinoma helps identify patients with tumors that respond to immune checkpoint blockade therapy
Lactate score classification of hepatocellular carcinoma helps identify patients with tumors that respond to immune checkpoint blockade therapy
Hepatocellular carcinoma (HCC) responds poorly to immunotherapy, and the durable response rate is 10-20%. Here, we aim to ...
CircGLIS3 inhibits thyroid cancer invasion and metastasis through miR-146b-3p/AIF1L axis
CircGLIS3 inhibits thyroid cancer invasion and metastasis through miR-146b-3p/AIF1L axis
Studies have shown that circRNA is involved in the occurrence and development of human cancers. However, it remains unclea...
Perineural invasion in colorectal cancer: mechanisms of action and clinical relevance
Perineural invasion in colorectal cancer: mechanisms of action and clinical relevance
In recent years, the significance of the nervous system in the tumor microenvironment has gained increasing attention. The...
Triggering pyroptosis enhances the antitumor efficacy of PARP inhibitors in prostate cancer
Triggering pyroptosis enhances the antitumor efficacy of PARP inhibitors in prostate cancer
PARP inhibitors have revolutionized the treatment landscape for advanced prostate cancer (PCa) patients who harboring muta...
Single-cell transcriptomic profiling reveals immune cell heterogeneity in acute myeloid leukaemia peripheral blood mononuclear cells after chemotherapy
Single-cell transcriptomic profiling reveals immune cell heterogeneity in acute myeloid leukaemia peripheral blood mononuclear cells after chemotherapy
Acute myeloid leukaemia (AML) is a heterogeneous disease characterised by the rapid clonal expansion of abnormally differe...
Prognostic significance of collagen signatures at breast tumor boundary obtained by combining multiphoton imaging and imaging analysis
Prognostic significance of collagen signatures at breast tumor boundary obtained by combining multiphoton imaging and imaging analysis
Collagen features in breast tumor microenvironment is closely associated with the prognosis of patients. We aim to explore...
Loss of RACK1 promotes glutamine addiction via activating AKT/mTOR/ASCT2 axis to facilitate tumor growth in gastric cancer
Loss of RACK1 promotes glutamine addiction via activating AKT/mTOR/ASCT2 axis to facilitate tumor growth in gastric cancer
Metabolic reprogramming is closely related to the development of gastric cancer (GC), which remains as the fourth leading ...
Immunosuppressive MFAP2+ cancer associated fibroblasts conferred unfavorable prognosis and therapeutic resistance in gastric cancer
Immunosuppressive MFAP2+ cancer associated fibroblasts conferred unfavorable prognosis and therapeutic resistance in gastric cancer
To explore the predictive merit of MFAP2+ cancer associated fibroblasts (CAFs) infiltration for clinical outcomes and adju...
Survivin degradation by bergenin overcomes pemetrexed resistance
Survivin degradation by bergenin overcomes pemetrexed resistance
Chemoresistance is a primary factor for treatment failure and tumor recurrence in non-small cell lung cancer (NSCLC) patie...
Correction to: CoQ10 reduces glioblastoma growth and infiltration through proteome remodeling and inhibition of angiogenesis and inflammation
Correction to: CoQ10 reduces glioblastoma growth and infiltration through proteome remodeling and inhibition of angiogenesis and inflammation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Crosstalk between long noncoding RNA and microRNA in Cancer
Crosstalk between long noncoding RNA and microRNA in Cancer
miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has b...
DNA 6mA demethylase ALKBH1 regulates DDX18 expression to promote proliferation of human head and neck squamous cell carcinoma
DNA 6mA demethylase ALKBH1 regulates DDX18 expression to promote proliferation of human head and neck squamous cell carcinoma
Human head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Currently, surgical res...
Induction of promyelocytic leukemia zinc finger protein by miR-200c-3p restores sensitivity to anti-androgen therapy in androgen-refractory prostate cancer and inhibits the cancer progression via down-regulation of integrin α3β4
Induction of promyelocytic leukemia zinc finger protein by miR-200c-3p restores sensitivity to anti-androgen therapy in androgen-refractory prostate cancer and inhibits the cancer progression via down-regulation of integrin α3β4
Androgen-refractory prostate cancer (ARPC) is one of the aggressive human cancers with metastatic capacity and resistance ...
ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer
ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer
Gemcitabine is the standard treatment for gallbladder cancer (GBC) patients, and the development of resistance frequently ...
Epigenetic modulation of ferroptosis in cancer: Identifying epigenetic targets for novel anticancer therapy
Epigenetic modulation of ferroptosis in cancer: Identifying epigenetic targets for novel anticancer therapy
Ferroptosis is a newly recognized form of oxidative-regulated cell death resulting from iron-mediated lipid peroxidation a...
Genomic analysis and filtration of novel prognostic biomarkers based on metabolic and immune subtypes in pancreatic cancer
Genomic analysis and filtration of novel prognostic biomarkers based on metabolic and immune subtypes in pancreatic cancer
Patients with pancreatic cancer (PC) can be classified into various molecular subtypes and benefit from some precise thera...
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