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The LINC00152/miR-205-5p/CXCL11 axis in hepatocellular carcinoma cancer-associated fibroblasts affects cancer cell phenotypes and tumor growth
The LINC00152/miR-205-5p/CXCL11 axis in hepatocellular carcinoma cancer-associated fibroblasts affects cancer cell phenotypes and tumor growth
CXCL11 has been reported to be up-regulated in hepatocellular carcinoma (HCC) tissues and cancer-associated fibroblasts (C...
Correction to: Colorectal cancer organoid models uncover oxaliplatin-resistant mechanisms at single cell resolution
Correction to: Colorectal cancer organoid models uncover oxaliplatin-resistant mechanisms at single cell resolution
Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzh...
Tumour-derived exosomal lncRNA SNHG16 induces telocytes to promote metastasis of hepatocellular carcinoma via the miR-942-3p/MMP9 axis
Tumour-derived exosomal lncRNA SNHG16 induces telocytes to promote metastasis of hepatocellular carcinoma via the miR-942-3p/MMP9 axis
Hepatocellular carcinoma (HCC) cell-derived exosomal LncRNA SNHG16 is highly expressed and associated with poor overall su...
Single cell profiling of γδ hepatosplenic T-cell lymphoma unravels tumor cell heterogeneity associated with disease progression
Single cell profiling of γδ hepatosplenic T-cell lymphoma unravels tumor cell heterogeneity associated with disease progression
Hepatosplenic T-cell lymphoma (HSTCL), mostly derived from γδ T cells, is a rare but very aggressive lymphoma wi...
PD-1-CD28 fusion protein strengthens mesothelin-specific TRuC T cells in preclinical solid tumor models
PD-1-CD28 fusion protein strengthens mesothelin-specific TRuC T cells in preclinical solid tumor models
T cell receptor fusion constructs (TRuC) consist of an antibody-based single chain variable fragment (scFv) fused to a T c...
Immunosuppression, immune escape, and immunotherapy in pancreatic cancer: focused on the tumor microenvironment
Immunosuppression, immune escape, and immunotherapy in pancreatic cancer: focused on the tumor microenvironment
Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is characterized by poor treatment res...
PKMYT1 inhibits lung adenocarcinoma progression by abrogating AKT1 activity
PKMYT1 inhibits lung adenocarcinoma progression by abrogating AKT1 activity
AKT hyperactivation drives malignant phenotypes in lung cancer via promoting tumor cell proliferation and survival. Howeve...
TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells
TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells
TNFR2 expression is a characteristic of highly potent immunosuppressive tumor infiltrating CD4+Foxp3+ regulatory T cells (...
FUT8 is regulated by miR‐122‐5p and promotes malignancies in intrahepatic cholangiocarcinoma via PI3K/AKT signaling
FUT8 is regulated by miR‐122‐5p and promotes malignancies in intrahepatic cholangiocarcinoma via PI3K/AKT signaling
Intrahepatic cholangiocarcinoma (iCCA) is the second-most lethal primary liver cancer and its prognosis remains dismal. N-...
Role of nerves in neurofibromatosis type 1-related nervous system tumors
Role of nerves in neurofibromatosis type 1-related nervous system tumors
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that affects nearly 1 in 3000 infants. Neurofibro...
ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation
ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation
Integrin alpha 2 (ITGA2, also known as CD49b or VLA-2) is the alpha subunit of a transmembrane receptor for collagens and ...
CoQ10 reduces glioblastoma growth and infiltration through proteome remodeling and inhibition of angiogenesis and inflammation
CoQ10 reduces glioblastoma growth and infiltration through proteome remodeling and inhibition of angiogenesis and inflammation
Most monotherapies available against glioblastoma multiforme (GBM) target individual hallmarks of this aggressive brain tu...
DNASE1L3 inhibits hepatocellular carcinoma by delaying cell cycle progression through CDK2
DNASE1L3 inhibits hepatocellular carcinoma by delaying cell cycle progression through CDK2
Dysregulated cell cycle targeting is a well-established therapeutic strategy against hepatocellular carcinoma (HCC). Disse...
Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
Tumor microenvironment consists of various kind of cells, forming complex interactions and signal transductions for tumor ...
Research advances and treatment perspectives of pancreatic adenosquamous carcinoma
Research advances and treatment perspectives of pancreatic adenosquamous carcinoma
As a malignant tumor, pancreatic cancer has an extremely low overall 5-year survival rate. Pancreatic adenosquamous carcin...
Distinct expression and function of breast cancer metastasis suppressor 1 in mutant P53 glioblastoma
Distinct expression and function of breast cancer metastasis suppressor 1 in mutant P53 glioblastoma
Glioblastoma (GBM) is the most malignant subtype of astrocytic tumors with the worst prognosis in all its progressive form...
Novel preclinical gastroenteropancreatic neuroendocrine neoplasia models demonstrate the feasibility of mutation-based targeted therapy
Novel preclinical gastroenteropancreatic neuroendocrine neoplasia models demonstrate the feasibility of mutation-based targeted therapy
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) form a rare and remarkably heterogeneous group of tumors. Theref...
Distinct tumor microenvironment landscapes of rectal cancer for prognosis and prediction of immunotherapy response
Distinct tumor microenvironment landscapes of rectal cancer for prognosis and prediction of immunotherapy response
Tumor microenvironment (TME) affects the progression of rectal cancer (RC), and the clinical relevance of its immune eleme...
Correction to: YAP1 acts as a negative regulator of pro-tumor TAZ expression in esophageal squamous cell carcinoma
Correction to: YAP1 acts as a negative regulator of pro-tumor TAZ expression in esophageal squamous cell carcinoma
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which ...
Blockade of USP14 potentiates type I interferon signaling and radiation-induced antitumor immunity via preventing IRF3 deubiquitination
Blockade of USP14 potentiates type I interferon signaling and radiation-induced antitumor immunity via preventing IRF3 deubiquitination
The adaptive immune responses induced by radiotherapy has been demonstrated to largely rely on STING-dependent type I inte...
Comparative oncology reveals DNMT3B as a molecular vulnerability in undifferentiated pleomorphic sarcoma
Comparative oncology reveals DNMT3B as a molecular vulnerability in undifferentiated pleomorphic sarcoma
Undifferentiated pleomorphic sarcoma (UPS), an aggressive subtype of soft-tissue sarcoma (STS), is exceedingly rare in hum...
OSW-1 induces apoptosis and cyto-protective autophagy, and synergizes with chemotherapy on triple negative breast cancer metastasis
OSW-1 induces apoptosis and cyto-protective autophagy, and synergizes with chemotherapy on triple negative breast cancer metastasis
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer. As yet, chemotherapy with drugs such ...