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IRE1α inhibitor enhances paclitaxel sensitivity of triple-negative breast cancer cells
IRE1α inhibitor enhances paclitaxel sensitivity of triple-negative breast cancer cells
Breast cancer is the most commonly diagnosed cancer in women, and triple-negative breast cancer (TNBC) accounts for approx...
Deciphering the molecular landscape: evolutionary progression from gynecomastia to aggressive male breast cancer
Deciphering the molecular landscape: evolutionary progression from gynecomastia to aggressive male breast cancer
Gynecomastia denotes the benign proliferation of glandular breast tissue and stands as a recognized risk factor for male b...
The PPP2R1A cancer hotspot mutant p.R183W increases clofarabine resistance in uterine serous carcinoma cells by a gain-of-function mechanism
The PPP2R1A cancer hotspot mutant p.R183W increases clofarabine resistance in uterine serous carcinoma cells by a gain-of-function mechanism
Uterine serous carcinoma (USC) is generally associated with poor prognosis due to a high recurrence rate and frequent trea...
Antitumor activity of afatinib in EGFR T790M-negative human oral cancer therapeutically targets mTOR/Mcl-1 signaling axis
Antitumor activity of afatinib in EGFR T790M-negative human oral cancer therapeutically targets mTOR/Mcl-1 signaling axis
This study investigates the role and effectiveness of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibito...
ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity
ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity
Tumor heterogeneity complicates patient treatment and can be due to transitioning of cancer cells across phenotypic cell s...
HVEM in acute lymphocytic leukemia facilitates tumour immune escape by inhibiting CD8+ T cell function
HVEM in acute lymphocytic leukemia facilitates tumour immune escape by inhibiting CD8+ T cell function
Leukaemia remains a major contributor to global mortality, representing a significant health risk for a substantial number...
OrganoIDNet: a deep learning tool for identification of therapeutic effects in PDAC organoid-PBMC co-cultures from time-resolved imaging data
OrganoIDNet: a deep learning tool for identification of therapeutic effects in PDAC organoid-PBMC co-cultures from time-resolved imaging data
Pancreatic Ductal Adenocarcinoma (PDAC) remains a challenging disease due to its complex biology and aggressive behavior w...
A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine
A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine
Cancer is a highly heterogeneous disease, and thus treatment responses vary greatly between patients. To improve therapy e...
Targeted gene delivery systems for T-cell engineering
Targeted gene delivery systems for T-cell engineering
T lymphocytes are indispensable for the host systems of defense against pathogens, tumors, and environmental threats. The ...
Deciphering fatty acid biosynthesis-driven molecular subtypes in pancreatic ductal adenocarcinoma with prognostic insights
Deciphering fatty acid biosynthesis-driven molecular subtypes in pancreatic ductal adenocarcinoma with prognostic insights
Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge due to its high heterogeneity and aggressiveness. Re...
Research advances in the molecular classification of gastric cancer
Research advances in the molecular classification of gastric cancer
Gastric cancer (GC) is a malignant tumor with one of the lowest five-year survival rates. Traditional first-line treatment...
LILRB2 promotes immune escape in breast cancer cells via enhanced HLA-A degradation
LILRB2 promotes immune escape in breast cancer cells via enhanced HLA-A degradation
Increased expression of leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is associated with immune eva...
Targeting Dectin-1 and or VISTA enhances anti-tumor immunity in melanoma but not colorectal cancer model
Targeting Dectin-1 and or VISTA enhances anti-tumor immunity in melanoma but not colorectal cancer model
Acquired resistance to immune checkpoint blockers (ICBs) is a major barrier in cancer treatment, emphasizing the need for ...
Chordoma cells possess bone-dissolving activity at the bone invasion front
Chordoma cells possess bone-dissolving activity at the bone invasion front
Chordomas are malignant tumors that destroy bones, compress surrounding nerve tissues and exhibit phenotypes that recapitu...
Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis
Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis
The overall survival rate for metastatic osteosarcoma hovers around 20%. Responses to second-line chemotherapy, targeted t...
The emerging role of CARM1 in cancer
The emerging role of CARM1 in cancer
Coactivator-associated arginine methyltransferase 1 (CARM1), pivotal for catalyzing arginine methylation of histone and no...
Establishment, characterization, and biobanking of 36 pancreatic cancer organoids: prediction of metastasis in resectable pancreatic cancer
Establishment, characterization, and biobanking of 36 pancreatic cancer organoids: prediction of metastasis in resectable pancreatic cancer
Early dissemination of primary pancreatic ductal adenocarcinoma (PDAC) is the main cause of dismal prognosis as it highly ...
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling
α2-adrenoceptor agonist dexmedetomidine (DEX) has been reported to promote tumorigenesis. Stem-cell protein Piwil2 is...
Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its rol...
Hedgehog ligand and receptor cooperatively regulate EGFR stability and activity in non-small cell lung cancer
Hedgehog ligand and receptor cooperatively regulate EGFR stability and activity in non-small cell lung cancer
The hyperactivation of epidermal growth factor receptor (EGFR) plays a crucial role in non-small cell lung cancer (NSCLC)....
Copy number signatures and CCNE1 amplification reveal the involvement of replication stress in high-grade endometrial tumors oncogenesis
Copy number signatures and CCNE1 amplification reveal the involvement of replication stress in high-grade endometrial tumors oncogenesis
Managing high-grade endometrial cancer in Martinique poses significant challenges. The diversity of copy number alteration...
DNA hypomethylation patterns and their impact on the tumor microenvironment in colorectal cancer
DNA hypomethylation patterns and their impact on the tumor microenvironment in colorectal cancer
Recent research underscores the pivotal role of immune checkpoints as biomarkers in colorectal cancer (CRC) therapy, highl...
The Ribonuclease ZC3H12A is required for self-inflicted DNA breaks after DNA damage in small cell lung cancer cells
The Ribonuclease ZC3H12A is required for self-inflicted DNA breaks after DNA damage in small cell lung cancer cells
Radiotherapy is the first line treatment for small cell lung cancer (SCLC); However, radio-resistance accompanies with the...
Multi-dimensional characterization of apoptosis in the tumor microenvironment and therapeutic relevance in melanoma
Multi-dimensional characterization of apoptosis in the tumor microenvironment and therapeutic relevance in melanoma
Melanoma is widely utilized as a prominent model for the development of immunotherapy, thought an inadequate immune respon...